Summary CRL-40,941, known by its alternative names fladrafinil and fluorafinil, falls within the category of eugeroics and shares a close chemical relationship with adrafinil and modafinil. Specifically, it is the bis(p-fluoro) ring-substituted derivative of adrafinil. One noteworthy distinction is that CRL-40,941 has demonstrated anti-aggressive effects in animals, a characteristic not observed with adrafinil, and it … Read more
Summary CRL-40,940, also referred to as flmodafinil, bisfluoromodafinil, and lauflumide, represents the bisfluoro derivative of modafinil. This compound falls under the category of eugeroics and functions as a mild dopamine reuptake inhibitor. Its developers assert that it exhibits superior efficacy to modafinil and adrafinil while presenting a reduced risk of side effects. CRL-40,940 was patented … Read more
Summary Camfetamine, chemically known as N-methyl-3-phenyl-norbornan-2-amine, is a stimulant substance closely tied to the appetite suppressant fencamfamine, representing its N-methyl counterpart. This compound has gained popularity as a designer drug due to the prohibition of mephedrone and similar substituted cathinone derivatives in numerous countries. It delivers slightly more potent stimulant effects than fencamfamine, albeit accompanied … Read more
Summary Amfonelic acid (AFA), also known as WIN 25,978, is a research compound characterized by its dopaminergic stimulant effects and potential antibiotic properties. While clinical trials are scarce, their predominant application lies within scientific research. Identifiers IUPAC name CAS Number 15180-02-6 PubChem CID 2137 ChemSpider 2052 UNII RR302AR19Y KEGG D02897 ChEMBL ChEMBL35337 CompTox Dashboard (EPA) … Read more
Summary PD-137889, also known as N-methylhexahydrofluorenamine, is a chemical compound recognized for its potent activity as an NMDA receptor antagonist within the central nervous system. Its potency in this regard is approximately 30 times greater than the well-known representative of this class, ketamine. In animal studies, PD-137889 has demonstrated the ability to substitute for phencyclidine. … Read more
Summary Dizocilpine, also known as MK-801, is a compound discovered by Merck in 1982, functioning as a pore blocker for the N-Methyl-D-aspartate (NMDA) receptor, which is a vital glutamate receptor in the brain. Glutamate serves as the primary excitatory neurotransmitter in the brain.Under normal conditions, the NMDA receptor channel is blocked by a magnesium ion … Read more
Summary 1,3-Dimethylbutylamine, commonly known as DMBA, is a synthetic compound that has garnered attention in the realms of fitness and sports supplementation. Structurally similar to the banned substance DMAA (1,3-dimethylamylamine), DMBA has been marketed as a potential alternative with identical stimulant properties. Identifiers CAS Number 108-09-8 3D model (JSmol) Interactive image ChemSpider 7620 ECHA InfoCard … Read more
Summary Methylhexanamine, also known as methylhexanamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA, was created and developed by Eli Lilly and Company. It was introduced as an inhaled nasal decongestant in 1948 and remained on the market until the 1980s when it was voluntarily withdrawn.Since 2006, methylhexanamine has resurfaced under various names and has been widely sold … Read more
Summary Mazindol, available under brand names such as Mazanor and Sanorex, is classified as a stimulant medication primarily employed for appetite suppression. This medication was originally formulated by Sandoz-Wander during the 1960s. Identifiers IUPAC name CAS Number 22232-71-9 PubChem CID 4020 IUPHAR/BPS 4797 DrugBank DB00579 ChemSpider 3880 UNII C56709M5NH KEGG D00367 ChEMBL ChEMBL781 CompTox Dashboard … Read more
Summary Diclofensine (Ro 8-4650) emerged from Hoffmann-La Roche’s research efforts in the 1970s aimed at discovering a novel antidepressant. Subsequent investigations revealed that the active component was the (S)-isomer. This compound functions as a stimulant by operating as a triple monoamine reuptake inhibitor, primarily impeding the reuptake of dopamine and norepinephrine, exhibiting binding affinities (Ki) … Read more
