5F-AB-PINACA

Summary

5F-AB-PINACA is an indazole-derived synthetic cannabinoid originating from a group of compounds initially created by Pfizer in 2009 for pain relief. This substance has gained notoriety as a designer drug available for purchase online.
In research, 5F-AB-PINACA has demonstrated notable potency as an agonist, affecting both the CB1 receptor and CB2 receptor, with EC50 values recorded at 0.48 nM and 2.6 nM, respectively. The metabolic processes associated with this compound have also been documented in scientific literature.

Identifiers

IUPAC name
CAS Number	1800101-60-3
PubChem CID	91936927
ChemSpider	29763723
UNII	3L83B2298V
CompTox Dashboard (EPA)	DTXSID401009970
Chemical and physical data
Formula	C18H25FN4O2
Molar mass	348.422 g·mol−1

Legality

As of October 2015, 5F-AB-PINACA is a controlled substance in China.
Germany

5F-AB-PINACA is an Anlage II controlled substance in Germany as of May 2015.
Singapore
It is also controlled under the Fifth Schedule of the Misuse of Drugs Act (MDA) in Singapore as of May 2015

FAQ

• What is 5F-AB-PINACA?
• 5F-AB-PINACA is an indazole-based synthetic cannabinoid that was originally developed by Pfizer for analgesic purposes in 2009. It has since been available as a designer drug.
• How does 5F-AB-PINACA affect the body?
• 5F-AB-PINACA is known to be a potent agonist of both the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system and play a role in various physiological processes.
• What are the legal restrictions on 5F-AB-PINACA?
• The legal status of 5F-AB-PINACA varies by country. As of my knowledge, the cutoff date in 2022 was controlled in China, Germany, and Singapore. However, the legal status of such substances can change over time, so it’s important to stay updated with local regulations.
• Is 5F-AB-PINACA safe to use?
• Synthetic cannabinoids like 5F-AB-PINACA can have unpredictable effects and potential health risks. Due to their varying potency and unknown long-term effects, these substances are generally considered unsafe for human consumption.
• Is 5F-AB-PINACA addictive?
• The potential for addiction to synthetic cannabinoids is a concern. These substances may lead to dependence, and users should be aware of the risks associated with their use.
• Are there any known side effects of 5F-AB-PINACA?
• The side effects of synthetic cannabinoids can be severe and include anxiety, paranoia, hallucinations, increased heart rate, and more. Additionally, there have been reports of adverse health effects and hospitalizations associated with their use.
• Is 5F-AB-PINACA the same as natural cannabis (marijuana)?
• No, 5F-AB-PINACA is a synthetic compound designed to mimic the effects of natural cannabinoids found in marijuana. However, its effects and risks can be different from those of natural cannabis.
• Where can I find more information about 5F-AB-PINACA?
• For the most current and detailed information about 5F-AB-PINACA, it is recommended to consult relevant government agencies, scientific research publications, and drug control authorities in your region. Always prioritize your safety and well-being when dealing with substances of this nature.

References

1. Pfizer’s Involvement: WO 2009106980 documents the development of indazole derivatives, including 5F-AB-PINACA. This patent, published on September 3, 2009, is attributed to Pfizer.
2. Cayman Chemical Reference: The compound 5F-AB-PINACA is mentioned in Cayman Chemical, which is a widely recognized source for biochemical research.
3. Pharmacology Research: A study titled “Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs” delves into the pharmacological properties of various synthetic cannabinoids, including 5F-AB-PINACA. It was published in September 2015.
4. Metabolite Profiling: Another research article published in May 2015 explores the primary metabolites produced by pentylindole/pentylindazole synthetic cannabinoids, including AB-PINACA and its 5-fluoro analogs, such as 5F-AB-PINACA.
5. Quantification in Human Urine: A study conducted in July 2015 aimed to simultaneously quantify 37 synthetic cannabinoid metabolites in human urine through liquid chromatography-tandem mass spectrometry.
6. Chinese Legal Control: As of September 2015, China had classified 5F-AB-PINACA as a controlled substance, as indicated by the “关于印发《非药用类麻醉药品和精神药品列管办法》的通知” (Chinese notification).
7. German Controlled Substance: In Germany, 5F-AB-PINACA was listed as an Anlage II controlled substance by May 2015, according to the “Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) Anlage II” (German law).
8. Singapore’s Control: The Central Narcotics Bureau (CNB) in Singapore released a news article on April 30, 2015, regarding controlled substances, which included 5F-AB-PINACA.