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Summary
Cloniprazepam, a benzodiazepine derivative, serves as a prodrug for clonazepam, generating 7-aminoclonazepam and various other metabolites.
Among these minor metabolites are 3-hydroxyclonazepam, 6-hydroxyclonazepam, 3-hydroxycloniprazepam, and ketocloniprazepam, which features a ketone group formed in place of the 3-hydroxy group.
Cloniprazepam is categorized as a designer drug and falls under the umbrella of “new psychoactive substances” (NPS). Towards the conclusion of 2017, it remained unregulated in most countries.
| Identifiers | |
|---|---|
| IUPAC name | |
| CAS Number | 1998158-84-1 |
|---|---|
| PubChem CID | 137700140 |
| ChemSpider | 68003855 |
| UNII | YSL4SM8QYP |
| CompTox Dashboard (EPA) | DTXSID60893511 |
| Chemical and physical data | |
| Formula | C19H16ClN3O3 |
| Molar mass | 369.81 g·mol−1 |
FAQ
- What is Cloniprazepam?
- Clonazepam is a benzodiazepine derivative and a prodrug of clonazepam, which means it metabolizes into clonazepam and other related compounds within the body.
- What are the minor metabolites of Clonazepam?
- Minor metabolites of Cloniprazepam include 3-hydroxyclonazepam, 6-hydroxyclonazepam, 3-hydroxycloniprazepam, and ketocloniprazepam, the latter featuring a ketone group formed in place of the 3-hydroxy group.
- Is Clonazepam a designer drug?
- Yes, Cloniprazepam is considered a designer drug and falls under the category of “new psychoactive substances” (NPS).
- Is Cloniprazepam regulated in most countries?
- As of the end of 2017, Cloniprazepam remained an uncontrolled substance in many countries.
References
- Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V (November 2016). “Metabolic Characterization of Designer Benzodiazepines”This study provides an update on the in vitro phase I microsomal metabolism of designer benzodiazepines. The research covers various compounds, including adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam.
- Mortelé O, Vervliet P, Gys C, et al. (May 2018). “Metabolism Study of Cloniprazepam Using Liquid Chromatography and Mass Spectrometry”This research delves into the in vitro phase I and phase II metabolism of cloniprazepam, a new designer benzodiazepine. The study employs liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to analyze the compound’s metabolic pathways.