Where to buy Methylphenidate for sale online

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Methylphenidate, a central nervous system stimulant commonly prescribed for attention deficit hyperactivity disorder (ADHD), has unfortunately become a target for illicit online sellers peddling it as a “research chemical.” This practice raises significant concerns regarding such transactions’ safety, ethics, and legality.
First and foremost, the online sale of Methylphenidate as a research chemical raises red flags about the legitimacy and authenticity of the product. While there may be some legitimate research purposes for studying this compound, the vast majority of online sellers selling it need more scientific oversight and infrastructure to ensure the quality and purity of the substance. This puts unsuspecting buyers at risk of receiving impure or counterfeit products, which could have serious health consequences.
Furthermore, the marketing of Methylphenidate as a “designer drug” or “research chemical” exploits a legal loophole, as these substances are often not subject to the same regulations as prescription medications. This undermines public health and contributes to the rise of substance misuse and abuse, as these compounds are readily available to individuals with no legitimate research intentions.
The online vendors who engage in such practices prioritize profit over the well-being of their customers, capitalizing on the desire for easy access to psychoactive substances. This unethical behavior endangers the health of those who buy these products and adds to the burden on healthcare systems and addiction treatment programs.

Summary

Methylphenidate, known by various names such as MPH, MPD, Ritalin, Concerta, and Methylin, belongs to the classical stimulant category within the phenidate class. Within this family of stimulants, one can find related compounds like ethylphenidate and isopropylphenidate. The primary mode of action of Methylphenidate involves elevating the levels of neurotransmitters dopamine and norepinephrine in the brain.

This substance was initially synthesized in 1944 and gained approval for medical use in the United States in 1955. The Swiss company CIBA, which has since become Novartis, was the original distributor. Methylphenidate is primarily sanctioned for the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Notably, it is also employed by students, both with and without ADHD, as a cognitive enhancer and study aid.

The subjective effects attributed to Methylphenidate encompass stimulation, improved focus, enhanced motivation, heightened libido, reduced appetite, and feelings of euphoria. Typically administered orally, it can also be taken through insufflation or rectal administration. Its effects are often likened to those of amphetamine, albeit with less pronounced euphoria and generally lower recreational value. Some users additionally report a more pronounced comedown compared to amphetamine.

Methylphenidate does pose a moderate risk of abuse. Prolonged use, characterized by high doses and repeated administration, can lead to compulsive redosing, escalating tolerance, and psychological dependence. Therefore, responsible use and the implementation of harm reduction strategies are strongly recommended for individuals considering the use of this substance.

Identifiers
showIUPAC name
CAS Number20748-11-2 
PubChem CID4158
IUPHAR/BPS7236
DrugBankDB00422 
ChemSpider4015 
UNII207ZZ9QZ49
KEGGD04999 
ChEBICHEBI:6887 
ChEMBLChEMBL796 
CompTox Dashboard (EPA)DTXSID5023299 
ECHA InfoCard100.003.662 
Chemical and physical data
FormulaC14H19NO2
Molar mass233.311 g·mol−1

History and culture

Methylphenidate received its first approval from the U.S. Food and Drug Administration (FDA) back in 1955, primarily intended for the treatment of a condition then referred to as “hyperactivity.” Although it was prescribed to patients as early as the 1960s, its widespread use only gained momentum in the 1990s, coinciding with the broader recognition and acceptance of ADHD as a legitimate medical diagnosis.
In 2013, there was a notable surge in the global consumption of methylphenidate, with an estimated 66% increase compared to the previous year, reflecting a growing reliance on this medication. By 2019, it had secured a position as the 51st most frequently prescribed medicine in the United States, with over 14 million prescriptions written annually. Notably, generic versions of this medication are readily available, contributing to its accessibility and widespread use.

Chemistry

Methylphenidate belongs to the synthetic molecules falling within the substituted phenethylamine and substituted phenidate classes. Its chemical structure comprises a phenethylamine core characterized by a phenyl ring linked to an amino (-NH2) group via an ethyl chain.
Structurally akin to amphetamine, Methylphenidate features a substitution at the Rα position, forming a piperidine ring culminating at the terminal amine of the phenethylamine chain. Additionally, it incorporates a methyl acetate group bound to its Rβ place.
Within chiral compounds, Methylphenidate is presumed to exist as a racemic mixture. However, an enantiopure variant is also accessible as a pharmaceutical product; this dextrorotary enantiopure form is commonly known as “dexmethylphenidate” and is frequently marketed under the names Focalin and Focalin XR.
Considering the two chiral centers within its structure, Methylphenidate presents the possibility of four isomers. Among these, d-three-methylphenidate predominantly manifests the pharmacologically desired effects. Notably, the erythro diastereomers possess pressor amine properties, distinguishing them from the threo diastereomers. Initially, the drug was available as a 4:1 mixture of erythro:threo diastereomers, but it was subsequently reformulated to consist exclusively of the threo diastereomers. “TMP” denotes a three-product devoid of any erythro diastereomers, specifically (±)-three-methylphenidate. Since the three isomers are energetically favored, removing undesired erythro isomers is straightforward.
The variant containing solely dextrorotatory Methylphenidate is occasionally referred to as d-TMP, although this terminology is infrequent. It is more commonly recognized as dexmethylphenidate, d-MPH, or d-three-methylphenidate. A comprehensive synthesis review of enantiomerically pure (2R,2’R)-(+)-three-methylphenidate hydrochloride has been published.

Pharmacology

Methylphenidate primarily functions as a norepinephrine-dopamine reuptake inhibitor (NDRI), with its primary impact centered on dopamine modulation and, to a lesser degree, norepinephrine regulation. This action occurs by binding to and obstructing dopamine and norepinephrine transporters.
It is essential to recognize that while amphetamine and Methylphenidate have dopaminergic properties, their mechanisms of action differ somewhat. Specifically, Methylphenidate serves as a dopamine reuptake inhibitor, whereas amphetamine acts as both a releasing agent and a reuptake inhibitor for dopamine and norepinephrine. It is worth noting that the influence of these drugs on norepinephrine is relatively less potent than their effects on dopamine.
The precise mechanism by which Methylphenidate affects dopamine-norepinephrine release remains controversial. However, it deviates fundamentally from the majority of other phenethylamine derivatives. Methylphenidate is believed to augment the general firing rate, while amphetamine diminishes the firing rate and alters the monoamine flow via TAAR1 activation, representing a distinctive contrast in their modes of action.

Subjective effects

Disclaimer: The following effects are derived from the Subjective Effect Index (SEI), a research literature based on anecdotal user accounts and personal analyses conducted by contributors to PsychonautWiki. Therefore, they should be approached with a degree of caution.

Understanding that these effects may not manifest predictably or consistently, with higher doses more likely to encompass the complete spectrum of products, is essential. Adverse effects become more probable at elevated amounts and can contain addiction, severe harm, or even fatality ☠.

Physical:

  • Stimulation: Methylphenidate typically imparts an energetic and stimulating sensation, though milder compared to amphetamine or methamphetamine and more robust than that of modafinil and caffeine. Lower to moderate doses promote general productivity, while higher doses may encourage physical activities like dancing, socializing, running, or cleaning. This stimulation can be characterized as “forced,” leading to difficulty remaining still, jaw clenching, involuntary bodily shakes, vibrations, extreme body shaking, unsteady hands, and reduced motor control.
  • Increased heart rate
  • Irregular heartbeat
  • Dehydration
  • Frequent urination
  • Dry mouth
  • Appetite suppression
  • Increased perspiration
  • Nausea (more likely at higher doses, tends to diminish quickly)
  • Dizziness (more likely at higher doses, tends to diminish quickly)
  • Teeth grinding (more common at higher doses but less pronounced than with other stimulants like amphetamine or MDMA)
  • Vasoconstriction
  • Increased libido (not as intense or reliable as amphetamines or cocaine, especially at higher doses)
  • Pupil dilation

Cognitive:

  • Anxiety (slightly more frequent than with other common stimulants like amphetamine or cocaine)
  • Cognitive euphoria (milder than other stimulants, may occur at higher or non-oral doses)
  • Ego inflation
  • Emotion suppression (most intense at light and typical doses, often associated with medical usage rather than recreational)
  • Derealization (common at moderate/high doses)
  • Focus enhancement (most effective at low to moderate doses; higher doses can impair concentration)
  • Wakefulness
  • Memory enhancement (therapeutic doses improve working memory in both standard and ADHD individuals)
  • Time distortion (perception of time speeding up)
  • Thought acceleration
  • Thought organization
  • Analysis enhancement
  • Motivation enhancement
  • Suggestibility suppression
  • Increased music appreciation (milder compared to amphetamine or cocaine, more prominent at higher doses)
  • Compulsive redosing (reported but less frequent than with other common stimulants, usually at high or non-oral doses)

After: 

The after-effects during the decline of a stimulant experience are generally negative and uncomfortable compared to the peak effects. This is often called a “comedown” and results from neurotransmitter depletion. Common after-effects include:

  • Anxiety
  • Cognitive fatigue
  • Depression
  • Irritability
  • Motivation suppression
  • Increased heart rate
  • Thought deceleration
  • Wakefulness

Compared to other stimulants like amphetamine and caffeine, methylphenidate exhibits more pronounced after-effects akin to MDMA.

Toxicity

A toxic dose of Methylphenidate is considered to be more than 2 mg/kg or 60 mg of an immediate-release formulation or more than 4 mg/kg or 120 mg of an intact extended-release formulation. In most cases in one study, methylphenidate overdose was asymptomatic or characterized by minor symptoms, even in children under age 6.

However, a significant amount of patients (31%) in the study developed symptoms typical of stimulant overdose, most commonly tachycardia, agitation, and paradoxically lethargy. In the 2012 National Poison Data System report, methylphenidate exposure was reported 9,787 times, with 1,609 reporting no adverse effects, 1,009 reporting mild effects, 662 reporting moderate effects, 33 reporting significant symptoms, and no cases resulting in death.

It is strongly advised to use harm reduction practices if using this substance.

Dependence and abuse potential

In terms of its tolerance, Methylphenidate can be used multiple days in a row for extended periods and is often prescribed to be used in this way. Tolerance to many of the effects of Methylphenidate develops with prolonged and repeated use. Users have to administer increasingly large doses to achieve the same impact.

In the case of acute (i.e., one-off) exposure, it generally takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). Methylphenidate presents cross-tolerance with all dopaminergic stimulants, meaning that after consuming Methylphenidate, all stimulants will have a reduced effect.”

As with other stimulants, the chronic use of Methylphenidate can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Methylphenidate has some potential for abuse due to its action on dopamine transporters. Methylphenidate, like other stimulants, increases dopamine levels in the brain. However, at therapeutic doses, this increase is slow, and thus, euphoria only rarely occurs, even when it is administered intravenously. The abuse and addiction potential of Methylphenidate is, therefore, significantly lower than other dopaminergic stimulants.

The abuse potential is increased when Methylphenidate is crushed and insufflated (snorted) or injected. It should be noted that due to the fillers in the pill, however, this can harm the nasal cavities, and intravenous use can cause emphysema (a lower respiratory tract disease, aka Ritalin lung, when caused by Ritalin tablets). The intravenous use of Methylphenidate, commonly marketed as Ritalin and widely used as a stimulant in treating attention deficit hyperactivity disorder, can lead to emphysematous changes known as Ritalin lung.

. The primary source of Methylphenidate for abuse is the diversion from legitimate prescriptions rather than illicit synthesis. Those who use Methylphenidate medicinally generally take it orally as instructed, while intranasal and intravenous are the preferred means for recreational use. [26]

Psychosis

Main article: Stimulant psychosis

Chronic use (i.e., high dose, repeat dosing) may increase the risk of psychosis. The safety profile of short-term methylphenidate therapy has been well-established, with short-term clinical trials revealing a very low incidence (0.1%) of methylphenidate-induced psychosis at therapeutic dose levels.

Psychotic symptoms from Methylphenidate can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, disinhibition, paranoid and grandiose delusions, confusion, emotional suppression, increased aggression, and irritability.

Combination with alcohol

Methylphenidate (when taken orally) has a low bioavailability, around 30%. Suppose taken with alcohol (ethanol), blood plasma levels of dexmethylphenidate increase by up to 40%. A metabolite called ethylphenidate is also formed.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use alone can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g., Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • 25x-NBOMe & 25x-NBOH – 25x compounds are highly stimulating and physically straining. Combinations with Methylphenidate should be strictly avoided due to excessive stimulation and heart strain risk. In extreme cases, this can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure.
  • Alcohol – Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol’s depressant effects, which most people use to assess their degree of intoxication. Once the motivation wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, users should strictly limit themselves to only drinking a certain amount of alcohol per hour.
  • DXM – Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks, hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
  • MDMA – Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. Excess blood pressure and heart strain (cardiotoxicity) are also risks.
  • MXE – Some reports suggest that combinations with MXE may dangerously increase blood pressure and the risk of mania and psychosis.
  • Dissociatives – Both classes risk delusions, mania, and psychosis, and these risks may be multiplied when combined.
  • Stimulants – Methylphenidate may be dangerous to combine with other stimulants like cocaine as they can increase one’s heart rate and blood pressure to dangerous levels.
  • Tramadol – Tramadol is known to lower the seizure threshold[31], and combinations with stimulants may further increase this risk.
  • MDMA – The neurotoxic effects of MDMA may be increased when combined with other stimulants.
  • MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include Syrian rue, banisteriopsis caapi, and some antidepressants.

Legal status

Internationally, methylphenidate is subject to various legal classifications:

Australia: Methylphenidate is categorized as a ‘Schedule 8’ controlled substance. These substances must be securely stored and can only be dispensed with a prescription. Possession without a prescription carries substantial fines and possible imprisonment.

Austria: Methylphenidate is permitted for medical use under the AMG (Arzneimittelgesetz Österreich) but is illegal when sold or possessed without a prescription, as per the SMG (Suchtmittelgesetz Österreich).

Canada: Methylphenidate is listed in Schedule III of the Controlled Drugs and Substances Act, placing it in the same category as LSD, psychedelic mushrooms, and mescaline. Possessing without a prescription under Part G (section G.01.002) of the Food and Drug Regulations as outlined in the Food and Drugs Act is unlawful.

Germany: Methylphenidate is classified as a controlled substance under Anlage III of the BtMG. It can only be prescribed on a narcotic prescription form.

New Zealand: Methylphenidate is classified as a ‘Class B2 controlled substance.’ Unauthorized possession can result in a six-month prison sentence, while distribution is punishable by a 14-year sentence.

Sweden: Methylphenidate is designated a List II controlled substance with recognized medical utility. Possession without a prescription may lead to up to three years of imprisonment.

Switzerland: Methylphenidate is explicitly named as a controlled substance under Verzeichnis A. Medicinal use is permitted.

Turkey: Methylphenidate is available only with a ‘red prescription’ and is illegal to sell or possess without a prescription.

United Kingdom: Methylphenidate is categorized as a controlled ‘Class B’ substance. Possession without a prescription can result in a sentence of up to 5 years and an unlimited fine, while supplying it may lead to 14 years and an unlimited fine.

United States: Methylphenidate is classified as a Schedule II controlled substance, applied to substances with recognized medical value but a high potential for abuse.

It’s important to note that the belief that methylphenidate can yield false-positive results for amphetamines in drug screenings is a widespread misconception. Extensive laboratory studies have found no immunoassay cross-reactivity, debunking this myth.

FAQ

1. What is Methylphenidate? 

Methylphenidate is commonly prescribed to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy. It belongs to the class of drugs known as central nervous system (CNS) stimulants.

2. How does Methylphenidate work? 

Methylphenidate primarily works by increasing the levels of certain neurotransmitters, specifically dopamine and norepinephrine, in the brain. This helps improve focus, attention, and impulse control in individuals with ADHD.

3. What are the common brand names for Methylphenidate? 

Methylphenidate is available under various brand names, including Ritalin, Concerta, Metadate, Daytrana, and Quillivant XR.

4. What are the common uses for Methylphenidate? 

Methylphenidate is primarily prescribed for ADHD and narcolepsy. It helps manage the symptoms of these conditions, such as inattention, hyperactivity, and impulsivity.

5. Is Methylphenidate safe to use? 

Methylphenidate is generally considered safe when used as prescribed by a healthcare professional. However, like all medications, it can have side effects, and a healthcare provider should closely monitor its use.

6. What are the potential side effects of Methylphenidate? 

Common side effects of Methylphenidate may include insomnia, loss of appetite, nervousness, stomach upset, and increased heart rate. It’s essential to discuss any side effects with your healthcare provider.

7. Can Methylphenidate be abused or addictive? 

Yes, Methylphenidate has a potential for abuse and addiction, mainly when not used as prescribed. It is classified as a Schedule II controlled substance in the United States due to its abuse potential.

8. How should Methylphenidate be taken? 

Methylphenidate is typically taken orally in the form of tablets or capsules. Follow your healthcare provider’s instructions carefully regarding dosing and timing. Only crush or break extended-release records with approval from your doctor.

9. Can Methylphenidate be used by children and adults? 

Yes, Methylphenidate is approved for use in children and adults, depending on the diagnosis and the healthcare provider’s recommendations.

10. Are there any drug interactions with Methylphenidate? 

Methylphenidate can interact with certain medications, including monoamine oxidase inhibitors (MAOIs), and should not be taken with them. Always inform your healthcare provider of all your drugs and supplements to avoid potential interactions.

11. Can Methylphenidate be stopped suddenly? 

It is generally not recommended to stop Methylphenidate abruptly, especially if you have been taking it for an extended period. Consult your healthcare provider to discuss the best way to discontinue the medication.

12. Is it safe to drive or operate machinery while taking Methylphenidate? 

Methylphenidate can affect your alertness and coordination, so assessing how it affects you personally before driving or operating heavy machinery is crucial. Your healthcare provider can offer guidance based on your specific situation.

13. Can Methylphenidate be used for purposes other than ADHD or narcolepsy? 

Using Methylphenidate for non-medical or recreational purposes is illegal and unsafe. It can lead to serious health consequences and legal issues.

14. Is Methylphenidate available over-the-counter (OTC)? 

No, Methylphenidate is not available without a prescription from a licensed healthcare provider. It is a controlled substance due to its potential for abuse. 

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  39. KIRMIZI REÇETEYE TABİ İLAÇLAR
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  41. Breindahl, Torben; Hindersson, Peter (2012). “Methylphenidate is Distinguished from Amphetamine in Drug-of-Abuse Testing”. Journal of Analytical Toxicology. 36 (7): 538–539. doi:10.1093/jat/bks056. ISSN 0146-4760.

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