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Summary

Pyrovalerone, also known as Centroton, 4-Methyl-β-keto-prolintane, Thymergix, or O-2371, is a psychoactive substance known for its stimulant properties. It achieves these effects by functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI). This compound has been utilized in clinical settings for managing chronic fatigue and lethargy and as an appetite suppressant for weight loss.
Initially developed in the late 1960s, pyrovalerone found use in France and several other European countries. However, its prescription has dwindled over time due to concerns related to misuse and dependence. Pyrovalerone is similar to various other stimulants, including α-PVP, MDPV, and prolintane (Promotil, Katovit).
Some common side effects associated with pyrovalerone usage encompass reduced appetite or anorexia, heightened anxiety, disrupted sleep patterns or insomnia, and muscle tremors or trembling. Discontinuing its use after prolonged abuse can often lead to symptoms of depression.
It’s worth noting that the R-enantiomer of pyrovalerone does not exhibit any significant activity.

Legal status

FAQ

1. What is Pyrovalerone?

Pyrovalerone is a psychoactive substance known for its stimulant effects. It operates as a norepinephrine-dopamine reuptake inhibitor (NDRI) and has been utilized in clinical settings to manage chronic fatigue, lethargy, and weight loss.

2. What are some familiar brand names for Pyrovalerone?

Pyrovalerone is marketed under various brands, including Centroton, 4-Methyl-β-keto-prolintane, Thymergix, and O-2371.

3. When was Pyrovalerone developed?

Pyrovalerone was initially developed in the late 1960s.

4. In which countries is Pyrovalerone used?

Pyrovalerone has been used in France and several other European countries. However, its usage has decreased over time due to concerns regarding misuse and dependence.

5. What are the common side effects of Pyrovalerone?

Side effects associated with Pyrovalerone use may include reduced appetite or anorexia, increased anxiety, disrupted sleep patterns or insomnia, and muscle tremors or trembling.

6. Can Pyrovalerone lead to withdrawal symptoms?

Yes, discontinuing using Pyrovalerone after prolonged abuse can often result in withdrawal symptoms, including depression.

7. Is there a difference between the enantiomers of Pyrovalerone?

Yes, the R-enantiomer of Pyrovalerone does not exhibit significant activity.

8. Is Pyrovalerone available as a prescription medication?

While Pyrovalerone was previously prescribed for specific medical conditions, its prescription and usage have become infrequent due to concerns related to abuse and dependence.

9. Can Pyrovalerone be addictive?

Yes, Pyrovalerone has the potential for abuse and dependence, which is one of the reasons for its decreased usage in clinical settings.

10. Is Pyrovalerone legal?

The legal status of Pyrovalerone can vary by country and region. To determine their legality, it is essential to check your area’s specific regulations and laws.

References

1. Anvisa, the Brazilian health regulatory agency, published Collegiate Board Resolution No. 784 on March 31, 2023. This resolution contains lists of substances categorized as narcotic, psychotropic, precursor, and other substances under special control in Brazil. It was officially published in the Diário Oficial da União on April 4, 2023, and can be accessed through the official archives until August 3, 2023.
2. Pyrovalerone was the subject of US Patent 3314970, indicating its history of research and development.
3. In October 1971, a study titled “Evaluation of pyrovalerone in chronically fatigued volunteers” was conducted by Gardos G and Cole JO, which assessed the effects of pyrovalerone on individuals experiencing chronic fatigue.
4. In November 1975, a report titled “[Abuse of pyrovalerone by drug addicts]” was published by Deniker P, Lôo H, Cuche H, and Roux JM, highlighting issues related to the misuse of pyrovalerone among drug addicts.
5. In February 2006, Meltzer PC, Butler D, Deschamps JR, and Madras BK conducted research on analogues of pyrovalerone, a compound known as “1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone).” These analogues were investigated as potential monoamine uptake inhibitors.