5-MeO-DiBF, also written 5-MeO-DIBF, is a benzofuran analogue of 5-MeO-DiPT. Its structure contains a 5-methoxybenzofuran ring and an N,N-diisopropylaminoethyl side chain. The oxygen-containing benzofuran ring replaces the indole ring found in conventional tryptamines. The compound has been analytically identified in grey-market samples, but no direct pharmacological or clinical study has established its effects in humans.
Chemistry and structural distinction
The FDA Substance Registration System records 5-MeO-DIBF as 2-(5-methoxy-1-benzofuran-3-yl)-N,N-diisopropylethanamine, with the molecular formula C17H25NO2. It is achiral and carries two isopropyl groups on the terminal nitrogen (FDA Substance Registration System: 5-MeO-DIBF).
The benzofuran scaffold is an important distinction. 5-MeO-DiBF is not simply another spelling of 5-MeO-DiPT: the indole nitrogen in the latter is replaced by oxygen in the benzofuran ring. That change creates a different molecule and prevents direct transfer of receptor or toxicity data.
Analytical identification
A 2018 analytical paper reported proton NMR spectra for 43 grey-market tryptamines and benzofuran analogues. The authors included 5-MeO-DiBF hydrochloride among the benzofuran samples and found that its spectrum was consistent with the compound’s label. The study was designed for chemical identification, not to determine biological activity (Chapman, PeakAL: Protons I Have Known and Loved, Too, 2018).
Pharmacology and reported effects
No published receptor-binding assay, functional study or controlled human observation specific to 5-MeO-DiBF was identified in the scientific literature reviewed here. Its structural relationship to 5-MeO-DiPT suggests avenues for research, without establishing activity at the same receptors or comparable potency.
Online descriptions are too limited to support a reliable subjective effect profile. They should not be used as a substitute for analytical or pharmacological evidence.
Toxicology and research gaps
Human metabolism, acute toxicity, dependence potential and long-term effects have not been characterised. The available evidence confirms a chemical identity and an NMR reference spectrum, but provides no validated concentration-toxicity relationship or clinical safety information.
Its structure is documented, while its pharmacological effects remain largely unknown.
Related compounds
5-MeO-DiBF is structurally related to 5-MeO-DiPT and other benzofuran analogues of tryptamines. Its benzofuran ring distinguishes it from indole-based compounds such as 5-MeO-DiPT and 5-MeO-DMT.
