1,3-Dimethylbutylamine

Summary

1,3-Dimethylbutylamine, commonly known as DMBA, is a synthetic compound that has garnered attention in the realms of fitness and sports supplementation. Structurally similar to the banned substance DMAA (1,3-dimethylamylamine), DMBA has been marketed as a potential alternative with identical stimulant properties.

Identifiers
CAS Number	108-09-8
3D model (JSmol)	Interactive image
ChemSpider	7620
ECHA InfoCard	100.003.227
PubChemCID	7908 CID 7908
UNII	KXP599H5R6
CompTox Dashboard(EPA)	DTXSID4025113

Effects

DMBA is primarily included in dietary supplements for its stimulant effects. These effects may include:

1. Enhanced Energy: DMBA is known for its ability to boost energy levels, helping individuals power through intense workouts or demanding physical activities.
2. Improved Focus and Alertness: Like other stimulants, DMBA can enhance mental focus and alertness, which can be valuable during training or other cognitive tasks.
3. Appetite Suppression: Some users have reported a reduction in appetite while taking DMBA, which can aid in weight management efforts by curbing food cravings.
4. Potential Fat Burning: DMBA is believed to increase thermogenesis and metabolic rate, potentially aiding in fat loss. This effect has led to its popularity among those seeking to shed body fat.

Dosage

The recommended dosage for DMBA varies among products and brands, making it crucial to follow the specific guidelines provided on the supplement’s label. Users are advised not to exceed the recommended dosage to minimize the risk of adverse effects. It’s also essential to consult with a healthcare professional before starting any supplementation regimen, especially if you have underlying health conditions.

Toxicity

DMBA’s safety profile remains a subject of debate and concern. Some potential issues associated with DMBA use include:

1. Cardiovascular Effects: DMBA, like other stimulants, can lead to increased heart rate and elevated blood pressure, which may be problematic for individuals with cardiovascular conditions.
2. Unknown Long-term Effects: Limited research exists on the long-term effects of DMBA, and its safety over extended periods remains uncertain.
3. Interactions with Medications: DMBA’s potential interactions with other medications or supplements are not well-understood, raising concerns about unintended side effects.

Legal Status

The legal status of DMBA varies by country. In the United States, the FDA has taken action against products containing DMBA, considering it an unsafe dietary ingredient. Consequently, many DMBA-containing supplements have been removed from the market or reformulated to exclude this compound. In other countries, DMBA may also be subject to varying degrees of regulation, highlighting the importance of staying informed about its status in your region.

Pharmacology

DMBA’s pharmacological mechanisms still need to be fully understood due to the limited research available. It is believed to act as a central nervous system stimulant, affecting neurotransmitters like dopamine and norepinephrine, which play a role in mood, focus, and energy regulation. However, further studies are needed to elucidate its precise pharmacological actions.

Chemistry

1,3-Dimethylbutylamine is a synthetic compound with the chemical formula C6H15N. Its molecular structure consists of a butylamine backbone with two methyl groups (CH3) attached at the 1 and 3 positions, hence the name “1,3-dimethylbutylamine.” The compound’s chemical structure is similar to DMAA but with slight variations in the placement of methyl groups.

Conclusion

1,3-Dimethylbutylamine (DMBA) is a synthetic compound that has gained popularity in the fitness and sports supplementation industry for its potential stimulant effects. While some users report benefits such as increased energy, improved focus, appetite suppression, and possible fat burning, DMBA’s safety remains a matter of concern.

The limited research on DMBA, coupled with its varying legal status across different countries, underscores the need for caution. Users should follow recommended dosages, consult with healthcare professionals, and stay informed about regulatory changes in their region. Additionally, further research is needed to understand DMBA’s pharmacological mechanisms and long-term safety implications. As with any supplement, individuals should approach DMBA with prudence and prioritize their health and safety.

FAQ

1. What is 1,3-dimethylbutylamine (DMBA)?

1,3-Dimethylbutylamine, commonly referred to as DMBA, is a synthetic compound often found in dietary supplements and pre-workout products. It is structurally similar to DMAA (1,3-dimethylamylamine) and is used for its stimulant properties.

2. What are the potential effects of DMBA?

DMBA is believed to have several potential effects, including increased energy, improved focus and alertness, appetite suppression, and possible fat-burning properties. It is commonly used by individuals seeking enhanced physical and cognitive performance.

3. Is DMBA safe to use?

The safety of DMBA remains a subject of debate and concern. Limited research exists on its long-term safety, and it may have cardiovascular risks, especially for individuals with pre-existing heart conditions. It is essential to consult with a healthcare professional before using any product containing DMBA.

4. What is the recommended dosage of DMBA?

The recommended dosage of DMBA can vary among products and brands. It is crucial to follow the specific dosage instructions provided on the supplement’s label. Do not exceed the recommended dosage to minimize the risk of adverse effects.

5. Are there any potential side effects of DMBA?

Some potential side effects associated with DMBA use may include increased heart rate, elevated blood pressure, jitteriness, and possible interactions with medications or other supplements. Individual responses to DMBA can vary, so it’s essential to monitor your body’s reaction closely.

6. Is DMBA legal to use?

The legal status of DMBA varies by country and region. In the United States, the FDA has taken action against products containing DMBA, considering it an unsafe dietary ingredient. Consequently, many DMBA-containing supplements have been removed from the market or reformulated. Always check the legal status of DMBA in your area.

7. Can DMBA be used for weight loss?

Some users have reported appetite suppression and potential fat-burning effects while taking DMBA, which has led to its use in weight loss supplements. However, it’s essential to approach any weight loss product with caution, consult a healthcare professional, and maintain a balanced diet and exercise regimen for safe and effective weight management.

8. How does DMBA work in the body?

The precise pharmacological mechanisms of DMBA have yet to be fully understood due to limited research. It is believed to act as a central nervous system stimulant, affecting neurotransmitters like dopamine and norepinephrine, which can influence mood, focus, and energy levels.

9. Can DMBA be taken with other supplements or medications?

DMBA’s potential interactions with other supplements or medications are not well-documented. It’s crucial to consult with a healthcare professional before combining DMBA with other substances to avoid possible adverse effects or interactions.

10. Where can I find products containing DMBA?

Due to regulatory concerns, the availability of products containing DMBA has significantly decreased in recent years. Always purchase supplements from reputable sources, and check for legal compliance in your region before using products containing DMBA.

11. Should I use DMBA for athletic performance?

Athletes considering the use of DMBA or any other supplements should consult with their sports organization and healthcare professionals to ensure compliance with anti-doping regulations and to prioritize their health and safety.

12. Is DMBA safe for everyone to use?

DMBA is not recommended for individuals with underlying health conditions, especially heart-related issues. Pregnant or nursing individuals, minors, and those with sensitivities to stimulants should avoid DMBA use.

13. Should I consult a healthcare professional before using DMBA?

Yes, it is strongly recommended to consult with a healthcare professional before using any product containing DMBA. They can assess your health, guide safe usage, and help you make informed decisions regarding its potential benefits and risks.

References

1. 1,3-Dimethylbutylamine: This compound, also known as DMBA, has become a subject of interest due to its presence in dietary supplements and its potential stimulant effects. It is structurally similar to DMAA and has gained attention for its role in various products.
2. Anvisa Regulation: Anvisa (National Health Surveillance Agency) in Brazil has listed DMBA as a substance under special control in RDC Nº 804, effective from July 24, 2023. This regulation highlights the need for stricter control and monitoring of DMBA-containing products.
3. Identification in Dietary Supplements: Researchers Cohen, Travis, and Venhuis identified DMBA in multiple dietary supplements. Their study, published in “Drug Testing and Analysis,” raised concerns about the use of a synthetic stimulant in these products. The stimulant had never been tested in humans, further fueling safety concerns.
4. Unapproved Synthetic Stimulant: The presence of DMBA in dietary supplements caught the attention of regulatory bodies like NSF International. They noted that DMBA was unapproved and found in various supplements, highlighting the need for further investigation into its safety and legality.
5. FDA Warnings: The U.S. Food and Drug Administration (FDA) issued warnings to 14 sports supplement companies regarding the inclusion of illegal DMBA (also known as AMP Citrate) in their products. This action underscored the potential risks associated with DMBA use.
6. Safety Concerns: The FDA raised concerns about the safety of DMBA, labeling it as a stimulant potentially dangerous to health. These warnings were aimed at informing consumers and regulating the inclusion of DMBA in dietary supplements.
7. Regulatory Actions: The FDA has been actively involved in addressing the presence of DMBA in dietary supplements. They have taken enforcement actions to prevent its use in products, emphasizing the need for regulatory oversight in the supplement industry.
8. Research Findings: Research by Cohen, Wen, and Gerona highlighted the presence of prohibited stimulants, including DMBA, in dietary supplements. This study, published in JAMA Internal Medicine, shed light on the continued challenges of regulating and monitoring the supplement market.
9. Hidden Dangers: The presence of DMBA in dietary supplements underscores the hidden dangers associated with these products. This concern was brought to light by the scientific community, emphasizing the need for consumer awareness and stricter regulatory measures.