PX-1, which is also recognized under the names 5F-APP-PICA and SRF-30, is an indole-derived synthetic cannabinoid available for purchase online as a designer drug.

IUPAC name
CAS Number2221100-71-4 
PubChem CID125181260
Chemical and physical data
Molar mass395.478 g·mol−1


On November 10, 2014, Sweden’s public health agency recommended categorizing PX-1 as a hazardous substance.
As of May 2015, PX-1 has been included in the Fifth Schedule of the Misuse of Drugs Act (MDA), rendering it illegal in Singapore.


1. What is PX-1?

  • PX-1 is a synthetic cannabinoid, also known as 5F-APP-PICA and SRF-30. It belongs to the indole-based class of designer drugs.

2. Is PX-1 legal to use or possess?

  • The legal status of PX-1 varies by country and jurisdiction. It’s essential to check the specific laws and regulations in your area. In some places, it may be classified as illegal due to its potential health risks.

3. What are the effects of PX-1?

  • PX-1, like other synthetic cannabinoids, can produce psychoactive effects when consumed. These effects may include altered perception, relaxation, and, in some cases, adverse reactions such as anxiety or paranoia.

4. How is PX-1 typically used?

  • PX-1 is typically consumed by smoking, vaporizing, or inhaling as an aerosol. Users often seek its psychoactive properties, but the safety and purity of such products are not guaranteed.

5. Is PX-1 safe to use?

  • The safety of PX-1 is a matter of concern. Synthetic cannabinoids can be unpredictable and may lead to severe adverse effects, including health risks. Using unregulated designer drugs is strongly discouraged.

6. Has PX-1 been banned or regulated in any countries?

  • Yes, PX-1 has been classified as a hazardous substance in Sweden, and it is illegal in Singapore as of May 2015. Regulations and bans may exist in other regions as well, so it is crucial to stay informed about local laws.

7. Where can I find more information about PX-1?

  • Information about PX-1, its effects, and its legal status can be sought from credible sources, including government agencies, health organizations, and substance abuse resources. Always rely on up-to-date and reputable information.


  1. PX 1. Cayman Chemical. Retrieved 15 July 2015.
  2. In March 2020, Presley BC, Logan BK, and Jansen-Varnum SA delved into the Phase I metabolism of the synthetic cannabinoid receptor agonist PX-1 (also known as 5F-APP-PICA) using human liver microsomes and UHPLC-HRMS in their study published in Biomedical Chromatography (Volume 34, Issue 3). Their research sheds light on the compound’s metabolic pathways. [doi:10.1002/bmc.4786] [PMID 31863591] [S2CID 209435138].
  3. In July 2022, Dahm P, Thomas A, Rothschild MA, Thevis M, and Mercer-Chalmers-Bender K conducted Phase I-metabolism studies on the synthetic cannabinoids PX-1 and PX-2 using various in vitro models. Their findings were published in Forensic Toxicology (Volume 40, Issue 2), providing insights into the metabolism of these compounds. [doi:10.1007/s11419-021-00606-6] [PMID 36454402] [PMC 9715525] [S2CID 245540105].
  4. The Swedish Folkhälsomyndigheten proposed classifying cannabinoids as dangerous to health, emphasizing concerns surrounding these substances. [Source: “Cannabinoider föreslås bli klassade som hälsofarlig vara” – Folkhälsomyndigheten, in Swedish. Retrieved 16 July 2015].
  5. As of April 30, 2015, the Misuse of Drugs Act in Singapore lists PX-1 as a controlled substance, making it illegal in the country. [Source: “Misuse of Drugs Act” – Singapore Government. Retrieved 24 July 2015].

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