Summary Adamantyl-THPINACA, often abbreviated as ATHPINACA or AD-THPINACA, is a synthetic cannabinoid compound based on the indazole structure. Its presence was initially documented in Slovenia in January 2015, and it exists in two distinct isomeric forms: the 1-adamantyl and 2-adamantyl isomers, identified as SGT-40 and SGT-194, respectively, a differentiation that can be established through GC-EI-MS … Read more
Summary AB-PINACA, originally detected as an ingredient in synthetic cannabis products in Japan back in 2012, has a notable history. Initially, it was formulated by Pfizer in 2009 with the intent of serving as an analgesic medication.This compound exhibits a strong affinity for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and … Read more
Summary AB-CHMINACA is a synthetic cannabinoid rooted in the indazole structure. It is a robust agonist for the CB1 receptor (Ki = 0.78 nM) and CB2 receptor (Ki = 0.45 nM). In rat discrimination studies, AB-CHMINACA demonstrates a complete substitution for Δ9-THC, surpassing its potency by 16. Following the pattern observed in other cannabinoids of … Read more
Summary 5F-EMB-PINACA, alternatively referred to as EMB-5F-PINACA by the naming conventions of synthetic cannabinoids outlined by the EMCCDA, and also known as 5F-AEB, is a synthetic cannabinoid derived from the indazole-3-carboxamide family. This compound has been marketed as a designer drug and is readily available for purchase online.The EMCDDA brought attention to 5F-EMB-PINACA when it … Read more
Summary 5F-CUMYL-PINACA, also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, is a synthetic cannabinoid with an indazole-3-carboxamide base.This compound acts as a potent agonist for cannabinoid receptors. According to the initial patent, it displayed approximately fourfold selectivity for CB1 receptors, boasting an EC50 of <0.1 nM for human CB1 receptors and … Read more
Summary 5F-EMB-PINACA, alternatively recognized as EMB-5F-PINACA by the EMCCDA’s nomenclature for synthetic cannabinoids and also referred to as 5F-AEB is a member of the indazole-3-carboxamide family of synthetic cannabinoids. This compound has been marketed on the internet as a designer drug.In April 2015, the EMCDDA initially documented its existence as part of a seizure in … Read more
Summary 5F-CUMYL-PINACA also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, belongs to the category of indazole-3-carboxamide-based synthetic cannabinoids. It exerts its action as a potent agonist on cannabinoid receptors, with the original patent asserting approximately fourfold selectivity for CB1. It exhibits an EC50 of less than 0.1 nM for human CB1 … Read more
Summary 5F-APINACA, also recognized as 5F-AKB-48 or 5F-AKB48, is a synthetic cannabinoid based on the indazole structure and has been available for purchase as a designer drug online. In terms of its chemical structure, it closely resembles cannabinoid compounds outlined in patent WO 2003/035005, differing by the presence of a 5-fluorophenyl chain on the indazole … Read more
Summary 5F-AMB, also recognized as 5F-MMB-PINACA and 5F-AMB-PINACA, belongs to the indazole-3-carboxamide family, making it a synthetic cannabinoid of this class. It has been employed as an active constituent in synthetic cannabis products and was initially pinpointed in Japan in the early months of 2014. While there is limited pharmacological data available specifically for 5F-AMB … Read more
Summary 5F-ADB, also known as 5F-MDMB-PINACA, falls within the indazole-3-carboxamide family, making it a synthetic cannabinoid of this class. It has been actively utilized as a key component in synthetic cannabis products and has been marketed online as a designer drug. This compound exerts a potent agonistic effect on the CB1 receptor, although its selectivity … Read more
