2,5-Dimethoxy-4-nitroamphetamine (DON) is classified as a psychedelic compound within the amphetamine family. Notably, it shares structural similarities with DOM and DOB while exhibiting a close relationship with 2C-N.

CAS Number67460-68-8 
3D model (JSmol)Interactive imageInteractive image
CompTox Dashboard(EPA)DTXSID00874243


Belonging to the category of alpha-methyl phenethylamines, or amphetamines, DON’s complete chemical name is 1-(2,5-dimethoxy-4-nitrophenyl)propan-2-amine. Importantly, it possesses a stereocenter.


In his book PiHKAL, Alexander Shulgin lists a dosage of DON as being 3-4.5 mg orally with amphetamine-like stimulation lasting 8–15 hours.


DON is not officially scheduled in the United States; however, due to its structural and functional resemblance to DOM and DOB, the possession and distribution of DON may be liable to prosecution under the Federal Analog Act. In the United Kingdom, DON has been categorized as a Class A drug following the addition of its classification in the Misuse of Drugs Act, triggered by its inclusion in the PiHKAL and TiHKAL schedules.


  • What is 2,5-Dimethoxy-4-nitroamphetamine (DON)?
  • DON is a chemical compound that falls into the amphetamine class of substances. It is known for its psychoactive properties and is related to other compounds like DOM (STP) and DOB.
  • What are the effects of DON when consumed?
  • The effects of DON are primarily hallucinogenic, leading to alterations in perception, mood, and thought. Users may experience visual and auditory distortions, changes in consciousness, and other psychedelic effects.
  • Is DON legal in the United States?
  • DON is not explicitly scheduled in the United States; however, due to its structural and functional similarities to controlled substances like DOM and DOB, its possession and distribution may be subject to prosecution under the Federal Analog Act.
  • What is the Federal Analog Act?
  • The Federal Analog Act in the United States allows authorities to prosecute substances that are structurally or functionally similar to controlled substances, even if they are not explicitly listed as illegal.
  • Is DON regulated in the United Kingdom?
  • Yes, DON is classified as a Class A drug under the Misuse of Drugs Act in the United Kingdom.
  • Can DON be used safely?
  • The safety of using DON is not well established, and it is considered a powerful hallucinogen. It can lead to intense and potentially unpredictable experiences. Using DON can be risky and is generally discouraged.
  • What are the risks associated with DON use?
  • Risks associated with DON use include hallucinations, anxiety, paranoia, and the potential for dangerous behavior. In high doses, it can also lead to physical health risks.
  • Is DON used recreationally or for therapeutic purposes?
  • DON is primarily used recreationally for its hallucinogenic effects. It is not recognized for any therapeutic use.
  • How is DON typically consumed?
  • DON is usually ingested orally, often as a pill or powder. The dosage can vary, and users should exercise extreme caution.
  • Is DON addictive?
  • DON itself is not typically considered physically addictive. However, like other hallucinogens, it can be psychologically habit-forming in some individuals.
  • Is there a risk of overdose with DON?
  • Yes, there is a risk of overdose, especially when DON is consumed in high doses. Overdose symptoms may include severe hallucinations, disorientation, and potentially life-threatening physical effects.
  • Where can I find more information about DON and its effects?
  • It’s essential to stay informed and make safe choices. Consult reputable sources and seek guidance from healthcare professionals or harm reduction organizations for more information on the effects and risks associated with DON.


  1. DON Entry in PiHKAL

Leave a Comment

Your email address will not be published. Required fields are marked *