Summary JWH-133, also known as Dimethylbutyl-deoxy-Delta-8-THC, stands out as a potent and highly selective agonist of the CB2 receptor, exhibiting a remarkable Ki value of 3.4nM and an impressive selectivity of approximately 200 times for CB2 over CB1 receptors. This…
Summary JWH-051 is an analgesic medication that functions as a cannabinoid agonist. Its chemical structure closely resembles the potent cannabinoid agonist HU-210, with the sole distinction being the absence of the hydroxyl group at position 1 of the aromatic ring.…
Summary HU-210, a synthetic cannabinoid, was initially synthesized in 1988 by a research team led by Raphael Mechoulam at the Hebrew University. It boasts an astonishing potency, ranging from 100 to 800 times greater than naturally occurring THC found in…
Summary Dimethylheptylpyran, also known as DMHP, 3-(1,2-dimethylheptyl)-Δ6a(10a)-THC, 1,2-dimethylheptyl-Δ3-THC, A-40824, or EA-2233, represents a synthetic analogue of THC. This compound was first developed in 1949 as part of scientific efforts aimed at unraveling the structure of Δ9-THC, one of the primary…
Summary Parahexyl, also known as Synhexyl or n-hexyl-Δ3-THC, is a synthetic counterpart to THC (tetrahydrocannabinol). It was developed in 1941 as part of efforts to decipher the chemical structure of Δ9-THC, one of the primary active compounds found in cannabis.Parahexyl…
Summary Nabilone, marketed under the trade name Cesamet and other brands, is a synthetic cannabinoid recognized for its therapeutic applications as an antiemetic and as a supplementary analgesic in managing neuropathic pain. This compound emulates tetrahydrocannabinol (THC), the primary psychoactive…
Summary W-18 belongs to a group of 32 compounds designated as W-1 to W-32, initially developed during research on analgesic drug discovery in the 1980s. While it was first synthesized at the University of Alberta as part of this analgesic…
Summary Tolibut, scientifically known as 3-(p-tolyl)-4-aminobutyric acid or β-(4-methylphenyl)-GABA, is a pharmaceutical compound developed in Russia. This substance is categorized as a derivative of γ-aminobutyric acid (GABA), making it a GABA analog. Specifically, halibut is the 4-methyl variant of phenibut…
Summary Phenibut, available under various brand names such as Anvifen, Fenibut, and Noofen, is a central nervous system depressant known for its anxiolytic properties. It is prescribed to address conditions like anxiety, insomnia, and other related indications. Typically administered orally…
Summaru Pagoclone, a member of the cyclopyrrolone family, is classified as an anxiolytic agent, sharing its lineage with more familiar drugs like the sleep aid zopiclone. This compound was initially synthesized by a team of French researchers working for Rhone-Poulenc…
