Summary XLR-11, also known as 5″-fluoro-UR-144 or 5F-UR-144, operates as a potent agonist for cannabinoid receptors CB1 and CB2, displaying EC50 values of 98 nM and 83 nM, respectively. This compound belongs to the 3-(tetramethylcyclopropylmethanoyl)indole derivative family, sharing structural relations with compounds like UR-144, A-796,260, and A-834,735. However, it is noteworthy that XLR-11 needs to …
Summary UR-144, also known by its aliases TMCP-018, KM-X1, MN-001, and YX-17, is a pharmaceutical developed by Abbott Laboratories. It operates as a selective full agonist of the peripheral cannabinoid receptor CB2 while displaying a significantly reduced affinity for the psychoactive CB1 receptor. Identifiers IUPAC name CAS Number 1199943-44-6 PubChem CID 44626619 ChemSpider 24634882 UNII …
Summary STS-135, also known as 5F-APICA, represents a designer drug available through online vendors, positioned as a cannabimimetic agent. While the origins of its design remain unclear, STS-135 appears to leverage insights into structure-activity relationships within the indole class of cannabimimetics. It serves as the terminally-fluorinated counterpart to SDB-001, mirroring the relationship between AM-2201 and …
Summary SDB-006 is a pharmacological agent known for its potent agonistic activity on cannabinoid receptors. Its effectiveness is noteworthy, with an EC50 of 19 nM for human CB2 receptors and 134 nM for human CB1 receptors. This compound was initially uncovered while investigating its analogue, SDB-001, which had gained notoriety as “2NE1” when sold illicitly. …
Summary PX-1, which is also recognized under the names 5F-APP-PICA and SRF-30, is an indole-derived synthetic cannabinoid available for purchase online as a designer drug. Identifiers IUPAC name CAS Number 2221100-71-4 PubChem CID 125181260 ChemSpider 32055575 UNII BJ7SBQ2H5I Chemical and physical data Formula C23H26FN3O2 Molar mass 395.478 g·mol−1 Legality On November 10, 2014, Sweden’s public health …
Summary PTI-2 (SGT-49) is a synthetic cannabinoid with an indole-based structure. Notably, it stands out as one of the rare synthetic cannabinoids that incorporates a thiazole group, and it shares a close relationship with PTI-1. These compounds can be considered simplified analogues of the indole-3-heterocycle compounds initially pioneered by Organon and later subjected to extensive …
Summary PTI-1, also known as SGT-48, belongs to the category of indole-based synthetic cannabinoids, notable for its unique inclusion of a thiazole group. This compound is closely associated with PTI-2 and shares a common origin in the lineage of indole-3-heterocycle compounds initially pioneered by Organon and later explored by Merck. Identifiers IUPAC name CAS Number …
Summary Org 28611 (SCH-900,111) is a pharmaceutical compound created by Organon International, functioning as a potent full agonist at both the CB1 and CB2 cannabinoid receptors. Its development was driven by the quest for a water-soluble cannabinoid agonist intended for intravenous administration as an analgesic. While it effectively met its goal and advanced to Phase …
Summary NNE1 also recognized as NNEI, MN-24, and AM-6527, is an indole-based synthetic cannabinoid, a molecular fusion of APICA and JWH-018. This compound acts as an agonist for cannabinoid receptors, boasting Ki values of 60.09 nM at CB1 and 45.298 nM at CB2, along with EC50 values of 9.481 nM at CB1 and 1.008 nM …
Summary MN-25 (UR-12) is a pharmaceutical creation credited to Bristol-Myers Squibb. This drug primarily functions as a relatively selective agonist, predominantly stimulating peripheral cannabinoid receptors. Its affinity for CB2 receptors is moderate, featuring a Ki value of 11 nM. Notably, it displays significantly lower affinity, approximately 22 times lower, for the psychoactive CB1 receptors, with …
