Summary RCS-8, also known as 1-(2-cyclohexyl ethyl)-3-(2-methoxyphenylacetyl)indole and referred to as SR-18 and BTM-8, is a synthetic cannabinoid that has been identified as an ingredient in “herbal” synthetic cannabis mixtures. Structurally, it can be characterized as an analog of JWH-250, where the 1-pentyl group is replaced by 1-(2-cyclohexylethyl). As a result of this structural modification, …
Summary JWH-251, scientifically referred to as 1-pentyl-3-(2-methylphenylacetyl)indole, belongs to the phenylacetylindole family, characterized as a synthetic cannabinoid. It acts as a cannabinoid agonist, exhibiting approximately five times more selectivity for CB1 receptors, with a Ki of 29 nM, compared to CB2 receptors, with a Ki of 146 nM. Similar to its counterparts, such as the …
Summary JWH-250, scientifically known as 1-pentyl-3-(2-methoxyphenylacetyl)indole, is a member of the phenylacetylindole family recognized for its analgesic properties. This chemical compound operates as a cannabinoid agonist, engaging with CB1 and CB2 receptors, featuring a Ki of approximately 11 nM at CB1 and 33 nM at CB2. It’s noteworthy that JWH-250 distinguishes itself from many older …
Summary JWH-249, also known as 1-pentyl-3-(2-bromophenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. It operates as a cannabinoid agonist with approximately 2.4 times higher selectivity for CB1 receptors, having a Ki of roughly 8.4 ± 1.8 nM, compared to CB2 receptors, where its Ki is around 20 ± 2 nM. Much like its …
Summary JWH-203, also known as 1-pentyl-3-(2-chlorophenylacetyl)indole, is a member of the phenylacetylindole family and serves as an analgesic chemical. This compound functions as a cannabinoid agonist, demonstrating nearly equal affinity for CB1 and CB2 receptors, with a Ki of approximately 8.0 nM at CB1 and 7.0 nM at CB2. Originally named after its discoverer, John …
Summary JWH-167, also known as 1-pentyl-3-(phenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. This compound acts as a cannabinoid agonist with approximately 1.75 times higher selectivity for CB1 receptors, exhibiting a Ki of about 90 nM ± 17 and around 159 nM ± 14 at CB2 receptors. Notably, JWH-167 shares structural similarities with …
