Where to buy 5-MeO-DMT for sale online

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The availability of 5-MeO-DMT through various online sellers and vendors has raised concerns within the scientific and psychedelic communities. This potent designer drug, classified as a research chemical, has garnered attention for its powerful psychoactive effects, but its online sale and purchase present several issues that demand careful consideration.
First and foremost, the online sale of 5-MeO-DMT blurs the lines between legitimate research and recreational use. While research chemicals have value in scientific studies, their accessibility to the general public can lead to misuse and potential harm. Sellers must exercise caution in marketing and distributing such substances, as they can easily be abused by individuals seeking mind-altering experiences rather than conducting legitimate research.
Another concern is the need for more regulation and quality control in the production and distribution of 5-MeO-DMT. Some sellers may not adhere to strict manufacturing standards, potentially leading to variations in purity and potency. This poses significant risks to consumers who may inadvertently ingest substances of unknown origin and composition.
Furthermore, the online sale of 5-MeO-DMT often bypasses traditional medical and ethical safeguards. Users may not receive proper guidance or support, increasing the likelihood of adverse experiences and psychological distress. This unregulated market can put individuals at risk, especially those unprepared for the compound’s intense and profound effects.

Summary

5-MeO-DMT, scientifically known as 5-methoxy-N,N-dimethyltryptamine or O-methyl-bufotenin, belongs to the tryptamine class of psychedelics. It is naturally occurring in a diverse range of plant species and is also produced by the glands of at least one species of toad, specifically the Colorado River toad. Like its close chemical relatives, DMT and bufotenin (5-HO-DMT), 5-MeO-DMT has traditionally been employed as an entheogen in various cultural practices in South America. Some common slang terms for this substance include Five-methoxy, the power, bufo, and toad venom.

Identifiers
IUPAC name
CAS Number1019-45-0 
PubChem CID1832
IUPHAR/BPS145
ChemSpider1766 
UNIIX0MKX3GWU9
KEGGC08309 
ChEBICHEBI:2086 
ChEMBLChEMBL7257 
CompTox Dashboard (EPA)DTXSID70144324
ECHA InfoCard100.012.558
Chemical and physical data
FormulaC13H18N2O
Molar mass218.300 g·mol−1

Chemistry

5-MeO-DMT was initially synthesized in 1936, and its psychoactive properties were discovered when it was isolated in 1959 as one of the active compounds found in Anadenanthera peregrina seeds, commonly used in the preparation of Yopo snuff. It was once believed to be a primary contributor to the psychoactive effects of the snuff. However, recent research has cast doubt on this assumption. This doubt arises from the limited or, in some cases, nonexistent amounts of 5-MeO-DMT present in the seeds. Instead, the psychoactivity of the sources appears to be primarily derived from bufotenin, the O-demethylated metabolite of 5-MeO-DMT. Notably, 5-MeO-DMT is metabolized mainly by the enzyme CYP2D6.

Effects

The duration of the experience with 5-MeO-DMT depends on the route of administration. When smoked, the total experience typically lasts around 10 minutes, whereas when insufflated (snorted), it can extend up to 2 hours. The effects are diverse and encompass a broad spectrum, including profound changes in perspective, the revelation of new insights, feelings of euphoria, immersive experiences, dissociation leading to non-responsiveness, heightened sensual and erotic sensations, as well as potential adverse effects such as dysphoria, fear, terror, and panic.

Uses

It exhibits anti-anxiety and anti-depressant properties.
Religious Usage: The Church of the Tree of Life, established in California in 1971 by John Mann (now defunct), officially recognized using 5-MeO-DMT as a sacrament. For approximately two decades, from around 1971 to the late 1980s, 5-MeO-DMT was discreetly accessible to its members. From 1970 to 1990, smoking 5-MeO-DMT on parsley was likely among the two most prevalent consumption methods in the United States.

Pharmacology

5-MeO-DMT, a methoxylated derivative of DMT, exhibits a distinct pharmacological profile compared to most common psychedelics. While many psychedelics are thought to primarily exert their psychological effects by activating serotonin 5-HT2A receptors, 5-MeO-DMT stands out for its exceptional affinity for 5-HT1A receptors, which is approximately 1000 times greater than its affinity for 5-HT2A receptors. This heightened affinity for 5-HT1A receptors aligns with its potent ability to inhibit the firing of dorsal raphe 5-HT neurons. Notably, experiments in rats have shown that the effects of 5-MeO-DMT were diminished when a 5-HT1A selective antagonist called WAY-100635 was administered, whereas a 5-HT2A selective antagonist called volinanserin had no discernible impact.
In addition to its interaction with serotonin receptors, 5-MeO-DMT’s mechanisms of action may also involve the inhibition of monoamine reuptake. A notable European study conducted in 2019 involving 42 volunteers revealed that a single inhalation of 5-MeO-DMT resulted in a sustained improvement in overall life satisfaction, along with reductions in anxiety, depression, and symptoms of post-traumatic stress disorder (PTSD). Furthermore, a study from 2018 demonstrated that a single dose of 5-MeO-DMT stimulated neurogenesis in mice, suggesting potential therapeutic implications.

Clinical Development

5-MeO-DMT is currently undergoing development and assessment for its potential therapeutic applications in patients with Treatment-Resistant Depression (TRD). GH Research, a biopharmaceutical company, has sponsored and successfully completed a phase 1 study involving healthy volunteers and a phase 1/2 study with TRD patients. Remarkably, during the phase 2 segment of the survey, 87.5% of TRD patients achieved remission by day 7. GH Research is presently planning a phase 2b trial with TRD patients. It has obtained approval to conduct studies involving patients with bipolar II disorder and a current depressive episode, as well as patients with postpartum depression.
Furthermore, Beckley Psytech, in collaboration with King’s College London, is conducting a phase 1 study to assess the safety and tolerability of intranasal 5-MeO-DMT in healthy subjects. Beckley Psytech’s CEO, Cosmo Feilding-Mellen, recognizes the potential benefits of 5-MeO-DMT’s short-acting nature compared to substances like psilocybin. Feilding-Mellen points out that the prolonged presence of therapists during an MDMA or psilocybin experience, which can span an entire working day, may be resource-intensive and costly. Considering the global shortage of psychotherapists, this could pose a potential bottleneck to patient access.

Sources

FamilyPlants
RutaceaeDictyoloma incanescens, Limonia acidissima, Melicope leptococca
FabaceaeAnadenanthera peregrina, Acacia auriculiformis, Acacia victoriae, Desmodium gangeticum, Lespedeza bicolor, Mimosa pudica, Mucuna pruriens, Phyllodium pulchellum
PoaceaePhalaris tuberosa
MalpighiaceaeDiplopterys cabrerana
CactaceaeEchinocereus salm-dyckianus, Echinocereus triglochidiatus
MyristicaceaeHorsfieldia superba, Iryanthera macrophylla, Osteophloeum platyspermum, Virola theiodora, V. calophylla, V. multinervia, V. peruviana, V. rufula,V. venosa
FamilyAnimals
BufonidaeColorado River toad (Bufo alvarius)
FamilyFungi
AmanitaceaeAmanita citrina, Amanita porphyria

Legal status

China: As of October 2015, 5-MeO-DMT was categorized as a controlled substance in China.

Australia: 5-MeO-DMT, a structural analog of N,N-dimethyltryptamine (DMT), falls under Schedule 9 as a prohibited substance by the Poisons Standard.

Sweden: The health ministry, Statens folkhälsoinstitut, classified 5-MeO-DMT, referred to as 5-metoxi-N,N-dimetyltryptamin (5-MeO-DMT) in their regulation SFS 2004:696, as a “health hazard” under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) in October 2004, rendering it illegal to sell or possess.

Germany: 5-MeO-DMT has been listed as a controlled substance since 2001, specifically under Attachment I of the BtMG (Betäubungsmittelgesetz). This regulation is documented in BGBl. I 2001, 1180 – 1186.

Turkey: Turkey has controlled 5-MeO-DMT since December 2013.[34]

United States: 5-MeO-DMT was classified as a Schedule I controlled substance in January 2011 in the United States.

FAQ

1. What is 5-MeO-DMT?

  • 5-MeO-DMT is a naturally occurring psychedelic compound found in various plants and the secretions of the Colorado River toad (Bufo alvarius). It is known for its powerful psychoactive effects.

2. How is 5-MeO-DMT different from DMT?

  • While both are psychedelic, 5-MeO-DMT and DMT (N, N-Dimethyltryptamine) have distinct effects. 5-MeO-DMT is often described as producing a more intense, ego-dissolving experience that lacks the visual elaborate impact commonly associated with DMT.

3. Is 5-MeO-DMT legal?

  • The legal status of 5-MeO-DMT varies by country and region. In many places, it is considered a controlled substance and is illegal to possess, sell, or use. Always check your local laws before considering its use.

4. What are the effects of 5-MeO-DMT?

  • Effects of 5-MeO-DMT can include intense and rapid-onset psychedelic experiences, a sense of ego dissolution or unity with the universe, vivid sensory and emotional experiences, and profound shifts in perception. The effects can vary from person to person.

5. How is 5-MeO-DMT typically used?

  • 5-MeO-DMT is most commonly smoked, vaporized, or insufflated (snorted). It can also be found in some traditional shamanic rituals, particularly in South America.

6. What are the potential risks and side effects of 5-MeO-DMT?

  • Using 5-MeO-DMT carries risks, including intense psychological experiences that can be overwhelming or distressing. Physical hazards may include increased heart rate and blood pressure. Additionally, there is a risk of legal consequences due to its status as a controlled substance in many places.

7. Is 5-MeO-DMT addictive?

  • There is limited research on the addictive potential of 5-MeO-DMT, but it is generally considered to have a low potential for physical dependence. However, psychological support is possible, especially in individuals prone to substance misuse.

8. Can 5-MeO-DMT be used for therapeutic purposes?

  • Some research suggests that 5-MeO-DMT may have therapeutic potential for depression, anxiety, and addiction. However, more research is needed, and it should only be used in a therapeutic context under the guidance of trained professionals where legal.

9. How should I prepare if I’m considering using 5-MeO-DMT?

  • If you are considering using 5-MeO-DMT, it’s essential to research the substance thoroughly, be aware of the legal status in your area, and consider potential risks. If you decide to proceed, ensure that you are in a safe and supportive environment and consider having a trusted trip sitter present.

10. What should I do if I or someone I know experiences a problematic trip on 5-MeO-DMT? 

  • If you or someone you know is having a challenging experience with 5-MeO-DMT, staying calm and reassuring is crucial. If the situation worsens, seek immediate medical attention if necessary. It’s essential to approach the substance cautiously and respect its potential effects.

References

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