4-Acetoxy-N-methyl-N-ethyltryptamine, commonly called 4-AcO-MET or metacetin, is a hallucinogenic tryptamine compound. This chemical represents the acetate ester of 4-HO-MET and serves as a homolog of 4-AcO-DMT. With a minimal documented history of human usage, it is a relatively novel substance in the world of psychedelics. Some online retailers market it as a research chemical.
Although this compound is anticipated to rapidly undergo hydrolysis within the human body, converting into the free phenolic 4-HO-MET due to serum esterases, comprehensive human studies concerning the metabolic fate of 4-AcO-MET remain absent.

IUPAC name
CAS Number1445751-40-5
PubChem CID71308138
Chemical and physical data
Molar mass260.337 g·mol−1


4-Acetoxy-MET currently holds an unscheduled status in the United States. Nevertheless, it may be viewed as an analog of Psilocin, a Schedule I controlled substance under the Controlled Substances Act. Engaging in the sale for human consumption or employing it for illicit non-medical purposes could constitute a legal offense under the Federal Analogue Act. However, this requires further citation for confirmation.
In Switzerland, 4-Acetoxy-MET is classified as a controlled substance under Verzeichnis E.
Within the United Kingdom, 4-Acetoxy-MET is categorized as a Class A drug. This classification arises from its status as an ester of 4-HO-MET, which is classified as a Class A drug under the tryptamine catch-all clause.


  • What is 4-Acetoxy-MET?
  • 4-Acetoxy-N-methyl-N-ethyltryptamine, commonly known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine compound. It is chemically related to other substances such as 4-HO-MET and 4-AcO-DMT.
  • Is 4-Acetoxy-MET legal in the United States?
  • As of the last available information, 4-Acetoxy-MET is not scheduled as a controlled substance in the United States. However, it may be considered an analog of psilocin, a Schedule I drug. The sale for human consumption or illicit non-medical use could be subject to legal consequences under the Federal Analogue Act. Always verify the current legal status in your area.
  • What is the legal status of 4-Acetoxy-MET in Switzerland?
  • 4-Acetoxy-MET is classified as a controlled substance in Switzerland under Verzeichnis E.
  • Is 4-Acetoxy-MET illegal in the United Kingdom?
  • Yes, 4-Acetoxy-MET is considered a Class A drug in the United Kingdom. It falls under this classification due to its relationship with 4-HO-MET, classified as a Class A drug under the tryptamine catch-all clause.
  • What are the potential effects of 4-Acetoxy-MET?
  • Anecdotal reports suggest that 4-Acetoxy-MET may induce various psychoactive effects, including altered perception, visual distortions, and changes in consciousness. However, individual experiences can vary, and more research is needed to understand its effects fully.
  • Is 4-Acetoxy-MET safe to use?
  • The safety of 4-Acetoxy-MET is not well-documented, and its effects on the human body and mind are still being studied. Like with all psychoactive substances, it is crucial to exercise caution, use harm-reduction practices, and be in a safe and controlled environment when experimenting with it.
  • Can 4-Acetoxy-MET be used for therapeutic purposes?
  • There is limited research on the therapeutic potential of 4-Acetoxy-MET. Any therapeutic use should be conducted under the guidance of a qualified healthcare professional and in a controlled clinical setting.
  • Where can I obtain 4-Acetoxy-MET?
  • The availability of 4-Acetoxy-MET may vary by region and be subject to legal restrictions. Obtaining it from unverified sources can be risky, as the quality and purity of the substance may not be guaranteed. It’s essential to exercise caution and seek reputable sources to acquire it.


  1. The emergence of “New psychoactive substances reported to the EMCDDA and Europol for the first time in 2009 under the terms of Council Decision 2005/387/JHA” can be found in a document available on www.emcdda.europa.eu. This report provides insights into the evolving landscape of psychoactive substances. (Retrieved on 6 May 2022).
  2. For legal reference and information on new substances, you can explore “Fedlex” at www.fedlex.admin.ch. This resource offers valuable insights into legal regulations. (Retrieved on 15 August 2021).
  3. The “Misuse of Drugs Act 1971” remains an essential legislative document. Please note that this source was accessed on 15 August 2021 and is archived from the original, highlighting its historical significance in drug regulation.

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