Summary XLR-11, also known as 5″-fluoro-UR-144 or 5F-UR-144, operates as a potent agonist for cannabinoid receptors CB1 and CB2, displaying EC50 values of 98 nM and 83 nM, respectively. This compound belongs to the 3-(tetramethylcyclopropylmethanoyl)indole derivative family, sharing structural relations…
Summary UR-144, also known by its aliases TMCP-018, KM-X1, MN-001, and YX-17, is a pharmaceutical developed by Abbott Laboratories. It operates as a selective full agonist of the peripheral cannabinoid receptor CB2 while displaying a significantly reduced affinity for the…
Summary STS-135, also known as 5F-APICA, represents a designer drug available through online vendors, positioned as a cannabimimetic agent. While the origins of its design remain unclear, STS-135 appears to leverage insights into structure-activity relationships within the indole class of…
Summary SDB-006 is a pharmacological agent known for its potent agonistic activity on cannabinoid receptors. Its effectiveness is noteworthy, with an EC50 of 19 nM for human CB2 receptors and 134 nM for human CB1 receptors. This compound was initially…
Summary PX-1, which is also recognized under the names 5F-APP-PICA and SRF-30, is an indole-derived synthetic cannabinoid available for purchase online as a designer drug. Identifiers IUPAC name CAS Number 2221100-71-4 PubChem CID 125181260 ChemSpider 32055575 UNII BJ7SBQ2H5I Chemical and…
Summary PTI-2 (SGT-49) is a synthetic cannabinoid with an indole-based structure. Notably, it stands out as one of the rare synthetic cannabinoids that incorporates a thiazole group, and it shares a close relationship with PTI-1. These compounds can be considered…
Summary PTI-1, also known as SGT-48, belongs to the category of indole-based synthetic cannabinoids, notable for its unique inclusion of a thiazole group. This compound is closely associated with PTI-2 and shares a common origin in the lineage of indole-3-heterocycle…
Summary Org 28611 (SCH-900,111) is a pharmaceutical compound created by Organon International, functioning as a potent full agonist at both the CB1 and CB2 cannabinoid receptors. Its development was driven by the quest for a water-soluble cannabinoid agonist intended for…
Summary NNE1 also recognized as NNEI, MN-24, and AM-6527, is an indole-based synthetic cannabinoid, a molecular fusion of APICA and JWH-018. This compound acts as an agonist for cannabinoid receptors, boasting Ki values of 60.09 nM at CB1 and 45.298…
Summary MN-25 (UR-12) is a pharmaceutical creation credited to Bristol-Myers Squibb. This drug primarily functions as a relatively selective agonist, predominantly stimulating peripheral cannabinoid receptors. Its affinity for CB2 receptors is moderate, featuring a Ki value of 11 nM. Notably,…
