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# Best Research Chem Stores Review

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- [Mephedrene Online Market Overview 2026: Trends, Legality & Safety Insights](https://researchem.net/mephedrene-online-market-overview/) - Summary 5-Methylmethiopropamine, also known as 5-MMPA or mephedrene, is a stimulant substance that represents a ring-substituted variant of methiopropamine. Unlike mephedrone, it is not a substituted cathinone derivative, as it lacks a ketone group at the β position of the aliphatic side chain. Instead, its chemical structure bears a closer resemblance to substituted amphetamines. This
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- [JWH-251](https://researchem.net/jwh-251/) - Summary JWH-251, scientifically referred to as 1-pentyl-3-(2-methylphenylacetyl)indole, belongs to the phenylacetylindole family, characterized as a synthetic cannabinoid. It acts as a cannabinoid agonist, exhibiting approximately five times more selectivity for CB1 receptors, with a Ki of 29 nM, compared to CB2 receptors, with a Ki of 146 nM. Similar to its counterparts, such as the
- [JWH-250](https://researchem.net/jwh-250/) - Summary JWH-250, scientifically known as 1-pentyl-3-(2-methoxyphenylacetyl)indole, is a member of the phenylacetylindole family recognized for its analgesic properties. This chemical compound operates as a cannabinoid agonist, engaging with CB1 and CB2 receptors, featuring a Ki of approximately 11 nM at CB1 and 33 nM at CB2. It's noteworthy that JWH-250 distinguishes itself from many older
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- [JWH-167](https://researchem.net/jwh-167/) - Summary JWH-167, also known as 1-pentyl-3-(phenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. This compound acts as a cannabinoid agonist with approximately 1.75 times higher selectivity for CB1 receptors, exhibiting a Ki of about 90 nM ± 17 and around 159 nM ± 14 at CB2 receptors. Notably, JWH-167 shares structural similarities with
- [NM-2201](https://researchem.net/nm-2201/) - Summary NM-2201, alternatively recognized as CBL-2201, belongs to the family of indole-based synthetic cannabinoids. It is theorized to exhibit analogous characteristics to its closely related counterparts, 5F-PB-22 and NNE1. These compounds are categorized as full agonists, demonstrating an indiscriminate binding affinity to CB1 and CB2 receptors at a low nanomolar level. Pharmacology NM-2201 functions as
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- [JWH-424](https://researchem.net/jwh-424/) - Summary JWH-424 is a member of the naphthoylindole family, characterized by its role as a cannabinoid agonist targeting both the CB1 and CB2 receptors. However, it demonstrates moderate selectivity for the CB2 receptor, with a Ki value of 5.44nM at CB2 in contrast to 20.9 nM at CB1. The heavier 8-iodo analog of this compound
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- [JWH-200](https://researchem.net/jwh-200/) - Summary JWH-200, also known as WIN 55,225, is a member of the aminoalkylindole family, functioning as an analgesic compound with cannabinoid receptor agonist properties. This chemical exhibits a binding affinity, denoted as Ki, of 42 nM at the CB1 receptor, a level of relationship similar to that of THC. Notably, in vivo studies revealed that
- [JWH-198](https://researchem.net/jwh-198/) - Summary JWH-198 is a medication hailing from both the aminoalkyl indole and naphthoylindole drug families, and it functions as a cannabinoid receptor agonist. This compound was initially developed by the pharmaceutical company Sanofi-Winthrop during the early 1990s. JWH-198 exhibits a notable binding affinity for the CB1 receptor, measuring at 10 nM, approximately four times stronger
- [JWH-210](https://researchem.net/jwh-210/) - Summary JWH-210, a member of the naphthoylindole family, is a potent analgesic compound. It is a robust cannabinoid agonist, acting on CB1 and CB2 receptors. It demonstrates a remarkable binding affinity with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. Notably, JWH-210 ranks among the most potent 4-substituted naphthoyl derivatives within
- [JWH-149](https://researchem.net/jwh-149/) - Summary JWH-149, a synthetic cannabimimetic compound, was initially identified by John W. Huffman. This substance is the N-pentyl analog of JWH-148. Notably, it demonstrates significant binding affinity for the CB2 receptor, with a Ki (inhibition constant) of approximately 0.73 ± 0.03 nM for this subtype. Additionally, it exhibits more than six times selectivity for CB2
- [JWH-122](https://researchem.net/jwh-122/) - Summary JWH-122, a synthetic cannabimimetic compound, was first identified by John W. Huffman. This compound is a methylated derivative of JWH-018 and exhibits a Ki of 0.69 nM at CB1 and 1.2 nM at CB2 receptors.In January 2015, a concerning incident occurred when more than 40 individuals reportedly fell ill after consuming Rosca de Reyes,
- [JWH-116](https://researchem.net/jwh-116/) - Summary JWH-116, a member of the naphthoylindole family, is a synthetic ligand that interacts with cannabinoid receptors. It represents the indole 2-ethyl variant of its closely related compound, JWH-018. JWH-116 exhibits a binding affinity for the CB1 receptor with a reported Ki value of approximately 52 ± 5 nM.In the United States, JWH-116, like other
- [JWH-098](https://researchem.net/jwh-098/) - Summary JWH-098 belongs to the naphthoylindole family and is classified as a synthetic cannabinoid receptor agonist. It represents the indole 2-methyl variant of a closely related compound, JWH-081. Notably, JWH-098 exhibits distinctive binding preferences for the CB1 and CB2 receptors compared to JWH-081. While JWH-081 displays approximately tenfold selectivity for CB1 over CB2, JWH-098 reverses
- [JWH-081](https://researchem.net/jwh-081/) - Summary JWH-081, a member of the naphthoylindole family, is an analgesic compound that functions as a cannabinoid agonist, affecting both CB1 and CB2 receptors. It exhibits a degree of selectivity for the CB1 subtype, with a Ki of 1.2nM, making its affinity for CB1 approximately 10 times greater than its affinity for CB2 (12.4nM). This
- [JWH-073](https://researchem.net/jwh-073/) - Summary WH-073, a synthetic cannabinoid, is a member of the naphthoylindole family known for its analgesic properties. It functions as a partial agonist at both the CB1 and CB2 cannabinoid receptors, displaying a degree of selectivity for the CB1 subtype, with approximately 5 times the affinity for CB1 compared to CB2. The abbreviation "JWH" represents
- [JWH-019](https://researchem.net/jwh-019/) - Summary JWH-019, a member of the naphthoylindole family, is recognized as an analgesic compound acting as a cannabinoid agonist at both CB1 and CB2 receptors. Notably, it is the N-hexyl homolog of the known synthetic cannabinoid JWH-018. In contrast to the butyl homolog, JWH-073, which exhibits significantly lower potency than JWH-018, the hexyl homolog, JWH-019,
- [JWH-015](https://researchem.net/jwh-015/) - Summary JWH-015, a member of the naphthoylindole family, functions as a cannabinoid agonist with subtype selectivity. Notably, it exhibits a high affinity for CB2 receptors, with a binding relationship of 13.8 nM, while its affinity for CB1 receptors is notably lower at 383 nM. This results in JWH-015 binding nearly 28 times more strongly to
- [JWH-007](https://researchem.net/jwh-007/) - Summary JWH-007, a member of the naphthoylindole family, is a chemical compound primarily recognized for its analgesic properties. It functions as a cannabinoid agonist, engaging both CB1 and CB2 receptors. This compound was initially documented in 1994, and its discovery is attributed to a group led by the renowned cannabinoid chemist John W. Huffman.This compound
- [FUB-JWH-018](https://researchem.net/fub-jwh-018/) - Summary FUB-JWH-018, sometimes referred to as FUB-018, is a synthetic cannabinoid derived from naphthoylindole. It can be described as a molecular hybrid, combining elements of JWH-018 and AB-FUBICA or ADB-FUBICA. Legal status In the United States, substances that activate CB1 receptors in the 3-(1-naphthyl)indole class, like FUB-JWH-018, are classified as Schedule I Controlled Substances. Furthermore,
- [EAM-2201](https://researchem.net/eam-2201/) - Summary EAM-2201, also known as 4'-ethyl-AM-2201, 5"-fluoro-JWH-210, or SGT-14, is a substance believed to function as a potent agonist for cannabinoid receptors. This compound was not documented in scientific or patent literature until Japanese laboratories initially detected it in July 2012 as an ingredient in synthetic cannabis smoking mixtures. Much like its closely related counterpart,
- [AM-2232](https://researchem.net/am-2232/) - Summary AM-2232, known chemically as 1-4-cyclobutyl)-3-(naphthalene-1-oyl)indole, is a potent yet non-specific agonist for cannabinoid receptors. It exhibits a Ki of 0.28 nM at CB1 and 1.48 nM at CB2, indicating its affinity for these receptor types.In the United States, all CB1 receptor agonists belonging to the 3-(1-naphthyl)indole class, including AM-2232, are classified as Schedule I
- [AM-1235](https://researchem.net/am-1235/) - Summary AM-1235, also known as 1-(5-fluorophenyl)-3-(naphthalene-1-oyl)-6-nitroindole, is a potent and moderately selective agonist targeting the cannabinoid receptor CB1. Pharmacology Pharmacodynamics AM-1235 functions as a cannabinoid receptor agonist, with a Ki value of 1.5 nM at CB1 and 20.4 nM at CB2 receptors. A 6-nitro substitution on the indole ring reduces the affinity for both CB1
- [AM-1221](https://researchem.net/am-1221/) - Summary AM-1221 is a potent and selective agonist that primarily targets the cannabinoid receptor CB2, exhibiting a remarkable Ki of 0.28 nM at CB2 and 52.3 Nm at CB1. This translates to an approximately 180-fold preference for CB2 over CB1. The presence of both 2-methyl and 6-nitro groups on the indole ring contributes to enhanced
- [AM-1220](https://researchem.net/am-1220/) - Summary AM-1220 is recognized for its potent and moderately selective agonistic effects on the cannabinoid receptor CB1, demonstrating approximately 19-fold selectivity for CB1 compared to the related CB2 receptor. This compound initially emerged in the early 1990s as a creation by a team led by Thomas D'Ambra at Sterling Winthrop. In the subsequent years, AM-1220
- [AM-1248](https://researchem.net/am-1248/) - Summary AM-1248 is a compound with disputed potency and selectivity, acting as a moderately potent agonist for both cannabinoid receptors CB1 and CB2. When the typical 3-(1-naphthyl) group found in many indole-derived cannabinoid ligands is replaced with an adamantyl group, it often imparts significant CB2 selectivity. However, by incorporating an N-methylpiperidin-2-ylmethyl substitution at the indole
- [AB-001](https://researchem.net/ab-001/) - Summary AB-001, also known as 1-pentyl-3-(1-adamantyl)indole, is a designer drug that emerged as an ingredient in synthetic cannabis smoking blends in 2010 in Ireland and 2011 in Hungary and Germany. The original developer of AB-001 remains uncertain; however, it shares structural similarities with compounds like AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are recognized as
- [RCS-4](https://researchem.net/rcs-4/) - Summary RCS-4, also known as 1-pentyl-3-(4-methoxybenzoyl)indole, is a synthetic cannabinoid compound that has been marketed and sold under various names, including SR-19, BTM-4, Eric-4 (later abbreviated to E-4), and initially, OBT-199. Pharmacology RCS-4, a potent agonist for cannabinoid receptors, exhibits EC50 values of 146 nM for human CB1 receptors and 46 nM for human CB2
- [AM-2233](https://researchem.net/am-2233/) - Summary AM-2233 is a pharmaceutical compound recognized for its exceptional role as a potent full agonist for cannabinoid receptors. Specifically, the (R) enantiomer of AM-2233 exhibits a remarkable Ki of 1.8 nM at CB1 and 2.2 nM at CB2, underscoring its potent activity at these receptors.One of its primary purposes is as a selective radioligand
- [AM-1241](https://researchem.net/am-1241/) - Summary AM-1241, also known as 1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole, is a member of the aminoalkylindole family, recognized for its role as a potent and highly selective agonist for the cannabinoid receptor CB2. With a remarkable Ki value of 3.4 nM at CB2, it exhibits substantial selectivity, being approximately 80 times more selective for CB2 compared to the related
- [AM-694](https://researchem.net/am-694/) - Summary AM-694, known chemically as 1-(5-fluorophenyl)-3-(2-iodobenzoyl)indole, functions as a designer drug with a specific role as a potent and selective agonist for the cannabinoid receptor CB1. This compound is frequently utilized in scientific research to map the distribution of CB1 receptors within the body. Pharmacology AM-694 acts as an agonist for cannabinoid receptors, demonstrating remarkable
- [AM-679 (cannabinoid)](https://researchem.net/am-679-cannabinoid/) - Summary AM-679, a member of the AM cannabinoid series, is a moderately potent agonist for cannabinoid receptors. It exhibits a Ki of 13.5 nM at CB1 and 49.5 nM at CB2, signifying its affinity for these receptors. Notably, AM-679 was among the pioneering 3-(2-iodobenzoyl)indole derivatives to display a noteworthy affinity for cannabinoid receptors. While AM-679
- [AM-630](https://researchem.net/am-630/) - Summary AM-630, or 6-Iodopravadoline, is a potent and highly selective inverse agonist targeting the cannabinoid receptor CB2. It exhibits a remarkable affinity for CB2, boasting a Ki value of 32.1 nM, while showing a notable 165-fold selectivity over CB1 receptors, where it only exhibits weak partial agonist activity. Researchers employ AM-630 to investigate CB2-mediated responses,
- [FUB-PB-22](https://researchem.net/fub-pb-22/) - Summary FUB-PB-22, or QUFUBIC, is a synthetic cannabinoid rooted in the indole structure. It exhibits potent agonistic activity on the CB1 receptor and has been made available for purchase on the internet as a designer drug. Pharmacology FUB-PB-22 functions as a complete agonist, demonstrating exceptional binding affinity with a mere 0.386nM at CB1 and 0.478nM
- [FDU-PB-22](https://researchem.net/fdu-pb-22/) - Summary FDU-PB-22 is a chemical compound believed to be a highly active stimulant of the CB1 receptor, derived from JWH-018, and has been distributed over the internet as a synthetic designer drug. Pharmacology FDU-PB-22 functions as a complete agonist, exhibiting a binding affinity of 1.19nM at CB1 and 2.43nM at CB2 cannabinoid receptors. Legal status
- [QUCHIC](https://researchem.net/quchic/) - Summary QUCHIC (also known as BB-22, SGT-32, or 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a synthetic designer drug available through online vendors, marketed as a cannabimimetic agent. It initially surfaced in the artificial cannabis market in Japan in early 2013 and subsequently made its way to New Zealand.QUCHIC's structural composition suggests a comprehensive understanding of structure-activity
- [XLR-11](https://researchem.net/xlr-11/) - Summary XLR-11, also known as 5"-fluoro-UR-144 or 5F-UR-144, operates as a potent agonist for cannabinoid receptors CB1 and CB2, displaying EC50 values of 98 nM and 83 nM, respectively. This compound belongs to the 3-(tetramethylcyclopropylmethanoyl)indole derivative family, sharing structural relations with compounds like UR-144, A-796,260, and A-834,735. However, it is noteworthy that XLR-11 needs to
- [UR-144](https://researchem.net/ur-144/) - Summary UR-144, also known by its aliases TMCP-018, KM-X1, MN-001, and YX-17, is a pharmaceutical developed by Abbott Laboratories. It operates as a selective full agonist of the peripheral cannabinoid receptor CB2 while displaying a significantly reduced affinity for the psychoactive CB1 receptor. Pharmacology UR-144 exhibits a notably high affinity for the CB2 receptor, boasting
- [STS-135 (drug)](https://researchem.net/sts-135-drug/) - Summary STS-135, also known as 5F-APICA, represents a designer drug available through online vendors, positioned as a cannabimimetic agent. While the origins of its design remain unclear, STS-135 appears to leverage insights into structure-activity relationships within the indole class of cannabimimetics. It serves as the terminally-fluorinated counterpart to SDB-001, mirroring the relationship between AM-2201 and
- [SDB-006](https://researchem.net/sdb-006/) - Summary SDB-006 is a pharmacological agent known for its potent agonistic activity on cannabinoid receptors. Its effectiveness is noteworthy, with an EC50 of 19 nM for human CB2 receptors and 134 nM for human CB1 receptors. This compound was initially uncovered while investigating its analogue, SDB-001, which had gained notoriety as "2NE1" when sold illicitly.
- [PX-1](https://researchem.net/px-1/) - Summary PX-1, which is also recognized under the names 5F-APP-PICA and SRF-30, is an indole-derived synthetic cannabinoid available for purchase online as a designer drug. Legality On November 10, 2014, Sweden's public health agency recommended categorizing PX-1 as a hazardous substance.As of May 2015, PX-1 has been included in the Fifth Schedule of the Misuse
- [PTI-2](https://researchem.net/pti-2/) - Summary PTI-2 (SGT-49) is a synthetic cannabinoid with an indole-based structure. Notably, it stands out as one of the rare synthetic cannabinoids that incorporates a thiazole group, and it shares a close relationship with PTI-1. These compounds can be considered simplified analogues of the indole-3-heterocycle compounds initially pioneered by Organon and later subjected to extensive
- [PTI-1](https://researchem.net/pti-1/) - Summary PTI-1, also known as SGT-48, belongs to the category of indole-based synthetic cannabinoids, notable for its unique inclusion of a thiazole group. This compound is closely associated with PTI-2 and shares a common origin in the lineage of indole-3-heterocycle compounds initially pioneered by Organon and later explored by Merck. FAQ What is PTI-1 (SGT-48)?
- [Org 28611](https://researchem.net/org-28611/) - Summary Org 28611 (SCH-900,111) is a pharmaceutical compound created by Organon International, functioning as a potent full agonist at both the CB1 and CB2 cannabinoid receptors. Its development was driven by the quest for a water-soluble cannabinoid agonist intended for intravenous administration as an analgesic. While it effectively met its goal and advanced to Phase
- [NNE1](https://researchem.net/nne1/) - Summary NNE1 also recognized as NNEI, MN-24, and AM-6527, is an indole-based synthetic cannabinoid, a molecular fusion of APICA and JWH-018. This compound acts as an agonist for cannabinoid receptors, boasting Ki values of 60.09 nM at CB1 and 45.298 nM at CB2, along with EC50 values of 9.481 nM at CB1 and 1.008 nM
- [MN-25](https://researchem.net/mn-25/) - Summary MN-25 (UR-12) is a pharmaceutical creation credited to Bristol-Myers Squibb. This drug primarily functions as a relatively selective agonist, predominantly stimulating peripheral cannabinoid receptors. Its affinity for CB2 receptors is moderate, featuring a Ki value of 11 nM. Notably, it displays significantly lower affinity, approximately 22 times lower, for the psychoactive CB1 receptors, with
- [Mepirapim](https://researchem.net/mepirapim/) - Summary MEPIRAPIM, classified as an indole-based cannabinoid, distinguishes itself from JWH-018 by featuring a 4-methylpiperazine group instead of the naphthyl group. This compound has found applications as a critical component in synthetic cannabis products. Its discovery dates back to 2013, when it was initially recognized in Japan alongside FUBIMINA. It's worth noting that MEPIRAPIM primarily
- [MDMB-FUBICA](https://researchem.net/mdmb-fubica/) - Summary MDMB-FUBICA, an indole-based synthetic cannabinoid, is thought to exhibit strong agonistic activity on the CB1 receptor and has gained notoriety as a designer drug available for online purchase. The EMCDDA first identified MDMB-FUBICA in Sweden in February 2015. This synthetic compound is commonly marketed in e-liquid form, intended for use in electronic cigarettes. Side
- [MDMB-CHMICA](https://researchem.net/mdmb-chmica/) - Summary MDMB-CHMICA, classified as an indole-based synthetic cannabinoid, exhibits robust agonistic activity toward the CB1 receptor and has been commercialized online as a designer drug. Notably, while it was initially available under the name "MMB-CHMINACA," the version corresponding to this codename (distinguished by the presence of isopropyl instead of t-butyl) emerged as AMB-CHMINACA in the
- [FUB-144](https://researchem.net/fub-144/) - Summary FUB-144, alternatively known as FUB-UR-144, belongs to the family of synthetic cannabinoids with an indole base. This compound is believed to exhibit vigorous agonistic activity toward the CB1 receptor and has been distributed on the internet as a designer drug. It is an analogue of UR-144 and XLR-11, differing in that the pentyl chain
- [FDU-NNE1](https://researchem.net/fdu-nne1/) - Summary FDU-NNE1, alternatively known as FDU-NNEI and FDU-MN-24, is a synthetic cannabinoid with an indole-based structure. It is believed to act as a potent agonist of the CB1 receptor and has been available for purchase as a designer drug through online channels. An interesting note is that similar to its related compound APINACA, the metabolic
- [CUMYL-PICA](https://researchem.net/cumyl-pica/) - Summary CUMYL-PICA, or SGT-56, is a synthetic cannabinoid rooted in indole-3-carboxamide. This compound represents the α,α-dimethylbenzyl analogue of SDB-006. Notably, it made a brief appearance in the New Zealand market in 2013 as an ingredient in synthetic cannabis products, which were legal at the time. However, the product containing CUMYL-BICA and CUMYL-PICA faced a setback
- [CUMYL-PEGACLONE](https://researchem.net/cumyl-pegaclone/) - Summary CUMYL-PEGACLONE, also known as SGT-151, is a synthetic cannabinoid rooted in the gamma-carboline structure and has been available as a designer drug. What sets CUMYL-PEGACLONE apart is its unique gamma-carboline core structure, which had not been observed in designer cannabinoids previously. However, it resembles other gamma-carboline cannabinoids disclosed by Bristol-Myers Squibb in 2001. Legal
- [BzODZ-EPyr](https://researchem.net/bzodz-epyr/) - Summary BzODZ-EPyr is a synthetic cannabinoid with an indole base and has been marketed as a designer drug in Russia.This compound functions as a CB1 receptor agonist, boasting a pKB value 7.2. Notably, it highlights that substituting the ketone in 3-carbonyl indoles with an oxadiazole spacer typically does not result in a loss of activity.
- [MMB-CHMICA](https://researchem.net/mmb-chmica/) - Summary MMB-CHMICA, also known as AMB-CHMICA, is a synthetic cannabinoid and designer drug. In the year 2018, it held the distinction of being the sixth most frequently encountered synthetic cannabinoid in substances confiscated by the Drug Enforcement Administration. FAQ 1. What is MMB-CHMICA (AMB-CHMICA)? MMB-CHMICA, also known as AMB-CHMICA, is a synthetic cannabinoid and designer
- [APICA (synthetic cannabinoid drug)](https://researchem.net/apica-synthetic-cannabinoid-drug/) - Summary APICA also referred to as 2NE1, SDB-001, or N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide, stands as an indole-based compound renowned for its robust agonistic effects on cannabinoid receptors.This distinctive compound debuted in the scientific and patent literature when laboratories in Japan identified it in March 2012. It was found as an ingredient in synthetic cannabis smoking blends, notably in
- [ADBICA](https://researchem.net/adbica/) - Summary ADBICA, also known as ADB-PICA, surfaced as a designer drug within synthetic cannabis blends in Japan back in 2013. Notably, before its inclusion as a component of synthetic cannabis blends, ADBICA had remained absent from scientific literature. This compound shares a distinctive feature with SDB-001 and STS-135, namely the presence of a carboxamide group
- [ADB-FUBICA](https://researchem.net/adb-fubica/) - Summary ADB-FUBICA is a pharmaceutical compound that exerts substantial agonistic effects on cannabinoid receptors, displaying EC50 values of 2.6 nM at CB1 and 3.0 nM at CB2. FAQ 1. What is ADB-FUBICA? ADB-FUBICA is a chemical compound that functions as a potent agonist for cannabinoid receptors. It has drawn attention for its potential pharmacological effects.
- [ADB-FUBIATA](https://researchem.net/adb-fubiata/) - Summary ADB-FUBIATA, also known as AD-18 or FUB-ACADB, emerged as a synthetic cannabinoid compound in 2021. It shares structural similarities with the older combination ADB-FUBICA, with a notable distinction – an extended amide linker group by adding a methylene bridge. This compound found its way into the market as an ingredient in grey-market synthetic cannabis
- [AB-PICA](https://researchem.net/ab-pica/) - Summary AB-PICA exhibits significant potency as an agonist for both the CB1 receptor (with an EC50 of 12 nM) and the CB2 receptor (also with an EC50 of 12 nM). fAQ 1. What is AB-PICA? AB-PICA is a synthetic compound categorized as a synthetic cannabinoid. It is known for interacting with the CB1 and CB2
- [AB-FUBICA](https://researchem.net/ab-fubica/) - Summary AB-FUBICA is a compound that is a potent agonist for cannabinoid receptors, displaying notable EC50 values of 21 nM at CB1 and 15 nM at CB2. FAQ What is AB-FUBICA? AB-FUBICA is a synthetic compound known for its pharmacological activity as a potent agonist for cannabinoid receptors, particularly CB1 and CB2. How does AB-FUBICA
- [AB-005](https://researchem.net/ab-005/) - Summary AB-005, also known as 1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl-methanone, is a designer drug offered by online vendors, positioned as a cannabimimetic agent. This compound's structure and pharmacological activity were first documented in 2010, well before its availability in the commercial market in 2012. Studies revealed that AB-005 exhibits a notable affinity for CB1 receptors (Ki = 5.5 nM) and
- [5F-SDB-006](https://researchem.net/5f-sdb-006/) - Summary 5F-SDB-006 is a substance known to function as a potent agonist for cannabinoid receptors. It exhibits an EC50 of 50 nM for human CB1 receptors and 123 nM for human CB2 receptors. This compound was first identified during investigations into the closely related substance APICA, which had been illicitly marketed under the name "2NE1".
- [5F-NNE1](https://researchem.net/5f-nne1/) - Summary 5F-NNE1, also recognized by its aliases 5F-NNEI and 5F-MN-24, represents an indole-derived synthetic cannabinoid. This compound is believed to act as a robust agonist of the CB1 receptor and has been made available for purchase on online platforms as a designer drug. It's noteworthy that, in connection with the related substance APINACA, which has
- [MMB-2201](https://researchem.net/mmb-2201/) - Summary MMB-2201, known by various aliases such as 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB, is a potent synthetic cannabinoid founded on the indole-3-carboxamide structure. This compound has gained notoriety for its presence in the designer drug market and its use as an active component in synthetic cannabis blends. While it initially emerged in Russia and Belarus in
- [5F-ADBICA](https://researchem.net/5f-adbica/) - Summary 5F-ADBICA, also referred to as 5F-ADB-PICA, is an indole-derived synthetic cannabinoid recognized for its agonistic solid activity at both CB1 and CB2 receptors, displaying remarkable EC50 values of 0.77 nM and 1.2 nM, respectively. Legal Status In China, 5F-ADBICA has been designated as a controlled substance since October 2015. FAQ 1. What is 5F-ADBICA?
- [4F-MDMB-BINACA](https://researchem.net/4f-mdmb-binaca-2/) - Summary 4F-MDMB-BINACA, also recognized as 4F-MDMB-BUTINACA or 4F-ADB, belongs to the indazole-3-carboxamide family and is classified as a synthetic cannabinoid. This compound has been utilized as an active component in synthetic cannabis products and has been available as a designer drug since late 2018. It acts as an agonist for the CB1 receptor, with an
- [4-HTMPIPO](https://researchem.net/4-htmpipo/) - Summary 4-HTMPIPO is a synthetic cannabinoid compound that was initially detected in smoking products acquired from online retailers back in 2012. This substance, 4-HTMPIPO, is formed through the electrophilic addition of water to the cyclopropane segment of the synthetic cannabinoid UR-144. However, there is currently no available information regarding the in vitro or in vivo
- [THJ-2201](https://researchem.net/thj-2201/) - Summary THJ-2201 is a synthetic cannabinoid based on the indazole structure, and it is believed to function as a potent agonist for the CB1 receptor. This compound has been available for purchase online as a designer drug. Structurally, THJ-2201 is akin to AM-2201, with the central indole ring substituted by an indazole ring. Pharmacology THJ-2201
- [SDB-005](https://researchem.net/sdb-005/) - Summary SDB-005 is a synthetic cannabinoid based on the indazole structure and has been made available for purchase online as a designer drug. It is believed to act as an agonist for the CB1 and CB2 cannabinoid receptors. Notably, SDB-005 shares the indazole core with PB-22, but it distinguishes itself by replacing the 8-hydroxyquinoline with
- [PX-3](https://researchem.net/px-3/) - Summary PX-3, or APP-CHMINACA, is a synthetic cannabinoid rooted in the indazole structure. Developed by Pfizer in 2009, its original purpose was as an analgesic medication, showcasing potential pharmaceutical utility.This compound's acronym, 'APP,' signifies its structural elements: 'amino,' 'phenyl,' and 'propanone.' In late 2014, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) reported
- [PX-2](https://researchem.net/px-2/) - Summary PX-2, also recognized as 5F-APP-PINACA, FU-PX, and PPA(N)-2201, represents an indazole-based synthetic cannabinoid that has been available for online purchase under the designation of a designer drug. This compound incorporates a phenylalanine amino acid amide within its structural composition. Legality On November 10, 2014, Sweden's public health agency proposed the classification of PX-2 as
- [MN-18](https://researchem.net/mn-18/) - Summary MN-18, an indazole-based synthetic cannabinoid, acts as an agonist for cannabinoid receptors, featuring Ki values of 45.72 nM at CB1 and 11.098 nM at CB2, alongside EC50 values of 2.028 nM at CB1 and 1.233 nM at CB2, highlighting its affinity for these receptors. This compound has been available online under the guise of
- [MDMB-CHMINACA](https://researchem.net/mdmb-chminaca/) - Summary MDMB-CHMINACA, also recognized as MDMB(N)-CHM, is an indazole-derived synthetic cannabinoid renowned for its robust affinity as a CB1 receptor agonist. This compound has gained notoriety as an online designer drug. Originally developed by Pfizer in 2008, MDMB-CHMINACA is among the most potent cannabinoid agonists, boasting an impressive binding affinity of 0.0944 nM at the
- [FAB-144](https://researchem.net/fab-144/) - Summary FAB-144, classified as an indazole-derived synthetic cannabinoid, is believed to exhibit vigorous agonistic activity towards the CB1 receptor. This compound has gained notoriety for its online availability as a designer drug and is the indazole counterpart of XLR-11. Legal status On November 10, 2014, Sweden's public health agency recommended the classification of FAB-144 as
- [CUMYL-THPINACA](https://researchem.net/cumyl-thpinaca/) - Summary CUMYL-THPINACA also recognized as SGT-42, is categorized as an indazole-3-carboxamide-based synthetic cannabinoid. This compound is a robust agonist for cannabinoid receptors, exhibiting approximately 6 times greater selectivity for CB1. Specifically, it boasts an EC50 of 0.1nM for human CB1 receptors and 0.59nM for human CB2 receptors. Legal status On November 10, 2014, Sweden's public
- [CUMYL-PINACA](https://researchem.net/cumyl-pinaca/) - Summary CUMYL-PINACA also referred to as SGT-24, belongs to the class of indazole-3-carboxamide synthetic cannabinoids. It is a robust agonist for cannabinoid receptors, demonstrating about threefold selectivity for CB1. Its affinity for human CB1 receptors is notably high, with an EC50 of 0.15nM, and it exhibits a similar potency for human CB2 receptors, with an
- [CUMYL-4CN-BINACA](https://researchem.net/cumyl-4cn-binaca/) - Summary CUMYL-4CN-BINACA, also known as CUMYL-CYBINACA or SGT-78, is an indazole-3-carboxamide-based synthetic cannabinoid that has been distributed online as a designer drug. This compound acts as a potent agonist for CB1 and CB2 cannabinoid receptors, with EC50 values of 0.58 nM and 6.12 nM, respectively, as demonstrated in in vitro studies.In animal models, CUMYL-4CN-BINACA has
- [APP-FUBINACA](https://researchem.net/app-fubinaca/) - Summary APP-FUBINACA is a synthetic cannabinoid based on the indazole structure, and it has been distributed online as a designer drug. Regarding its pharmacological profile, research has indicated that APP-FUBINACA exhibits only moderate binding affinity for the CB1 receptor, with a Ki value of 708 nM. However, specific data regarding its EC50 has yet to
- [APINACA](https://researchem.net/apinaca/) - Summary APINACA, also known as AKB48 or N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide, is a substance that functions as a reasonably potent agonist for cannabinoid receptors. It exhibits full agonist activity at the CB1 receptor, with an EC50 of 142 nM and a Ki of 3.24 nM. To provide context, this Ki value is notably lower than that of Δ9-THC
- [AMB-CHMINACA](https://researchem.net/amb-chminaca/) - Summary AMB-CHMINACA, alternatively known as MMB-CHMINACA or MA-CHMINACA, belongs to the family of indazole-based synthetic cannabinoids. Notably, it exhibits strong agonistic activity towards the CB1 receptor and has entered the online market as a designer drug. Legal status As of May 2015, AMB-CHMINACA was added to the Fifth Schedule of the Misuse of Drugs Act
- [ADSB-FUB-187](https://researchem.net/adsb-fub-187/) - Summary ADSB-FUB-187, an indazole-based synthetic cannabinoid, exhibits remarkable potency as a CB1 receptor agonist, boasting an impressively low binding affinity with a Ki value of 0.09 nM and an EC50 of 1.09 nM. Pfizer's 2009 patent, WO 2009/106982, introduced this compound as example 187. While it stands out as the most tightly binding substance within
- [ADB-PINACA](https://researchem.net/adb-pinaca/) - Summary ADB-PINACA, a cannabinoid designer drug, finds its place as a constituent in certain synthetic cannabis products. It stands out as a robust agonist of both the CB1 and CB2 receptors, boasting impressive EC50 values of 0.52 nM and 0.88 nM, respectively. Notably, akin to MDMB-FUBINACA, this compound incorporates a tert-leucine amino acid residue Side
- [ADB-FUBINACA](https://researchem.net/adb-fubinaca/) - Summary ADB-FUBINACA, a synthetic designer drug, initially surfaced in synthetic cannabis mixtures in Japan back in 2013. Notably, by 2018, it had risen to become the third most frequently detected synthetic cannabinoid in drug seizures by the Drug Enforcement Administration.The (S)-enantiomer of ADB-FUBINACA was detailed in a Pfizer patent dating back to 2009. This enantiomer
- [ADB-BINACA](https://researchem.net/adb-binaca/) - Summary ADB-BINACA is a synthetic cannabinoid designer drug that has been identified as a component in certain synthetic cannabis formulations. Initially conceived by Pfizer for its potential analgesic properties, this compound is a robust agonist for the CB1 receptor, boasting an impressive binding affinity (Ki) of 0.33 nM and an EC50 of 14.7 nM. ADB-BUTINACA
- [Adamantyl-THPINACA](https://researchem.net/adamantyl-thpinaca/) - Summary Adamantyl-THPINACA, often abbreviated as ATHPINACA or AD-THPINACA, is a synthetic cannabinoid compound based on the indazole structure. Its presence was initially documented in Slovenia in January 2015, and it exists in two distinct isomeric forms: the 1-adamantyl and 2-adamantyl isomers, identified as SGT-40 and SGT-194, respectively, a differentiation that can be established through GC-EI-MS
- [5F-EMB-PINACA](https://researchem.net/5f-emb-pinaca-2/) - Summary 5F-EMB-PINACA, alternatively referred to as EMB-5F-PINACA by the naming conventions of synthetic cannabinoids outlined by the EMCCDA, and also known as 5F-AEB, is a synthetic cannabinoid derived from the indazole-3-carboxamide family. This compound has been marketed as a designer drug and is readily available for purchase online.The EMCDDA brought attention to 5F-EMB-PINACA when it
- [5F-CUMYL-PINACA](https://researchem.net/5f-cumyl-pinaca-2/) - Summary 5F-CUMYL-PINACA, also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, is a synthetic cannabinoid with an indazole-3-carboxamide base.This compound acts as a potent agonist for cannabinoid receptors. According to the initial patent, it displayed approximately fourfold selectivity for CB1 receptors, boasting an EC50 of
- [5F-EMB-PINACA](https://researchem.net/5f-emb-pinaca/) - Summary 5F-EMB-PINACA, alternatively recognized as EMB-5F-PINACA by the EMCCDA's nomenclature for synthetic cannabinoids and also referred to as 5F-AEB is a member of the indazole-3-carboxamide family of synthetic cannabinoids. This compound has been marketed on the internet as a designer drug.In April 2015, the EMCDDA initially documented its existence as part of a seizure in
- [5F-CUMYL-PINACA](https://researchem.net/5f-cumyl-pinaca/) - Summary 5F-CUMYL-PINACA also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, belongs to the category of indazole-3-carboxamide-based synthetic cannabinoids. It exerts its action as a potent agonist on cannabinoid receptors, with the original patent asserting approximately fourfold selectivity for CB1. It exhibits an EC50 of less than 0.1 nM for human CB1
- [5F-APINACA](https://researchem.net/5f-apinaca/) - Summary 5F-APINACA, also recognized as 5F-AKB-48 or 5F-AKB48, is a synthetic cannabinoid based on the indazole structure and has been available for purchase as a designer drug online. In terms of its chemical structure, it closely resembles cannabinoid compounds outlined in patent WO 2003/035005, differing by the presence of a 5-fluorophenyl chain on the indazole
- [5F-AMB](https://researchem.net/5f-amb/) - Summary 5F-AMB, also recognized as 5F-MMB-PINACA and 5F-AMB-PINACA, belongs to the indazole-3-carboxamide family, making it a synthetic cannabinoid of this class. It has been employed as an active constituent in synthetic cannabis products and was initially pinpointed in Japan in the early months of 2014. While there is limited pharmacological data available specifically for 5F-AMB
- [5F-ADB-PINACA](https://researchem.net/5f-adb-pinaca/) - Summary 5F-ADB-PINACA, a synthetic cannabinoid designer drug found in certain synthetic cannabis blends, exhibits significant agonistic activity towards both the CB1 and CB2 receptors, boasting low EC50 values of 0.24 nM and 2.1 nM, respectively. Metabolism A total of twelve major metabolites of 5F-ADB-PINACA were discovered in various incubations involving cryopreserved human hepatocytes. The primary
- [5F-AB-PINACA](https://researchem.net/5f-ab-pinaca/) - Summary 5F-AB-PINACA is an indazole-derived synthetic cannabinoid originating from a group of compounds initially created by Pfizer in 2009 for pain relief. This substance has gained notoriety as a designer drug available for purchase online.In research, 5F-AB-PINACA has demonstrated notable potency as an agonist, affecting both the CB1 receptor and CB2 receptor, with EC50 values
- [4F-MDMB-BINACA](https://researchem.net/4f-mdmb-binaca/) - Summary 4F-MDMB-BINACA, also recognized as 4F-MDMB-BUTINACA or 4F-ADB, belongs to the indazole-3-carboxamide family, making it an indazole-based synthetic cannabinoid. It has been prevalent as an active component in synthetic cannabis products and has been accessible as a designer drug since late 2018. 4F-MDMB-BINACA acts as an agonist of the CB1 receptor (with an EC50 of
- [WIN 55,212-2](https://researchem.net/win-55212-2/) - Sumamry WIN 55,212-2, classified as an aminoalkylindole derivative, exerts effects akin to cannabinoids such as tetrahydrocannabinol (THC) but boasts a distinctly unique chemical structure.Functionally, WIN 55,212-2 acts as a robust cannabinoid receptor agonist,[6] demonstrating potent analgesic properties in a rat model of neuropathic pain, activating p42 and p44 MAP kinase through receptor-mediated signaling.At a concentration
- [QMPSB](https://researchem.net/qmpsb/) - Summary QMPSB, initially identified as an aryl sulfonamide-based synthetic cannabinoid, found its place in the realm of designer drugs.In 2007, Nathalie Lambeng and her research team unearthed QMPSB, unveiling its role as a robust full agonist of the CB1 and CB2 receptors, boasting impressive Ki values of 3 nM and 4 nM, respectively. Following this
- [NESS-040C5](https://researchem.net/ness-040c5/) - Summary NESS-040C5, designed for glaucoma treatment, is a robust cannabinoid agonist. It demonstrates a notable preference for the CB2 receptor subtype, boasting a remarkable CB2 affinity at 0.4 nanomolar and a selectivity exceeding 25-fold when compared to the closely related CB1 receptor. FAQ 1. What is NESS-040C5? NESS-040C5 is a pharmaceutical compound designed for the
- [NESS-0327](https://researchem.net/ness-0327/) - Summary NESS-0327 is a pharmaceutical substance utilized in scientific investigations, recognized for its remarkable role as a highly potent and exceedingly selective antagonist of the cannabinoid receptor CB1. Its antagonistic potency greatly surpasses the more commonly employed ligand, rimonabant. With an astounding Ki at CB1 measuring a mere 350 femtomolar (0.00035 nanomolar), NESS-0327 exhibits an
- [MDA-19](https://researchem.net/mda-19/) - Summary MDA-19 also recognized as BZO-HEXOXIZID, is a potent and highly selective agonist specifically designed for the cannabinoid receptor CB2. It maintains reasonable selectivity over the psychoactive CB1 receptor, although variations are observed among different species. In animal studies, MDA-19 has shown effectiveness in addressing neuropathic pain, with no significant impact on rat locomotor activity
- [LY-2183240](https://researchem.net/ly-2183240/) - Summary LY-2183240 is a multifaceted compound known for its dual role as a robust inhibitor of both endocannabinoid anandamide reuptake and the enzyme fatty acid amide hydrolase (FAAH), responsible for anandamide degradation. This distinctive mechanism leads to a significant increase in anandamide levels within the brain, resulting in observed analgesic and anxiolytic effects in animal
- [JTE 7-31](https://researchem.net/jte-7-31/) - Summary JTE 7-31, a creation of Japan Tobacco, emerges as a selective agonist for cannabinoid receptors. This compound exhibits significant selectivity for CB2 receptors, yet it maintains a noteworthy affinity for CB1 receptors, boasting a Ki of 0.088nM at CB2 compared to 11nM at CB1. Legality JTE 7-31 is illegal in Alabama. FAQ 1. What
- [JTE-907](https://researchem.net/jte-907/) - Summary JTE-907 is a pharmaceutical compound employed in scientific investigations, functioning as a discerning CB2 inverse agonist. This substance has demonstrated anti-inflammatory properties in animal experiments, with these effects believed to stem from an interplay between the CB2 receptor and IgE. FAQ 1. What is JTE-907? JTE-907 is a pharmaceutical compound primarily used in scientific
- [FUBIMINA](https://researchem.net/fubimina/) - Summary FUBIMINA, also recognized under the aliases BIM-2201, BZ-2201, and FTHJ, is a synthetic cannabinoid, constituting the benzimidazole counterpart to AM-2201. This compound has gained prominence as an active ingredient within synthetic cannabis blends. Its initial discovery took place in Japan in 2013, concurrently with the identification of MEPIRAPIM.FUBIMINA exerts its influence as a moderately
- [EG-018](https://researchem.net/eg-018/) - Summary EG-018, a synthetic cannabinoid rooted in the carbazole structure, has found a niche in online markets as a designer drug. This compound is a partial agonist for CB1 and CB2 receptors, exhibiting a notably robust binding affinity. However, its effectiveness in eliciting a signaling response still needs to be higher. Legal status EG-018 is
- [CB-13](https://researchem.net/cb-13/) - Summary CB-13, also known as CRA13 and SAB-378, is a cannabinoid pharmaceutical compound. This substance is a robust agonist for CB1 and CB2 receptors, yet it cannot breach the blood-brain barrier. Consequently, at lower doses, CB-13 primarily elicits peripheral effects, while indications of central effects, such as catalepsy, manifest only when administered at significantly higher
- [BIM-018](https://researchem.net/bim-018/) - Summary BIM-018 is a synthetic cannabinoid belonging to the benzimidazole family and is considered the analog of JWH-018. It is believed to act as a potent agonist of the CB2 receptor and has been marketed online as a designer drug.Other benzimidazole derivatives with a similar structure have demonstrated high selectivity as agonists for the CB2
- [BAY 38-7271](https://researchem.net/bay-38-7271/) - Sumamry Initially synthesized by chemist Wayne E. Kenney, BAY 38-7271 (also known as KN 38-7271) is a pharmaceutical compound developed by Bayer AG. This drug is a cannabinoid receptor agonist, exhibiting analgesic and neuroprotective properties. BAY 38-7271 is primarily employed in scientific research and has shown promise for potential applications in treating traumatic brain injury.In
- [AB-CHFUPYCA](https://researchem.net/ab-chfupyca/) - Summary AB-CHFUPYCA, also known as AB-CHMFUPPYCA, is a compound initially discovered as part of synthetic cannabis products in Japan back in 2015. The name "AB-CHFUPYCA" is an abbreviation derived from its systematic name, N-(1-Amino-3-methyl-1-oxoButan-2-yl)-1-(cyclohexylmethyl)-3-(4-FlUorophenyl)-1H-PYrazole-5-CarboxAmide. Two distinct regioisomers of AB-CHFUPYCA exist: 3,5-AB-CHMFUPPYCA and 5,3-AB-CHMFUPPYCA. Both collectively refer to as AB-CHMFUPPYCA isomers, meaning that AB-CHMFUPPYCA and AB-CHFUPYCA
- [A-836,339](https://researchem.net/a-836339/) - Summary A-836,339, a product of Abbott Laboratories, is a potent full agonist of the cannabinoid receptor. Notably, it exhibits selectivity for CB2, with Ki values of 0.64 nM at CB2 compared to 270 nM at the psychoactive CB1 receptor. At lower doses, A-836,339 displays selective analgesic, anti-inflammatory, and anti-hyperalgesic effects. However, its high efficacy at
- [5F-PCN](https://researchem.net/5f-pcn/) - Summary 5F-PCN, also identified as 5F-MN-21, belongs to the category of azaindole-based synthetic cannabinoids. It is presumed to possess potent agonistic effects on the CB1 receptor and has found its way into online markets as a designer drug. Notably, it shares a close chemical relationship with NNE1.An intriguing aspect to consider is the metabolic processes
- [5F-AB-FUPPYCA](https://researchem.net/5f-ab-fuppyca/) - summary 5F-AB-FUPPYCA, or AZ-037, is a synthetic cannabinoid rooted in the pyrazole structure. It is presumed to act as an agonist targeting the CB1 receptor and has gained popularity as a designer drug available for purchase online. Notably, it came into the spotlight when the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) identified
- [3-(4-Hydroxymethylbenzoyl)-1-pentylindole](https://researchem.net/3-4-hydroxymethylbenzoyl-1-pentylindole/) - Summary 3-(4-Hydroxymethylbenzoyl)-1-pentylindole is classified as a synthetic cannabinoid, and there are plans to include it in Schedule I-N in Poland. This compound was first reported to the EMCDDA and Europol in 2010 by the provisions of the European Council Decision 2005/387/JHA dated 10 May 2005, which pertains to the exchange of information, risk assessment, and
- [CP 55,244](https://researchem.net/cp-55244/) - Summary CP 55,244, a chemical compound, serves as a potent agonist of cannabinoid receptors. Renowned for its analgesic properties, it finds significant utility in scientific investigations. With an extraordinary potency, CP 55,244 emerges as an extremely formidable CB1 full agonist, boasting a remarkable Ki of 0.21 nM, surpassing the commonly employed full agonist HU-210. FAQ
- [CP 55,940](https://researchem.net/cp-55940/) - Summary CP 55,940, a synthetic cannabinoid, replicates the effects of naturally found THC, one of the active compounds present in cannabis. This compound was originally developed by Pfizer in 1974 but was never brought to the market. Today, it is a valuable research tool for investigating the endocannabinoid system. Pharmacology CP 55,940 exhibits exceptional potency,
- [CP 47,497](https://researchem.net/cp-47497/) - Summary CP 47,497, also known as (C7)-CP 47,497, is a cannabinoid receptor agonist medication initially crafted by Pfizer during the 1980s. This compound, valued for its analgesic properties, is crucial in scientific investigations. Notably, CP 47,497 is a robust CB1 agonist with a Kd value of 2.1 nM. Legal status Germany:On January 22, 2009, CP
- [HU-308](https://researchem.net/hu-308/) - Summary HU-308, referred to as onternabez, PPP-003, and ARDS-003, represents a drug derived from cannabidiol (CBD) and functions as a potent cannabinoid agonist. Notably, HU-308 exhibits a remarkable degree of selectivity, primarily targeting the cannabinoid-2 receptor (CB2 receptor) subtype. Its selectivity for the CB2 receptor surpasses that of the CB1 receptor by over 5,000 times.The
- [Ajulemic acid](https://researchem.net/ajulemic-acid/) - Sumamry Ajulemic acid, also known as DMH-D8-THC-11-OIC, AB-III-56, HU-239, IP-751, CPL 7075, CT-3, JBT-101, Anabasum, Resunab, or Lenabasum, is a synthetic cannabinoid that exhibits anti-fibrotic and anti-inflammatory properties in pre-clinical research without inducing a subjective "high." While its design was inspired by delta-9-THC metabolites, such as delta-9-THC-11-oic acid, academic acid is an analog of delta-8-THC
- [AM-087](https://researchem.net/am-087/) - Summary AM-087, a member of the AM cannabinoid series, is an analgesic medication functioning as a cannabinoid agonist. Derived from Δ8-THC, it features a substitution on the 3-position side chain. AM-087 stands out as a potent CB1 agonist, boasting a Ki value of 0.43 nM, rendering it approximately 100 times more potent than THC. This
- [HU-243](https://researchem.net/hu-243/) - Summary HU-243, also known as AM-4056, is a synthetic cannabinoid compound representing the single enantiomer of the hydrogenated derivative derived from the widely referenced agonist HU-210. It serves as a methylene homolog of canbisol. Remarkably, HU-243 displays robust agonistic activity at both the CB1 and CB2 receptors, boasting an impressive binding affinity of 0.041 nM
- [JWH-133](https://researchem.net/jwh-133/) - Summary JWH-133, also known as Dimethylbutyl-deoxy-Delta-8-THC, stands out as a potent and highly selective agonist of the CB2 receptor, exhibiting a remarkable Ki value of 3.4nM and an impressive selectivity of approximately 200 times for CB2 over CB1 receptors. This compound owes its name to the pioneering researcher John W. Huffman.In scientific literature, JWH-133 has
- [JWH-051](https://researchem.net/jwh-051/) - Summary JWH-051 is an analgesic medication that functions as a cannabinoid agonist. Its chemical structure closely resembles the potent cannabinoid agonist HU-210, with the sole distinction being the absence of the hydroxyl group at position 1 of the aromatic ring. This compound was first identified and named in honor of John W. Huffman.JWH-051 maintains a
- [HU-210](https://researchem.net/hu-210/) - Summary HU-210, a synthetic cannabinoid, was initially synthesized in 1988 by a research team led by Raphael Mechoulam at the Hebrew University. It boasts an astonishing potency, ranging from 100 to 800 times greater than naturally occurring THC found in cannabis. Additionally, HU-210 exhibits a significantly prolonged duration of action. In terms of its receptor
- [Parahexyl](https://researchem.net/parahexyl/) - Summary Parahexyl, also known as Synhexyl or n-hexyl-Δ3-THC, is a synthetic counterpart to THC (tetrahydrocannabinol). It was developed in 1941 as part of efforts to decipher the chemical structure of Δ9-THC, one of the primary active compounds found in cannabis.Parahexyl closely resembles THC in terms of both its structure and its effects, with the only
- [Nabilone](https://researchem.net/nabilone/) - Summary Nabilone, marketed under the trade name Cesamet and other brands, is a synthetic cannabinoid recognized for its therapeutic applications as an antiemetic and as a supplementary analgesic in managing neuropathic pain. This compound emulates tetrahydrocannabinol (THC), the primary psychoactive component naturally found in the Cannabis plant. In the United States, the Food and Drug
- [Tolibut](https://researchem.net/tolibut/) - Summary Tolibut, scientifically known as 3-(p-tolyl)-4-aminobutyric acid or β-(4-methylphenyl)-GABA, is a pharmaceutical compound developed in Russia. This substance is categorized as a derivative of γ-aminobutyric acid (GABA), making it a GABA analog. Specifically, halibut is the 4-methyl variant of phenibut and shares structural similarities with baclofen, replacing the 4-chloro group with a 4-methyl substitution.Tolibut has
- [Phenibut](https://researchem.net/phenibut/) - Summary Phenibut, available under various brand names such as Anvifen, Fenibut, and Noofen, is a central nervous system depressant known for its anxiolytic properties. It is prescribed to address conditions like anxiety, insomnia, and other related indications. Typically administered orally in tablet form, it can also be given intravenously.Phenibut may induce several side effects, including
- [Pagoclone](https://researchem.net/pagoclone/) - Summaru Pagoclone, a member of the cyclopyrrolone family, is classified as an anxiolytic agent, sharing its lineage with more familiar drugs like the sleep aid zopiclone. This compound was initially synthesized by a team of French researchers working for Rhone-Poulenc & Rorer S.A. It falls within the nonbenzodiazepine category, which, despite yielding effects akin to
- [Benzylbutylbarbiturate](https://researchem.net/benzylbutylbarbiturate/) - Summary Benzylbutylbarbiturate, scientifically referred to as 5-benzyl-5-n-butylbarbituric acid, stands as an uncommon instance of a designer drug within the barbiturate class, potentially one of the few of its kind identified in recent times. This substance came to the attention of law enforcement in Japan in the year 2000, and it is presumed to have been
- [4-Fluorophenibut](https://researchem.net/4-fluorophenibut/) - Summary 4-Fluorophenibut, which also goes by the developmental code name CGP-11130, is recognized as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA. It operates as an agonist for the GABAB receptor, although it never reached the commercial market.In its selectivity, 4-Fluorophenibut demonstrates a preference for the GABAB receptor over the GABAA receptor, with respective IC50 values of 1.70 μM
- [2-Methyl-2-pentanol](https://researchem.net/2-methyl-2-pentanol/) - Summary 2-Methyl-2-pentanol, also known by its IUPAC name, 2-methylpentan-2-ol, is an organic chemical compound. It finds utility in gas chromatography as an additive for the differentiation of branched compounds, particularly alcohols, due to its unique properties.Moreover, the detection of 2-Methyl-2-pentanol in urine serves as an indicator for exposure to 2-methylpentane, making it valuable in toxicological
- [tert-Amyl alcohol](https://researchem.net/tert-amyl-alcohol/) - Summary Throughout its history, Trichloroethanol (TAA) has served as an anesthetic, as documented in the past. More recently, it has gained notoriety as a recreational drug. TAA primarily functions as a positive allosteric modulator for GABAA receptors, akin to ethanol. Notably, both TAA and ethanol share psychotropic effects, although each possesses distinct characteristics. TAA tends
- [SL-164](https://researchem.net/sl-164/) - Summary SL-164, also recognized as dicloqualone or DCQ, is a compound that serves as an analogue of methaqualone. It was formulated in the late 1960s by a research team at Sumitomo. SL-164 shares comparable properties, including sedative, hypnotic, and anticonvulsant effects, with its parent compound. However, it was never introduced to the clinical market for
- [Nitromethaqualone](https://researchem.net/nitromethaqualone/) - Summary Nitromethaqualone, often referred to as NMQ, is a chemical analog of methaqualone known for sharing similar sedative and hypnotic properties. Notably, Nitromethaqualone exhibits significantly increased potency, being approximately ten times more potent than its parent compound. A typical dosage of Nitromethaqualone is around 25 milligrams. FAQ 1. What is Nitromethaqualone (NMQ)? Nitromethaqualone, often abbreviated
- [Methylmethaqualone](https://researchem.net/methylmethaqualone/) - Sumamry Methylmethaqualone (MMQ) is a compound classified under the quinazolinone group and serves as an analog of methaqualone. It shares similar sedative and hypnotic properties with its parent compound, primarily due to its agonistic influence on the β subtype of the GABAA receptor. Notably, in animal models, Methylmethaqualone has been shown to be approximately three
- [Mecloqualone](https://researchem.net/mecloqualone/) - Summary Mecloqualone, also known by trade names such as Nubarene and Casfen, belongs to the Quinazolinone class of compounds. It is categorized as a GABAergic substance and serves as an analog of methaqualone. This compound was first synthesized in 1960 and primarily found its market in France and several other European countries. Mecloqualone exhibits notable
- [Mebroqualone](https://researchem.net/mebroqualone/) - Summary Mebroqualone (often abbreviated as MBQ) belongs to the quinazolinone class of compounds and is recognized as a GABAergic substance. It serves as an analog of mecloqualone, sharing comparable sedative and hypnotic properties with its parent compound, owing to its agonistic effects at the β subtype of the GABA receptor. The synthesis of Mebroqualone dates
- [Etaqualone](https://researchem.net/etaqualone/) - Summary Methaqualone, known by trade names such as Aolan, Athinazone, and Ethinazone, belongs to the quinazolinone class of compounds. This substance is a GABAergic agent and serves as an analog of methaqualone. It was initially developed during the 1960s and found its primary market in France and a few other European countries. Ethaqualone exhibits various
- [Afloqualone](https://researchem.net/afloqualone/) - Summary Afloqualone, also known as Arofuto, belongs to the quinazolinone family of GABAergic drugs. It is an analog of methaqualone that was developed in the 1970s by researchers at Tanabe Seiyaku. This compound exerts sedative and muscle-relaxant effects through its agonistic activity at the β subtype of the GABA receptor. Afloqualone has found some clinical
- [γ-Valerolactone](https://researchem.net/γ-valerolactone/) - Summary γ-Valerolactone, often abbreviated as GVL, represents an organic compound characterized by the chemical formula C5H8O2. This clear, colourless liquid ranks among the more prevalent lactones. Although GVL possesses chirality, it is commonly employed in its racemic form. It can be readily derived from cellulosic biomass and holds promise as both a potential fuel source
- [gamma-Hydroxyvaleric acid](https://researchem.net/gamma-hydroxyvaleric-acid/) - Summary Gamma-hydroxyvaleric acid (GHV), also referred to as 4-methyl-GHB, is a synthetic substance classified as a designer drug closely related to gamma-hydroxybutyric acid (GHB). Occasionally, it appears on the grey market as a legal substitute for GHB. However, it is characterized by lower potency and increased toxicity compared to GHB, factors that have, in practice,
- [gamma-Butyrolactone](https://researchem.net/gamma-butyrolactone/) - Summary Gamma-butyrolactone (GBL), also known as γ-butyrolactone, is a colourless liquid that readily absorbs moisture from the air and has a faint, distinct odour. This compound represents the simplest form of a four-carbon lactone. Its primary application lies in serving as an intermediate compound for the synthesis of various other chemicals, including methyl-2-pyrrolidone.In the context
- [1,4-Butanediol](https://researchem.net/14-butanediol/) - Summary Butane-1,4-diol, distinct from 1,3-butanediol, represents primary alcohol and an organic compound identified by the chemical formula HOCH2CH2CH2CH2OH. This substance is a clear and thick liquid, comprising one of the four enduring isomeric forms of butanediol. Synthesis In the realm of industrial chemical synthesis, acetylene undergoes a reaction with two portions of formaldehyde to yield
- [Metizolam](https://researchem.net/metizolam/) - Summary Metizolam, alternatively recognized as desmethyl etizolam, stands as a thienotriazolodiazepine, characterized by its status as the demethylated counterpart of the closely linked etizolam. Legal status After being offered as a designer drug, metizolam was designated as a controlled substance in Sweden on January 26, 2016. FAQ What is Metizolam? Metizolam, also known as desmethyletizolam,
- [Fluclotizolam](https://researchem.net/fluclotizolam/) - Summary Fluclotizolam, initially synthesised in 1979 as a thienotriazolodiazepine derivative, remained unmarketed at the time. However, it resurfaced as a designer drug and was definitively identified for this purpose in 2017. FAQ What is Fluclotizolam? Fluclotizolam is a chemical compound classified as a thienotriazolodiazepine derivative. It was first synthesized in 1979 but was never marketed
- [Flubrotizolam](https://researchem.net/flubrotizolam/) - Summary Flubrotizolam, known chemically as 2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, is a thienotriazolodiazepine analog. It possesses significant sedative and anxiolytic properties, and it has been marketed and distributed as a substance falling under the category of designer drugs. FAQ What is Flubrotizolam? Flubrotizolam is a chemical compound belonging to the thienotriazolodiazepine class. It is known for its sedative and
- [Etizolam](https://researchem.net/etizolam/) - Summary Etizolam, available under numerous brand names, is a derivative of thienodiazepine, essentially an analogue of benzodiazepine. It distinguishes itself by substituting the benzene ring with a thiophene ring and fusing a triazole ring, effectively categorizing it as a thienotriazolodiazepine.Although categorized as a thienodiazepine, Etizolam is clinically treated as a benzodiazepine due to its mechanism
- [Deschloroclotizolam](https://researchem.net/deschloroclotizolam/) - Summary Deschloroclotizolam, a derivative of thienotriazolodiazepine, emerged as a designer drug, with its first detection in Sweden in 2021. FAQ 1. What is Deschloroclotizolam? Deschloroclotizolam is a chemical compound belonging to the thienotriazolodiazepine class. It is used as a psychoactive substance and has gained attention as a designer drug. 2. How is Deschloroclotizolam used? Deschloroclotizolam
- [Ro5-4864](https://researchem.net/ro5-4864/) - Summary Ro5-4864, also known as 4'-chlorodiazepam, is a benzodiazepine derivative with its origins traced back to diazepam. Unlike the majority of benzodiazepine derivatives, Ro5-4864 exhibits a unique pharmacological profile. It does not display an affinity for GABAA receptors, thus lacking the typical effects associated with benzodiazepines.Instead, Ro5-4864 manifests as a soothing substance, but it is
- [Phenazepam](https://researchem.net/phenazepam/) - Summary Phenazepam, also recognized as bromdihydrochlorphenylbenzodiazepine in Russia, belongs to the benzodiazepine class of drugs. Initially developed in the Soviet Union in 1975, it is currently manufactured in Russia and several associated countries.Phenazepam serves various clinical purposes, notably in the treatment of mental disorders, including psychiatric schizophrenia and anxiety. Additionally, it finds application as a
- [Nitrazolam](https://researchem.net/nitrazolam/) - Summary Nitrazolam is categorized as a triazolobenzodiazepine (TBZD), which belongs to the class of benzodiazepine (BZD) derivatives. This compound has been illicitly marketed online as a designer drug. It shares a close chemical relationship with substances like clonazolam and flunitrazolam, differing only in the absence of a chlorine or fluorine group, respectively, on the benzene
- [Nifoxipam](https://researchem.net/nifoxipam/) - Summary Nifoxipam, also known as 3-hydroxy desmethyl flunitrazepam or DP 370, is classified as a benzodiazepine. This compound serves as a minor byproduct of flunitrazepam and has been illicitly marketed online as a designer drug.Notably, Nifoxipam induces potent sedative and sleep-prolonging effects. Moreover, it demonstrates significantly lower toxicity in mice when compared to lormetazepam and
- [Nimetazepam](https://researchem.net/nimetazepam/) - Summary Nimetazepam, known by its brand names Erimin and Lavol, is an intermediate-acting hypnotic drug belonging to the benzodiazepine derivative class. It was initially synthesized in 1964 by a team at Hoffmann-La Roche. This compound is renowned for its potent hypnotic, anxiolytic (anxiety-reducing), soothing, and skeletal muscle relaxant properties. Additionally, Nimetazepam exhibits remarkable anticonvulsant effects.Erimin,
- [N-Desalkylflurazepam](https://researchem.net/n-desalkylflurazepam/) - Summary N-Desalkylflurazepam, also referred to as norflurazepam, is classified as a benzodiazepine analog and serves as an active metabolite for several other benzodiazepine drugs, which encompass flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate.This compound is known for its long-lasting effects and tends to accumulate in the body. It binds to a range of
- [Flunitrazolam](https://researchem.net/flunitrazolam/) - Summary Flunitrazolam (also known as FNTZ or Flunazolam) belongs to the class of triazolobenzodiazepines (TBZD), a group of derivatives stemming from benzodiazepines (BZD). This compound has gained popularity as a designer drug available for purchase online. It exhibits pronounced hypnotic and sedative effects resembling those of closely related substances like Flunitrazepam, clonazolam, and flubromazolam.The emergence
- [Flubromazolam](https://researchem.net/flubromazolam/) - Summary Flubromazolam, also known as JYI-73, belongs to the class of triazolobenzodiazepines (TBZDs), which are derivatives of benzodiazepines (BZDs). This compound has gained a reputation for its remarkably high potency. Concerns have emerged regarding the safety of substances like clonazolam and flubromazolam, mainly due to their potential to induce profound sedation and amnesia, even at
- [Flubromazepam](https://researchem.net/flubromazepam/) - Summary Flubromazepam initially synthesised in 1960 but never officially marketed or extensively studied, resurfaced in late 2012 within the grey market as an emerging designer drug. This benzodiazepine derivative gained renewed attention and interest.Structurally, it bears a resemblance to phenazepam, with the notable substitution of a chlorine atom for a fluorine atom.It's worth noting that
- [Diclazepam](https://researchem.net/diclazepam/) - Summary Diazepam (also referred to as chlorodiazepam and 2'-chloro-diazepam) is a benzodiazepine compound and serves as a functional analogue of diazepam. This chemical entity was initially synthesized by Leo Sternbach and his research team at Hoffman-La Roche in 1960. Despite its origins, diazepam has not obtained approval for clinical use as a medication and is
- [Desmethylflunitrazepam](https://researchem.net/desmethylflunitrazepam/) - Summary Desmethylflunitrazepam, which is also referred to as norflunitrazepam, Ro05-4435, and fonazepam, is a benzodiazepine compound. This substance is a metabolite of flunitrazepam and has been made available for purchase online as a designer drug. It exhibits a notable IC50 value of 1.499 nM for its interaction with the GABAA receptor. FAQ What is Desmethylflunitrazepam?
- [Cloniprazepam](https://researchem.net/cloniprazepam/) - Summary Cloniprazepam, a benzodiazepine derivative, serves as a prodrug for clonazepam, generating 7-aminoclonazepam and various other metabolites.Among these minor metabolites are 3-hydroxyclonazepam, 6-hydroxyclonazepam, 3-hydroxycloniprazepam, and ketocloniprazepam, which features a ketone group formed in place of the 3-hydroxy group.Cloniprazepam is categorized as a designer drug and falls under the umbrella of "new psychoactive substances" (NPS). Towards
- [Clonazolam](https://researchem.net/clonazolam/) - Summary Clonazolam, also referred to as clonitrazolam, belongs to the triazolobenzodiazepine (TBZD) class, a category combining traditional benzodiazepines (BZDs) with a triazole ring. The existing knowledge about its effects and metabolic processes is limited, and clonazolam is available for purchase online as a designer drug. The synthesis of clonazolam was first documented in 1971, and
- [Adinazolam](https://researchem.net/adinazolam/) - Summary Adinazolam, marketed under the brand name Deracyn, is a tranquilizer belonging to the triazolobenzodiazepine (TBZD) class. This class combines traditional benzodiazepines (BZDs) with a triazole ring. Adinazolam is known for its anxiolytic, anticonvulsant, sedative, and antidepressant properties. The drug's development can be credited to Jackson B. Hester, who aimed to enhance the antidepressant effects
- [3-Hydroxyphenazepam](https://researchem.net/3-hydroxyphenazepam/) - Summary 3-Hydroxyphenazepam is a benzodiazepine renowned for its hypnotic, sedative, anxiolytic, and anticonvulsant attributes. Notably, it serves as an active metabolite of phenazepam and also acts as the active metabolite of the benzodiazepine prodrug cinazepam. In comparison to phenazepam, 3-hydroxyphenazepam exhibits reduced myorelaxant effects but remains largely on par in most other aspects.Much like its
- [Valerylfentanyl](https://researchem.net/valerylfentanyl/) - Summary Valerylfentanyl, an opioid analgesic analogue of fentanyl, has made appearances as a designer drug in online markets. Despite being relatively uncommon in illicit trade, limited information is available about this substance. It is generally thought to possess intermediate potency, with greater strength compared to benzyl fentanyl but lower power than butyrfentanyl. A study found
- [U-48800](https://researchem.net/u-48800/) - Summary U-48800 is an opioid analgesic that has found its way into the designer drug market. Differing from U-47700, it primarily functions as a kappa opioid receptor agonist with only moderate affinity for the mu-opioid receptor. Despite this distinction, it has emerged in the realm of recreational drug use, sometimes forming part of drug combinations.
- [Tetrahydrofuranylfentanyl](https://researchem.net/tetrahydrofuranylfentanyl/) - Summary Tetrahydrofuranylfentanyl is a designer drug that emerged in Europe in late 2016. It is classified as an opioid analgesic and is structurally related to fentanyl. Side effects The side effects associated with fentanyl analogues closely resemble those of fentanyl itself, encompassing symptoms such as itching, nausea, and the potential for severe respiratory depression, which
- [Protonitazene](https://researchem.net/protonitazene/) - Summary Protonitazene is a benzimidazole-derived compound recognized for its potent opioid properties. Since 2019, it has gained prominence as a designer drug available on the internet, being detected in multiple European nations, Canada, the USA, and Australia. However, it has also been associated with numerous instances of drug overdoses, leading to its classification as a
- [Piperidylthiambutene](https://researchem.net/piperidylthiambutene/) - Summary Piperidylthiambutene, also known as Piperidinohton, belongs to the thiambutene family and is a synthetic opioid analgesic drug. It shares a similar potency to morphine. Unlike fentanyl, its analogues, and previously known synthetic opioids, Piperidylthiambutene exhibits a unique chemical structure.It's important to note that in certain countries, including the United States, Australia, and New Zealand
- [Desmetramadol](https://researchem.net/desmetramadol/) - Summary Desmetramadol, also known by its International Nonproprietary Name (INN) as O-desmethyltramadol (O-DSMT), is an opioid analgesic and serves as the primary active metabolite of tramadol. Tramadol undergoes demethylation via the liver enzyme CYP2D6, leading to the formation of desmetramadol, a process akin to the way codeine is metabolized. Consequently, just as variations in the
- [Nortilidine](https://researchem.net/nortilidine/) - Summary Nortilidine represents the primary active metabolite derived from tilidine, arising through liver demethylation. The racemic form of nortilidine exhibits opioid analgesic effects that are approximately equivalent in potency to morphine. Notably, the (1R,2S) isomer of nortilidine displays NMDA antagonist activity. Furthermore, this compound also functions as a dopamine reuptake inhibitor. Variants of nortilidine include
- [MT-45](https://researchem.net/mt-45/) - Summary MT-45 (also known as IC-6) is an opioid analgesic medication that was initially created in the 1970s by Dainippon Pharmaceutical Co. Its chemical structure is that of a 1-substituted-4-(1,2-phenylmethyl) piperazine derivative, setting it apart from the majority of other opioid drugs. In its racemic form, MT-45 possesses approximately 80% of the potency of morphine,
- [Metonitazene](https://researchem.net/metonitazene/) - Summary Metonitazene, an analgesic compound closely related to etonitazene, was initially reported in 1957. When administered through central routes, it exhibits an astounding potency, approximately 100 times greater than morphine. However, when taken orally, its strength decreases to around 10 times that of morphine.Its effects mirror those of other opioids, such as fentanyl and heroin,
- [Metodesnitazene](https://researchem.net/metodesnitazene/) - Summary Metodesnitazene, also recognized as Metazene, belongs to the class of benzimidazole derivatives, exhibiting opioid-like properties. However, in contrast to closely related substances like metonitazene and etodesnitazene, which display significantly higher potency, metodesnitazene demonstrates a level of power in animal studies that is roughly equivalent to morphine. In December 2021, the United States Drug Enforcement
- [Methoxyacetylfentanyl](https://researchem.net/methoxyacetylfentanyl/) - Summary Methoxyacetylfentanyl, often referred to as MAF, is an opioid analgesic. It is structurally related to fentanyl and has been available for purchase on the internet as a designer drug. Side effects The side effects of fentanyl analogues closely mirror those of fentanyl itself, encompassing symptoms such as itching, nausea, and potentially severe respiratory depression,
- [Isotonitazene](https://researchem.net/isotonitazene/) - Summary Isotonitazene is an opioid analgesic drug derived from benzimidazole, and it shares a relationship with etonitazene. Marketed as a designer drug, it exhibits approximately half the potency of etonitazene in animal studies. However, it's likely even less potent in humans, mirroring the pattern observed with etonitazene (which was approximately 1000 times as potent as
- [Flunitazene](https://researchem.net/flunitazene/) - Summary Flunitazene, also known as Fluonitazene, is a benzimidazole-derived compound recognized for its opioid properties. It was initially formulated in the 1950s as part of the scientific exploration that eventually yielded more widely recognized substances like etonitazene. Despite being one of the less potent derivatives in its class, having roughly equivalent potency to morphine, Flunitazene
- [Etonitazepyne](https://researchem.net/etonitazepyne/) - Summary Etonitazepyne, also known as N-Pyrrolidino Etonitazene, is a benzimidazole-derived compound renowned for its powerful opioid properties. It has been illicitly marketed online as a designer drug and has been associated with a significant number of overdose incidents. FAQ 1. What is Etonitazepyne? Etonitazepyne, also referred to as N-Pyrrolidino Etonitazene, is a benzimidazole-derived substance known
- [Etodesnitazene](https://researchem.net/etodesnitazene/) - Summary Etodesnitazene, also known as Desnitroetonitazene, Etazen, Etazene, or Etazone, is an opioid analgesic drug derived from benzimidazole. Its origins date back to the late 1950s, when it was developed alongside etonitazene and a range of related derivatives. While Etodesnitazene is significantly less potent than etonitazene itself, it still exhibits about 70 times the potency
- [2,2'-Difluorofentanyl](https://researchem.net/22-difluorofentanyl/) - Summary 2,2'-Difluorofentanyl is a synthetic opioid analgesic, closely related to fentanyl, and has gained notoriety as a designer drug. Side effects The side effects of fentanyl analogs mirror those of fentanyl itself, encompassing symptoms such as itching, nausea, and the potential for severe respiratory depression, which poses a life-threatening risk. Throughout Europe and the former
- [Dipyanone](https://researchem.net/dipyanone/) - Summary Dipyanone, an opioid analgesic, emerged as a designer drug and was initially detected in Germany in 2021. This compound shares close structural similarities with medically approved opioids like methadone, dipipanone, and phenadoxone, although it exhibits slightly less potency. FAQ What is Dipyanone? Dipyanone is an opioid analgesic, which is a type of pain-relief medication.
- [Diphenpipenol](https://researchem.net/diphenpipenol/) - Summary Diphenpipenol, a synthetic opioid analgesic, emerged in the 1970s through the innovative work of Dainippon Pharmaceutical Co.Structurally, it belongs to the class of 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives, sharing similarities with compounds like MT-45 and AD-1211. Notably, within this group, diphenpipenol stands out as the most potent compound. In animal studies, the (S) enantiomer, in particular, exhibits
- [Desmethylmoramide](https://researchem.net/desmethylmoramide/) - Sumamry Desmethylmoramide, known by its INN (International Nonproprietary Name), is an opioid analgesic with a connection to dextromoramide, the active (+)-isomer of moramide. It was synthesized and characterized during the late 1950s but did not enter the market. FAQ What is Desmethylmoramide? Desmethylmoramide is an opioid analgesic that is related to dextromoramide, the active (+)-isomer
- [Desmethylprodine](https://researchem.net/desmethylprodine/) - Summary Desmethylprodine, also known as MPPP or Ro 2-0718, is an opioid analgesic initially developed in the 1940s by scientists at Hoffmann-La Roche. In the United States, the Drug Enforcement Administration (DEA) has classified Desmethylprodine as a Schedule I substance, which denotes its controlled and illegal status. Notably, it is an analog of pethidine (meperidine),
- [Crotonylfentanyl](https://researchem.net/crotonylfentanyl/) - Summary Crotonylfentanyl is an opioid pain reliever, structurally related to fentanyl, and a structural isomer of cyclopropylfentanyl. It has been available on the internet as a designer drug. In December 2019, the United Nations Office on Drugs and Crime (UNODC) introduced scheduling recommendations to classify crotonylfentanyl as a Schedule I substance. FAQ What is Crotonylfentanyl?
- [Cyclopropylfentanyl](https://researchem.net/cyclopropylfentanyl/) - Summary Cyclopropyl fentanyl is an opioid pain reliever, structurally similar to fentanyl, and has been distributed as a designer drug. Between June and December 2017, European countries reported a total of 78 fatalities linked to cyclopropyl fentanyl, with analytical confirmation from post-mortem samples. An additional 115 deaths associated with cyclopropyl fentanyl use were reported in
- [Cyclopentylfentanyl](https://researchem.net/cyclopentylfentanyl/) - Summary Cyclopentylfentanyl is an opioid pain reliever structurally related to fentanyl, which has been available on the internet as a designer drug, primarily in Sweden and other Nordic countries. Side effects The side effects of fentanyl analogs closely resemble those of fentanyl itself, encompassing symptoms such as itching, nausea, and potentially life-threatening respiratory depression. Fentanyl
- [Clonitazene](https://researchem.net/clonitazene/) - Summary Clonitazene is an opioid pain reliever that boasts nearly triple the potency of morphine. This compound shares a kinship with etonitazene, an opioid with notably greater power. Clonitazene is not commercially available at present. Regarded as a controlled substance, it holds a Schedule I classification in the United States as a Narcotic controlled substance,
- [Butonitazene](https://researchem.net/butonitazene/) - Summary Butonitazene, categorized as a benzimidazole-derived substance with opioid properties, has been available on the internet as a designer drug. In its natural form, it exhibits moderate potency when compared to its chemical counterparts. It is commonly found as part of blends containing various substances rather than in its unadulterated state. Nevertheless, it remains significantly
- [Brorphine](https://researchem.net/brorphine/) - Summary Brorphine is a piperidine-based opioid analgesic compound that first came to scientific attention in 2018. Initially, it was explored in research focused on functionally biased opioid compounds, with the aim of developing safer analgesics that induce less respiratory depression compared to conventional opioids. While it was initially reported as highly personal, more recent studies
- [Bromadoline](https://researchem.net/bromadoline/) - Summary Bromadoline, also known as U-47931E, is a μ-opioid receptor-selective opioid analgesic created by Upjohn in the 1970s. It falls within the range of potency between codeine and morphine, with slight superiority to pentazocine. Bromadoline shares a chemical relationship with AH-7921 and U-47700. FAQ What is Bromadoline? Bromadoline, also known as U-47931E, is an opioid
- [BDPC](https://researchem.net/bdpc/) - Summary BDPC, also known as bromadol, is a highly potent narcotic analgesic characterized by its unique arylcyclohexylamine chemical structure. This compound was initially developed by Daniel Lednicer at Upjohn during the 1970s.Early investigations suggested that BDPC exhibited a staggering potency, estimated to be approximately 10,000 times stronger than morphine in animal models. However, subsequent studies
- [AP-238](https://researchem.net/ap-238/) - Summary AP-238 is an opioid-designer drug sharing chemical kinship with compounds like azaprocin and bucinnazine, exhibiting a potency level akin to that of morphine. Originating in Italy during the 1960s, it remained unmarketed yet emerged on the underground market approximately in 2020, making notable appearances in both Slovenia and the United States. FAQ What is
- [α-Methylfentanyl](https://researchem.net/α-methylfentanyl/) - Summary α-Methylfentanyl, also known as alpha-Methylfentanyl, is an opioid analgesic that belongs to the fentanyl analog family. This substance is occasionally marketed under the street name "China White." History α-Methylfentanyl was initially synthesized by a team at Janssen Pharmaceutica during the 1960s. By 1976, it had started appearing as an additive mixed with heroin, and
- [AH-7921](https://researchem.net/ah-7921/) - Summary AH-7921, an opioid analgesic drug, exhibits selectivity for the μ-opioid receptor, boasting approximately 90% of the potency of morphine when administered orally. This compound was initially uncovered during the 1970s by a research team at Allen and Hanburys, situated in the United Kingdom.Distinguished as a new psychoactive substance (NPS), AH-7921 is meticulously crafted in
- [Acrylfentanyl](https://researchem.net/acrylfentanyl/) - Summary Acryl fentanyl, also recognized by names such as acryloyl fentanyl or Egyptenyl, is an exceptionally potent opioid analgesic. It belongs to the fentanyl family and has been made available for purchase online as a designer drug. In animal studies, Acrylfentanyl exhibits a half maximal inhibitory concentration (IC50) of 1.4 nM, slightly surpassing the potency
- [Acetoxymethylketobemidone](https://researchem.net/acetoxymethylketobemidone/) - Summary Acetoxymethylketobemidone (commonly referred to as O-AMKD) is a designer opioid substance that shares a kinship with ketobemidone, offering a potency level similar to morphine. Its presence came to light in Germany in October 2020, marking its initial identification. FAQ 1. What is Acetoxymethylketobemidone (O-AMKD)? Acetoxymethylketobemidone, often known as O-AMKD, is a synthetic opioid substance
- [Parafluorofentanyl](https://researchem.net/parafluorofentanyl/) - Summary Parafluorofentanyl (commonly referred to as 4-fluorofentanyl or pFF) is an opioid analgesic analog with its origins dating back to the 1960s, when Janssen Pharmaceuticals developed it.During the early 1980s, 4-Fluorofentanyl made a brief appearance on the US black market, a period marked by a lack of citation records. However, this was before the introduction
- [4-Methoxybutyrfentanyl](https://researchem.net/4-methoxybutyrfentanyl/) - Summary 4-Methoxybutyrfentanyl, commonly referred to as 4-MeO-BF, is categorized as an opioid analgesic. It shares structural similarities with buy fentanyl and has gained notoriety as a designer drug available for purchase on online platforms. Adverse Effects The side effects associated with fentanyl analogs mirror those of fentanyl itself, encompassing symptoms like itching, nausea, and the
- [4-Fluoroisobutyrfentanyl](https://researchem.net/4-fluoroisobutyrfentanyl/) - Summary 4-Fluoroisobutyrylfentanyl, also known as 4-FIBF or p-FIBF, belongs to the opioid analgesic class and shares structural similarities with butyrfentanyl. It is a structural isomer of 4-Fluorobutyrfentanyl and has been marketed and distributed online as a synthetic designer drug.This compound exhibits a solid connection to 4-fluoro fentanyl, with a measured EC50 value of 4.2 nM
- [4-Fluorobutyrfentanyl](https://researchem.net/4-fluorobutyrfentanyl/) - Summary 4-Fluorobutyrylfentanyl, also referred to as 4-FBF or para-fluorobutyrylfentanyl, is a synthetic opioid analgesic. This compound, closely related to buying fentanyl, has gained popularity as a designer drug and is available online. It shares a close chemical kinship with 4-fluoro fentanyl, a substance with a notable affinity for the human μ-opioid receptor, as indicated by
- [3-Methylbutyrfentanyl](https://researchem.net/3-methylbutyrfentanyl/) - Summary 3-Methylbutyrfentanyl (3-MBF) is an opioid analgesic, considered an analog of butyrfentanyl.Like fentanyl, the side effects of fentanyl analogs, including 3-MBF, encompass symptoms such as itching and nausea. Of particular concern is the potential for severe respiratory depression, which can be life-threatening. Notably, fentanyl analogs have been associated with numerous fatalities across Europe and the
- [Bucinnazine](https://researchem.net/bucinnazine/) - Summary Bucinnazine, also known as AP-237 or 1-butyryl-4-cinnamylpiperazine, is an opioid analgesic drug with a significant history of use in China for managing pain in cancer patients dating back to 1986. This compound is among the most potent in a series of piperazine-amides that were initially synthesized and documented in Japan during the 1970s. Bucinnazine
- [2F-Viminol](https://researchem.net/2f-viminol/) - Summary 2F-Viminol, a pyrrole-derived opioid analgesic, originally emerged from the research efforts of the pharmaceutical company Zambon during the 1960s. It boasts roughly double the potency of its precursor compound, viminol. However, unlike viminol, 2F-viminol has not advanced through clinical trials or gained approval for medical purposes. Instead, it has made its way into the
- [CRL-40,941](https://researchem.net/crl-40941/) - Summary CRL-40,941, known by its alternative names fladrafinil and fluorafinil, falls within the category of eugeroics and shares a close chemical relationship with adrafinil and modafinil. Specifically, it is the bis(p-fluoro) ring-substituted derivative of adrafinil. One noteworthy distinction is that CRL-40,941 has demonstrated anti-aggressive effects in animals, a characteristic not observed with adrafinil, and it
- [CRL-40,940](https://researchem.net/crl-40940/) - Summary CRL-40,940, also referred to as flmodafinil, bisfluoromodafinil, and lauflumide, represents the bisfluoro derivative of modafinil. This compound falls under the category of eugeroics and functions as a mild dopamine reuptake inhibitor. Its developers assert that it exhibits superior efficacy to modafinil and adrafinil while presenting a reduced risk of side effects. CRL-40,940 was patented
- [Camfetamine](https://researchem.net/camfetamine/) - Summary Camfetamine, chemically known as N-methyl-3-phenyl-norbornan-2-amine, is a stimulant substance closely tied to the appetite suppressant fencamfamine, representing its N-methyl counterpart. This compound has gained popularity as a designer drug due to the prohibition of mephedrone and similar substituted cathinone derivatives in numerous countries. It delivers slightly more potent stimulant effects than fencamfamine, albeit accompanied
- [Amfonelic acid](https://researchem.net/amfonelic-acid/) - Summary Amfonelic acid (AFA), also known as WIN 25,978, is a research compound characterized by its dopaminergic stimulant effects and potential antibiotic properties. While clinical trials are scarce, their predominant application lies within scientific research. History The discovery of AFA's stimulant properties occurred serendipitously during research on the antibiotic nalidixic acid at Sterling-Winthrop. While initially
- [G-130](https://researchem.net/g-130/) - Summary G-130 (also known as GP-130 or 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine) is a pharmaceutical compound recognized for its stimulant and anorectic properties, and it shares a chemical relationship with phenmetrazine. Synthesis Ex 1: 2 moles of 2-methyl-2-aminopropanol (aminomethyl propanol) (1) is reacted with 1 moles of styrene oxide (phenyloxirane) [96-09-3] (2) in 0.2 mole water. FAQ What is
- [2-Phenyl-3,6-dimethylmorpholine](https://researchem.net/2-phenyl-36-dimethylmorpholine/) - Summary 2-Phenyl-3,6-dimethylmorpholine, a pharmaceutical compound, is known for its stimulant and anorectic properties and is closely associated with phenmetrazine. With structural similarities to other phenylmorpholine compounds, it is believed to function as a serotonin reuptake inhibitor, potentially yielding effects akin to antidepressants. Nonetheless, anecdotal accounts propose that its activity primarily involves inducing anorectic effects, with
- [4-Methylphenmetrazine](https://researchem.net/4-methylphenmetrazine/) - Summary 4-Methylphenmetrazine, also known as mephenmetrazine, 4-MPM, or PAL-747, is a recreational designer substance celebrated for its stimulating effects. This compound is a derivative of phenylmorpholine, sharing a close structural relation with more widely recognized substances like phenmetrazine and 3-fluorophenmetrazine. It initially came to attention in Slovenia in 2015, and subsequent research has revealed its
- [4'-Fluoro-4-methylaminorex](https://researchem.net/4-fluoro-4-methylaminorex/) - Summary 4'-Fluoro-4-methylaminorex, commonly called 4F-MAR or 4-FPO, is a recreational designer drug from the substituted aminorex class. This compound is known for its stimulant properties. Its presence was initially identified in Slovenia in the year 2018. Notably, it was subjected to legal prohibition in Italy in March 2020. FAQ What is 4'-Fluoro-4-methylaminorex (4F-MAR)? 4'-Fluoro-4-methylaminorex, often
- [Propylphenidate](https://researchem.net/propylphenidate/) - Summary Propylphenidate, sometimes called PPH, belongs to the class of piperidine-based stimulant drugs. It shares a close structural relationship with methylphenidate, differing primarily in replacing the methyl ester with a propyl ester. Notably, in April 2015, the United Kingdom classified Propylphenidate as a Temporary Class Drug due to its unauthorized distribution and sale as a
- [Benocyclidine](https://researchem.net/benocyclidine/) - Summary Benocyclidine, also recognized as benzo​thiophenyl​cyclo​hexylpiperidine (BTCP), represents a psychoactive recreational substance within the arylcyclohexylamine class, closely associated with phencyclidine (PCP). The initial documentation of this compound can be traced back to a patent application submitted by Marc Caron and a team at Duke University in 1997.This potent and selective dopamine reuptake inhibitor (DRI) substance
- [4-Methylmethylphenidate](https://researchem.net/4-methylmethylphenidate/) - Summary Threo-4-methylmethylphenidate (4-MeTMP) is a stimulant drug with a chemical relationship with methylphenidate. While it is akin to methylphenidate, its stimulant properties are somewhat milder, and it exhibits relatively limited effectiveness in inhibiting dopamine reuptake despite its high binding affinity. This unique profile has prompted investigations into its potential use as an alternative treatment for
- [Thiothinone](https://researchem.net/thiothinone/) - Summary Thiothinone, also known as βk-MPA, is a stimulant classified as the beta-keto substituted counterpart of methiopropamine. It has gained popularity as a designer drug and has been available for purchase on online platforms. Structurally, Thiothinone resembles methcathinone, except that the phenyl group has been replaced by a thiophene group.Interestingly, Thiothinone has also been identified
- [4'-Fluoro-α-pyrrolidinooctanophenone](https://researchem.net/4-fluoro-α-pyrrolidinooctanophenone/) - Summary 4'-Fluoro-α-pyrrolidinooctanophenone, alternatively referred to as 4-Fluoro-PV-9, FPOP, or 4-Fluoro-α-POP, is classified as a cathinone stimulant. This compound has gained recognition as an emerging designer drug with novel properties. Legality 4-F-α-POP is illegal in Japan. FAQ What is 4'-Fluoro-α-pyrrolidinooctanophenone (4-Fluoro-PV-9)? 4'-Fluoro-α-pyrrolidinooctanophenone, or 4-Fluoro-PV-9, is a synthetic stimulant drug in the cathinone class. It is considered
- [Methylenedioxypyrovalerone](https://researchem.net/methylenedioxypyrovalerone/) - Summary Methylenedioxypyrovalerone (MDPV) is a cathinone-class stimulant that functions as a norepinephrine-dopamine reuptake inhibitor (NDRI). It originated in the 1960s through development by a team at Boehringer Ingelheim. Notably, MDPV exhibits considerably stronger activity at the dopamine transporter compared to the norepinephrine transporter, while showing minimal activity at the serotonin transporter. MDPV remained relatively obscure
- [3',4'-Methylenedioxy-α-pyrrolidinopropiophenone](https://researchem.net/34-methylenedioxy-α-pyrrolidinopropiophenone/) - Summary 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) is a stimulant designer drug. During the late 1990s and early 2000s, it was available in Germany and often used as an ingredient in counterfeit ecstasy (MDMA) tablets. MDP resembles the chemical structure of α-PPP and MDPV and has demonstrated reinforcing effects in rat studies. Metabolism MDPPP seems to undergo a metabolic
- [N-Ethylheptedrone](https://researchem.net/n-ethylheptedrone/) - Summary N-Ethylheptedrone, belonging to the substituted cathinone family, is a recreational designer drug known for its stimulant properties. It is categorized as a homolog of other substances like ethcathinone, N-ethylbuphedrone, and N-ethylhexedrone but distinct due to its extended pentyl side chain. Initially discovered in Hungary in 2019, it has been found in New Zealand. FAQ
- [N-Ethylbuphedrone](https://researchem.net/n-ethylbuphedrone/) - Summary N-Ethylbuphedrone, commonly called NEB, is a member of the cathinone class of stimulants and has been marketed as a designer drug. It serves as the β-ketone counterpart of N,alpha-diethylphenylethylamine. Legal status In October 2015, China categorized NEB as a controlled substance.NEB is classified as a Schedule 1 controlled substance in the United States due
- [Ethcathinone](https://researchem.net/ethcathinone/) - Summary Ethcathinone, alternatively recognized as ethylpropion or ETH-CAT, falls within the category of stimulant drugs in the phenethylamine, amphetamine, and cathinone chemical classes. It serves as the primary active metabolite of the prodrug diethylcathinone, solely responsible for producing its effects. Ethcathinone has been detected as a component in quasi-legal "party pills." Moreover, it has occasionally
- [Benzedrone](https://researchem.net/benzedrone/) - Summary Benzedrone, also known as 4-MBC, is a synthetic designer drug that emerged around 2010 and has been detected as a component in various "bath salt" blends marketed for recreational purposes. FAQ 1. What is Benzedrone (4-MBC)? Benzedrone, commonly called 4-MBC, is a synthetic designer drug known for its stimulant properties. It belongs to the
- [2-Methylmethcathinone](https://researchem.net/2-methylmethcathinone/) - Summary 2-Methylmethcathinone (2-MMC), sometimes referred to as ortomephedrone, is a recreational designer drug celebrated for its stimulating effects. This compound is a cathinone derivative with substitutions, closely akin to more familiar substances like 3-methylmethcathinone and 4-methylmethcathinone (commonly known as mephedrone). In 2014, its presence was initially documented in Sweden, and since then, it has surfaced
- [4-Fluoroamphetamine](https://researchem.net/4-fluoroamphetamine/) - Summary 4-Fluoroamphetamine (4-FA), also recognized as 4-FMP, PAL-303, or "Flux," and alternatively referred to as para-fluoroamphetamine (PFA), belongs to the realm of psychoactive research chemicals, falling within the phenethylamine and substituted amphetamine categories. It is characterized by its capacity to induce both stimulating and entactogenic effects. In recreational contexts, 4-FA is occasionally available alongside analogous
- [para-Chloroamphetamine](https://researchem.net/para-chloroamphetamine/) - Summary Para-chloroamphetamine (PCA), also recognized as 4-chloroamphetamine (4-CA), falls within the category of substituted amphetamines and serves as a monoamine releaser. It shares similarities with MDMA but is notably more neurotoxic, primarily attributed to the uncontrolled release of both serotonin and dopamine by a metabolite.This compound is frequently employed by neurobiologists as a neurotoxin for
- [para-Bromoamphetamine](https://researchem.net/para-bromoamphetamine/) - Summary Parabromoamphetamine (PBA), alternatively referred to as 4-bromoamphetamine (4-BA), belongs to the amphetamine family and functions as a serotonin-norepinephrine-dopamine releasing agent (SNDRA), resulting in stimulant properties.In addition, there is a closely related compound known as parabromomethamphetamine, identified under the codename V-111. Neurotoxicity Similar to numerous other para-substituted amphetamines, PBA has the potential to be neurotoxic,
- [5-MeO-aMT](https://researchem.net/5-meo-amt/) - Summary 5-MeO-aMT, also known as 5-methoxy-α-methyltryptamine or α, O-Dimethylserotonin (Alpha-O), is a highly potent psychedelic tryptamine. This compound exhibits solubility in ethanol. Pharmacokinetics Recreational usage 5-MeO-AMT, also known as Alpha-O, is purportedly available in 4 mg tablet form and is used recreationally. Notably, since the DEA cracked down on a significant portion of LSD production
- [5-MeO-AET](https://researchem.net/5-meo-aet/) - Summary 5-Methoxy-alpha-ethyltryptamine, often referred to as 5-MeO-α-ET, is a psychoactive substance belonging to the tryptamine chemical class. It is known to induce both psychedelic and stimulant effects. Effects 5-MeO-α-ET induces entactogenic and stimulant effects with a typical duration of 4 to 6 hours. It's important to note that limited research is available regarding the psychopharmacological
- [α-Ethyltryptamine](https://researchem.net/α-ethyltryptamine/) - Summary α-Ethyltryptamine (αET, AET), also referred to as etryptamine (INN, BAN, USAN), is a member of the tryptamine class of compounds, exhibiting psychedelic, stimulant, and entactogenic properties. During the 1960s, it was initially created and introduced as an antidepressant by Upjohn, bearing the brand name Monase. History Initially, it was thought that α-ethyltryptamine primarily influenced
- [5-IT](https://researchem.net/5-it/) - Summary 5-(2-Aminopropyl)indole, also known as 5-API, 5-IT, or PAL-571, is a compound belonging to the indole and phenethylamine families, and it is known for its empathogenic effects. This substance was initially synthesized by Albert Hofmann in 1962. Since 2011, it has been openly marketed as a designer drug and sold by online vendors for recreational
- [NM-2-AI](https://researchem.net/nm-2-ai/) - Summary NM-2-AI, also known as N-methyl-2-aminoindane, is a psychoactive substance and a research chemical that has been distributed via online platforms as a designer drug. Structurally, it is a rigid counterpart to methamphetamine and is derived from 2-aminoindane. Pharmacology Pharmacodynamics: NM-2-AI exhibits pronounced pharmacological actions, serving as a highly selective norepinephrine reuptake inhibitor and releasing
- [5-APDI](https://researchem.net/5-apdi/) - Summary 5-(2-Aminopropyl)-2,3-dihydro-1H-indene (commonly known as 5-APDI or indanylaminopropane/IAP) is a member of the amphetamine family, with diverse aliases including IAP (psychedelic), 2-API (2-aminopropylindane), indanametamine, and, occasionally, indanylamphetamine. This compound is recognized for its entactogenic and psychedelic properties. 5-APDI and Its Availability: 5-APDI has been accessible through online vendors on the internet and has been present
- [MDMAI](https://researchem.net/mdmai/) - Summary 5,6-Methylenedioxy-N-methyl-2-aminoindane, commonly referred to as MDMAI is a compound created in the 1990s by a research team led by David E. Nichols at Purdue University. In animal studies, it operates as a selective serotonin-releasing agent (SSRA) without neurotoxic effects, while in humans, it is believed to have the potential to act as an entactogen,
- [6-MAPDB](https://researchem.net/6-mapdb/) - Summary 6-MAPDB, formally known as 1-(2,3-dihydrobenzofuran-6-yl)-N-methylpropan-2-amine, is a chemical compound with potential entactogenic properties. It shares structural similarities with substances like 6-APDB and 6-MAPB, both of which are known to produce effects akin to MDMA and have been utilized for recreational purposes. It's worth noting that 6-MAPDB has not undergone extensive pharmacological studies to establish
- [6-MAPB](https://researchem.net/6-mapb/) - Summary 6-MAPB, chemically known as 1-(benzofuran-6-yl)-N-methylpropan-2-amine, is a substance known for its psychedelic and entactogenic properties. It shares a structural resemblance with both 6-APB and MDMA, established through multiple references.While not widely recognized as a "designer drug," 6-MAPB has been identified in analytical samples obtained from individuals who required hospitalization due to the use of
- [6-EAPB](https://researchem.net/6-eapb/) - Summary 6-EAPB, which is formally known as 1-(benzofuran-6-yl)-N-ethylpropan-2-amine, belongs to the benzofuran class of compounds. It is a substance with the potential for psychedelic and entactogenic effects. In terms of its chemical structure, 6-EAPB shares similarities with both 6-APB and MDMA. FAQ 1. What is 6-EAPB? 6-EAPB is a chemical compound belonging to the benzofuran
- [5-MBPB](https://researchem.net/5-mbpb/) - Summary 5-MBPB, also known as 5-MPBP and 5-MABB, is an amphetamine derivative with structural similarities to MDMA. This compound has been distributed as a designer drug. It can be characterized as the benzofuran-5-yl counterpart of MBDB or the butanamine half of 5-MAPB. FAQ 1. What is 5-MBPB? 5-MBPB, also known as 5-MPBP and 5-MABB, is
- [5-MAPDB](https://researchem.net/5-mapdb/) - Summary 5-MAPDB, also known as 1-(2,3-dihydrobenzofuran-5-yl)-N-methylpropan-2-amine, belongs to the category of entactogenic compounds. It shares structural similarities with substances like 5-APDB and 5-MAPB, both of which produce effects akin to MDMA and are often used for recreational purposes. Extensive research has explored the pharmacological properties of 5-MAPDB, revealing its role as a relatively specific serotonin
- [5-APDB](https://researchem.net/5-apdb/) - Summary 5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB, also known as 3-Desoxy-MDA or EMA-4) is a potential entactogenic substance belonging to the phenethylamine and amphetamine classes. It is derived from MDA, where a methylene bridge has replaced the oxygen atom at the 3-position of the 3,4-methylenedioxy ring. Another related compound is 6-APDB, which differs from 5-APDB by having a methylene
- [5-EAPB](https://researchem.net/5-eapb/) - Summary 5-EAPB (1-(benzofuran-5-yl)-N-ethylpropan-2-amine) is a chemical compound that falls into the category of potentially entactogenic amphetamines. Structurally, it shares similarities with substances like 5-MAPB and 5-APB. While it may be anticipated to exhibit effects akin to these drugs in humans, the pharmacology of 5-EAPB remains unexplored mainly as of 2020.In terms of structural resemblance, 5-EAPB
- [Putylone](https://researchem.net/putylone/) - Summary Putylone, alternatively referred to as β-keto-1,3-benzodioxolyl-N-propyldioxybutanamine, bk-PBDB, and N-propylbutylone, emerged on the scene in 2023. This stimulant and empathogenic compound came into the spotlight, notably around the time when a ban was imposed on its related combination, eutylone. Legal status The legal status of butylene remains unaddressed by any official agency or government. However,
- [MMDA-2](https://researchem.net/mmda-2/) - Summary MMDA-2, formally known as 2-methoxy-4,5-methylenedioxyamphetamine, is a member of the psychedelic amphetamine class. It shares a close chemical kinship with substances like MMDA and MDA.The pioneering synthesis of MMDA-2 is often attributed to Alexander Shulgin, a prominent figure in the realm of psychopharmacology. In his comprehensive book "PiHKAL," Shulgin notes that the recommended dosage
- [3,4-Methylenedioxy-N-hydroxy-N-methylamphetamine](https://researchem.net/34-methylenedioxy-n-hydroxy-n-methylamphetamine/) - Summary 3,4-Methylenedioxy-N-hydroxy-N-methylamphetamine (MDHMA), also known as FLEA, falls within the realm of entactogenic, psychedelic, and stimulant compounds, classifying it under the phenethylamine and amphetamine chemical categories. This chemical entity serves as the N-hydroxy homolog of MDMA, commonly referred to as "Ecstasy," and the N-methyl homolog of MDOH. Alexander Shulgin carried out the pioneering work on
- [EDMA](https://researchem.net/edma/) - Summary 3,4-Ethylenedioxy-N-methylamphetamine (EDMA) is a member of the entactogen drug family belonging to the methamphetamine class. In essence, it is an analog of MDMA, where the characteristic methylenedioxy ring has been replaced by an ethylenedioxy call. The synthesis of EDMA is credited to Alexander Shulgin. In his notable work "PiHKAL," the recommended dosage for EDMA
- [Dipentylone](https://researchem.net/dipentylone/) - Summary N,N-Dimethylpentylone, commonly referred to as Dipentylone or simply Dimethylpentylone, is a derivative of cathinone with stimulant properties. This compound has been marketed as a designer drug and was initially identified in Sweden in 2014. Metabolism and pharmacology Pentylone is a known metabolite of Dimethylpentylone. Society and Culture Dimethylpentylone was first detected in toxicology samples
- [DiFMDA](https://researchem.net/difmda/) - Summary Difluoromethylenedioxyamphetamine (DiFMDA) is a modified derivative of 3,4-methylenedioxyamphetamine (MDA), a compound initially developed by Daniel Trachsel and colleagues. This development also included the creation of fluorinated variants of MDMA, MDEA, BDB, and MBDB. The primary objective was to identify a non-neurotoxic substance that could serve as a safer alternative to entactogenic drugs like MDMA.The
- [Trifluoromethylphenylpiperazine](https://researchem.net/trifluoromethylphenylpiperazine/) - Summary 3-Trifluoromethylphenylpiperazine (TFMPP) belongs to the phenylpiperazine chemical class and is a substituted piperazine with recreational use. It is often marketed alongside benzylpiperazine (BZP) and similar compounds as a substitute for the illegal substance MDMA, commonly known as "Ecstasy." Pharmacology TFMPP exhibits a notable affinity for various serotonin receptors, specifically 5-HT1A (Ki = 288 nM),
- [Methylenedioxybenzylpiperazine](https://researchem.net/methylenedioxybenzylpiperazine/) - Summary 1-(3,4-Methylenedioxybenzyl)piperazine, also known as MDBZP or piperonylpiperazine, is a chemical compound within the piperazine class, bearing a close relation to benzylpiperazine (BZP). MDBZP has been distributed as a designer drug and has been detected as an additive in street Ecstasy tablets. FAQ What is Methylenedioxybenzylpiperazine (MDBZP)? Methylenedioxybenzylpiperazine, commonly abbreviated as MDBZP, is a chemical
- [Methylbenzylpiperazine](https://researchem.net/methylbenzylpiperazine/) - Summary Methylbenzylpiperazine (MBZP), also known as 1-methyl-4-benzylpiperazine, is a stimulant drug that originates from the benzylpiperazine family. This substance gained popularity as an ingredient in legal recreational substances commonly referred to as "party pills." These party pills were initially introduced in New Zealand and later became available in various countries worldwide.MBZP produces effects akin to
- [Methoxypiperamide](https://researchem.net/methoxypiperamide/) - Summary Methoxypiperamide, often referred to as MeOP or MEXP, is a psychoactive substance belonging to the piperazine class and has been available for purchase on the internet as a designer drug. It serves as the 4-methoxy-α-keto analog of methylbenzylpiperazine. Information about the pharmacology and potential toxicity of methoxypiperamide is quite limited. Nevertheless, the state of
- [Dibenzylpiperazine](https://researchem.net/dibenzylpiperazine/) - Summary Dibenzylpiperazine (DBZP) is a piperazine derivative commonly detected as an unintended byproduct in the recreational stimulant known as benzylpiperazine (BZP). The existence of DBZP serves as an indicator of substandard or poorly produced BZP. DBZP can form as a byproduct during the synthesis of BZP due to factors like excessive reaction temperatures or the
- [Benzylpiperazine](https://researchem.net/benzylpiperazine/) - Summary Benzylpiperazine (BZP) is a recreational substance known for its euphoric and stimulant effects. The impact of BZP on the user is often likened to the effects of amphetamine. However, it's crucial to note that BZP usage has been associated with adverse outcomes, including instances of acute psychosis, renal toxicity, and seizures. While fatalities linked
- [para-Methoxyphenylpiperazine](https://researchem.net/para-methoxyphenylpiperazine/) - Summary Para-Methoxyphenylpiperazine (MeOPP, pMPP, 4-MPP; commonly known as Paraperazine) is a piperazine-derived compound known for its stimulant properties. It gained notoriety for being incorporated into "Party pills," initially introduced in New Zealand and later distributed in various countries across the globe. Pharmacology MeOPP is often reported anecdotally to induce notably lower levels of anxiety when
- [para-Fluorophenylpiperazine](https://researchem.net/para-fluorophenylpiperazine/) - Summary Para-fluorophenylpiperazine (pFPP), also known as 4-FPP or Fluoperazine, is a derivative of piperazine that exhibits mild psychedelic and euphoric effects. It gained prominence as an ingredient in legal recreational substances commonly referred to as "Party pills." Initially, these products were introduced in New Zealand and subsequently became available in various countries worldwide.In laboratory settings,
- [meta-Chlorophenylpiperazine](https://researchem.net/meta-chlorophenylpiperazine/) - Sumamry meta-Chlorophenylpiperazine (mCPP) belongs to the phenylpiperazine class of psychoactive drugs. Originally developed for scientific research purposes in the late 1970s, it later found its way into the designer drug market in the mid-2000s. Notably, mCPP has been identified in pills marketed as legal alternatives to illicit stimulants in New Zealand, and it has also
- [2C-B-BZP](https://researchem.net/2c-b-bzp/) - Summary 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP) is a psychoactive compound belonging to the piperazine chemical class, and it has been marketed as a "designer drug." This substance induces stimulating effects that closely resemble those of benzylpiperazine (BZP). Chemistry 2C-B-BZP comprises a benzylpiperazine core combined with the ring-substitution structure found in the psychedelic phenethylamine 2C-B. Notably, 2C-B-BZP doesn't belong
- [PD-137889](https://researchem.net/pd-137889/) - Summary PD-137889, also known as N-methylhexahydrofluorenamine, is a chemical compound recognized for its potent activity as an NMDA receptor antagonist within the central nervous system. Its potency in this regard is approximately 30 times greater than the well-known representative of this class, ketamine. In animal studies, PD-137889 has demonstrated the ability to substitute for phencyclidine.
- [Dizocilpine](https://researchem.net/dizocilpine/) - Summary Dizocilpine, also known as MK-801, is a compound discovered by Merck in 1982, functioning as a pore blocker for the N-Methyl-D-aspartate (NMDA) receptor, which is a vital glutamate receptor in the brain. Glutamate serves as the primary excitatory neurotransmitter in the brain.Under normal conditions, the NMDA receptor channel is blocked by a magnesium ion
- [Fluorolintane](https://researchem.net/fluorolintane/) - Summary Fluorolintane, commonly referred to as 2-FPPP and 2-F-DPPy, is a dissociative anaesthetic substance that has been available for purchase online as a designer drug.These compounds, including Fluorolintane, belong to the group of diarylethylamines and exhibit properties as antagonists of the NMDA receptor. They have been examined in laboratory settings as prospective remedies for conditions
- [Ephenidine](https://researchem.net/ephenidine/) - Summary Ephenidine, also recognized under the aliases NEDPA and EPE, is categorized as a dissociative anaesthetic with a history of availability as a designer drug via online markets. While its legality status varies globally, certain nations have prohibited it due to its structural resemblance to the banned opioid, lefetamine. Nevertheless, Ephenidine continues to be commercially
- [Diphenidine](https://researchem.net/diphenidine/) - Summary Diphenidine, also known as 1,2-DEP, DPD, or DND, is a dissociative anesthetic that has been distributed as a designer drug. The synthesis of piperidine dates back to 1924 when a method employing a Bruylants reaction was first reported, a process that would later be utilized to discover phencyclidine in 1956. Following the 2013 ban
- [N-Ethylnorketamine](https://researchem.net/n-ethylnorketamine/) - Summary N-Ethylnorketamine, also known as eth ketamine, NENK, or 2-Cl-2'-Oxo-PCE, is a designer drug believed to share characteristics with ketamine. Ketamine is a dissociative anesthetic drug recognized for its hallucinogenic and sedative effects. N-Ethylnorketamine emerged in online markets around September 2012 and has been detected in drug samples seized by analytical laboratories in the UK
- [Methoxyketamine](https://researchem.net/methoxyketamine/) - Summary Methoxyketamine, also known as 2-MeO-2-deschloroketamine, is a designer drug belonging to the arylcyclohexylamine class. It was initially documented in 1963. This compound serves as an analog to ketamine, with the chlorine atom replaced by a methoxy group. Its synthesis, involving the rearrangement of an amino ketone, has been detailed in reports.Being classified as an
- [Methoxisopropamine](https://researchem.net/methoxisopropamine/) - Summary MXiPr, also known as Methoxisopropamine, Isopropyloxetamine, and Isopropyxetamine, is a recreational designer drug celebrated for its dissociative effects. It falls under the arylcyclohexylamine derivative category, sharing kinship with well-known substances like ketamine and methoxetamine. This compound was initially detected in Slovenia in December 2020 and became subject to legal restrictions, being prohibited in Hungary
- [Methoxpropamine](https://researchem.net/methoxpropamine/) - Summary Methoxpropamine, also known as MXPr and 2-Oxo-3'-methoxy-PCPr, falls within the category of dissociative anesthetic drugs belonging to the arylcyclohexylamine class. It functions as an NMDA receptor antagonist. Methoxpropamine shares structural similarities with other substances like methoxetamine and PCPr. This compound has been marketed online as a designer drug and was initially detected in Denmark
- [Methoxmetamine](https://researchem.net/methoxmetamine/) - Summary Methoxetamine, which is also recognized under names such as 3-MeO-2'-Oxo-PCM, MXM, and MMXE, belongs to the arylcyclohexylamine class of dissociative anesthetics. It shares close structural similarities with substances like methoxetamine and methoxetamine. Methoxetamine has gained popularity as a designer drug available for purchase on the internet. FAQ 1. What is Methoxmetamine (MXM)? Methoxetamine, often
- [Methoxetamine](https://researchem.net/methoxetamine/) - Summary Methoxetamine, often abbreviated as MXE, is a dissociative hallucinogenic substance that has been distributed as a designer drug. What sets it apart from many dissociatives, such as ketamine and phencyclidine (PCP), developed initially as pharmaceutical anesthetics, is that MXE was intentionally crafted to enhance the antidepressant effects of ketamine.MXE belongs to the class of
- [Eticyclidine](https://researchem.net/eticyclidine/) - Summary Eticyclidine (PCE, CI-400) is a dissociative anesthetic substance renowned for its hallucinogenic properties. It shares similarities in effects with phencyclidine but is marginally more potent. Developed by Parke-Davis during the 1970s, PCE underwent anesthetic evaluation under the codename CI-400. However, research into PCE was discontinued following the emergence of ketamine, a comparable drug with
- [Deschloroketamine](https://researchem.net/deschloroketamine/) - Summary Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic compound available through online sources as a designer drug. Additionally, it has been suggested for potential use in the treatment of bacterial, fungal, viral, or protozoal infections, as well as for immunomodulation at a dosage of 2 mg per day. History In 2019, it joined a
- [4-MeO-PCP](https://researchem.net/4-meo-pcp/) - Summary 4-Methoxyphencyclidine, also known as methoxydine or 4-MeO-PCP, is a dissociative anesthetic drug that has been made available for purchase as a research chemical via online channels. The synthesis of 4-MeO-PCP traces back to 1965 when Victor Maddox, a medicinal chemist at Parke-Davis, first documented its production. In 1999, an anonymous chemist using the pseudonym
- [3-MeO-PCP](https://researchem.net/3-meo-pcp/) - Summary 3-Methoxyphencyclidine (3-MeO-PCP) belongs to the arylcyclohexylamine class and is a dissociative hallucinogenic substance closely related to phencyclidine (PCP). It has been available for purchase online as a designer drug. This compound primarily functions as an antagonist of the NMDA receptor. Additionally, it has been observed to interact with the sigma σ1 receptor and the
- [3-MeO-PCMo](https://researchem.net/3-meo-pcmo/) - Summary 3-MeO-PCMo is a dissociative anesthetic drug with structural similarities to phencyclidine (PCP). This substance has been available for purchase online as a designer drug. Notably, its inhibitory effect on the reduction of drebrin cluster density induced by NMDAR stimulation with glutamic acid is comparatively weaker when compared to PCP or 3-MeO-PCP. The half-maximal inhibitory
- [3-MeO-PCE](https://researchem.net/3-meo-pce/) - Summary 3-Methoxyeticyclidine (3-MeO-PCE), also referred to as methoxieticyclidine, is a dissociative anesthetic that shares qualitative similarities with PCE and PCP. It has gained prominence as a designer drug and has been made available through online channels.On October 18, 2012, the Advisory Council on the Misuse of Drugs in the United Kingdom issued a report concerning
- [3-Methyl-PCPy](https://researchem.net/3-methyl-pcpy/) - Summary 3-Methyl-PCPy, also referred to as 3-Me-PCPy, is a derivative of arylcyclohexylamine known for its unique range of pharmacological effects. Legal Status 3-Methyl-PCPy falls under drug analog regulations in several jurisdictions, including the UK, Germany, Japan, Australia, and others. It is categorized as a typical arylcyclohexylamine derivative and is considered a structural isomer of phencyclidine.
- [3-HO-PCP](https://researchem.net/3-ho-pcp/) - Summary 3-Hydroxyphencyclidine, known as 3-HO-PCP, is a dissociative substance belonging to the arylcyclohexylamine class and is closely related to phencyclidine (PCP). This compound has been available for purchase online as a designer drug. Pharmacology 3-Hydroxyphencyclidine, or 3-HO-PCP, exerts its pharmacological actions through high-affinity uncompetitive antagonism at the NMDA receptor, explicitly targeting the dizocilpine (MK-801) site
- [3-Fluoro-PCP](https://researchem.net/3-fluoro-pcp/) - Summary 3-Fluoro-PCP, also known as 3'-F-PCP or 3F-PCP, is a synthetic designer drug belonging to the arylcyclohexylamine family. It is recognized for its dissociative effects, which can lead to altered perceptions and a sense of detachment from reality. This compound was initially discovered in Slovenia in October 2020 and was subject to legal restrictions in
- [3-Chloro-PCP](https://researchem.net/3-chloro-pcp/) - Summary 3-Chloro-PCP, also known as 3'-Cl-PCP, is a synthetic designer drug classified within the arylcyclohexylamine family. It is renowned for its dissociative effects. While it exhibits potency similar to phencyclidine (PCP), it offers a slightly distinct effects profile. Specifically, it is recognized for its enhanced potency as an NMDA antagonist while maintaining a comparable strength
- [Trifluoromethyldeschloroketamine](https://researchem.net/trifluoromethyldeschloroketamine/) - Summary Trifluoromethyldeschloroketamine, known as TFMDCK, is a member of the arylcyclohexylamine designer drug category. It is believed to share specific properties with ketamine, a dissociative anesthetic renowned for its hallucinogenic and sedative effects. TFMDCK has been available for purchase on the internet since approximately 2016, although authentic samples seem to be scarce. Additionally, the o-trifluoromethyl
- [Deoxymethoxetamine](https://researchem.net/deoxymethoxetamine/) - Summary Deoxymethoxetamine, also known as 3'-methyl-2-oxo-PCE, DMXE, or 3D-MXE, is a synthetic designer drug classified within the arylcyclohexylamine family, known for its dissociative effects. This substance is a derivative of methoxetamine, with the 3-methoxy group being substituted by a methyl group. It became available for online purchase approximately in October 2020, and a forensic laboratory
- [2-Oxo-PCE](https://researchem.net/2-oxo-pce/) - Summary 2-Oxo-PCE, which is also referred to as N-ethyldeschloroketamine, eticyclidone, and O-PCE, is a dissociative anesthetic belonging to the arylcyclohexylamine class. It shares a close structural resemblance with deschloroketamine and eticyclidine and has been available for purchase online as a designer drug. FAQ 1. What is 2-Oxo-PCE? 2-Oxo-PCE, also known as N-ethyldeschloroketamine, eticyclidone, and O-PCE,
- [3-Fluorodeschloroketamine](https://researchem.net/3-fluorodeschloroketamine/) - Summary 3-Fluorodeschloroketamine (often abbreviated as 3F-DCK, 3-FDCK, or FXM) belongs to the family of arylcyclohexylamine designer drugs and is associated with recreational use similar to ketamine. This substance produces dissociative effects. Finland officially prohibited its possession and use in August 2019. FAQ 1. What is 3-Fluorodeschloroketamine (3F-DCK)? 3-Fluorodeschloroketamine, often abbreviated as 3F-DCK, is a synthetic
- [2-Bromodeschloroketamine](https://researchem.net/2-bromodeschloroketamine/) - Summary 2-Bromodeschloroketamine (also referred to as 2-Br-2'-Oxo-PCM and Bromoketamine) is a chemical compound categorized within the arylcyclohexylamine class. It is analogous to the dissociative anesthetic drug ketamine, wherein the chlorine atom is substituted with a bromine atom. This compound is primarily utilized in scientific research as a reference or control substance in investigations focused on the
- [Trimethoxyamphetamine](https://researchem.net/trimethoxyamphetamine-2/) - Summary Trimethoxyamphetamines (TMAs) constitute a family of isomeric psychedelic hallucinogenic substances. This family comprises six distinct TMAs, each differing solely in the arrangement of three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. These TMAs are analogs of the phenethylamine cactus alkaloid mescaline. While they fall under the category of substituted amphetamines, their mechanism
- [Trimethoxyamphetamine](https://researchem.net/trimethoxyamphetamine/) - Summary Trimethoxyamphetamines (TMAs) comprise a group of isomeric psychedelic hallucinogenic substances. There are six distinct TMAs, differentiated solely by the arrangement of three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. These compounds are analogs of mescaline, a phenethylamine cactus alkaloid. TMAs are substituted amphetamines, and their action mechanism is more intricate than the unaltered
- [2,5-Dimethoxy-4-propylamphetamine](https://researchem.net/25-dimethoxy-4-propylamphetamine/) - Summary 2,5-Dimethoxy-4-propylamphetamine (DOPR) belongs to the phenethylamine and amphetamine chemical classes and was initially synthesized by Alexander Shulgin. Shulgin introduced this compound in his renowned work, "PiHKAL" (Phenethylamines I Have Known And Loved). DOPR, according to Shulgin, is a profoundly potent psychedelic substance capable of inducing substantial alterations in thought processes and significant visual distortions. Regrettably,
- [2,5-Dimethoxy-4-nitroamphetamine](https://researchem.net/25-dimethoxy-4-nitroamphetamine/) - Summary 2,5-Dimethoxy-4-nitroamphetamine (DON) is classified as a psychedelic compound within the amphetamine family. Notably, it shares structural similarities with DOM and DOB while exhibiting a close relationship with 2C-N. Chemistry Belonging to the category of alpha-methyl phenethylamines, or amphetamines, DON's complete chemical name is 1-(2,5-dimethoxy-4-nitrophenyl)propan-2-amine. Importantly, it possesses a stereocenter. Effects In his book PiHKAL,
- [2,5-Dimethoxy-4-methylamphetamine](https://researchem.net/25-dimethoxy-4-methylamphetamine/) - Summary 2,5-Dimethoxy-4-methylamphetamine (DOM), also recognized by the acronym STP (representing "Serenity, Tranquility, and Peace"), belongs to the class of psychedelics and substituted amphetamines. Renowned chemist Alexander Shulgin was the first to synthesize this compound, later documenting its properties in his famous book, PiHKAL: A Chemical Love Story. DOM is classified as a Schedule I substance
- [2,5-Dimethoxy-4-isopropylamphetamine](https://researchem.net/25-dimethoxy-4-isopropylamphetamine/) - Summary 2,5-Dimethoxy-4-isopropylamphetamine also recognized as DOiP and DOiPr, is classified as a psychedelic substance belonging to the phenethylamine and amphetamine chemical groups. The pioneering synthesis of this compound was attributed to Alexander Shulgin and was documented in his book PiHKAL (Phenethylamines I Have Known And Loved). Shulgin noted that DOiPR demonstrated significantly lower potency than
- [2,5-Dimethoxy-4-iodoamphetamine](https://researchem.net/25-dimethoxy-4-iodoamphetamine/) - Summary 2,5-Dimethoxy-4-iodoamphetamine (DOI) is categorized as a psychedelic substance and a form of substituted amphetamine. Unlike other substituted amphetamines, DOI's primary effects do not primarily manifest as stimulants. The R-(−)-DOI stereoisomer demonstrates more excellent activity with a stereocenter. In neuroscience research, [125I]-R-(−)-DOI is employed as a radioligand, indicating the presence of 5-HT2A serotonin receptors. Comparisons
- [2,5-Dimethoxy-4-ethylamphetamine](https://researchem.net/25-dimethoxy-4-ethylamphetamine/) - Summary 2,5-Dimethoxy-4-ethylamphetamine, also known as DOET, DOE, or Hecate, belongs to the psychedelic realm of drugs within the phenethylamine and amphetamine chemical categories. The compound was initially created by Alexander Shulgin and was documented in his literary work, PiHKAL (Phenethylamines I Have Known And Loved). Chemistry DOET belongs to a group of substances widely recognized
- [2,5-Dimethoxy-4-chloroamphetamine](https://researchem.net/25-dimethoxy-4-chloroamphetamine/) - Summary 2,5-Dimethoxy-4-chloroamphetamine (DOC) belongs to the phenethylamine and amphetamine chemical groups and is recognized as a psychedelic substance. Its initial synthesis is attributed to Alexander Shulgin and is documented in detail within his seminal work "PiHKAL" (Phenethylamines I Have Known And Loved). Chemistry DOC falls within the category of substituted alpha-methylated phenethylamines, a well-known subgroup
- [2,5-Dimethoxy-4-bromoamphetamine](https://researchem.net/25-dimethoxy-4-bromoamphetamine/) - Summary Dimethoxybromoamphetamine (DOB), alternatively referred to as brolamfetamine (INN), represents a psychedelic substance and substituted amphetamine belonging to the phenethylamine class of compounds. The synthesis of DOB was initially carried out by Alexander Shulgin in 1967, with comprehensive details regarding its production and effects extensively documented in Shulgin's renowned publication "PiHKAL: A Chemical Love Story."
- [Aleph (psychedelic)](https://researchem.net/aleph-psychedelic/) - Summary Aleph, also recognized as DOT or 2,5-dimethoxy-4-methylthioamphetamine, belongs to the class of substituted amphetamines within the phenethylamine compound group, renowned for its hallucinogenic properties. This compound can serve as a psychedelic drug and is often employed as an entheogen. The distinguished chemist Alexander Shulgin pioneered its synthesis and bestowed the name "Aleph" in homage
- [NBOMe-mescaline](https://researchem.net/nbome-mescaline/) - Summary NBOMe-mescaline or mescaline-NBOMe is a synthetic substituted phenethylamine that acts as a partial agonist of serotonin receptors. It has a 5-HT2A pKi of 7.3 (i.e., Ki of approximately 50nM) as initially reported. However, more modern techniques have assayed it as 140nM at 5-HT2A and 640nM at 5-HT2C, making it one of the least potent
- [25P-NBOMe](https://researchem.net/25p-nbome/) - Summary 25P-NBOMe, also known as 2C-P-NBOMe or NBOMe-2C-P, belongs to the phenethylamine family and is derived from 2C-P. Its pharmacological behaviour closely resembles other compounds, notably 25I-NBOMe, which exhibits potent agonistic activity at the 5HT2A receptor. The substance has been distributed in the market as a recreational drug. It is known to elicit effects in
- [25N-NBOMe](https://researchem.net/25n-nbome/) - Summary 25N-NBOMe (2C-N-NBOMe, NBOMe-2C-N) represents a derivative of the hallucinogenic compound 2C-N. Although the scientific literature has not extensively explored the pharmacological properties 25N-NBOMe, it is believed to operate similarly to its related counterparts, such as 25I-NBOMe and 25C-NBOMe. These related compounds are recognized as potent agonists at the 5HT2A receptor. Notably, 25N-NBOMe has been
- [25H-NBOMe](https://researchem.net/25h-nbome/) - Summary 25H-NBOMe (also known as NBOMe-2C-H) is a compound derived from the phenethylamine hallucinogen 2C-H. It functions as a remarkably potent full agonist targeting the human 5-HT2A receptor. Toxicity NBOMe substances are frequently linked to severe toxicity and fatalities. Research on the NBOMe compound family has revealed their neurotoxic and cardiotoxic properties. Autonomic dysfunction, including
- [25iP-NBOMe](https://researchem.net/25ip-nbome/) - Summary 25iP-NBOMe (2C-iP-NBOMe, NBOMe-2C-iP) is a compound derived from the phenethylamine hallucinogen 2C-iP, renowned for its exceptional potency as an agonist for the human 5-HT2A receptor. Toxicity and harm potential NBOMe compounds are frequently linked to severe toxicity and fatalities, often exhibiting neurotoxic and cardiotoxic properties. Autonomic dysfunction, including sympathomimetic toxicity such as vasoconstriction, hypertension,
- [25I-NBOH](https://researchem.net/25i-nboh/) - Summary 25I-NBOH (also known as NBOH-2CI, Cimbi-27, 2-C-I-NBOH) belongs to the group of derivatives derived from the phenethylamine hallucinogen 2C-I, initially discovered in 2006 by a team at Purdue University. Pharmacology 25I-NBOH exhibits potent agonistic effects on the 5HT2A receptor, with a Ki of 0.061 nM at the human 5HT2A receptor, comparable to the well-known
- [25I-NBMD](https://researchem.net/25i-nbmd/) - Summary 25I-NBMD (NBMD-2C-I, Cimbi-29) was first identified as a derivative of the phenethylamine hallucinogen 2C-I in 2006 by Purdue University researchers under David Nichols's leadership. Acting as a potent partial agonist for the 5HT2A receptor, it exhibits a Ki of 0.049 nM at the human 5HT2A receptor. Notably, the related 4-bromo analogue, 25B-NBMD, has been
- [25I-NBF](https://researchem.net/25i-nbf/) - Summary 25I-NBF (2C-I-NBF, NBF-2C-I, Cimbi-21) is a compound derived from the phenethylamine hallucinogen 2C-I. It exhibits potent partial agonism for the human 5-HT2A receptor, known for its involvement in various neurological processes. Notably, it isn't very objective towards the β-arrestin 2 coupled signalling pathway, indicating its complex interaction within the receptor system. In research, its
- [25E-NBOMe](https://researchem.net/25e-nbome/) - Summary 25E-NBOMe (also known as 2C-E-NBOMe or NBOMe-2C-E) is a chemical derivative originating from the phenethylamine 2C-E. It exhibits analogous behaviour to its counterparts, including 25I-NBOMe, known for their powerful activation of the 5HT2A receptor. This substance has been circulated as a recreational drug, eliciting effects comparable to related compounds like 25I-NBOMe and 25C-NBOMe in
- [25D-NBOMe](https://researchem.net/25d-nbome/) - Summary 25D-NBOMe, also known as NBOMe-2C-D, stems from the phenethylamine-derived hallucinogen 2C-D. Functioning similarly to its counterparts like 25I-NBOMe, this compound acts as a potent stimulator at the 5HT2A receptor. Since it emerged as a street drug in 2010, 25D-NBOMe has exhibited comparable impacts on human physiology, as observed with 25I-NBOMe and 25C-NBOMe. Due to
- [25C-NBOH](https://researchem.net/25c-nboh/) - Summary 25-C-NBOH (2C-C-NBOH or NBOH-2CC) is a chemically derived compound from the phenethylamine hallucinogen 2C-C. This substance has gained popularity as a designer drug. Notably, it exhibits comparable serotonin receptor affinities to the more widely recognized compound, 25C-NBOMe. Analytical chemistry 25C-NBOH, much like other NBOH substances, degrades when subjected to standard Gas Chromatography (GC) conditions,
- [25C-NBF](https://researchem.net/25c-nbf/) - Summary 25C-NBF (also known as 2C-C-NBF or NBF-2C-C) represents a chemical compound derived from the phenethylamine hallucinogen 2C-C. It exhibits significant potency as a partial agonist for the human 5-HT2A receptor. Legality Sweden:On January 26, 2016, the Swedish Riksdag incorporated 25C-NBF into the Narcotic Drugs Punishments Act, categorizing it under Swedish Schedule I. This category
- [25B-NBOMe](https://researchem.net/25b-nbome/) - Summary 25B-NBOMe, also known as NBOMe-2C-B, Cimbi-36, Nova, or BOM 2-CB, belongs to the phenethylamine psychedelic class and was initially discovered in 2004 by Ralf Heim at the Free University of Berlin. This compound functions as a potent full agonist for the 5HT2A receptor.Anecdotal reports from users have suggested that 25B-NBOMe can induce hallucinogenic effects
- [25B-NBOH](https://researchem.net/25b-nboh/) - Summary 25B-NBOH, also recognized as 2C-B-NBOH or NBOH-2C-B, is a derivative stemming from the phenethylamine family of hallucinogenic substances, specifically derived from 2C-B. It has been marketed as a designer drug. Functionally, 25B-NBOH acts as a potent serotonin receptor agonist, exhibiting a similar affinity to the more widely known compound, 25B-NBOMe, at both the 5-HT2A
- [25B-NBF](https://researchem.net/25b-nbf/) - Summary 25B-NBF, also known as 2C-B-NBF or NBF-2C-B, represents a derivative of the phenethylamine hallucinogen 2C-B. This compound functions as an exceptionally potent partial agonist for the human 5-HT2A receptor. Legality Sweden:The Riksdag included 25B-NBF in the Narcotic Drugs Punishments Act, categorizing it under Swedish Schedule I, which encompasses "substances, plant materials, and fungi with
- [2CBCB-NBOMe](https://researchem.net/2cbcb-nbome/) - Summary 2CBCB-NBOMe (also known as NBOMe-TCB-2) is a compound indirectly derived from the phenethylamine family of hallucinogenic substances. This compound came to light in 2007 during research at Purdue University led by David Nichols, which focused on understanding the precise amino acid residues responsible for binding ligands to the 5HT2A receptor.Notably, 2CBCB-NBOMe demonstrates powerful and
- [N-Ethyl-2C-B](https://researchem.net/n-ethyl-2c-b/) - Summary N-Ethyl-2C-B is a designer drug known for its recreational and psychedelic properties, as documented in reference. Its initial synthesis dates back to the 1990s, while its identification as a novel psychoactive substance took place in Finland in 2007, as outlined in reference and respectively. Currently, it holds a banned status in Finland, as specified
- [HOT-7](https://researchem.net/hot-7/) - Summary HOT-7, also known as 2,5-dimethoxy-4-(β-propylthio)-N-hydroxyphenethylamine, stands as a member of the 2C family, a group of psychedelic phenethylamines. It is believed to have been initially crafted by Alexander Shulgin and documented in his literary work, PiHKAL. Chemistry The comprehensive chemical nomenclature for HOT-7 reads as 2-[4-(2-propylthio)-2,5-dimethoxyphenyl–N–hydroxyethanamine. Its structural characteristics bear resemblance to 2C-T-7 and
- [BOD (psychedelic)](https://researchem.net/bod-psychedelic/) - Summary BOD, scientifically known as 4-methyl-2,5,β-trimethoxyphenethylamine, is a relatively lesser-known psychedelic substance. This compound is recognized as the beta-methoxy analog of 2C-D and was originally synthesized by the renowned chemist Alexander Shulgin.In his groundbreaking book PiHKAL (Phenethylamines I Have Known and Loved), Shulgin provides valuable insights into the world of psychoactive substances. For BOD, the
- [BOB (psychedelic)](https://researchem.net/bob-psychedelic/) - Summary BOB (4-bromo-2,5,beta-trimethoxyphenethylamine) is a relatively obscure psychedelic substance characterized as the beta-methoxy counterpart of 2C-B. Alexander Shulgin initially synthesized this compound. According to his book PiHKAL, the recommended dosage range for BOB falls within 10–20 mg, with the effects lasting approximately 10–20 hours.The experience induced by BOB typically encompasses an altered state of consciousness,
- [βk-2C-B](https://researchem.net/βk-2c-b/) - Summary βk-2C-B, also known as Bk-2C-B, is a recently developed psychedelic compound. This novel substance is structurally related to 2C-B, belonging to the 2C family of psychedelics. Typically consumed orally, βk-2C-B is used for recreational purposes. Notably, it is classified as a controlled substance in several countries, including Canada, Germany, Switzerland, and the United Kingdom.
- [2C-T-21](https://researchem.net/2c-t-21/) - Summary 2C-T-21, also known as 4-(2-fluoroethylthio)-2,5-dimethoxyphenethylamine, belongs to the psychedelic phenethylamine family of 2C compounds. This substance is occasionally employed as an entheogen, and its initial synthesis can be attributed to Alexander Shulgin. Effects 2C-T-21 is typically ingested orally, and its effects tend to endure for a duration of 7 to 10 hours. Myron Stolaroff
- [2C-T-7](https://researchem.net/2c-t-7/) - Summary 2C-T-7, belonging to the psychedelic 2C family of phenethylamines, is highlighted in Alexander Shulgin's book, "PiHKAL: A Chemical Love Story," with a recommended dosage range of 10 to 30 mg. Typically administered orally, this compound elicits enduring psychedelic and entactogenic effects spanning 8 to 15 hours. It was commercially available in Dutch and Japanese
- [2C-T-4](https://researchem.net/2c-t-4/) - Summary 2C-T-4, scientifically known as 2,5-dimethoxy-4-isopropylthiophenethylamine, belongs to the 2C family of psychedelic phenethylamines. Renowned chemist Alexander Shulgin was the first to synthesize this compound. It is primarily utilized as a recreational drug with entheogenic properties. Chemistry 2C-T-4 is the structural counterpart of aleph-4, with a full chemical designation as 2-[4-(isopropylthio)-2,5-dimethoxyphenyl]-ethanamine. This compound shares structural
- [2C-T-2](https://researchem.net/2c-t-2/) - Summary 2C-T-2 belongs to the 2C family and is a phenethylamine known for its psychedelic and entactogenic properties. This compound was initially synthesized by Alexander Shulgin in 1981 and earned its place among the "magical half-dozen" due to its significant role in the realm of psychedelic phenethylamines. 2C-T-2 shares similarities in both structure and pharmacodynamics
- [2C-P](https://researchem.net/2c-p/) - Summary 2C-P is a notably potent and long-lasting psychedelic phenethylamine within the 2C family. Chemistry 2C-P is scientifically known as 2,5-dimethoxy-4-n-propylphenethylamine or, more elaborately, 2-(2,5-dimethoxy-4-propylphenyl)ethanamine. In its most common form, it appears as a white powder or white crystals, often in the hydrochloride salt form.Alexander Shulgin's 2C-P crude freebase, which is soluble in chloroform, initially
- [2C-I](https://researchem.net/2c-i/) - Summary 2C-I is a psychedelic phenethylamine belonging to the 2C family. Alexander Shulgin originally synthesized it and extensively detailed it in his 1991 publication, "PiHKAL" (Phenethylamines I Have Known and Loved). This compound has found recreational use due to its psychedelic properties, and its effects have been reported. It's worth noting that in some cases,
- [2C-iP](https://researchem.net/2c-ip/) - Summary 2C-iP, also known as Jelena, is a potent and long-lasting psychedelic phenethylamine compound belonging to the 2C family. It was initially synthesized by Dmitri Ger and has been made available online as a designer drug. Legality In Canada, effective from October 31, 2016, 2C-iP is classified as a controlled substance under Schedule III. FAQ
- [2C-G](https://researchem.net/2c-g/) - Summary 2C-G belongs to the 2C-series of psychedelic phenethylamines. Alexander Shulgin originally synthesized it, and it is occasionally utilized as an entheogen. This compound shares structural and pharmacodynamic similarities with 2C-D and Ganesha. Similar to several phenethylamines detailed in PiHKAL, 2C-G and its analogs have primarily been explored by Shulgin and a limited test group.
- [2C-E](https://researchem.net/2c-e/) - Summary 2C-E is a member of the 2C family, a group of psychedelic phenethylamines. It was created by Alexander Shulgin and is detailed in his publication "PiHKAL." Similar to its counterparts within the same chemical family, 2C-E elicits sensory and cognitive effects when interacting with living organisms. Properties 2,5-Dimethoxy-4-ethylphenethylamine exists as a colourless oil. To
- [2C-D](https://researchem.net/2c-d/) - Summary 2C-D, also known as 2,5-dimethoxy-4-methylphenethylamine or 2C-M, is a member of the 2C family of psychedelic compounds and is occasionally used as an entheogen. This substance was initially synthesized in 1970 by a team at the Texas Research Institute of Mental Sciences. Subsequently, its effects on humans were investigated by Alexander Shulgin. In his
- [2C (psychedelics)](https://researchem.net/2c-psychedelics/) - Summary 2C (2C-x) is a collective term used to refer to a group of psychedelic phenethylamines characterized by the presence of methoxy groups on the 2 and 5 positions of a benzene ring. Additionally, most members of this group feature lipophilic substituents at the 4 position, which often results in more potent compounds, have enhanced
- [Proscaline](https://researchem.net/proscaline/) - Summary Proscaline, also known as 4-propoxy-3,5-dimethoxyphenethylamine or 4-propoxy-3,5-DMPEA, is a substance with psychedelic and hallucinogenic properties. It shares structural similarities with mescaline, isoproscaline, and mescaline.According to Alexander Shulgin's account in PiHKAL (Phenethylamines I Have Known And Loved), a dosage of 30 to 60 mg is associated with effects that endure for approximately 8 to 12
- [Methallylescaline](https://researchem.net/methallylescaline/) - Summary Methallylescaline, chemically known as 4-Methylallyloxy-3,5-dimethoxyphenethylamine, is a relatively lesser-known psychedelic substance. It serves as the 4-methyl analogue of allylescaline. Alexander Shulgin originally synthesized this compound.In Shulgin's book PiHKAL (Phenethylamines I Have Known And Loved), the recommended dosage range for Methallylescaline is noted as 40 to 65 mg, with the effects typically extending throughout 12
- [Isoproscaline](https://researchem.net/isoproscaline/) - Summary Isoproscaline, scientifically known as 4-isopropoxy-3,5-dimethoxyphenethylamine, is an analog of mescaline. This compound shared a close kinship with prescaling and was initially synthesized by David E. Nichols, although specific sourcing details might require citation.Isoproscaline is renowned for its capacity to induce hallucinogenic, psychedelic, and entheogenic effects. Chemistry Isoproscaline belongs to the category of compounds commonly
- [Allylescaline](https://researchem.net/allylescaline/) - Summary Allylescaline, known chemically as 4-allyloxy-3,5-dimethoxyphenethylamine, is a relatively lesser-known psychedelic substance. Structurally, it bears a close resemblance to mescaline. This unique compound was first synthesized by Otakar Leminger in 1972.Notably, Alexander Shulgin later synthesized allylescaline and included a detailed description of its properties in his book PiHKAL (Phenethylamines I Have Known and Loved). The
- [3C-P](https://researchem.net/3c-p/) - Summary 3C-P, scientifically identified as α-Methyl-4-propoxy-3,5-dimethoxyphenethylamine, is classified as a psychedelic phenethylamine. This compound shares structural and pharmacodynamic characteristics with substances like mescaline, proscaline, and amphetamine. Although limited information is available regarding the human pharmacology of 3C-P, anecdotal reports suggest that a psychedelic dosage typically falls within the range of 20 to 40 mg. When
- [3C-E](https://researchem.net/3c-e/) - Summary 3C-E, scientifically known as 3,5-Dimethoxy-4-ethoxyamphetamine, belongs to the amphetamine class and is renowned for its psychedelic properties. Alexander Shulgin, a prominent figure in the field of psychopharmacology, initially synthesized it.In Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved), the recommended dosage for 3C-E, when taken orally, is noted to be within the range
- [Dimemebfe](https://researchem.net/dimemebfe/) - Summary Dimemebfe (5-MeO-BFE) is both a recreational drug and a research chemical. This compound functions as an agonist for the serotonin receptors within the 5-HT1A and 5-HT2 families. Structurally, it bears a resemblance to the psychedelic tryptamine derivative 5-MeO-DMT, albeit with a notable difference - the substitution of the indole nitrogen with oxygen, thus categorizing
- [5-MeO-DiBF](https://researchem.net/5-meo-dibf/) - Summary 5-MeO-DiBF is a psychedelic substance that has been available for purchase online as a designer drug. It gained recognition in December 2015 when a forensic laboratory in Slovenia conclusively identified it. This compound is believed to function as an agonist for the serotonin receptors within the 5-HT1A and 5-HT2 families. Structurally, it shares a
- [Methylisopropyltryptamine](https://researchem.net/methylisopropyltryptamine/) - Summary N-Methyl-N-isopropyltryptamine (MiPT) is a psychedelic tryptamine compound that shares a close structural relationship with DMT, DiPT, and Miprocin. Chemistry MiPT base distinguishes itself from many other tryptamines in its free form by displaying a remarkable resistance to rapid decomposition in the presence of light or oxygen. In August 2019, Chadeayne et al. successfully determined
- [Ethylpropyltryptamine](https://researchem.net/ethylpropyltryptamine/) - Summary Ethylpropyltryptamine (EPT), also known as N-ethyl-N-propyltryptamine, is an infrequently encountered psychedelic compound belonging to the tryptamine class. This classification establishes its structural similarity to other tryptamines, including DMT, MET, DET, and DPT. Legal status United Kingdom: The sale, distribution, supply, transport, or trade of this pharmaceutical drug is prohibited under the Psychoactive Substances Act of
- [Ethylisopropyltryptamine](https://researchem.net/ethylisopropyltryptamine/) - Summary Ethylisopropyltryptamine (EiPT) is a member of the tryptamine family, known for its capacity to induce psychedelic and hallucinogenic experiences. This compound is believed to have been initially synthesized by the American psychopharmacologist Alexander Shulgin. Chemistry EiPT, a shortened form of N-ethyl-N-isopropyl-tryptamine, possesses the complete chemical name N-ethyl-N-[2-(1H-indol-3-yl)ethyl]propan-2-amine. It falls within the tryptamine category, part
- [Ethocybin](https://researchem.net/ethocybin/) - Summary Ethocybin, also known as CEY-19 or 4-phosphoryloxy-DET, is a semi-synthetic psychedelic alkaloid belonging to the tryptamine family. This compound shares structural similarities with psilocybin, a natural alkaloid found in certain mushrooms. Ethocybin's psychoactive effects are akin to those of shorter LSD or psilocybin experiences. However, the specific intensity and duration of these effects can
- [Dipropyltryptamine](https://researchem.net/dipropyltryptamine/) - Summary N, N-Dipropyltryptamine (DPT) is a member of the tryptamine family, known for its psychedelic and entheogenic properties. Although law enforcement officials have noted its use as a designer drug as far back as 1968, its potential therapeutic applications were explored in the 1970s. DPT is typically encountered in the form of a crystalline hydrochloride
- [Diisopropyltryptamine](https://researchem.net/diisopropyltryptamine/) - Summary Diisopropyltryptamine, often abbreviated as DiPT and also referred to as N, N-diisopropyltryptamine, is a member of the tryptamine family known for its psychedelic and hallucinogenic properties. What sets DiPT apart from many other hallucinogens is its distinctive effect: instead of predominantly influencing the visual sense, DiPT primarily impacts the auditory perception. Hallucinogenic properties The
- [DALT](https://researchem.net/dalt/) - Summary N, N-Diallyltryptamine, often referred to as DALT, is a derivative of tryptamine that has emerged as a novel psychoactive substance. It is known for its use as an intermediate compound in the synthesis of radiolabeled diethyltryptamine.One of the notable effects associated with DALT is a significant increase in body temperature, which bears resemblance to
- [5-MeO-2-TMT](https://researchem.net/5-meo-2-tmt/) - Summary 5-Methoxy-2, N, N-dimethyltryptamine, often referred to as 5-MeO-2, N, N-TMT or 5-MeO-TMT, belongs to the tryptamine chemical class and possesses psychoactive properties as a psychedelic substance. It was initially synthesized by Alexander Shulgin and documented in his book "TiHKAL" (short for "Tryptamines I Have Known And Loved").When taken orally, 5-MeO-TMT is reported to produce
- [5-MeO-MPMI](https://researchem.net/5-meo-mpmi/) - Summary 5-MeO-MPMI, scientifically referred to as 5-Methoxy-N-methyl-(α, N-trimethylene)tryptamine, is a derivative of tryptamine known for its psychedelic properties. The compound was initially synthesized in 1992 by a team led by JE Macor. Subsequently, in the late 1990s, it underwent investigations by a team led by David Nichols at Purdue University. In animal tests, this substance
- [5-MeO-MiPT](https://researchem.net/5-meo-mipt/) - Summary 5-MeO-MiPT is a substance known for its psychedelic and hallucinogenic effects, occasionally employed by individuals as an entheogen. This compound shares both structural and pharmacodynamic similarities with other drugs like 5-MeO-DiPT, DiPT, and MiPT. Due to its strikingly comparable structure and effects, it is frequently utilized as an alternative to 5-MeO-DiPT. Chemistry 5-MeO-MiPT belongs
- [5-MeO-MET](https://researchem.net/5-meo-met/) - Summary 5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) belongs to the relatively uncommon group of designer drugs known as substituted tryptamines. This compound shares a kinship with substances like N-methyl-N-ethyltryptamine and 5-MeO-DMT. While it was originally synthesized in the 1960s and underwent limited research, it didn't surface on the illicit market until June 2012 in Sweden. Subsequently, Norway classified it
- [5-MeO-MALT](https://researchem.net/5-meo-malt/) - Summary 5-MeO-MALT, or 5-methoxy-N-methyl-N-allyltryptamine, is a relatively obscure psychedelic compound. This substance shares a close chemical kinship with 5-MeO-DALT and has been available for purchase on the internet and marketed as a designer drug. Legality 5-MeO-MALT is prohibited in Hungary. On May 15, 2019, Sweden's public health agency recommended categorizing 5-MeO-MALT as a hazardous substance.
- [5-MeO-EPT](https://researchem.net/5-meo-ept/) - Summary 5-MeO-EPT is a designer drug known for its psychedelic effects, and it belongs to the tryptamine derivative class. Legality 5-MeO-EPT is prohibited in Singapore and Japan, and it also falls under the purview of drug analog laws in various jurisdictions. However, it's important to note that in many countries, its seizure is contingent on
- [5-MeO-EiPT](https://researchem.net/5-meo-eipt/) - Summary 5-MeO-EiPT belongs to the tryptamine class of psychedelics and has been distributed online as a designer drug. Legality As of the provided information, 5-MeO-EiPT is prohibited in Japan, Italy, and was recommended for classification as a hazardous substance by Sweden's public health agency on May 15, 2019. FAQ What is 5-MeO-EiPT? 5-MeO-EiPT is a
- [5-MeO-DPT](https://researchem.net/5-meo-dpt/) - Summary 5-MeO-DPT, alternatively referred to as 5-methoxy-N,N-Dipropyltryptamine, is a designer drug with psychedelic and entheogenic properties. Chemistry Its complete chemical nomenclature is N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-propylpropan-1-amine, belonging to the category of tryptamine derivatives. Effects There is limited knowledge regarding the subjective effects of 5-MeO-DPT, but its characteristics are likely akin to other psychedelic tryptamines/indoles such as 5-MeO-DiPT, 5-MeO-DMT,
- [5-MeO-DMT](https://researchem.net/5-meo-dmt/) - Summary 5-MeO-DMT, scientifically known as 5-methoxy-N,N-dimethyltryptamine, and informally referred to as O-methyl-bufotenin, belongs to the tryptamine class of psychedelics. It's widely distributed in various plant species and is notably secreted by the glands of specific toad species, such as the Colorado River toad. This compound, along with its close counterparts DMT and bufotenin (5-HO-DMT), has
- [5-Methoxy-N,N-diisopropyltryptamine](https://researchem.net/5-methoxy-nn-diisopropyltryptamine/) - Summary 5-Methoxy-N,N-diisopropyltryptamine (often referred to as 5-MeO-DiPT, colloquially known as foxy methoxy or simply foxy) is a member of the psychedelic tryptamine class and represents the methoxy derivative of diisopropyltryptamine (DiPT). Pharmacology The hallucinogenic and entheogenic effects of 5-MeO-DiPT are believed to be primarily generated through 5-HT2A receptor agonism. However, it's worth noting that additional
- [5-MeO-DET](https://researchem.net/5-meo-det/) - Summary 5-MeO-DET, also known as 5-methoxy-N,N-diethyltryptamine, is a hallucinogenic tryptamine compound. Pharmacology 5-MeO-DET demonstrates an inhibition of serotonin reuptake with an IC50 value of 2.4 μM and activates 5-HT2A receptors with an EC50 value of 8.11 nM. Effects At low dosages (ranging from 0.5 to 1 mg), individuals have reported experiencing a relaxing body high
- [5-Chloro-DMT](https://researchem.net/5-chloro-dmt/) - Summary 5-Chloro-N, N-dimethyltryptamine, commonly referred to as 5-chloro-DMT, belongs to the family of tryptamine derivatives, sharing a kinship with substances like 5-bromo-DMT and 5-fluoro-DMT. In its function, it serves as an agonist of serotonin receptors and, in animal studies, has predominantly exhibited sedative effects. Notably, it has been marketed and distributed as a designer drug.
- [5-Bromo-DMT](https://researchem.net/5-bromo-dmt/) - Summary 5-Bromo-DMT, scientifically known as 5-Bromo-N, N-dimethyltryptamine, is a psychedelic compound in the class of brominated indole alkaloids. This particular alkaloid can be found in sponges like Smenospongia aurea and Smenospongia echina, as well as in Verongula rigida, where it constitutes a minute fraction of the dry weight (approximately 0.00142%). It is found alongside 5,6-Dibromo-DMT
- [4-MeO-MiPT](https://researchem.net/4-meo-mipt/) - Summary 4-MeO-MiPT, also known as 4-methoxy-N-methyl-N-isopropyltryptamine, is a relatively obscure psychedelic substance. It represents the 4-methoxy counterpart to MiPT. This compound was initially synthesized by Alexander Shulgin and is documented in his book "TiHKAL" (Tryptamines I Have Known And Loved).In human trials conducted by Shulgin, an effective dose of 20-30 mg (equivalent to 0.4 mg
- [4-HO-EPT](https://researchem.net/4-ho-ept/) - Summary 4-HO-EPT, also known as 4-hydroxy-N-ethyl-N-propyltryptamine, is an infrequently encountered chemical compound in the tryptamine class. It shares a structural similarity with psilocin (4-HO-DMT). Legality United Kingdom: The use of 4-HO-EPT is prohibited in the United Kingdom due to the enactment of the Psychoactive Substances Act of 2016. United States: In the United States, 4-HO-EPT may fall
- [4-HO-MPT](https://researchem.net/4-ho-mpt/) - Summary 4-HO-MPT, also referred to as meprocin, is a psychedelic substance classified within the tryptamine family of compounds. It serves as a higher homologue of psilocin, a naturally occurring substituted tryptamine, and is specifically the 4-hydroxyl analog of MPT. History The initial synthesis and evaluation of 4-HO-MPT were conducted by biochemist Alexander Shulgin, with his
- [4-HO-McPT](https://researchem.net/4-ho-mcpt/) - Summary 4-HO-McPT, 4-hydroxy-N-methyl-N-cyclopropyltryptamine, is a derivative of tryptamine known for its psychedelic properties. It exerts serotonergic effects, contributing to its psychoactive nature. Although it has been available as a designer drug in the market since approximately 2016, forensic laboratories didn't definitively identify it until 2018. Notably, 4-HO-McPT is classified as illegal in Finland. FAQ 1.
- [4-HO-MPMI](https://researchem.net/4-ho-mpmi/) - Summary 4-HO-MPMI, alternatively referred to as 4-Hydroxy-N-methyl-(α, N-trimethylene)-tryptamine or lucigenol, belongs to the category of tryptamine derivatives and possesses psychedelic properties. Originating in the late 1990s, it was developed under the leadership of David Nichols at Purdue University. This compound exhibits hallucinogenic effects in animal trials, displaying potency akin to the amphetamine-derived psychedelic DOI. Notably,
- [4-HO-DPT](https://researchem.net/4-ho-dpt/) - Summary 4-HO-DPT, or Deprocin, is a psychedelic compound in the substituted tryptamine class. It serves as the 4-hydroxyl analog of dipropyltryptamine (DPT).In 2019, Chadeayne et al. successfully determined the crystal structure of the fumarate salt of 4-HO-DPT. The authors' description of the system includes the presence of one 4-HO-DPT cation, protonated at the dipropylamine N
- [4-HO-DET](https://researchem.net/4-ho-det/) - Summary 4-HO-DET, also called 4-hydroxy-diethyl-tryptamine and sometimes known as CZ-74, is a hallucinogenic substance belonging to the class of psychedelic compounds with a moderate duration of action. It is classified as a substituted tryptamine, sharing structural similarities with psilocin, ethocybin, and 4-HO-DIPT. Analogs The acetic acid ester of 4-HO-DET is referred to as 4-AcO-DET, while
- [4-Acetoxy-MiPT](https://researchem.net/4-acetoxy-mipt/) - Summary 4-AcO-MiPT, which stands for 4-acetoxy-N-methyl-N-isopropyltryptamine or myricetin, belongs to the category of psychedelic tryptamines. It shares close chemical similarities with compounds like O-acetyl psilocin and MiPT.Unfortunately, scant information is available regarding the human pharmacology or potential toxicity of 4-AcO-MiPT. Nevertheless, analytical techniques have been established for its detection and identification. Drug prohibition laws In
- [4-AcO-DPT](https://researchem.net/4-aco-dpt/) - Summary 4-Acetyloxy-N, N-dipropyltryptamine, or 4-AcO-DPT, belongs to the tryptamine derivative class of compounds. This substance has been marketed and sold as a designer drug. It is essentially an esterified form of 4-HO-DPT, a psychedelic tryptamine initially synthesized by Alexander Shulgin. While anecdotal reports suggest that 4-AcO-DPT induces psychoactive effects in humans, it is worth noting
- [4-Acetoxy-DiPT](https://researchem.net/4-acetoxy-dipt/) - Summary 4-Acetoxy-DiPT, also known as ipracetin or 4-acetoxy-N,N-diisopropyltryptamine, is a synthetic psychedelic tryptamine. This compound is relatively rare and has a limited history of human consumption. Drug prohibition laws Denmark:4-AcO-DiPT has been included in the roster of controlled substances under Schedule B.Japan:In Japan, 4-Acetoxy-DiPT is classified as a controlled substance.[2]Sweden:The Ministry of Health within the
- [4-Acetoxy-DET](https://researchem.net/4-acetoxy-det/) - Summary 4-Acetoxy-DET, commonly referred to as ethacetin, ethylacybin, or 4-AcO-DET, is a type of psychedelic tryptamine. Albert Hofmann originally synthesized this compound in 1958 while working in the Sandoz laboratory.This compound is believed to undergo rapid hydrolysis, facilitated by serum esterases, converting it into the unbound phenolic form known as 4-HO-DET. However, there is a
- [4-AcO-DALT](https://researchem.net/4-aco-dalt/) - Summary 4-Acetyloxy-N,N-diallyltryptamine (abbreviated as 4-AcO-DALT) is a derivative of tryptamine. It has appeared on the market as a designer drug, but there is limited available information about it. The compound was initially detected in confiscated drug samples in the year 2012. FAQ What is 4-AcO-DALT? 4-AcO-DALT, or 4-Acetyloxy-N, N-diallyltryptamine, is a chemical compound in the
- [Methylisopropyllysergamide](https://researchem.net/methylisopropyllysergamide/) - Summary Methylisopropyllysergamide (MIPLA), also known as lysergic acid methylisopropyl amide, is an analog of LSD discovered initially by Albert Hofmann at Sandoz during the initial research on LSD's structure-activity relationship. Further investigations into MIPLA have been conducted by a team led by David E. Nichols at Purdue University. MIPLA is a structural isomer of LSD,
- [Lysergic acid 2,4-dimethylazetidide](https://researchem.net/lysergic-acid-24-dimethylazetidide/) - Summary Lysergic acid 2,4-dimethylacetamide (commonly known as LA-SS-Az or LSZ) is a derivative of LSD that was created by a research team led by David E. Nichols at Purdue University. Its development aimed to create a structured analog of LSD, with the diethylamide group constrained within an azetidine ring. This modification was intended to facilitate
- [LSM-775](https://researchem.net/lsm-775/) - Summary N-Morpholinyllysergamide (LSM-775) is a compound derived from ergine. While it is not as potent as LSD, it is known to induce LSD-like effects within a dosage range of 75 to 700 micrograms, albeit with a shorter duration of action. Notably, LSM-775 is associated with fewer indications of cardiovascular stimulation and peripheral toxicity when compared
- [ETH-LAD](https://researchem.net/buy-eth-lad-for-sale/) - Summary ETH-LAD, scientifically known as 6-ethyl-6-nor-lysergic acid diethylamide, represents an analog of LSD. Alexander Shulgin initially documented its effects on human psychopharmacology in the renowned book TiHKAL. ETH-LAD falls into the category of psychedelic substances akin to LSD but exhibits slightly higher potency, with reported active doses ranging from 20 to 150 micrograms. Notably, ETH-LAD
- [1V-LSD](https://researchem.net/1v-lsd/) - Summary 1V-LSD, also known colloquially as Valerie, is a psychotropic substance and a research chemical known for its psychedelic effects. This compound is an artificial derivative of natural lysergic acid, found in ergot alkaloids, and serves as an analog of LSD. Until 2022, 1V-LSD was available for purchase online. However, after an amendment to the
- [1P-ETH-LAD](https://researchem.net/1p-eth-lad/) - Summary 1P-ETH-LAD, scientifically known as 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, is an analog of LSD (lysergic acid diethylamide). This psychedelic compound shares similarities with LSD and belongs to the lysergamide chemical class. Research has indicated that 1P-ETH-LAD can undergo a conversion to ETH-LAD when incubated in human serum, suggesting it may function as a prodrug. Notably, like
- [1P-AL-LAD](https://researchem.net/1p-al-lad/) - Summary 1P-AL-LAD is a compound derived from lysergic acid diethylamide (LSD) known for its psychedelic properties and association with the designer drug market. It is thought to function as a prodrug for AL-LAD and has demonstrated the ability to induce a head-twitch response in animal research studies. FAQ 1. What is 1P-AL-LAD? 1P-AL-LAD is a
- [1D-LSD](https://researchem.net/1d-lsd/) - Summary 1D-LSD, scientifically known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-lysergic acid diethylamide, is a psychotropic compound classified as a research chemical. It is recognized for its potential to induce psychedelic effects. It is theorized to act as a prodrug for LSD, undergoing metabolic conversion to LSD within the body. Notably, 1D-LSD has replaced 1V-LSD in Germany following the inclusion
- [1cP-AL-LAD](https://researchem.net/1cp-al-lad/) - Summary 1cP-AL-LAD is a compound closely related to lysergic acid diethylamide (LSD) and is known for its psychedelic properties. It is believed to function as a precursor for AL-LAD. This substance has been distributed as a designer drug, with its presence first noted in France in June 2021. FAQ What is 1cP-AL-LAD? 1cP-AL-LAD is a
- [4-Fluoroethcathinone](https://researchem.net/buy-4-fluoroethcathinone-for-sale/) - Summary 4-Fluoroethcathinone, commonly called 4-FEC, is categorized as a stimulant within the cathinone class. It is a structural analog to mephedrone (4-fluoro methcathinone) and has been distributed as a designer drug in the market. FAQ 1. What is 4-Fluoroethcathinone (4-FEC)? 4-Fluoroethcathinone, or 4-FEC, is a synthetic stimulant under the cathinone class. It is chemically related
- [4-Bromomethcathinone (4-BMC)](https://researchem.net/buy-4-bromomethcathinone-for-sale/) - Summary 4-Bromomethcathinone, also known as 4-BMC or Brephedrone, is a psychoactive substance and research chemical that falls within the phenethylamine, amphetamine, and cathinone chemical classes. As supported by scientific studies, its primary mode of action involves acting as a serotonin and norepinephrine reuptake inhibitor. However, it exhibits characteristics more in line with an antidepressant rather
- [beta-Phenylmethamphetamine](https://researchem.net/beta-phenylmethamphetamine/) - Summary β-Phenylmethamphetamine, also known as N,α-dimethyl-β-phenyl-phenethylamine, is a highly potent and enduring stimulant substance. FAQ 1. What is Beta-Phenylmethamphetamine (BPM)? BPM is a chemical compound that belongs to the phenethylamine class of compounds. It is structurally related to amphetamines and is sometimes referred to as a research chemical. 2. Is BPM the same as Methamphetamine
- [3-Methylamphetamine](https://researchem.net/buy-3-methylamphetamine-for-sale/) - Summary 3-Methylamphetamine (3-MeA; PAL-314) is classified as a stimulant compound belonging to the amphetamine family. When tested in mice, it exhibits a self-administration behavior similar to that observed with 4-fluoroamphetamine. Notably, it shares characteristics with monoamine releasers, although it distinguishes itself by facilitating a more evenly distributed release of all three monoamines. This sets it
- [Ortetamine](https://researchem.net/buy-ortetamine-for-sale/) - Summary Ortetamine (INN), recognized as 2-methylamphetamine, belongs to the amphetamine class of stimulant drugs. In animal tests for drug discrimination, it demonstrated a closer similarity to dextroamphetamine compared to 3- or 4-methylamphetamine, albeit with approximately one-tenth the potency of dextroamphetamine. Legal status On January 18, 2019, Sweden's public health agency categorized 2-MA as a narcotic
- [5-Methyl-MDA](https://researchem.net/buy-5-methyl-mda-for-sale/) - Summary 5-Methyl-3,4-methylenedioxyamphetamine (5-Methyl-MDA) is a designer drug belonging to the amphetamine class, known for its entactogenic and psychedelic properties. It is characterized by a methyl group on the amphetamine ring, making it a ring-methylated homolog of MDA and a structural isomer of MDMA. Effects and research Drug discrimination studies have revealed that 5-methyl-MDA can substitute
- [Pentylone](https://researchem.net/pentylone/) - Summary Pentylone, also known as β-Keto-Methyl​benzo​dioxolyl​pentanamine, βk-Methyl-K, βk-MBDP, methyl​enedioxy​pentedrone, or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one, is a stimulant that was developed during the 1960s. This compound falls under the category of substituted cathinones, which are a type of substituted phenethylamines.Pentylone has been detected in specific samples of powders that were marketed as "NRG-1." These samples sometimes contained varying mixtures
- [3,4-Methylenedioxy-N-ethylamphetamine](https://researchem.net/34-methylenedioxy-n-ethylamphetamine/) - Summary 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) is a psychoactive drug with empathogenic properties, sometimes referred to as MDE or colloquially known as Eve. It falls into the category of substituted amphetamines and substituted methylenedioxyphenethylamines. MDEA is a substance that releases and inhibits the reuptake of serotonin, norepinephrine, and dopamine in the brain.It's important to note that the possession
- [3,4-Methylenedioxy-N-hydroxyamphetamine](https://researchem.net/34-methylenedioxy-n-hydroxyamphetamine/) - Summary 3,4-Methylenedioxy-N-hydroxyamphetamine (MDOH), also known as MDH or N-hydroxytenamphetamine, is a compound that falls into the categories of entactogen, psychedelic, and stimulant. It belongs to the phenethylamine and amphetamine chemical classes. MDOH is the N-hydroxy counterpart of MDA and the N-desmethyl counterpart of MDHMA.This compound was initially synthesized and evaluated by Alexander Shulgin. In his
- [4-Methylcathinone](https://researchem.net/4-methylcathinone/) - Summary 4-Methylcathinone, alternatively recognized as Nor-Mephedrone, 4-MC, and NSC-60487, is a stimulant substance in the cathinone chemical class. This compound has been made available online and is often marketed as a designer drug.It is important to note that 4-methylcathinone is a metabolite of the more widely known drug mephedrone (4-methylmethcathinone).4-Methylcathinone exhibits a 2.4-fold selectivity in
- [4-Methylbuphedrone](https://researchem.net/4-methylbuphedrone/) - Summary 4-Methylbuphedrone, alternatively recognized as 4-MeMABP, BZ-6378, and 4-Methyl-α-methylamino-butyrophenone, is a stimulant substance belonging to the cathinone class. This compound has been made available online and is often marketed as a designer drug.Its presence was initially reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in November 2011. Legal status In Germany,
- [3',4'-Dimethoxy-α-pyrrolidinopentiophenone](https://researchem.net/34-dimethoxy-α-pyrrolidinopentiophenone/) - Summary 3',4'-Dimethoxy-α-pyrrolidinopentiophenone, commonly referred to as O-2512, 3,4-dimethoxy-α-PVP, or DMPVP, is a synthetic stimulant substance categorized within the cathinone class. It has been marketed online as a designer drug. Notably, DMPVP is characterized by its relatively modest inhibition of serotonin reuptake and shows minimal affinity in laboratory settings for dopamine or noradrenaline transporters. Legal status
- [α-PCYP](https://researchem.net/α-pcyp/) - Summary Alpha-PCyP is a stimulant substance classified within the cathinone class and marketed online as a designer drug. Within a group of alpha-substituted pyrrolidinyl cathinone derivatives created in 2015, the alpha-cyclopentyl variation was identified to possess roughly equivalent in vitro potency as an inhibitor of the dopamine transporter compared to the alpha-propyl derivative α-PVP. Conversely,
- [4'-Methyl-α-pyrrolidinobutiophenone](https://researchem.net/4-methyl-α-pyrrolidinobutiophenone/) - Summary 4'-Methyl-α-pyrrolidinobutiophenone, also known as MPBP, is a stimulating compound that has emerged as a novel designer drug. It bears a close chemical relationship to pyrovalerone, essentially its homologue with a shorter carbon chain. Legal status FAQ 1. What is 4'-Methyl-α-pyrrolidinobutiophenone (MPBP)? 4'-Methyl-α-pyrrolidinobutiophenone, commonly known as MPBP, is a synthetic compound with stimulant properties. It
- [3',4'-Methylenedioxy-α-pyrrolidinobutiophenone](https://researchem.net/34-methylenedioxy-α-pyrrolidinobutiophenone/) - Summary 3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone (MDPBP) is a stimulant belonging to the cathinone class, initially developed in the 1960s. It has gained notoriety as a novel designer drug. MDPBP is sometimes marketed under the alias "NRG-1" in combination with other cathinone derivatives, including flephedrone, pentylone, MαPPP, and its higher homologue MDPV. As observed with other cathinones, MDPBP has
- [4'-Methoxy-α-pyrrolidinopropiophenone](https://researchem.net/4-methoxy-α-pyrrolidinopropiophenone/) - Summary 4'-Methoxy-α-pyrrolidinopropiophenone (MOPPP) belongs to the pyrrolidinophenone class of designer stimulant drugs. It can induce euphoria, an effect commonly observed in other traditional stimulants. Please note that additional research and references are needed to verify this claim. Recreational use MOPPP is relatively uncommonly used compared to other recreational amphetamines or stimulants like meth, cocaine, or
- [Diphenylprolinol](https://researchem.net/diphenylprolinol/) - Summary Diphenylprolinol (commonly known as D2PM) or (R/S)-(±)-diphenyl-2-pyrrolidinyl-methanol, is a substance categorized as a norepinephrine-dopamine reuptake inhibitor and has been utilized as a designer drug. Pharmacology The more pharmacologically active enantiomer of diphenylprolinol is the dextrorotary (R)-(+)-enantiomer, although researchers have explored several related derivatives.Side effects such as chest pain (which may indicate potential cardiovascular toxicity)
- [4-methoxy-α-pyrrolidinopentiophenone](https://researchem.net/4-methoxy-α-pyrrolidinopentiophenone/) - Summary 4'-Methoxy-α-pyrrolidinopentiophenone also referred to as O-2417, 4-MeO-α-PVP, and MOPVP, is a member of the cathinone class of stimulant drugs. This compound has been made available online and categorized as a designer drug. Legal Status Since October 2015, China has classified 4-MeO-α-PVP as a controlled substance. FAQ 1. What is 4'-Methoxy-α-pyrrolidinopentiophenone (4-MeO-α-PVP)? 4'-Methoxy-α-pyrrolidinopentiophenone, or 4-MeO-α-PVP
- [alpha-Pyrrolidinopentiothiophenone (α-PVT)](https://researchem.net/buy-alpha-pvt-for-sale/) - Summary α-Pyrrolidinopentiophenone (α-PVT), also known as α-PVT, is a synthetic stimulant in the cathinone class. This compound has been available for purchase as a designer drug on online platforms. It is structurally related to α-PVP, with the key distinction being the replacement of the phenyl ring with a thiophene ring.The initial discovery of α-PVT occurred
- [Indapyrophenidone](https://researchem.net/indapyrophenidone/) - Summary Indapyrophenidone is a synthetic compound categorized within the cathinone class, and it has been made available for purchase online as a designer drug.This substance is characterized as the indanyl-α-phenyl analogue of the stimulant drug α-PVP. Furthermore, it shares structural similarities with diarylethylamines like fluorolintane and UWA-001. Despite its usage, the precise mechanism of action
- [5-DBFPV](https://researchem.net/5-dbfpv/) - Summary 5-DBFPV, alternatively known as 5-dihydro-benzofuran pyrovalerone and 3-desoxy-MDPV, is a stimulant belonging to the cathinone class. This compound has been available for purchase online under the category of designer drugs. It serves as an analogue of MDPV, with the notable substitution of the methylenedioxyphenyl group by dihydrobenzofuran. Legal status As of January 26, 2016,
- [Thiopropamine](https://researchem.net/thiopropamine/) - Summary Thiopropamine is a stimulant substance that is an analogue of amphetamine, featuring replacing the phenyl ring with thiophene. While it shares stimulant properties with amphetamine, its potency is approximately one-third less. Additionally, variations such as the N-methyl and thiophene-3-yl analogues are known to be somewhat more potent but generally remain less powerful than their
- [Pipradrol](https://researchem.net/pipradrol/) - Summary Pipradrol, known as Meratran, is a gentle central nervous system stimulant with norepinephrine-dopamine reuptake-inhibiting properties. It has fallen out of everyday use in many countries due to concerns about its potential abuse. However, Pipradrol continues to have limited utilization in certain European countries and the United States, though infrequently. History Pipradrol, initially patented in
- [Nitracaine](https://researchem.net/nitracaine/) - Summary Nitracaine is a synthetic compound categorized as a local anaesthetic with stimulant attributes. It falls within the drug classification of local anaesthetics and exhibits a chemical connection to cocaine. Although Nitracaine shares specific effects reminiscent of cocaine, it possesses its unique pharmacological profile. Structurally, Nitracaine comprises a benzoic acid ester and a para-substituted phenyl
- [HDMP-28](https://researchem.net/hdmp-28/) - Summary HDMP-28, also known as methylnaphthidate, is a synthetic compound belonging to the substituted phenethylamine class. It is structurally related to both methylphenidate (commonly known as Ritalin) and ethylphenidate. HDMP-28 has gained attention in the world of research chemicals due to its stimulant properties and potential for cognitive enhancement. However, it's essential to understand the
- [4-Fluoroethylphenidate](https://researchem.net/4-fluoroethylphenidate/) - Summary 4-Fluoroethylphenidate, often abbreviated as 4-FEP, is a synthetic psychoactive compound that falls within the substituted phenidate class. It is structurally related to methylphenidate, which is a commonly prescribed medication for attention deficit hyperactivity disorder (ADHD). 4-FEP is known for its stimulating properties and potential for recreational use, though it is important to note that
- [4-Benzylpiperidine](https://researchem.net/4-benzylpiperidine/) - Summary 4-Benzylpiperidine is a chemical compound that falls under the class of piperidines, which are heterocyclic compounds containing a six-membered ring structure. It is a synthetic compound with potential pharmaceutical applications, primarily in the development of various drugs and medications. The mixture is characterized by the presence of a piperidine ring, which is a saturated
- [3,4-Dichloromethylphenidate](https://researchem.net/34-dichloromethylphenidate/) - What is 3,4-dichloromethylphenidate? 3,4-Dichloromethylphenidate, often referred to as 3,4-DCMP, is a synthetic chemical compound with stimulant properties. It belongs to the class of substituted phenolates and is structurally related to methylphenidate, a commonly prescribed medication for attention deficit hyperactivity disorder (ADHD). 3,4-DCMP is a research chemical and is not approved for medical use. Effects Stimulant
- [3-Chlorophenmetrazine](https://researchem.net/3-chlorophenmetrazine/) - Summary 3-Chlorophenmetrazine, often referred to as 3-CPM, is a synthetic chemical compound belonging to the class of phenylmorpholines. It is a member of the substituted phenmetrazine family, which includes other compounds with stimulant properties. Phenmetrazine and its derivatives have historically been used for their potential stimulating effects. Effects Stimulant Properties: 3-Chlorophenmetrazine is known for its
- [PDM-35](https://researchem.net/pdm-35/) - What is PDM-35? PDM-35, also known as 1,3-dimethylbutylamine, is a synthetic compound that has gained attention in the world of dietary supplements and sports nutrition. Similar to other compounds like DMAA (1,3-dimethylamylamine) and DMBA (1,3-dimethylbutylamine), PDM-35 has been marketed as a stimulant with potential benefits for exercise and energy enhancement. Effects Enhanced Energy: PDM-35 is
- [1,3-Dimethylbutylamine](https://researchem.net/13-dimethylbutylamine/) - Summary 1,3-Dimethylbutylamine, commonly known as DMBA, is a synthetic compound that has garnered attention in the realms of fitness and sports supplementation. Structurally similar to the banned substance DMAA (1,3-dimethylamylamine), DMBA has been marketed as a potential alternative with identical stimulant properties. Effects DMBA is primarily included in dietary supplements for its stimulant effects. These
- [Desoxypipradrol](https://researchem.net/desoxypipradrol/) - Summary Desoxypipradrol, also known as 2-DPMP, 2-diphenylmethylpiperidine, or Ivory Wave, is a stimulant drug based on the benzylpiperidine structure. It shares a close chemical relationship with methylphenidate and pipradol.Initially developed by Ciba in the 1950s, desoxypipradrol was explored for various purposes, including the treatment of conditions like narcolepsy and ADHD. However, its development was halted
- [Mirtazapine](https://researchem.net/mirtazapine/) - Summary Mirtazapine, marketed under the trade name Remeron and others, belongs to the piperazinoazepine class of antidepressant drugs. At elevated doses, it has been reported to exhibit atypical psychedelic and soothing properties. It is categorized as a noradrenergic and specific serotonergic antidepressant (NaSSA).Initially developed in the Netherlands, mirtazapine entered the United States pharmaceutical market in
- [Diphenhydramine](https://researchem.net/diphenhydramine/) - Summary Diphenhydramine, known by various names such as DPH, Dimedrol, and Benadryl, among others, belongs to the ethanolamine class and is classified as a deliriant substance. It falls into the category of first-generation H1 antihistamines and is widely available as an over-the-counter medication for managing allergies. When consumed in excess of recommended doses, diphenhydramine can
- [Clonidine](https://researchem.net/clonidine/) - Summary Clonidine, marketed under various trade names such as Catapres, Kapvay, Nexiclon, Clophelin, and more, is categorized as a depressant belonging to the imidazoline class of substances. While its primary application is in managing high blood pressure, it is versatile and can be employed for various medical conditions. These include attention deficit hyperactivity disorder, anxiety
- [Tramadol](https://researchem.net/tramadol/) - Summary Tramadol, which goes by the brand names Ultram, Ralivia, or Tramal, is classified as a synthetic opioid in the phenylpropylamine category. It shares structural similarities with codeine and morphine. Its primary actions include acting as a weak agonist at the μ-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin.Initially developed in 1962, Tramadol
- [Tianeptine](https://researchem.net/tianeptine/) - Summary Tianeptine, known by its trade names Stablon and Coaxil, represents an unconventional type of antidepressant. Although it is primarily prescribed for its antidepressant properties, it is sometimes taken in high doses recreationally to achieve opioid-like effects. Its mechanism of action is unique and not fully understood, primarily involving the modulation of the brain's monoaminergic
- [Tapentadol](https://researchem.net/tapentadol/) - Summary Tapentadol, frequently marketed under Nucynta, is a synthetic opioid analgesic that shares structural similarities with tramadol. Tapentadol exerts its effects through a dual mechanism of action, functioning as both a μ-opioid receptor agonist and a norepinephrine reuptake inhibitor. It is employed for the treatment of moderate to severe pain. Users often describe the subjective
- [Sufentanil](https://researchem.net/sufentanil/) - Summary Sufentanil, or sufentanyl, marketed under the brand name Sufenta, is an exceptionally potent synthetic anilidopiperidine opioid analgesic. It boasts rapid onset and a brief duration of action, making it a valuable tool in the medical field for pain management during surgical procedures and post-operative recovery. Regarding potency, Sufentanil surpasses pharmaceutical-grade morphine by approximately 500
- [Pethidine](https://researchem.net/pethidine/) - Summary Pethidine, also recognized as meperidine and marketed under the trade name Demerol and other brands, is a synthetic opioid analgesic belonging to the phenylpiperidine class. It was synthesized in 1938[10] with the initial intention of being an anticholinergic agent, a project led by the German chemist Otto Eisler. However, its pain-relieving properties were later
- [Oxymorphone](https://researchem.net/oxymorphone/) - Summary Oxymorphone, commonly recognized under the brand name Opana, is a semi-synthetic opioid analgesic employed for the treatment of moderate to severe pain. It shares a structural resemblance with other opioids like morphine and heroin. Oxymorphone's origins trace back to its development in Germany in 1914, and it was later introduced to the American market
- [O-Desmethyltramadol](https://researchem.net/o-desmethyltramadol/) - Summary O-Desmethyltramadol, also referred to as O-DSMT or desmetramadol, belongs to the phenylpropylamine class of opioid substances. This compound serves as an active metabolite originating from tramadol.Before emerging for sale in the research chemical market during the 2010s, O-DSMT had not been documented for human consumption.Subjectively, individuals who use O-DSMT report experiencing effects such as
- [Morphine](https://researchem.net/morphinee/) - Summary Morphine belongs to the morphinan class of naturally occurring opioid substances. It is one of the alkaloids naturally found in opium, derived from the poppy plant Papaver somniferum, alongside codeine. Furthermore, morphine serves as the prototype opiate, setting the standard against which other opioids are measured, including codeine, diacetylmorphine (commonly known as heroin), and
- [Methadone](https://researchem.net/methadone/) - Summary Methadone, available under trade names like Dolophine and Methadose, is a synthetic opioid analgesic utilized to manage moderate to severe pain and address opioid addiction. Its primary application is in the treatment and control of opioid addiction symptoms. While its subjective effects share similarities with other synthetic opioids like fentanyl, users often report a
- [Hydrocodone](https://researchem.net/hydrocodone/) - Summary Hydrocodone, commonly known as Vicodin or Norco when mixed with paracetamol, is a semi-synthetic opioid morphinan. This compound is synthesized or chemically derived from codeine, one of the opioid alkaloids naturally occurring in the opium poppy. It functions as a narcotic analgesic, typically administered orally to suppress coughs. Moreover, it is frequently taken orally
- [Ethylmorphine](https://researchem.net/ethylmorphine/) - Summary Ethylmorphine, recognized by its alternative names codethyline and dionine, originated as a semi-synthetic morphinan opioid, initially synthesized by Merck in the year 1884. It was developed as a milder substitute for morphine. In contemporary times, its primary application lies in its role as an antitussive agent. Ethylmorphine is commonly found in cough syrup formulations
- [Dihydrocodeine](https://researchem.net/dihydrocodeine/) - Summary Dihydrocodeine, a semi-synthetic morphinan opioid analgesic, is prescribed to alleviate pain or serve as an antitussive agent, either in isolation or in combination with paracetamol or aspirin. This pharmaceutical compound originated in Germany in 1908 and entered the market for medical use in 1911.Various names, including Drocode, Paracodeine, and Parzone, recognize Dihydrocodeine. It boasts
- [Heroin](https://researchem.net/heroin/) - Summary Heroin, recognized by various names, including diacetylmorphine and diamorphine, belongs to the morphinan opioid category and is derived from the dried latex of the Papaver somniferum plant. It is primarily sought after for its euphoric effects and is frequently used as a recreational drug. Medical-grade diamorphine, on the other hand, is administered as a
- [Dextropropoxyphene](https://researchem.net/dextropropoxyphene/) - Summary Dextropropoxyphene, also recognized as Propoxyphene and Darvon, is a synthetic opioid belonging to the phenylpropylamine chemical group. Similar to other compounds within this category, like tapentadol and tramadol, it elicits mild euphoric, analgesic, soothing, and antitussive effects when administered, typically through oral ingestion, though occasionally intravenous or rectal administration may occur.It is worth noting
- [Desomorphine](https://researchem.net/desomorphine/) - Summary Desomorphine, also known as Dihydrodesoxymorphine, belongs to the morphinan chemical class and exhibits various effects, including analgesia, muscle relaxation, sedation, and euphoria upon administration. This substance is a structural analog of morphine and is a key component in the drug mixture referred to as Krokodil (also known as Crocodile, Krok, or Croc). Initially developed
- [Codeine](https://researchem.net/codeine/) - Summary Codeine, also known as 3-methylmorphine, is a naturally occurring opioid substance belonging to the morphinan class. It is found in extracts of the poppy plant, especially in Papaver bracteatum. Substances within this class are known for their effects, which include sedation, cough suppression, and the induction of euphoria when administered.In opium, codeine ranks as
- [Buprenorphine](https://researchem.net/buprenorphine/) - Summary Buprenorphine, classified as a semisynthetic opioid within the morphinan chemical category, serves as a versatile compound that acts as a modulator of opioid receptors with mixed partial agonist properties.In higher doses, it is employed to address opioid addiction in individuals dependent on opioids. At lower doses, it finds application in managing moderate to acute
- [Acetylfentanyl](https://researchem.net/acetylfentanyl/) - Summary Acetyl fentanyl, often referred to as acetyl fentanyl, is an opioid analgesic substance and a derivative of fentanyl, a powerful synthetic opioid. Research indicates that acetyl fentanyl is approximately fifteen times more potent than morphine. This potency suggests that, although slightly less powerful than fentanyl, it remains significantly stronger than pure heroin. It has
- [Furanylfentanyl](https://researchem.net/furanylfentanyl/) - Summary Furanylfentanyl (Fu-F) is an opioid analgesic, structurally similar to fentanyl, and has been distributed as a designer drug.[2][3] In mice, it exhibits an ED50 value of 0.02 mg/kg, indicating it is roughly one-fifth as potent as fentanyl. Side effects The side effects associated with fentanyl analogs closely resemble those of fentanyl itself. These effects
- [Etonitazen](https://researchem.net/etonitazen/) - Summary Etonitazene, also referred to as EA-4941 or CS-4640, is a benzimidazole opioid. Its discovery dates back to 1957. Studies have indicated that it possesses an astonishing potency level, estimated to be roughly 1,000 to 1,500 times more potent than morphine when tested in animals.Due to its marked potential for causing dependence and a propensity
- [U-47700](https://researchem.net/u-47700/) - Summary U-47700 also recognized as U4, pink heroin, pinky, or pink, is an opioid analgesic drug initially developed by a team at Upjohn during the 1970s. In animal models, it boasts approximately 7.5 times the potency of morphine.A physical sample of U-47700 is available for reference.This compound is a structural isomer of the earlier opioid
- [Mazindol](https://researchem.net/mazindol/) - Summary Mazindol, available under brand names such as Mazanor and Sanorex, is classified as a stimulant medication primarily employed for appetite suppression. This medication was originally formulated by Sandoz-Wander during the 1960s. Medical uses Mazindol is utilized in the short-term, typically lasting a few weeks, as part of a comprehensive obesity management strategy. This strategy
- [Diclofensine](https://researchem.net/diclofensine/) - Summary Diclofensine (Ro 8-4650) emerged from Hoffmann-La Roche's research efforts in the 1970s aimed at discovering a novel antidepressant. Subsequent investigations revealed that the active component was the (S)-isomer. This compound functions as a stimulant by operating as a triple monoamine reuptake inhibitor, primarily impeding the reuptake of dopamine and norepinephrine, exhibiting binding affinities (Ki)
- [Bromantane](https://researchem.net/bromantane/) - Summary Bromantane, marketed under the brand name Ladasten, is an unconventional psychostimulant and anxiolytic medication belonging to the adamantane family, sharing connections with amantadine and memantine. It finds usage in Russia for the treatment of neurasthenia. Although researchers have established that bromantane's effects are tied to the dopaminergic and potentially serotonergic neurotransmitter systems, the precise
- [Amfonelic](https://researchem.net/amfonelic/) - Summary Amfonelic acid (AFA), also known as WIN 25,978, is a research compound and dopaminergic stimulant that possesses antibiotic characteristics. While there is a scarcity of extensive clinical trials involving AFA, it is predominantly employed within the realm of scientific research. History The stimulating attributes of AFA were serendipitously discovered during research conducted at Sterling-Winthrop
- [2-Aminoindane](https://researchem.net/2-aminoindane/) - Summary 2-Aminoindane (2-AI) is a compound utilized in scientific research for its potential in addressing neurological conditions and supporting psychotherapy practices. Additionally, it has found its way into the market as a designer drug. Its primary mechanism of action involves its selective interaction with the norepinephrine transporter (NET) and dopamine transporter (DAT). Therapeutic and illicit
- [Viloxazine](https://researchem.net/viloxazine/) - Summary Viloxazine, available under the brand name Qelbree and formerly known as Vivalan and by other trade names, is a medication classified as a selective norepinephrine reuptake inhibitor (NRI). It is employed in the treatment of attention deficit hyperactivity disorder (ADHD) in both children and adults. Interestingly, Viloxazine had a prior history of almost three
- [4,4'-Dimethylaminorex](https://researchem.net/44-dimethylaminorex/) - Summary 4,4'-Dimethylaminorex, commonly referred to as 4,4'-DMAR and colloquially known as "Serotonin," belongs to the category of psychostimulant and entactogen designer drugs. This compound shares chemical similarities with aminorex, 4-methylaminorex, and pemoline. It was initially identified in the Netherlands in December 2012 and subsequently emerged in the European designer drug market around mid-2013.By February 2014,
- [2-Diphenylmethylpyrrolidine](https://researchem.net/2-diphenylmethylpyrrolidine/) - Summary 2-Diphenylmethylpyrrolidine, also known as Desoxy-D2PM or 2-benzhydrylpyrrolidine, is a psychoactive stimulant drug. This compound is a structural analogue of diphenylprolinol (D2PM) with the removal of the hydroxyl group, and it shares structural similarities with desoxypipradrol (2-DPMP). Both D2PM and 2-DPMP function as norepinephrine-dopamine reuptake inhibitors (NDRIs). Desoxy-D2PM has been marketed and used as a
- [Desoxypipradrol](https://researchem.net/desoxypipradrol-2/) - Summary Desoxypipradrol, alternatively referred to as 2-diphenylmethylpiperidine (2-DPMP), is a pharmaceutical compound created by Ciba during the 1950s. It functions as a norepinephrine-dopamine reuptake inhibitor (NDRI). Chemistry Desoxypipradrol shares a structural resemblance with two other compounds, methylphenidate and pipradrol, and all three exhibit a similar pharmacological effect. Among these piperidine compounds, desoxypipradrol stands out with
- [Troparil](https://researchem.net/troparil/) - Summary Roparil, also recognized as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT, is a stimulant compound primarily employed in scientific research. Derived from methylecgonidine, troparil belongs to the phenyltropane class of drugs and acts as a potent dopamine reuptake inhibitor (DRI). Compared to cocaine, trail exhibits several times greater potency in inhibiting dopamine reuptake, but it is
- [2-Diphenylmethylpyrrolidine](https://researchem.net/2-diphenylmethylpyrrolidine-2/) - Summary 2-Diphenylmethylpyrrolidine, commonly known as Desoxy-D2PM or 2-benzhydrylpyrrolidine, is a potent psychoactive stimulant. It is structurally related to diphenylprolinol (D2PM) and shares similarities with desoxypipradrol (2-DPMP), both of which function as inhibitors of norepinephrine and dopamine reuptake (NDRIs). Desoxy-D2PM is often marketed as a designer drug and has been involved in the production of legal
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