Summary
JWH-167, also known as 1-pentyl-3-(phenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. This compound acts as a cannabinoid agonist with approximately 1.75 times higher selectivity for CB1 receptors, exhibiting a Ki of about 90 nM ± 17 and around 159 nM ± 14 at CB2 receptors. Notably, JWH-167 shares structural similarities with related compounds such as the 2′-methoxy compound JWH-250 and the 2′-chloro compound JWH-203. However, JWH-167 incorporates a phenyl acetyl group instead of the naphthyl ring commonly found in most aminoalkyl indole cannabinoid compounds.
It is essential to note that in the United States, CB1 receptor agonists falling under the 3-phenylacetylindole class, including JWH-167, are classified as Schedule I Controlled Substances.
| Identifiers | |
|---|---|
| CAS Number | 864445-37-4 |
| 3D model (JSmol) | Interactive image |
| ChEMBL | ChEMBL365878 |
| ChemSpider | 23256084 |
| PubChemCID | 44397502 |
| UNII | LQX1W3537N |
| CompTox Dashboard(EPA) | DTXSID20235554 |
FAQ
1. What is JWH-167?
JWH-167 is a synthetic cannabinoid from the phenylacetylindole family, known for its cannabinoid agonist properties. It has specific receptor selectivity, making it distinct from other synthetic cannabinoids.
2. How does JWH-167 work?
JWH-167 acts as a cannabinoid agonist, meaning it binds to and activates cannabinoid receptors in the body. It exhibits selectivity for CB1 receptors, making it different from some other synthetic cannabinoids.
3. What is the selectivity of JWH-167 for CB1 and CB2 receptors?
JWH-167 displays approximately 1.75 times greater selectivity for CB1 receptors with a Ki (binding affinity) of around 90 nM ± 17 compared to CB2 receptors, where its Ki is approximately 159 nM ± 14.
4. How does JWH-167 differ from related synthetic cannabinoids?
JWH-167 is unique among synthetic cannabinoids due to the presence of a phenylacetyl group in its chemical structure, which distinguishes it from aminoalkylindole cannabinoid compounds like JWH-250 and JWH-203.
5. Is JWH-167 legal in the United States?
No, JWH-167 is classified as a Schedule I Controlled Substance in the United States, which means it is illegal to manufacture, possess, or distribute for any purpose.
6. What are the potential effects and risks of using JWH-167?
The effects and risks of using JWH-167 may vary, but, like other synthetic cannabinoids, it may lead to products such as altered perception, relaxation, and anxiety. However, synthetic cannabinoids can also cause adverse effects, and their safety for human consumption is not well-established.
7. Is JWH-167 used for medical purposes?
JWH-167 is not approved for any medical use and is primarily associated with recreational or illicit use.
8. Where can I find more information about JWH-167?
You can learn more about JWH-167 in scientific literature, drug regulation sources, and reputable educational websites. Always ensure your sources are trustworthy and credible when seeking information about substances like JWH-167.
References
- Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, et al. (September 2005). “Exploring New Horizons: 1-Pentyl-3-phenylacetylindoles – A Fresh Class of Cannabimimetic Indoles”. Published in Bioorganic & Medicinal Chemistry Letters, Volume 15, Issue 18, Pages 4110–4113. DOI: 10.1016/j.bmcl.2005.06.008. PMID: 16005223.
- Manera C, Tuccinardi T, and Martinelli A. (April 2008). “Unlocking the Potential: Indoles and Their Kin as Cannabinoid Ligands”. Published in Mini Reviews in Medicinal Chemistry, Volume 8, Issue 4, Pages 370–387. DOI: 10.2174/138955708783955935. PMID: 18473928.
- “21 U.S.C. § 812: Navigating Controlled Substances Schedules.”