3,4-Methylenedioxy-N-hydroxyamphetamine (MDOH), also known as MDH or N-hydroxytenamphetamine, is a compound that falls into the categories of entactogen, psychedelic, and stimulant. It belongs to the phenethylamine and amphetamine chemical classes. MDOH is the N-hydroxy counterpart of MDA and the N-desmethyl counterpart of MDHMA.
This compound was initially synthesized and evaluated by Alexander Shulgin. In his book PiHKAL (Phenethylamines I Have Known And Loved), Shulgin provided information about MDOH, stating that the dosage range typically falls between 100 and 160 mg, with effects lasting approximately 3 to 6 hours. He described MDOH as highly psychedelic and noted that it enhanced the appreciation of beauty and nature. However, Shulgin also mentioned several adverse effects commonly associated with MDMA (“Ecstasy”), such as difficulties with urination and internal dryness.

IUPAC name
CAS Number74698-47-8
PubChem CID98528
Chemical and physical data
Molar mass195.218 g·mol−1


1. What is 3,4-methylenedioxy-N-hydroxyamphetamine (MDOH)?

3,4-Methylenedioxy-N-hydroxyamphetamine, MDOH, is a chemical compound categorized as an entactogen, psychedelic, and stimulant. It belongs to the phenethylamine and amphetamine chemical classes.

2. Who first synthesized and evaluated MDOH?

MDOH was initially synthesized and studied by Alexander Shulgin, a prominent researcher and chemist in psychoactive compounds.

3. What are the effects of MDOH?

MDOH is known for its psychedelic properties and ability to enhance the appreciation of beauty and nature. It may also produce stimulating effects. However, individual experiences can vary widely.

4. What is the recommended dosage for MDOH?

According to Alexander Shulgin’s book PiHKAL, the typical dosage range for MDOH is between 100 and 160 mg. Effects are reported to last approximately 3 to 6 hours.

5. Are there any potential side effects of MDOH use?

Users of MDOH have reported side effects similar to those associated with MDMA (“Ecstasy”), including difficulties with urination and sensations of internal dryness. However, it’s important to note that individual reactions can differ.

6. Is MDOH legal?

The legal status of MDOH varies by country and region. It may be subject to regulations and restrictions in some areas. Check local drug laws and rules before considering the use or possession of MDOH.

7. Is MDOH addictive?

While MDOH may have the potential for psychological dependence, there is limited research on its addiction potential. Like other psychoactive substances, using MDOH regularly and excessively may lead to cravings and withdrawal symptoms.


  1. Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN0-9630096-0-5. OCLC25627628.

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