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SUMMARY

STS-135, also known as 5F-APICA, is a designer drug readily available through online vendors and marketed as a cannabimimetic agent. Its chemical structure is based on understanding the structure-activity relationships within the indole class of cannabimimetics, although the exact origins of its design remain unclear.
STS-135 is considered the terminally-fluorinated analog of SDB-001, drawing a parallel to how AM-2201 is the terminally-fluorinated analog of JWH-018, and XLR-11 is the terminally-fluorinated analog of UR-144. In vitro studies have shown that STS-135 acts as a potent cannabinoid receptor agonist, with an EC50 of 51 nM for human CB2 and 13 nM for human CB1 receptors.
In animal studies conducted on rats, STS-135 has been found to induce effects consistent with cannabinoid activity. At doses ranging from 1 to 10 mg/kg, it produces bradycardia (a slower heart rate) and hypothermia (reduced body temperature). These findings suggest that STS-135 possesses cannabinoid-like properties.
It is important to note that using STS-135 and similar designer drugs has significant risks and safety concerns. The lack of comprehensive research on these substances and their potential adverse effects makes them unpredictable and potentially hazardous to users.
Individuals should exercise extreme caution when considering the use of STS-135 and should be aware of the legal status of such substances in their region. Furthermore, responsible and informed decision-making and consulting with healthcare professionals are strongly advised when dealing with novel and relatively untested compounds like STS-135.

Legal status

Detection

A forensic standard for STS-135 is readily accessible, and information about this compound has been included on the Forendex website as a potential substance of abuse.

FAQ

1. What is STS-135?

• STS-135, 5F-APICA, is a synthetic cannabinoid classified as a designer drug. It is chemically similar to compounds found in the cannabis plant and is often marketed as a legal alternative.

2. Is STS-135 legal?

• The legal status of STS-135 varies by country and region. It is essential to check your local laws and regulations regarding STS-135 before considering its possession or use, as it may be classified as a controlled substance in some areas.

3. What are the effects of STS-135?

• STS-135 is reported to have cannabinoid-like effects, including altered perception, relaxation, and potential adverse reactions like anxiety and paranoia. The specific effects can vary widely among individuals.

4. Is STS-135 safe to use?

• The safety of STS-135 is not well-established. Synthetic cannabinoids like STS-135 can have unpredictable and potentially harmful effects. There have been reports of adverse reactions associated with its use, including severe health issues.

5. Where can I get STS-135?

• STS-135 may be available online, but it is crucial to emphasize that purchasing synthetic cannabinoids from unverified or unregulated vendors can be dangerous. Always prioritize your safety and legality when considering any substance purchase.

6. Can STS-135 be detected in drug tests?

• Standard drug tests typically do not screen for STS-135. However, specialized tests may be able to detect its presence. Always be aware of the potential legal and employment consequences of consuming such substances.

7. Are there any known side effects of STS-135?

• Common side effects may include anxiety, paranoia, nausea, and other adverse reactions. Severe side effects have also been reported, including seizures and other health issues. It is essential to use caution if considering STS-135 and seek medical assistance if you experience adverse effects.

8. What precautions should I take when using STS-135?

• If you decide to use STS-135, it is crucial to do so in a safe and controlled environment, preferably under the supervision of a trusted individual. Start with a low dose, be aware of your mental and physical state, and have access to appropriate resources in case of emergencies. Always prioritize your well-being and safety.

9. Is STS-135 used for any legitimate research purposes?

• STS-135 may have limited legitimate research applications in studying cannabinoid receptors and their effects. However, most information about STS-135 pertains to its recreational use and potential risks.

References

1.  Wilkinson SM, Banister SD, Kassiou M (2015). “Bioisosteric Fluorine in the Clandestine Design of Synthetic Cannabinoids”. Australian Journal of Chemistry. 68: 4. doi:10.1071/CH14198.
2. ^ Jump up to:^a b Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, et al. (August 2015). “Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135”. ACS Chemical Neuroscience. 6 (8): 1445–58. doi:10.1021/acschemneuro.5b00107. PMID 25921407.
3. ^ “关于印发《非药用类麻醉药品和精神药品列管办法》的通知” (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
4. ^ Southern Association of Forensic Scientists