5F-ADB-PINACA, a synthetic cannabinoid designer drug found in certain synthetic cannabis blends, exhibits significant agonistic activity towards both the CB1 and CB2 receptors, boasting low EC50 values of 0.24 nM and 2.1 nM, respectively.

IUPAC name
CAS Number1863065-90-0
PubChem CID119058050
Chemical and physical data
Molar mass362.449 g·mol−1


A total of twelve major metabolites of 5F-ADB-PINACA were discovered in various incubations involving cryopreserved human hepatocytes. The primary metabolic transformations observed involved oxidative defluorination followed by carboxylati


In terms of legality, 5F-ADB-PINACA is classified in the Fifth Schedule of the Misuse of Drugs Act (MDA), rendering it illegal in Singapore since May 2015.


  • What is 5F-ADB-PINACA?
  • 5F-ADB-PINACA is a synthetic cannabinoid designer drug that is used as an active ingredient in some synthetic cannabis products. It acts as a potent agonist of the CB1 and CB2 receptors, which are part of the endocannabinoid system in the human body.
  • How does 5F-ADB-PINACA work?
  • 5F-ADB-PINACA exerts its effects by binding to and activating the CB1 and CB2 receptors in the endocannabinoid system. These receptors regulate various physiological processes, including mood, appetite, and pain perception.
  • What are the effects of 5F-ADB-PINACA use?
  • The effects of 5F-ADB-PINACA use can vary widely and may include feelings of relaxation, euphoria, altered perception of time, and changes in sensory perception. However, it’s important to note that the use of synthetic cannabinoids like 5F-ADB-PINACA can also lead to adverse effects such as anxiety, paranoia, and, in some cases, severe health risks.
  • Is 5F-ADB-PINACA legal?
  • The legal status of 5F-ADB-PINACA varies from one country to another. In some places, it is classified as a controlled substance and is illegal to manufacture, possess, or distribute. Always check your local laws and regulations regarding synthetic cannabinoids.
  • Are there any health risks associated with 5F-ADB-PINACA use?
  • Yes, there are potential health risks associated with 5F-ADB-PINACA use. These may include anxiety, hallucinations, cardiovascular issues, and, in extreme cases, life-threatening complications. Since the safety of synthetic cannabinoids is not well-documented, using them can be particularly dangerous.
  • Is 5F-ADB-PINACA addictive?
  • Synthetic cannabinoids like 5F-ADB-PINACA can be habit-forming and may lead to psychological dependence. Users may experience cravings and withdrawal symptoms when attempting to quit using these substances.
  • How can I stay safe if I’ve used or plan to use 5F-ADB-PINACA?
  • The safest approach is to avoid using 5F-ADB-PINACA or any synthetic cannabinoids altogether. If you have used it and are experiencing adverse effects, seek immediate medical attention. If you plan to use it, be aware of the potential risks and the legal status in your area. Always prioritize your safety and well-being.
  • What should I do if I suspect someone is using 5F-ADB-PINACA?
  • If you suspect someone is using 5F-ADB-PINACA or any synthetic cannabinoids and is experiencing adverse effects, it’s important to seek medical help immediately. Be supportive and encourage them to stop using these substances due to the associated risks.


  1. In September 2015, Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, and their colleagues conducted an investigation into the pharmacology of synthetic cannabinoid designer drugs, specifically AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. This research was published in the ACS Chemical Neuroscience journal (Volume 6, Issue 9, Pages 1546–1559) under the title “Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA.” The article can be accessed via the following DOI: 10.1021/acschemneuro.5b00112, and its PMID is 26134475.
  2. For information specifically regarding “5F-ADB-PINACA,” you can refer to Cayman Chemical.
  3. In May 2017, Carlier J, Diao X, Scheidweiler KB, and Huestis MA carried out a study aimed at distinguishing the intake of new synthetic cannabinoids, namely ADB-PINACA and 5F-ADB-PINACA, utilizing human hepatocyte metabolites and high-resolution mass spectrometry. Their findings were published in the Clinical Chemistry journal (Volume 63, Issue 5, Pages 1008–1021) under the title “Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry.” The article is accessible through the DOI: 10.1373/clinchem.2016.267575, and its PMID is 28302730.
  4. On April 30, 2015, the Central Narcotics Bureau (CNB) released news related to these synthetic cannabinoids. This news release is available in the CNB archives, with the original document dating back to July 15, 2015. You can verify this information by referencing the CNB News Release, and additional details can be obtained by referring to the publication date of July 24, 2015.

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