Etonitazepyne, also known as N-Pyrrolidino Etonitazene, is a benzimidazole-derived compound renowned for its powerful opioid properties. It has been illicitly marketed online as a designer drug and has been associated with a significant number of overdose incidents.

IUPAC name
PubChem CID155804760
Chemical and physical data
Molar mass394.475 g·mol−1


1. What is Etonitazepyne?

Etonitazepyne, also referred to as N-Pyrrolidino Etonitazene, is a benzimidazole-derived substance known for its potent opioid effects.

2. Is Etonitazepyne legal?

The legal status of Etonitazepyne can vary by country and region. It is often sold as a designer drug, which means it may not be regulated and could be illegal in some places.

3. What are the effects of Etonitazepyne?

Etonitazepyne is reported to produce opioid effects, including pain relief, sedation, and euphoria. However, it is crucial to note that these effects can also be hazardous and can lead to overdose.

4. Is Etonitazepyne safe to use?

No, Etonitazepyne is not safe to use. It is associated with numerous cases of overdose and can be highly dangerous, even fatal when consumed. Using it poses significant risks to health and life.

5. How is Etonitazepyne typically consumed?

Etonitazepyne is often ingested orally, but it may also be used through other routes, such as snorting or injecting, which can further increase its risks.

6. What are the potential health risks of using Etonitazepyne?

Etonitazepyne use is linked to a range of health risks, including overdose, respiratory depression, addiction, and even death. It can be hazardous due to its high potency.

7. Can Etonitazepyne be detected in drug tests?

Depending on the specific drug test, Etonitazepyne may or may not be detected. It is essential to note that drug tests can vary in what they screen for, so it’s not a safe assumption that it won’t be detected.

8. Is there a treatment for Etonitazepyne overdose?

In the event of an overdose, immediate medical attention is crucial. Opioid overdoses can often be reversed with the administration of naloxone, but professional medical care is necessary to ensure the best outcome.

9. Can Etonitazepyne be addictive?

Yes, Etonitazepyne, like other opioids, can be highly addictive. The repeated use of this substance can lead to physical and psychological dependence.

10. Where can I find more information about Etonitazepyne and its risks?

It is essential to seek information from reputable sources such as government health agencies, addiction treatment centres, or substance abuse hotlines. Additionally, consulting with a healthcare professional is advisable if you have concerns about Etonitazepyne or its effects.


1. Blanckaert P, Balcaen M, Vanhee C, Risseeuw M, Canfyn M, Desmedt B, Van Calenbergh S, Deconinck E (June 2021). “Analytical characterization of “etonitazepyne,” a new pyrrolidinyl-containing 2-benzylbenzimidazole opioid sold online”. The study was published in Drug Testing and Analysis, Volume 13, Issue 9, Pages 1627–1634. DOI: 10.1002/dta.3113. Link to study. PMID: 34145779. S2CID: 235479893.

2. Krotulski AJ, Papsun DM, Walton SE, Logan BK (2021). “New High Potency Synthetic Opioid N-Pyrrolidino Etonitazene (Etonitazepyne) Linked to Overdoses Across United States” [PDF].

3. Montanari, Eva; Madeo, Graziella; Pichini, Simona; Busardò, Francesco Paolo; Carlier, Jeremy (February 9, 2022). “Acute intoxications and fatalities associated with benzimidazole opioid (nitazene analog) use: A systematic review”. Published in Therapeutic Drug Monitoring, Volume 44, Issue 4, Pages 494–510. DOI: 10.1097/FTD.0000000000000970. PMID: 35149665. S2CID: 246776288.

4. Vandeputte, Marthe M.; Krotulski, Alex J.; Walther, Donna; Glatfelter, Grant C.; Papsun, Donna; Walton, Sara E.; Logan, Barry K.; Baumann, Michael H.; Stove, Christophe P. (April 2022). “Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole ‘nitazene’ synthetic opioid”. Published in Archives of Toxicology, Volume 96, Issue 6, Pages 1845–1863. DOI: 10.1007/s00204-022-03276-4. Link to study. ISSN: 1432-0738. PMID: 35477798. S2CID: 248416539.

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