Summary
HU-243, also known as AM-4056, is a synthetic cannabinoid compound representing the single enantiomer of the hydrogenated derivative derived from the widely referenced agonist HU-210. It serves as a methylene homolog of canbisol. Remarkably, HU-243 displays robust agonistic activity at both the CB1 and CB2 receptors, boasting an impressive binding affinity of 0.041 nM at the CB1 receptor. This potency places it slightly ahead of HU-210, demonstrating an affinity of 0.061 nM in a similar assay.
| Identifiers | |
|---|---|
| IUPAC name | |
| CAS Number | 140835-18-3 |
|---|---|
| PubChem CID | 3081854 |
| IUPHAR/BPS | 735 |
| UNII | SKGOA1RZCT |
| Chemical and physical data | |
| Formula | C25H40O3 |
| Molar mass | 388.592 g·mol−1 |
Legal status
International Status
- HU-243, also known as AM-4056, is not specifically categorized in the schedules established by the United Nations Single Convention on Narcotic Drugs from 1961 or their Convention on Psychotropic Substances from 1971. As such, countries signatories to these international drug control treaties are not obligated to regulate or control HU-243 under these specific treaties.
United States Status
2. In the United States, HU-243 is not listed among the scheduled controlled substances at the federal level. However, it is important to note that HU-243 might be legally considered an analog of THC. THC is classified as a Schedule I substance under “tetrahydrocannabinol.” Consequently, sales or possession of HU-243 could potentially be subject to prosecution under the Federal Analogue Act.
Florida Status
3. In the state of Florida, HU-243 is classified as a Schedule I controlled substance, specifically categorized as a hallucinogen. This classification makes it illegal to purchase, sell, or possess HU-243 in Florida without the appropriate license or authorization.
Vermont Status
4. As of January 1, 2016, HU-243 is likely regulated in Vermont and categorized as a “Hallucinogenic Drug.” This designation includes substances such as stramonium, mescaline, lysergic acid diethylamide, and psilocybin, as well as synthetic equivalents of compounds found in Cannabis sativa resinous extractives. This regulation is part of the state’s efforts to control substances with hallucinogenic effects.
- It’s worth noting that HU-243 should not be confused with the chemical name “3-dimethylheptyl-11-hydroxyhexahydrocannabinol” or common/trade names like “canbisol” and “nabidrox.” These names refer to different compounds and are not synonymous with HU-243. HU-243 is specifically a methylene homolog of canbisol.
FAQ
1. What is HU-243?
HU-243, also known as AM-4056, is a synthetic cannabinoid compound often used for research purposes. It is a derivative of HU-210, a well-known reference agonist.
2. Is HU-243 regulated internationally?
HU-243 is not listed in the schedules outlined by the United Nations Single Convention on Narcotic Drugs from 1961 or their Convention on Psychotropic Substances from 1971. Therefore, it is not required to be controlled under these international drug treaties.
3. How is HU-243 classified in the United States?
At the federal level in the United States, HU-243 is not scheduled as a controlled substance. However, it could be considered an analog of THC and potentially subject to prosecution under the Federal Analogue Act.
4. Is HU-243 legal in Florida?
No, in the state of Florida, HU-243 is classified as a Schedule I controlled substance. This categorization makes it illegal to purchase, sell, or possess HU-243 in Florida without the appropriate license.
5. What is HU-243’s status in Vermont?
As of January 1, 2016, HU-243 is likely regulated in Vermont, designated as a “Hallucinogenic Drug” under state regulations. This aligns with Vermont’s efforts to control substances with hallucinogenic effects.
6. Is HU-243 the same as “3-dimethylheptyl-11-hydroxyhexahydrocannabinol,” “canbisol,” or “nabidrox”?
No, HU-243 should not be confused with other chemical names or common/trade names such as “3-dimethylheptyl-11-hydroxyhexahydrocannabinol,” “canbisol,” or “nabidrox.” These names represent different compounds and are not synonymous with HU-243. HU-243 is specifically a methylene homolog of canbisol.
7. Is HU-243 available for recreational use or medical purposes?
HU-243 is primarily used for research and is not intended for recreational or medical use. Its legality and intended use may vary by jurisdiction, so it is essential to understand and adhere to local laws and regulations.
8. What is the purpose of researching HU-243?
Research involving HU-243 may aim to understand better the pharmacological effects of synthetic cannabinoids and their potential applications. It can help expand our knowledge of cannabinoid receptor interactions and their role in various physiological processes.
9. Are there potential risks associated with HU-243 use?
As with any synthetic cannabinoid, the use of HU-243 can pose risks, including unpredictable effects and potential legal consequences. Researchers and individuals should exercise caution and consult with relevant authorities to ensure compliance with regulations.
10. Can HU-243 be legally obtained for research purposes?
The legality of obtaining HU-243 for research purposes varies by jurisdiction. Researchers should follow local regulations and seek the necessary approvals and licenses for its acquisition and use in scientific studies.
References
- In an August 2007 publication, Stern E and Lambert DM delved into “Medicinal chemistry endeavors around the phytocannabinoids.” Their work, featured in “Chemistry & Biodiversity,” explored the chemistry and diversity of phytocannabinoids, shedding light on their medicinal potential. [DOI: 10.1002/cbdv.200790149] [PMID: 17712816] [S2CID: 24920412]
- HU-243’s status in international drug control conventions is notable. It is not specifically listed in the UN’s Single Convention on Narcotic Drugs from 1961, or their Convention on Psychotropic Substances from 1971, freeing signatory countries from the obligation to regulate it under these treaties.
- The United States has a unique classification for HU-243. It is not designated as a controlled substance at the federal level, yet it could potentially be subject to prosecution under the Federal Analogue Act as an analog of THC, a Schedule I substance.
- In Florida, HU-243 is categorized as a Schedule I controlled substance, specifically as a hallucinogen. This classification makes it illegal to purchase, sell, or possess HU-243 in the state without the required license.
- In Vermont, HU-243 is subject to regulation as a “Hallucinogenic Drug” as of January 1, 2016. This aligns with the state’s efforts to control substances with hallucinogenic effects and ensure their responsible use.
- It’s important to clarify that HU-243 should not be confused with other chemical or common/trade names like “3-dimethylheptyl-11-hydroxyhexahydrocannabinol,” “canbisol,” or “nabidrox.” These names refer to different compounds and are not synonymous with HU-243, which is specifically a methylene homologue of canbisol.