Summary Etizolam, available under numerous brand names, is a derivative of thienodiazepine, essentially an analogue of benzodiazepine. It distinguishes itself by substituting the benzene ring with a thiophene ring and fusing a triazole ring, effectively categorizing it as a thienotriazolodiazepine.Although categorized as a thienodiazepine, Etizolam is clinically treated as a benzodiazepine due to its mechanism…

Summary Ro5-4864, also known as 4′-chlorodiazepam, is a benzodiazepine derivative with its origins traced back to diazepam. Unlike the majority of benzodiazepine derivatives, Ro5-4864 exhibits a unique pharmacological profile. It does not display an affinity for GABAA receptors, thus lacking the typical effects associated with benzodiazepines.Instead, Ro5-4864 manifests as a soothing substance, but it is…

Summary Pyrazolam, also known as SH-I-04, is a benzodiazepine derivative initially developed by a research team led by Leo Sternbach at Hoffman-La Roche during the 1970s. This compound has experienced a resurgence and is now being marketed as a designer drug since 2012. Pyrazolam exhibits structural resemblances to alprazolam and bromazepam. One notable characteristic that…

Summary Phenazepam, also recognized as bromdihydrochlorphenylbenzodiazepine in Russia, belongs to the benzodiazepine class of drugs. Initially developed in the Soviet Union in 1975, it is currently manufactured in Russia and several associated countries.Phenazepam serves various clinical purposes, notably in the treatment of mental disorders, including psychiatric schizophrenia and anxiety. Additionally, it finds application as a…

Summary Nitrazolam is categorized as a triazolobenzodiazepine (TBZD), which belongs to the class of benzodiazepine (BZD) derivatives. This compound has been illicitly marketed online as a designer drug. It shares a close chemical relationship with substances like clonazolam and flunitrazolam, differing only in the absence of a chlorine or fluorine group, respectively, on the benzene…

Summary Nifoxipam, also known as 3-hydroxy desmethyl flunitrazepam or DP 370, is classified as a benzodiazepine. This compound serves as a minor byproduct of flunitrazepam and has been illicitly marketed online as a designer drug.Notably, Nifoxipam induces potent sedative and sleep-prolonging effects. Moreover, it demonstrates significantly lower toxicity in mice when compared to lormetazepam and…

Summary Nimetazepam, known by its brand names Erimin and Lavol, is an intermediate-acting hypnotic drug belonging to the benzodiazepine derivative class. It was initially synthesized in 1964 by a team at Hoffmann-La Roche. This compound is renowned for its potent hypnotic, anxiolytic (anxiety-reducing), soothing, and skeletal muscle relaxant properties. Additionally, Nimetazepam exhibits remarkable anticonvulsant effects.Erimin,…

Summary N-Desalkylflurazepam, also referred to as norflurazepam, is classified as a benzodiazepine analog and serves as an active metabolite for several other benzodiazepine drugs, which encompass flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate.This compound is known for its long-lasting effects and tends to accumulate in the body. It binds to a range of…

Summary Meclonazepam, also known as (S)-3-methylclonazepam, was unearthed in the 1970s by a research team at Hoffmann-La Roche. This compound falls into the category of benzodiazepine derivatives, sharing structural similarities with clonazepam. Meclonazepam exhibits sedative and anxiolytic properties, mirroring the characteristics of other benzodiazepines. Additionally, it displays anti-parasitic effects against the parasitic worm Schistosoma mansoni.…

Summary Flunitrazolam (also known as FNTZ or Flunazolam) belongs to the class of triazolobenzodiazepines (TBZD), a group of derivatives stemming from benzodiazepines (BZD). This compound has gained popularity as a designer drug available for purchase online. It exhibits pronounced hypnotic and sedative effects resembling those of closely related substances like Flunitrazepam, clonazolam, and flubromazolam.The emergence…