Contents
- 1 Summary
- 2 Pharmacology
- 3 Legal status
- 4 FAQ
- 4.1 1. What is Mexedrone?
- 4.2 2. How does Mexedrone work?
- 4.3 3. What are the effects of Mexedrone?
- 4.4 4. Is Mexedrone legal?
- 4.5 5. What are the potential risks and side effects of Mexedrone?
- 4.6 6. Can Mexedrone be detected in drug tests?
- 4.7 7. Is Mexedrone addictive?
- 4.8 8. Can Mexedrone be used safely?
- 4.9 9. What precautions should I take if I choose to use Mexedrone?
- 5 References
Summary
Mexedrone, called 4-MMC-MeO, is categorized as a stimulant and entactogen drug in the cathinone class. This substance has been made available online, often as a designer drug. Notably, Mexedrone is the alpha-methoxy derivative of Mephedrone.
| Identifiers | |
|---|---|
| IUPAC name | |
| CAS Number | 2166915-02-0 |
|---|---|
| PubChem CID | 129318262 |
| ChemSpider | 52324347 |
| UNII | 2AFZ6G3X7J |
| Chemical and physical data | |
| Formula | C12H17NO2 |
| Molar mass | 207.273 g·mol−1 |
Pharmacology
Mexedrone exhibits relatively mild inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine, with IC50 values of 5289 nM, 8869 nM, and 6844 nM, respectively. Additionally, it displays a modest capacity as a serotonin-releasing agent (SRA), with an EC50 value of 2525 nM.
Legal status
Mexedrone has been prohibited in Sweden since January 26, 2016, and it is also banned in Japan as of August 24, 2016.
FAQ
1. What is Mexedrone?
Mexedrone, or 4-MMC-MeO, is a synthetic stimulant and entactogen in the cathinone class. It is chemically related to Mephedrone and is often sold as a designer drug.
2. How does Mexedrone work?
Mexedrone is a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and a weak serotonin-releasing agent (SRA). This means it affects the brain’s reuptake and release of neurotransmitters like serotonin, norepinephrine, and dopamine.
3. What are the effects of Mexedrone?
The effects of Mexedrone may include increased alertness, elevated mood, enhanced sociability, and heightened sensory perception. Some users also report experiencing euphoria and empathogenic impact, similar to other entactogen drugs.
4. Is Mexedrone legal?
The legal status of Mexedrone varies by country. It is illegal in several countries, including Sweden and Japan. Laws regarding designer drugs can change, so staying updated on the legal status in your specific location is essential.
5. What are the potential risks and side effects of Mexedrone?
The use of Mexedrone may come with potential risks and side effects. These include anxiety, paranoia, increased heart rate, high blood pressure, insomnia, and possible neurotoxicity. Long-term or heavy use may carry additional health risks.
6. Can Mexedrone be detected in drug tests?
Mexedrone may not be routinely included in standard drug tests. However, specific tests designed to detect cathinone or designer drugs may be able to identify it.
7. Is Mexedrone addictive?
While Mexedrone’s addictive potential is not fully understood, like many stimulant drugs, it may lead to psychological dependence in some users. Frequent or heavy use can increase the risk of addiction.
8. Can Mexedrone be used safely?
The safety of Mexedrone is not well established, and its use can be associated with health risks. Using any psychoactive substance carries potential dangers. It’s essential to exercise caution, start with low doses, and be aware of the risks involved.
9. What precautions should I take if I choose to use Mexedrone?
If you decide to use Mexedrone despite the risks, it’s crucial to prioritize harm reduction. Some precautions include starting with a small dose, avoiding mixing with other substances, staying hydrated, and being in a safe and comfortable environment.
References
- “Mexedrone”. New Synthetic Drug Database.
- Qian Z, Jia W, Li T, Liu C, Hua Z (February 2017). “Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC”. Drug Testing and Analysis. 9 (2): 274–281. doi:10.1002/dta.1983. PMID 27352812.
- Kuś P, Rojkiewicz M, Kusz J, Książek M, Sochanik A (14 May 2019). “Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone)”. Forensic Toxicology. 37 (2): 456–464. doi:10.1007/s11419-019-00477-y.
- Roberts L, Ford L, Patel N, Vale JA, Bradberry SM (March 2017). “11 analytically confirmed cases of mexedrone use among polydrug users”. Clinical Toxicology. 55 (3): 181–186. doi:10.1080/15563650.2016.1271424. PMID 28075189. S2CID 33220365.
- McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, et al. (March 2017). “Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone”. Drug Testing and Analysis. 9 (3): 358–368. doi:10.1002/dta.2053. PMC 5336524. PMID 27524685.
- “31 nya ämnen kan klassas som narkotika eller hälsofarlig vara” (in Swedish). Folkhälsomyndigheten. November 2015.
- “指定薬物一覧” (PDF) (in Japanese). Ministry of Health, Labour and Welfare.