AM-2232, known chemically as 1-4-cyclobutyl)-3-(naphthalene-1-oyl)indole, is a potent yet non-specific agonist for cannabinoid receptors. It exhibits a Ki of 0.28 nM at CB1 and 1.48 nM at CB2, indicating its affinity for these receptor types.
In the United States, all CB1 receptor agonists belonging to the 3-(1-naphthyl)indole class, including AM-2232, are classified as Schedule I Controlled Substances.

IUPAC name
CAS Number335161-19-8 
CompTox Dashboard (EPA)DTXSID90187157
Chemical and physical data
Molar mass352.437 g·mol−1


  • What is AM-2232?
  • AM-2232 is a synthetic compound with the chemical name 1-(4-cyclobutyl)-3-(naphthalene-1-oyl)indole. It is known for its interaction with cannabinoid receptors in the human body.
  • How does AM-2232 work?
  • AM-2232 functions as a cannabinoid receptor agonist. It binds to specific receptors, including CB1 and CB2, affecting various physiological processes.
  • What are the effects of AM-2232?
  • AM-2232 is reported to induce effects similar to those of cannabis, including altered perception, mood, and relaxation. These effects can vary depending on the individual and the dose.
  • Is AM-2232 legal?
  • In the United States, AM-2232 and similar compounds are classified as Schedule I Controlled Substances, meaning they are illegal to manufacture, possess, or distribute.
  • Is AM-2232 safe for use?
  • The safety of AM-2232 is a subject of concern. It is not approved for medical or recreational use, and its unregulated nature can lead to unpredictable risks and adverse effects.
  • What is the recommended dosage for AM-2232?
  • There is no established safe or recommended dosage for AM-2232. Its use is associated with a high potential for abuse and adverse health consequences.
  • Are there legal alternatives to AM-2232?
  • In many regions, there are legal and regulated alternatives available for those seeking the potential therapeutic benefits of cannabinoids. It is advisable to consult with a healthcare professional regarding these alternatives.
  • Can AM-2232 be detected in drug tests?
  • Yes, AM-2232 and similar compounds can often be detected in standard drug tests, as they can trigger positive results for cannabinoids.
  • What are the potential health risks associated with AM-2232?
  • The use of synthetic cannabinoids like AM-2232 has been linked to various health risks, including cardiovascular issues, psychiatric symptoms, and addiction. Long-term effects may not be well understood.
  • Is AM-2232 available for research purposes?
  • Researchers may obtain AM-2232 for legitimate scientific studies, but strict regulations and ethical guidelines must be followed when handling such substances.


  1. United States Patent 7241799 was granted on July 10, 2007, to Makriyannis A and Deng H for their work on “Cannabimimetic indole derivatives.”
  2. 21 U.S.C. § 812 delineates the Schedules of controlled substances in the United States, providing a framework for the classification and regulation of various substances.

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