5-Chloro-N, N-dimethyltryptamine, commonly referred to as 5-chloro-DMT, belongs to the family of tryptamine derivatives, sharing a kinship with substances like 5-bromo-DMT and 5-fluoro-DMT. In its function, it serves as an agonist of serotonin receptors and, in animal studies, has predominantly exhibited sedative effects. Notably, it has been marketed and distributed as a designer drug.

IUPAC name
CAS Number22120-32-7 
PubChem CID2762739
CompTox Dashboard (EPA)DTXSID90376408
Chemical and physical data
Molar mass222.72 g·mol−1


1. What is 5-Chloro-DMT?

  • 5-Chloro-DMT is a tryptamine derivative closely related to compounds like 5-bromo-DMT and 5-fluoro-DMT. It is known for its impact on serotonin receptors.

2. What are the reported effects of 5-Chloro-DMT?

  • In animal studies, 5-Chloro-DMT has demonstrated primarily sedative effects. However, individual responses to psychoactive substances can vary.

3. How is 5-Chloro-DMT typically used?

  • 5-Chloro-DMT has been sold as a designer drug, but its use is not widely documented. It’s important to note that the use of designer drugs carries potential health and legal risks.

4. Is 5-Chloro-DMT legal in my country?

  • The legal status of 5-Chloro-DMT varies by country and jurisdiction. It’s essential to check local regulations and laws, as it may be classified as a controlled substance in some regions.

5. Is there any ongoing research on the potential medical uses of 5-Chloro-DMT?

  • Currently, there is limited research on the medical applications of 5-Chloro-DMT. It is primarily considered a research chemical, and more studies would be needed to understand its potential benefits or risks.

6. What are the safety considerations for using 5-Chloro-DMT?

  • As with any designer drug or experimental substance, it is crucial to exercise caution. The use of such substances can be associated with unknown risks, including potential health effects and legal consequences.

7. Where can I find more information about 5-Chloro-DMT?

  • You can explore scientific literature, research papers, and online resources that focus on psychoactive substances for additional information about 5-Chloro-DMT. Ensure that the sources you consult are reputable and up-to-date.


  1. In September 1960, Benington F, Morin RD, and Clark LC published research in the “Journal of Organic Chemistry.” Their work focused on the synthesis of various derivatives of tryptamine, including 5- and 6-chloro, 5-methyl, and 5,6,7-trimethyl compounds.
  2. In August 2017, Ibrahim MA, El-Alfy AT, Ezel K, Radwan MO, Shilabin AG, Kochanowska-Karamyan AJ, and colleagues conducted a study featured in “Marine Drugs.” They explored the development of 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines inspired by marine compounds. This research shed light on the significance of bromine in the marine chemical space.
  3. A study conducted in May 2021 by Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, and others utilized an engineered biosensor for psychedelic-inspired drug discovery. The findings were published in “Cell,” illustrating innovative approaches to drug development.
  4. An analytical report titled “Analytical Report: 5-Cl-DMT” was produced in July 2020 by Nacionalni Forenzični Laboratorij in Slovenia. This report likely contains valuable information related to 5-Chloro-DMT, a derivative of tryptamine.

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