2,5-Dimethoxy-4-propylamphetamine (DOPR) belongs to the phenethylamine and amphetamine chemical classes and was initially synthesized by Alexander Shulgin. Shulgin introduced this compound in his renowned work, “PiHKAL” (Phenethylamines I Have Known And Loved). DOPR, according to Shulgin, is a profoundly potent psychedelic substance capable of inducing substantial alterations in thought processes and significant visual distortions.

Regrettably, there is a lack of information regarding the pharmacological properties, metabolic processes, and potential toxicity associated with DOPR.

An alternative structural isomer, known as DOIP (which features a 4-isopropyl substitution), also exists but is notably less potent than DOPR, requiring a significantly higher active dose of approximately 20–30 mg in contrast to the 2–5 mg needed for DOPR.

IUPAC name
CAS Number63779-88-4 
53581-55-8 (hydrochloride)
PubChem CID542051
CompTox Dashboard (EPA)DTXSID40337347
Chemical and physical data
Molar mass237.343 g·mol−1


  • What is 2,5-Dimethoxy-4-propylamphetamine (DOPR)?
  • DOPR is a psychedelic compound in the phenethylamine and amphetamine chemical classes. It’s known for its mind-altering properties.
  • Who first synthesized DOPR, and where can I find more information about it?
  • DOPR was first synthesized by Alexander Shulgin and is described in his book “PiHKAL” (Phenethylamines I Have Known And Loved). You can find more details about DOPR in this book.
  • How does DOPR affect the mind and perception?
  • DOPR is described as a “heavy-duty psychedelic” by Shulgin. It can lead to significant alterations in thought processes and induce visual distortions.
  • Is DOPR safe to use?
  • The safety of DOPR use is not well-documented, and it is considered a powerful psychedelic. It can lead to intense and potentially unpredictable experiences. Using DOPR can be risky and is generally discouraged.
  • What are the risks associated with DOPR use?
  • Risks include hallucinations, disorientation, and potentially harmful behavior. In high doses, it may also pose physical health risks.
  • Is DOPR addictive?
  • DOPR is not typically considered physically addictive. However, like other psychedelics, it can be psychologically habit-forming in some individuals.
  • What is the alternative isomer DOIP, and how does it compare to DOPR?
  • DOIP is a structural isomer of DOPR with a 4-isopropyl substitution. It is significantly less potent than DOPR, requiring a much higher dose (around 20–30 mg compared to 2–5 mg for DOPR) to achieve similar effects.
  • Where can I find more information about the pharmacological properties, metabolism, and toxicity of DOPR?
  • Unfortunately, very little data exists on these aspects of DOPR. You should exercise caution and seek information from reputable sources to explore this substance.
  • Is DOPR legal in the United States and other countries?
  • The legal status of DOPR varies by country and region. It’s essential to research and understand the laws and regulations regarding its use and possession in your area.
  • How can I ensure safety when using DOPR or similar substances?
  • Prioritize safety by being well-informed, using harm reduction practices, and seeking guidance from healthcare professionals or harm reduction organizations. Always be aware of the legal status and potential risks associated with the substance.


  1. Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. United States: Transform Press. p. 978. ISBN0-9630096-0-5.

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