N-Ethylbuphedrone, commonly called NEB, is a member of the cathinone class of stimulants and has been marketed as a designer drug. It serves as the β-ketone counterpart of N,alpha-diethylphenylethylamine.

IUPAC name
CAS Number1354631-28-9
PubChem CID20326296
CompTox Dashboard (EPA)DTXSID30605441
Chemical and physical data
Molar mass191.274 g·mol−1

Legal status

In October 2015, China categorized NEB as a controlled substance.
NEB is classified as a Schedule 1 controlled substance in the United States due to its structural similarity as a positional isomer of 4-Methylethcathinone (4-MEC).


1. What is N-Ethylbuphedrone (NEB)?

N-ethylbuphedrone, often referred to as NEB, is a synthetic stimulant drug belonging to the cathinone class. It is recognized for its stimulant properties and has been marketed as a designer drug.

2. Is NEB legal?

The legal status of NEB varies from one country to another. In some regions, it is classified as a controlled substance, making its possession and distribution illegal. Always consult your local and national drug laws to determine their legal status.

3. How is NEB typically used?

NEB is typically found in powder form and can be ingested orally, snorted, or used through other routes. However, its use is generally discouraged and associated with potential health risks.

4. What are the effects of NEB?

NEB is known for its stimulant effects, including increased energy, alertness, and euphoria. Users have reported effects similar to other amphetamine-like substances. Nevertheless, it can also lead to negative side effects and health risks.

5. What are the health risks associated with NEB use?

Using NEB can pose significant health risks. Users may experience side effects such as increased heart rate, elevated blood pressure, anxiety, paranoia, and potential addiction or dependence with frequent or heavy use. Overdose is also a risk.

6. Is NEB addictive?

Like many other stimulant drugs, NEB has the potential for addiction and dependence, especially with frequent or heavy use. Users should be aware of the risk and take necessary precautions.

7. Why is NEB banned in some countries?

Like other synthetic cathinones, NEB has been banned in several countries due to concerns about its potential health risks and misuse. It may be classified as a controlled substance because of its psychoactive effects and abuse potential.

8. How can the risks associated with NEB use be minimized?

The best way to minimize the risks associated with NEB is to avoid using it altogether. If someone chooses to use it, it is essential to be informed about potential dangers, use it in moderation, and avoid combining it with other substances. Additionally, harm reduction strategies and a support system are crucial.

9. Are there any treatment options for NEB addiction?

Treatment options for NEB addiction may include counseling, therapy, and support groups. If you or someone you know is struggling with NEB addiction, seek help from healthcare professionals or addiction support services.

10. Where can I find more information about NEB?

Consider consulting medical professionals, addiction support organizations, or drug education resources for more information about NEB. Always prioritize your health and safety when considering substance use and seek assistance.


  1. In a study conducted in September 2013, Lanza, Acton, Jürschik, Sulzer, Breiev, Jordan, and colleagues employed Selective Reagent Ionisation Mass Spectrometry (SRI-MS) to differentiate between two isomeric substitutes for mephedrone. Their research was published in the “Journal of Mass Spectrometry,” Volume 48, Issue 9, encompassing pages 1015–1018. The DOI is 10.1002/jms.3253, and the PMID is 24078242.
  2. Acton, Lanza, Agarwal, Jürschik, Sulzer, Breiev, and their team, in a March 2014 study, utilized a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer for the headspace analysis of new psychoactive substances. Their findings are documented in the “International Journal of Mass Spectrometry,” Volume 360, spanning pages 28–38. The DOI is 10.1016/j.ijms.2013.12.009, and the study is available through PMC with PMID 25844048.
  3. A study published in June 2014 by Uralets, Rana, Morgan, and Ross examined the metabolic profiles of 16 synthetic cathinones excreted in human urine. This research is featured in the “Journal of Analytical Toxicology,” Volume 38, Issue 5, with pages 233–241. The DOI is 10.1093/jat/bku021, and the PMID is 24668489.
  4. In November 2021, Pieprzyca, Skowronek, and Czekaj conducted a toxicological analysis of cases involving mixed poisonings with synthetic cathinones and other drugs of abuse. The results of their study are presented in the “Journal of Analytical Toxicology,” Volume 46, Issue 9, spanning pages 1008–1015. The DOI is 10.1093/jat/bkab119, and the PMID is 34849994.
  5. On September 27, 2015, the China Food and Drug Administration released a notification titled “关于印发《非药用类麻醉药品和精神药品列管办法》的通知” (in Chinese), outlining regulations concerning non-medicinal narcotic drugs and psychotropic drugs, including substances like mephedrone. This information is based on the original document, which was archived on October 1, 2015.
  6. The Diversion Control Division of the U.S. Department of Justice, Drug Enforcement Administration, published a report in February 2023 that includes lists of scheduling actions, controlled substances, and regulated chemicals. This report provides valuable insights into drug regulations and is accessible as a PDF document.

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