3-Methylamphetamine (3-MeA; PAL-314) is classified as a stimulant compound belonging to the amphetamine family. When tested in mice, it exhibits a self-administration behavior similar to that observed with 4-fluoroamphetamine. Notably, it shares characteristics with monoamine releasers, although it distinguishes itself by facilitating a more evenly distributed release of all three monoamines. This sets it apart from its fluoro analogs, which tend to exhibit a more excellent selectivity towards dopamine and noradrenaline release.

IUPAC name
CAS Number77083-25-1 
PubChem CID115806
CompTox Dashboard (EPA)DTXSID70998349
Chemical and physical data
Molar mass149.237 g·mol−1


  • What is 3-Methylamphetamine (3-MA)?
  • 3-Methylamphetamine, often abbreviated as 3-MA, is a synthetic compound in the amphetamine class of drugs. It is chemically similar to amphetamine and methamphetamine but has a methyl group attached to the nitrogen atom in the amphetamine molecule.
  • Is 3-methylamphetamine legal?
  • The legal status of 3-methylamphetamine varies from country to country. In many places, it is considered a controlled substance and is illegal to manufacture, possess, or distribute without proper authorization. It is essential to check the laws and regulations in your specific jurisdiction.
  • What are the effects of 3-methylamphetamine?
  • The effects of 3-methylamphetamine can vary depending on the dosage and individual response. Common effects may include increased alertness, energy, and a sense of euphoria. It can also lead to increased heart rate, elevated blood pressure, and decreased appetite. Like other amphetamines, it has the potential for abuse and addiction.
  • Is 3-methylamphetamine safe to use?
  • The safety of 3-methylamphetamine has not been extensively studied, and it may carry risks similar to other amphetamine compounds. Its use can lead to various adverse effects, including cardiovascular issues, psychiatric disturbances, and addiction. It is not recommended for recreational or non-medical use.
  • Can a doctor prescribe 3-methylamphetamine?
  • 3-Methylamphetamine is not approved for medical use in most countries. Healthcare professionals do not typically prescribe it. If you have a medical condition that may benefit from amphetamine-based medications, your doctor will consider legal and approved alternatives.
  • Are there any known side effects of 3-methylamphetamine?
  • Yes, side effects can be associated with using 3-Methylamphetamine, including increased heart rate, hypertension, insomnia, anxiety, paranoia, and appetite suppression. Prolonged or high-dose use can lead to more severe health complications.
  • Can 3-methylamphetamine be detected in drug tests?
  • Yes, 3-methylamphetamine can typically be detected in standard drug tests, such as urine or blood tests. Its metabolites can be seen for a certain period after use, depending on various factors, including the dosage and individual metabolism.
  • Is it possible to become addicted to 3-methylamphetamine?
  • Yes, like other amphetamines, 3-methylamphetamine has a potential for abuse and addiction. Regular use can lead to tolerance, dependence, and withdrawal symptoms when discontinuing use. Use caution and seek professional help if you or someone you know is struggling with substance abuse.
  • What are the risks associated with 3-methylamphetamine use?
  • Risks associated with 3-methylamphetamine use include addiction, cardiovascular problems, mental health issues (such as anxiety and paranoia), and potential legal consequences due to its controlled status in many places.
  • Where can I find more information about 3-methylamphetamine?
  • For more information about 3-methylamphetamine, it is advisable to consult with healthcare professionals, addiction counselors, or drug information resources provided by government health agencies. Always prioritize your health and safety when considering any substance use.


  1. In a study conducted by Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, and Woolverton WL in May 2005, they explored the connection between serotonergic activity and the reinforcing effects of a series of amphetamine analogs. Their research was published in “The Journal of Pharmacology and Experimental Therapeutics” (Volume 313, Issue 2), revealing valuable insights into these compounds (DOI: 10.1124/jpet.104.080101). The study can also be found under the PMID 15677348 and S2CID 12135483.
  2. In February 2007, Negus SS, Mello NK, Blough BE, Baumann MH, and Rothman RB conducted research on monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release. This research aimed to identify potential “agonist” medications for cocaine dependence. They conducted assays involving cocaine discrimination and cocaine self-administration in rhesus monkeys. The findings were published in “The Journal of Pharmacology and Experimental Therapeutics” (Volume 320, Issue 2) and can be accessed via DOI: 10.1124/jpet.106.107383. The study is also referenced by the PMID 17071819 and S2CID 8326027.

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