Summary AM-1248 is a compound with disputed potency and selectivity, acting as a moderately potent agonist for both cannabinoid receptors CB1 and CB2. When the typical 3-(1-naphthyl) group found in many indole-derived cannabinoid ligands is replaced with an adamantyl group, it often imparts significant CB2 selectivity. However, by incorporating an N-methylpiperidin-2-ylmethyl substitution at the indole …

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Summary AB-001, also known as 1-pentyl-3-(1-adamantyl)indole, is a designer drug that emerged as an ingredient in synthetic cannabis smoking blends in 2010 in Ireland and 2011 in Hungary and Germany. The original developer of AB-001 remains uncertain; however, it shares structural similarities with compounds like AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are recognized as …

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