Summary RCS-4, also known as 1-pentyl-3-(4-methoxybenzoyl)indole, is a synthetic cannabinoid compound that has been marketed and sold under various names, including SR-19, BTM-4, Eric-4 (later abbreviated to E-4), and initially, OBT-199. Identifiers IUPAC name CAS Number 1345966-78-0 ChemSpider 24769418 UNII Y6911BZ2UL CompTox Dashboard (EPA) DTXSID70158820 ECHA InfoCard 100.233.383 Chemical and physical data Formula C21H23NO2 Molar …
Summary AM-2233 is a pharmaceutical compound recognized for its exceptional role as a potent full agonist for cannabinoid receptors. Specifically, the (R) enantiomer of AM-2233 exhibits a remarkable Ki of 1.8 nM at CB1 and 2.2 nM at CB2, underscoring its potent activity at these receptors.One of its primary purposes is as a selective radioligand …
Summary AM-1241, also known as 1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole, is a member of the aminoalkylindole family, recognized for its role as a potent and highly selective agonist for the cannabinoid receptor CB2. With a remarkable Ki value of 3.4 nM at CB2, it exhibits substantial selectivity, being approximately 80 times more selective for CB2 compared to the related …
Summary AM-694, known chemically as 1-(5-fluorophenyl)-3-(2-iodobenzoyl)indole, functions as a designer drug with a specific role as a potent and selective agonist for the cannabinoid receptor CB1. This compound is frequently utilized in scientific research to map the distribution of CB1 receptors within the body. Identifiers IUPAC name CAS Number 335161-03-0 PubChem CID 9889172 ChemSpider 8064843 …
Summary AM-679, a member of the AM cannabinoid series, is a moderately potent agonist for cannabinoid receptors. It exhibits a Ki of 13.5 nM at CB1 and 49.5 nM at CB2, signifying its affinity for these receptors. Notably, AM-679 was among the pioneering 3-(2-iodobenzoyl)indole derivatives to display a noteworthy affinity for cannabinoid receptors. While AM-679 …
Summary AM-630, or 6-Iodopravadoline, is a potent and highly selective inverse agonist targeting the cannabinoid receptor CB2. It exhibits a remarkable affinity for CB2, boasting a Ki value of 32.1 nM, while showing a notable 165-fold selectivity over CB1 receptors, where it only exhibits weak partial agonist activity. Researchers employ AM-630 to investigate CB2-mediated responses, …
Summary W-18 belongs to a group of 32 compounds designated as W-1 to W-32, initially developed during research on analgesic drug discovery in the 1980s. While it was first synthesized at the University of Alberta as part of this analgesic drug research, preliminary studies in mice showed its potential as a pain-relieving agent.Notably, W-18 gained …
Summary Tolibut, scientifically known as 3-(p-tolyl)-4-aminobutyric acid or β-(4-methylphenyl)-GABA, is a pharmaceutical compound developed in Russia. This substance is categorized as a derivative of γ-aminobutyric acid (GABA), making it a GABA analog. Specifically, halibut is the 4-methyl variant of phenibut and shares structural similarities with baclofen, replacing the 4-chloro group with a 4-methyl substitution.Tolibut has …
Summary Phenibut, available under various brand names such as Anvifen, Fenibut, and Noofen, is a central nervous system depressant known for its anxiolytic properties. It is prescribed to address conditions like anxiety, insomnia, and other related indications. Typically administered orally in tablet form, it can also be given intravenously.Phenibut may induce several side effects, including …
Summaru Pagoclone, a member of the cyclopyrrolone family, is classified as an anxiolytic agent, sharing its lineage with more familiar drugs like the sleep aid zopiclone. This compound was initially synthesized by a team of French researchers working for Rhone-Poulenc & Rorer S.A. It falls within the nonbenzodiazepine category, which, despite yielding effects akin to …
