Flubromazolam

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Summary

Flubromazolam, also known as JYI-73, belongs to the class of triazolobenzodiazepines (TBZDs), which are derivatives of benzodiazepines (BZDs). This compound has gained a reputation for its remarkably high potency. Concerns have emerged regarding the safety of substances like clonazolam and flubromazolam, mainly due to their potential to induce profound sedation and amnesia, even at very low oral doses, sometimes as minimal as 0.5 mg. Notably, life-threatening adverse reactions have been documented with doses as low as 3 mg of flubromazolam.

Identifiers
IUPAC name
CAS Number612526-40-6 
PubChem CID21930924
ChemSpider10684757 
UNII1BF1HN5GWD
CompTox Dashboard (EPA)DTXSID40620266
Chemical and physical data
FormulaC17H12BrFN4
Molar mass371.213 g·mol−1

Legal status

Sweden:
In Sweden, Flubromazolam was designated as an illicit substance following seizures by customs and law enforcement agencies, coupled with indications from the EMCDDA of its increasing recreational use.
Switzerland:
Flubromazolam has been illegal in Switzerland since December 2015.
United Kingdom:
In the United Kingdom, Flubromazolam was classified as a Class C drug through an amendment to The Misuse of Drugs Act 1971 in May 2017. This reclassification also encompassed several other designer benzodiazepine drugs.
Australia:
Flubromazolam falls under Schedule 9 according to federal law in Australia.
United States:
In the United States, Flubromazolam is regulated in the state of Virginia. On December 23, 2022, the DEA initiated discussions concerning the temporary placement of Flubromazolam in Schedule I. Subsequently, on July 25, 2023, the DEA issued a pre-print notice, stipulating that Flubromazolam would be temporarily scheduled as a controlled substance under Schedule I from 07/26/2023 to 07/26/2025.

FAQ

  • What is Flubromazolam?
  • Flubromazolam is a synthetic compound belonging to the benzodiazepine class of drugs. It is known for its sedative and anxiolytic (anxiety-reducing) properties and is sometimes used recreationally.
  • Is Flubromazolam Legal?
  • The legal status of Flubromazolam varies by country and region. It is illegal in some places, while in others, it may be unregulated or subject to control measures.
  • How is Flubromazolam Used?
  • Flubromazolam is typically consumed orally, often in the form of tablets, capsules, or as a powdered substance. Users may swallow, snort, or dissolve it in a liquid for consumption.
  • What Are the Effects of Flubromazolam?
  • Flubromazolam can induce sedation, relaxation, and relief from anxiety. Some users also report memory impairment and amnesia. The effects can vary depending on the dosage and individual sensitivity.
  • What Are the Risks and Side Effects?
  • Flubromazolam, like other benzodiazepines, can lead to drowsiness, dizziness, and impaired coordination. It also has a risk of dependence and withdrawal symptoms. Overdose can lead to serious health complications.
  • Is Flubromazolam Addictive?
  • Yes, benzodiazepines, including Flubromazolam, have the potential for addiction. Prolonged use or misuse can lead to physical and psychological dependence.
  • Can Flubromazolam Be Used Safely?
  • It should only be used under the supervision of a medical professional and according to prescribed dosages. Using Flubromazolam recreationally or without a prescription can be dangerous.
  • What Is the Legal Status of Flubromazolam in My Country?
  • The legal status of Flubromazolam can vary widely. It is essential to check your local laws and regulations to understand their position in your region.
  • Are There Drug Interactions to Be Aware Of?
  • Flubromazolam can interact with other drugs, including alcohol. Combining it with other substances can amplify the sedative effects and increase the risk of adverse reactions.
  • What Should I Do in Case of Overdose or Adverse Reactions?
  • If you suspect an overdose or experience severe adverse effects, seek immediate medical attention. It’s essential to be transparent with healthcare providers about your substance use.
  • Can I Stop Taking Flubromazolam Abruptly?
  • No, abruptly discontinuing Flubromazolam can lead to withdrawal symptoms, including anxiety and seizures. It’s important to taper off the medication under the guidance of a healthcare professional.
  • Is There Support Available for Flubromazolam Dependence?
  • Yes, treatment and support options are available for benzodiazepine dependence. If you or someone you know is struggling with Flubromazolam use, consider seeking help from a medical or addiction treatment facility.

References

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  11. Wohlfarth A, Vikingsson S, Roman M, Andersson M, Kugelberg FC, Green H, Kronstrand R (May 2017). “Looking at flubromazolam metabolism from four different angles: Metabolite profiling in human liver microsomes, human hepatocytes, mice, and authentic human urine samples with liquid chromatography high-resolution mass spectrometry.” Published in Forensic Science International. Special Issue on the 54th Annual Meeting of the International Association of Forensic Toxicologists (TIAFT) Brisbane from August 28 to September 1, 2016. Volume 274, Pages 55–63. doi: 10.1016/j.forsciint.2016.10.021. PMID 27863836.
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