Summary NM-2201, alternatively recognized as CBL-2201, belongs to the family of indole-based synthetic cannabinoids. It is theorized to exhibit analogous characteristics to its closely related counterparts, 5F-PB-22 and NNE1. These compounds are categorized as full agonists, demonstrating an indiscriminate binding affinity to CB1 and CB2 receptors at a low nanomolar level. Identifiers IUPAC name CAS …
Summary NE-CHMIMO (also known as CHM-018) is a synthetic cannabinoid with an indole base believed to act as a potent agonist of the CB1 receptor. It has gained prominence as a designer drug available for purchase online. NE-CHMIMO distinguishes itself by having a 1-cyclohexyl methyl group instead of the 1-pentyl group found in the first-generation …
Summary MAM-2201, also known as 4′-methyl-AM-2201 or 5″-fluoro-JWH-122 is believed to act as a potent agonist for cannabinoid receptors. This compound remained undocumented in scientific or patent literature until laboratories in the Netherlands and Germany first discovered it in June 2011 when used as an ingredient in synthetic cannabis smoking blends. Like RCS-4 and AB-001, …
Summary JWH-424 is a member of the naphthoylindole family, characterized by its role as a cannabinoid agonist targeting both the CB1 and CB2 receptors. However, it demonstrates moderate selectivity for the CB2 receptor, with a Ki value of 5.44nM at CB2 in contrast to 20.9 nM at CB1. The heavier 8-iodo analog of this compound …
Summary JWH-398 is an analgesic compound belonging to the naphthoylindole family, functioning as a cannabinoid agonist with activity at both the CB1 and CB2 receptors. It exhibits mild selectivity for CB1, demonstrating a Ki of 2.3 nM while registering 2.8 nM at CB2 receptors. The EMCDDA identified this synthetic chemical as an ingredient in three …
Summary JWH-200, also known as WIN 55,225, is a member of the aminoalkylindole family, functioning as an analgesic compound with cannabinoid receptor agonist properties. This chemical exhibits a binding affinity, denoted as Ki, of 42 nM at the CB1 receptor, a level of relationship similar to that of THC. Notably, in vivo studies revealed that …
Summary JWH-198 is a medication hailing from both the aminoalkyl indole and naphthoylindole drug families, and it functions as a cannabinoid receptor agonist. This compound was initially developed by the pharmaceutical company Sanofi-Winthrop during the early 1990s. JWH-198 exhibits a notable binding affinity for the CB1 receptor, measuring at 10 nM, approximately four times stronger …
Summary JWH-210, a member of the naphthoylindole family, is a potent analgesic compound. It is a robust cannabinoid agonist, acting on CB1 and CB2 receptors. It demonstrates a remarkable binding affinity with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. Notably, JWH-210 ranks among the most potent 4-substituted naphthoyl derivatives within …
Summary JWH-149, a synthetic cannabimimetic compound, was initially identified by John W. Huffman. This substance is the N-pentyl analog of JWH-148. Notably, it demonstrates significant binding affinity for the CB2 receptor, with a Ki (inhibition constant) of approximately 0.73 ± 0.03 nM for this subtype. Additionally, it exhibits more than six times selectivity for CB2 …
Summary JWH-122, a synthetic cannabimimetic compound, was first identified by John W. Huffman. This compound is a methylated derivative of JWH-018 and exhibits a Ki of 0.69 nM at CB1 and 1.2 nM at CB2 receptors.In January 2015, a concerning incident occurred when more than 40 individuals reportedly fell ill after consuming Rosca de Reyes, …
