Summary JWH-116, a member of the naphthoylindole family, is a synthetic ligand that interacts with cannabinoid receptors. It represents the indole 2-ethyl variant of its closely related compound, JWH-018. JWH-116 exhibits a binding affinity for the CB1 receptor with a reported Ki value of approximately 52 ± 5 nM.In the United States, JWH-116, like other …
Summary JWH-098 belongs to the naphthoylindole family and is classified as a synthetic cannabinoid receptor agonist. It represents the indole 2-methyl variant of a closely related compound, JWH-081. Notably, JWH-098 exhibits distinctive binding preferences for the CB1 and CB2 receptors compared to JWH-081. While JWH-081 displays approximately tenfold selectivity for CB1 over CB2, JWH-098 reverses …
Summary JWH-081, a member of the naphthoylindole family, is an analgesic compound that functions as a cannabinoid agonist, affecting both CB1 and CB2 receptors. It exhibits a degree of selectivity for the CB1 subtype, with a Ki of 1.2nM, making its affinity for CB1 approximately 10 times greater than its affinity for CB2 (12.4nM). This …
Summary WH-073, a synthetic cannabinoid, is a member of the naphthoylindole family known for its analgesic properties. It functions as a partial agonist at both the CB1 and CB2 cannabinoid receptors, displaying a degree of selectivity for the CB1 subtype, with approximately 5 times the affinity for CB1 compared to CB2. The abbreviation “JWH” represents …
Summary JWH-019, a member of the naphthoylindole family, is recognized as an analgesic compound acting as a cannabinoid agonist at both CB1 and CB2 receptors. Notably, it is the N-hexyl homolog of the known synthetic cannabinoid JWH-018. In contrast to the butyl homolog, JWH-073, which exhibits significantly lower potency than JWH-018, the hexyl homolog, JWH-019, …
Summary JWH-015, a member of the naphthoylindole family, functions as a cannabinoid agonist with subtype selectivity. Notably, it exhibits a high affinity for CB2 receptors, with a binding relationship of 13.8 nM, while its affinity for CB1 receptors is notably lower at 383 nM. This results in JWH-015 binding nearly 28 times more strongly to …
Summary JWH-007, a member of the naphthoylindole family, is a chemical compound primarily recognized for its analgesic properties. It functions as a cannabinoid agonist, engaging both CB1 and CB2 receptors. This compound was initially documented in 1994, and its discovery is attributed to a group led by the renowned cannabinoid chemist John W. Huffman.This compound …
Summary FUB-JWH-018, sometimes referred to as FUB-018, is a synthetic cannabinoid derived from naphthoylindole. It can be described as a molecular hybrid, combining elements of JWH-018 and AB-FUBICA or ADB-FUBICA. Identifiers IUPAC name CAS Number 2365471-45-8 ChemSpider 34450892 UNII U0Z5KO073G Chemical and physical data Formula C26H18FNO Molar mass 379.434 g·mol−1 Legal status In the United States, …
Summary EAM-2201, also known as 4′-ethyl-AM-2201, 5″-fluoro-JWH-210, or SGT-14, is a substance believed to function as a potent agonist for cannabinoid receptors. This compound was not documented in scientific or patent literature until Japanese laboratories initially detected it in July 2012 as an ingredient in synthetic cannabis smoking mixtures. Much like its closely related counterpart, …
Summary AM-2232, known chemically as 1-4-cyclobutyl)-3-(naphthalene-1-oyl)indole, is a potent yet non-specific agonist for cannabinoid receptors. It exhibits a Ki of 0.28 nM at CB1 and 1.48 nM at CB2, indicating its affinity for these receptor types.In the United States, all CB1 receptor agonists belonging to the 3-(1-naphthyl)indole class, including AM-2232, are classified as Schedule I …
