4-Acetoxy-DET, commonly referred to as ethacetin, ethylacybin, or 4-AcO-DET, is a type of psychedelic tryptamine. Albert Hofmann originally synthesized this compound in 1958 while working in the Sandoz laboratory.
This compound is believed to undergo rapid hydrolysis, facilitated by serum esterases, converting it into the unbound phenolic form known as 4-HO-DET. However, there is a need for more human studies exploring the metabolic destiny of this particular drug.

IUPAC name
CAS Number1135424-15-5 
PubChem CID24801867
CompTox Dashboard (EPA)DTXSID60647359
Chemical and physical data
Molar mass274.364 g·mol−1


4-Acetoxy-DET can be taken orally and is known to be active at typical dosages ranging from 10 to 25 mg. Its effects typically endure for a duration of 4 to 6 hours. Additionally, the free base form of this substance is also effective when smoked, with a dosage range of 5 to 20 mg. Smoking 4-Acetoxy-DET notably accelerates the onset of effects, with peak experiences occurring within 10 minutes and the results usually concluding within 1 hour.

Drug prohibition laws

In Sweden, the Ministry of Health within the Swedish Parliament, known as Sveriges riksdag’s health ministry, categorized 4-AcO-DET as a “health hazard.” This classification was made under the Act on the Prohibition of Certain Goods Dangerous to Health, also known as “Lagen om förbud mot visa hälsofarliga varor.” This regulatory action, specified in SFS 2005:733 as 4-acetoxy-N, N-dimethyltryptamine (4-AcO-DET), took effect on November 1, 2005. Consequently, selling or possessing this substance in Sweden is now illegal.


  • What is 4-Acetoxy-DET?
  • 4-Acetoxy-DET, also known as ethacetin, ethylacybin, or 4-AcO-DET, is a psychedelic tryptamine compound.
  • How is 4-Acetoxy-DET typically consumed?
  • It can be ingested orally, with standard dosages ranging from 10 to 25 mg. It can also be smoked in its free base form, with dosages typically between 5 to 20 mg.
  • How long do the effects of 4-Acetoxy-DET last?
  • The effects typically last for about 4 to 6 hours when taken orally. If smoked, the onset is rapid, with peak effects within 10 minutes, and the experience usually ends within 1 hour.
  • Is 4-Acetoxy-DET legal?
  • The legal status of 4-Acetoxy-DET varies by country. In some places, it is classified as a controlled substance or a health hazard, making it illegal to sell or possess. It’s essential to check your local laws and regulations.
  • What are the potential risks associated with 4-Acetoxy-DET?
  • Since it is a psychedelic substance, there are potential risks, including hallucinations, altered perception, and psychological effects. The safety profile and long-term effects are not well-studied, so caution is advised.
  • Is 4-Acetoxy-DET the same as other psychedelic substances like psilocybin or LSD?
  • 4-Acetoxy-DET is a tryptamine compound that shares some similarities with other psychedelics but has distinct effects. Users should be aware of these differences and exercise caution.
  • Can 4-Acetoxy-DET be used for therapeutic purposes?
  • Some individuals have explored the potential therapeutic benefits of psychedelic substances, but research is limited. It’s essential to consult with a qualified healthcare professional if considering such use.
  • What should I do if someone I know is experiencing adverse effects from 4-Acetoxy-DET?
  • If you or someone you know is experiencing adverse effects or a bad reaction, seek medical attention immediately. Be honest with healthcare professionals about substance use to ensure proper care.
  • Is there a risk of addiction with 4-Acetoxy-DET?
  • The risk of addiction to 4-Acetoxy-DET is explicitly not well-documented, but as with any psychoactive substance, there is a potential for psychological dependence. It is essential to use such substances responsibly and in moderation.
  • Where can I find more information about 4-Acetoxy-DET?
  • For more information, consider consulting reputable sources such as scientific literature harm reduction organizations or seeking guidance from medical professionals. Always prioritize safety and responsible use.


  1. Explore the Erowid 4-Acetoxy-DET Vaults: A Primer. This resource was accessed on April 19, 2007.
  2. Delve into the work of Shulgin A and Shulgin A in entry “#16. 4-HO-DET” found in “Tikhal: The Chemistry Continues.” This information was retrieved on April 19, 2007.
  3. Discover the legal aspect of 4-Acetoxy-DET in Sweden. On October 13, 2005, Svensk författningssamling issued a regulation amending the ordinance (1999:58) concerning the prohibition of certain goods dangerous to health. You can access the full document in PDF format, with an archive available from the original PDF on March 4, 2016. This information was retrieved on October 10, 2015.

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