Tolibut, scientifically known as 3-(p-tolyl)-4-aminobutyric acid or β-(4-methylphenyl)-GABA, is a pharmaceutical compound developed in Russia. This substance is categorized as a derivative of γ-aminobutyric acid (GABA), making it a GABA analog. Specifically, halibut is the 4-methyl variant of phenibut and shares structural similarities with baclofen, replacing the 4-chloro group with a 4-methyl substitution.
Tolibut has been associated with potential analgesic, tranquilizing, and neuroprotective effects. However, it remains unclear whether this drug received medical approval or was utilized in clinical practice in Russia.

IUPAC name
CAS Number28311-38-8
28311-37-7 (HCl)
PubChem CID49344
CompTox Dashboard (EPA)DTXSID00951003
Chemical and physical data
Molar mass193.246 g·mol−1


  • What is Tolibut?
  • Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid, is a drug developed in Russia. It is considered an analog of γ-aminobutyric acid (GABA) and is closely related to phenibut and baclofen, with a 4-methyl substitution in place of the chlorine or phenyl group.
  • Is Tolibut a GABA analogue?
  • Yes, Tolibut is a GABA analogue. It shares structural similarities with GABA, a neurotransmitter in the central nervous system, which is known for its inhibitory effects.
  • What are the potential medical uses of Tolibut?
  • Tolibut has been described as having analgesic, tranquilizing, and neuroprotective properties. However, it’s not entirely clear whether the drug has been approved or used for medical purposes.
  • Is Tolibut available for medical use or as a medication?
  • The availability and approval status of Tolibut for medical use in Russia or other countries need to be well-documented. Information on its medical use is limited.
  • What are the differences between Tolibut and Phenibut?
  • Tolibut is the 4-methyl analog of halibut, and both substances share structural similarities. However, they may have variations in their pharmacological effects and properties. Further research is needed to understand these differences fully.
  • Is Tolibut legal for recreational use?
  • Information regarding the legal status of Tolibut for recreational use is limited. It’s essential to research and understand the legal regulations in your specific region before considering its use.
  • Are there potential risks or side effects associated with Tolibut?
  • The safety profile and potential side effects of Tolibut are not well-documented. Like any substance with psychoactive properties, using Tolibut may carry certain risks. It’s crucial to exercise caution and seek expert advice if considering its use.
  • Where can I find more information about Tolibut?
  • Due to the limited information available on Tolibut, further research may be required to obtain detailed insights. Consult with healthcare professionals or authoritative sources for the most up-to-date information.


  1. Investigating Neuroprotective Effects: A study conducted in September 2012 explored the neuroprotective properties of new salts and compositions of baclofen in the context of convulsive seizures induced by electroshock. The research delves into the functional aspects of these effects, shedding light on potential applications for neuroprotection.
  2. Understanding GABA Analog Uptake: In January 1977, research focused on the impact of γ-aminobutyric acid analogs on the uptake of [3H]-γ-aminobutyric acid by synaptosomes in the rat brain. This study aimed to better understand how analogs of this neurotransmitter may influence neuronal processes.
  3. Exploring Analgesic Activities: A study from 1987 investigated the spectrum of analgesic activity associated with both baclofen and tolibut. This research sought to elucidate the potential pain-relieving properties of these compounds. (Source)
  4. Proposing Mechanisms of Analgesic Action: In 1992, a hypothesis was formulated regarding the possible mechanisms behind the action of analgesic agents at the neuronal level. This study provides insights into how analgesics, possibly including tolibut and baclofen, might operate within neural systems.

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