25iP-NBOMe (2C-iP-NBOMe, NBOMe-2C-iP) is a compound derived from the phenethylamine hallucinogen 2C-iP, renowned for its exceptional potency as an agonist for the human 5-HT2A receptor.

IUPAC name
CAS Number1391487-83-4 
PubChem CID118796426
Chemical and physical data
Molar mass343.467 g·mol−1

Toxicity and harm potential

NBOMe compounds are frequently linked to severe toxicity and fatalities, often exhibiting neurotoxic and cardiotoxic properties. Autonomic dysfunction, including sympathomimetic toxicity such as vasoconstriction, hypertension, and tachycardia, is commonly observed with NBOMe use, accompanied by hallucinations and a range of severe symptoms including agitation, seizure, hyperthermia, hypertonia, and rhabdomyolysis. Notably, NBOMe intoxication often presents signs of serotonin syndrome and a heightened risk of seizures compared to other psychedelics.
These compounds are often sold as LSD, creating a dangerous misconception as their safety profiles significantly differ. Incidents involving NBOMe ingestion mistaken for LSD have resulted in fatalities and are additionally associated with self-harm and suicide under the drug’s influence. However, due to limited documentation, the long-term effects of NBOMe use remain unknown.
NBOMe compounds are administered sublingually, inducing a distinct metallic taste and numbness in the mouth. This effect is considered one of the primary discriminants between NBOMe and LSD consumption. Additionally, their high potency at 5-HT receptors, particularly 5-HT2B, has been implicated in cardiac valvulopathy and stimulant-type cardiovascular effects.
In vitro studies have highlighted the neurotoxicity of 25C-NBOMe, demonstrating its cytotoxic effects on neuronal and cardiomyocyte cell lines. While the toxicity of these compounds has been observed in various animal models, further research is needed to understand its full impact, especially on pregnant women and their fetuses.
Currently, there is no specific antidote for NBOMe intoxication, and treatments primarily focus on managing acute symptoms, including the administration of benzodiazepines, antipsychotic drugs, and beta-blockers. Specific interventions address complications such as rhabdomyolysis, metabolic acidosis, and acute kidney injury, which may arise from NBOMe use.


In the United Kingdom, this compound falls under the category of Class A drugs, according to the N-benzylphenethylamine catch-all clause stipulated in the Misuse of Drugs Act 1971.


  • What is 25iP-NBOMe?
  • 25iP-NBOMe is a derivative of the phenethylamine hallucinogen 2C-iP, known for its potent agonist activity on the human 5-HT2A receptor.
  • How does 25iP-NBOMe compare to 2C-iP?
  • 25iP-NBOMe is a modified version of 2C-iP, exhibiting enhanced potency and binding affinity for the 5-HT2A receptor compared to its precursor.
  • What are the critical effects of 25iP-NBOMe?
  • Users typically experience psychedelic effects such as altered perception, hallucinations, and sensory distortions, often accompanied by changes in mood and cognition.
  • Is 25iP-NBOMe known for any particular risks or dangers?
  • Like other compounds in the NBOMe family, 25iP-NBOMe is associated with potential risks of severe toxicity and adverse reactions, which could lead to life-threatening consequences.
  • How is 25iP-NBOMe administered?
  • Typically, 25iP-NBOMe is taken sublingually or through other oral mucosal routes. Users should be cautious about the accurate dosage to avoid accidental overdose.
  • What precautions should be taken while using 25iP-NBOMe?
  • Awareness of the substance’s potent nature and potential risks is imperative. Accurate dosing, proper identification, and harm reduction practices are essential when handling 25iP-NBOMe.
  • What are the legal implications of 25iP-NBOMe?
  • The legal status of 25iP-NBOMe varies across different jurisdictions. It is advisable to be informed about the regulatory measures in your specific region to avoid any legal complications.
  • Are there any known long-term effects of 25iP-NBOMe use?
  • Due to limited research and documentation, the long-term effects of 25iP-NBOMe still need to be discovered. Users are cautioned to be mindful of potential risks and conduct responsible usage.
  • What should be done in an emergency or adverse reaction to 25iP-NBOMe?
  • In the event of any adverse effects or emergencies related to 25iP-NBOMe consumption, seeking immediate medical assistance is crucial. Inform the medical professionals about the specific substance ingested for appropriate treatment.
  • How can the risks associated with 25iP-NBOMe use be minimized?
  • Risk reduction practices include accurate dosing, ensuring product purity, testing substances for authenticity, and being informed about the potential dangers and proper handling of 25iP-NBOMe.


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