Summary Dizocilpine, also known as MK-801, is a compound discovered by Merck in 1982, functioning as a pore blocker for the N-Methyl-D-aspartate (NMDA) receptor, which is a vital glutamate receptor in the brain. Glutamate serves as the primary excitatory neurotransmitter in the brain.Under normal conditions, the NMDA receptor channel is blocked by a magnesium ion …
Summary Methylhexanamine, also known as methylhexanamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA, was created and developed by Eli Lilly and Company. It was introduced as an inhaled nasal decongestant in 1948 and remained on the market until the 1980s when it was voluntarily withdrawn.Since 2006, methylhexanamine has resurfaced under various names and has been widely sold …
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Summary Mazindol, available under brand names such as Mazanor and Sanorex, is classified as a stimulant medication primarily employed for appetite suppression. This medication was originally formulated by Sandoz-Wander during the 1960s. Identifiers IUPAC name CAS Number 22232-71-9 PubChem CID 4020 IUPHAR/BPS 4797 DrugBank DB00579 ChemSpider 3880 UNII C56709M5NH KEGG D00367 ChEMBL ChEMBL781 CompTox Dashboard …
Summary Diclofensine (Ro 8-4650) emerged from Hoffmann-La Roche’s research efforts in the 1970s aimed at discovering a novel antidepressant. Subsequent investigations revealed that the active component was the (S)-isomer. This compound functions as a stimulant by operating as a triple monoamine reuptake inhibitor, primarily impeding the reuptake of dopamine and norepinephrine, exhibiting binding affinities (Ki) …
Summary Bromantane, marketed under the brand name Ladasten, is an unconventional psychostimulant and anxiolytic medication belonging to the adamantane family, sharing connections with amantadine and memantine. It finds usage in Russia for the treatment of neurasthenia. Although researchers have established that bromantane’s effects are tied to the dopaminergic and potentially serotonergic neurotransmitter systems, the precise …
Summary Amfonelic acid (AFA), also known as WIN 25,978, is a research compound and dopaminergic stimulant that possesses antibiotic characteristics. While there is a scarcity of extensive clinical trials involving AFA, it is predominantly employed within the realm of scientific research. Identifiers IUPAC name CAS Number 15180-02-6 PubChem CID 2137 ChemSpider 2052 UNII RR302AR19Y KEGG …
