Summary
1V-LSD, also known colloquially as Valerie, is a psychotropic substance and a research chemical known for its psychedelic effects. This compound is an artificial derivative of natural lysergic acid, found in ergot alkaloids, and serves as an analog of LSD. Until 2022, 1V-LSD was available for purchase online. However, after an amendment to the German NpSG (New Psychoactive Substances Act) in 2022, it, along with 1P-LSD and 1cP-LSD, as well as several other lysergamides, became subject to regulatory control.
| Identifiers | |
|---|---|
| IUPAC name | |
| PubChem CID | 162368540 |
|---|---|
| UNII | 23R2G2G79C |
| Chemical and physical data | |
| Formula | C25H33N3O2 |
| Molar mass | 407.558 g·mol−1 |
Pharmacology
As observed with other N-acylated derivatives of LSD, there is a belief that 1V-LSD functions as a prodrug for LSD. Additionally, it is suggested that it may also exhibit weak partial agonist activity at the 5-HT2A receptor.
Animal studies
An experiment involving a Head-twitch response assay conducted on mice revealed that 1V-LSD exhibits potency similar to that of 1P-LSD and 1cP-LSD. Moreover, the behavioral effects observed closely resemble those induced by these structural analogs.
Chemistry
1V-LSD results from a chemical reaction between valeric acid (pentanoic acid) and LSD. In this process, the valeroyl group is introduced at the NH position of the indole moiety.
Ehrlich’s reagent is typically employed to identify the presence of an indole moiety, which is a fundamental component of lysergamide and ergoline molecules. However, it’s important to note that 1V-LSD, like other N-acylated lysergamides, may exhibit slow reactivity with the Ehrlich reagent. Consequently, accurate results may only be obtained if the reagent is fresh and properly prepared.
Legal position
1V-LSD is classified as illegal in the United States and a Schedule 1 drug under the Federal Analogue Act.
In Sweden, an investigation regarding the legal status of 1V-LSD began on March 2, 2022, which may potentially lead to its classification as a controlled substance shortly.
South Korea took measures to place 1V-LSD under legal control in July 2022 temporarily. This control is subject to renewal.
In Germany, an amendment to the NpSG initially intended to ban the sale of 1V-LSD in September 2022. However, the ban did not take effect as planned due to a punctuation error in the updated NpSG. The law was subsequently amended in March 2023, officially banning 1V-LSD.
FAQ
1. What is 1V-LSD?
- 1V-LSD is a chemical compound that is related to LSD (lysergic acid diethylamide) and is known for its psychedelic effects.
2. Is 1V-LSD legal in the United States?
- No, 1V-LSD is classified as illegal in the United States and is considered a Schedule 1 drug under the Federal Analogue Act.
3. What is the legal status of 1V-LSD in Sweden?
- As of March 2, 2022, 1V-LSD is under investigation in Sweden, which may result in its classification as a controlled substance shortly.
4. How is 1V-LSD regulated in South Korea?
- In South Korea, 1V-LSD was temporarily under legal control in July 2022. This control is subject to renewal.
5. What happened with the legal status of 1V-LSD in Germany?
- Initially, an amendment to the NpSG in Germany intended to ban the sale of 1V-LSD in September 2022. However, the ban did not take effect as planned due to a punctuation error in the updated NpSG. The law was later amended in March 2023, officially banning 1V-LSD.
6. Is 1V-LSD similar to LSD in its effects?
- 1V-LSD is structurally related to LSD and is known for its psychedelic effects, which can be similar to those of LSD. However, it’s important to note that individual experiences may vary.
7. Can 1V-LSD be detected in drug tests?
- Standard drug tests typically do not screen precisely for 1V-LSD. However, if there are concerns about drug testing, it’s advisable to exercise caution, as the legal status of substances can change over time.
8. Where can I obtain 1V-LSD for research purposes?
- The availability of 1V-LSD may vary by region and local regulations. Researchers typically source it from reputable chemical suppliers that cater to scientific research needs, always adhering to applicable laws and guidelines.
9. Are there potential therapeutic applications for 1V-LSD?
– Research on the therapeutic potential of 1V-LSD is limited. Like other psychedelics, it may have potential applications in mental health and psychotherapy, but more studies are needed to determine its efficacy and safety.
10. Is 1V-LSD safe for recreational use?
– The safety of 1V-LSD, like other psychedelics, is poorly understood, and its effects can vary from person to person. Using caution and adhering to legal regulations are essential. Consulting with professionals and following safety guidelines is important to minimize risks.
References
“1V-LSD Solution.” Available at www.caymanchem.com.
“Exploring 1V-LSD: Insights from PsychonautWiki.”
Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, et al. (November 2021). “Return of the Lysergamides: Part VII – Analytical and Behavioral Characterization of 1-Valeroyl-D-Lysergic Acid Diethylamide (1V-LSD).” Published in Drug Testing and Analysis, Volume 14, Issue 4.
“1V-LSD – Legal LSD 3.0: An Overview (in German) on YouTube.”
Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD (August 2020). “Pharmacological and Biotransformation Studies of 1-Acyl-Substituted Derivatives of D-Lysergic Acid Diethylamide (LSD).” Published in Neuropharmacology, Volume 172.
Umehara A, Ueda H, Tokuyama H (November 2016). “Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O.” Published in The Journal of Organic Chemistry, Volume 81, Issue 22.
De Faubert Maunder MJ (August 1974). “A Field Test for Hallucinogens: Further Improvements.” Published in The Journal of Pharmacy and Pharmacology, Volume 26, Issue 8.
“Reactions of 1V-LSD” (Published on July 16, 2021).
“1V-LSD Reaction with the Ehrlich Reagent” (Published on July 16, 2021).
Kim Chan-hyuk, “Regulator Names 1V-LSD as Narcotic Drug Temporarily.” Published in Korea Biomedical Review on July 5, 2022.
“Gesetzespanne: Gefährliche LSD-Derivate Plötzlich Legal” (In German).