U-48800 is an opioid analgesic that has found its way into the designer drug market. Differing from U-47700, it primarily functions as a kappa opioid receptor agonist with only moderate affinity for the mu-opioid receptor. Despite this distinction, it has emerged in the realm of recreational drug use, sometimes forming part of drug combinations. Unfortunately, it has also been associated with various cases of drug overdose.

IUPAC name
CAS Number2370977-17-4
PubChem CID137700072
Chemical and physical data
Molar mass343.29 g·mol−1


  • What is U-48800?
  • U-48800 is an opioid analgesic that has gained notoriety as a designer drug. It exhibits its effects primarily as a kappa opioid receptor agonist with moderate affinity for the mu-opioid receptor.
  • Why is U-48800 considered a designer drug?
  • U-48800 is referred to as a designer drug because it is synthesized and distributed with the intention of recreational use or abuse, often evading legal regulations.
  • How does U-48800 differ from other opioids like U-47700?
  • Unlike U-47700, which acts as a potent mu-opioid receptor agonist, U-48800 mainly targets the kappa opioid receptor and only exhibits moderate activity at the mu-opioid receptor.
  • Is U-48800 safe for recreational use?
  • No, U-48800 is not considered safe for recreational use. Its potency and potential for abuse, along with the risk of overdose, make it a dangerous substance.
  • What are the potential risks associated with U-48800?
  • U-48800 has been linked to numerous cases of drug overdose. Its use can lead to adverse effects, including respiratory depression, which can be life-threatening.
  • Is U-48800 legal?
  • The legal status of U-48800 varies from one jurisdiction to another. In many places, it is considered illegal due to its potential for abuse and the associated health risks.
  • Can U-48800 be part of drug combinations?
  • Yes, U-48800 has been found as a component in drug combinations, which can further increase the risks of adverse effects and overdose.
  • Is there any legitimate medical use for U-48800?
  • U-48800 is not approved for medical use, and its recreational use is strongly discouraged due to its risks and potential harm.
  • What measures should be taken to avoid the risks of U-48800?
  • The best way to avoid the risks of U-48800 is to refrain from using it altogether. Additionally, staying informed about local drug laws and seeking help for substance abuse issues are essential steps to minimize harm.
  • Where can I find more information and support related to U-48800?
  • Suppose you or someone you know is struggling with substance abuse or has questions about U-48800. In that case, it is advisable to reach out to healthcare professionals, addiction support organizations, or local authorities for guidance and assistance.


  1. Investigating U-48800 Toxicokinetics and Metabolism: Gampfer TM and colleagues delved into the toxicokinetics and analytical toxicology of U-48800, an abused opioid. Their study explored in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding, providing insights into this synthetic opioid’s characteristics.
  2. Non-Fentanyl Synthetic Opioids in the Recreational Drug Market: Baumann MH and co-authors conducted research on U-47700 and its analogs, focusing on non-fentanyl synthetic opioids that impact the recreational drug market. The study sheds light on the emergence and prevalence of these substances.
  3. Fatalities Involving U-48800: Fogarty MF and team analyzed U-48800 and related compounds using LC-MS-MS. Additionally, they presented a case series of fatalities involving U-48800, highlighting the dangers associated with this synthetic opioid.
  4. Investigating Opioid Receptor Activation: Otte L and colleagues investigated the activation of μ- and κ-opioid receptors by eight new synthetic opioids, including U-48800, using the [35 S]-GTPγS assay. Their research contributes to our understanding of the pharmacological properties of these substances.
  5. A Smooth Muscle Bowel Model for Opioid Research: Amend N and co-authors developed a pharmacologically pre-contracted smooth muscle bowel model for studying highly potent opioid receptor agonists and antagonists. This model provides a valuable tool for opioid-related research and toxicology studies.

Leave a Comment

Your email address will not be published. Required fields are marked *