Acryl fentanyl, also recognized by names such as acryloyl fentanyl or Egyptenyl, is an exceptionally potent opioid analgesic. It belongs to the fentanyl family and has been made available for purchase online as a designer drug. In animal studies, Acrylfentanyl exhibits a half maximal inhibitory concentration (IC50) of 1.4 nM, slightly surpassing the potency of fentanyl itself (1.6 nM) and offering an extended duration of action.

IUPAC name
CAS Number82003-75-6HCl: 79279-03-1
PubChem CID10314851HCl: 12782338
ChemSpider8490316HCl: 24621155
ChEMBLChEMBL1196205HCl: ChEMBL556159
Chemical and physical data
Molar mass334.463 g·mol−1

Side effects

The side effects associated with fentanyl analogs mirror those of fentanyl itself, encompassing symptoms like itching, nausea, and the potential for severe respiratory depression. This condition can pose a life-threatening risk. Fentanyl analogs have tragically claimed the lives of hundreds across Europe and the former Soviet republics, with the most recent resurgence in use dating back to Estonia in the early 2000s. Additionally, new derivatives of these substances continue to emerge, perpetuating this public health concern.
One distinguishing feature of acryl fentanyl, often used in drug discovery to create irreversibly binding covalent inhibitors, is its claim to be naloxone-resistant. However, acute intoxication studies involving mice exposed to naloxone (2 mg/kg) have revealed that acryl fentanyl can indeed be displaced from the opioid receptor.
Notably, acryl fentanyl has been associated with 20 fatalities in Sweden, along with two deaths in Denmark during the summer of 2016. These cases underscore the substantial risks associated with this synthetic opioid.

Legal status

Acrylfentanyl holds a Schedule I classification as a controlled substance in the United States, designating it as illegal for use, possession, or distribution within the country. Furthermore, since August 16, 2016, it has been officially classified as an illicit substance in Sweden.


1. What is Acrylfentanyl?

Acryl fentanyl is a synthetic opioid analgesic and a member of the fentanyl family. It is often sold online as a designer drug.

2. How is Acrylfentanyl used?

Acryl fentanyl can be consumed in various forms, such as powder or crystalline substances. It is administered through different routes, including oral ingestion, nasal inhalation, or intravenous injection. However, its use is illegal and extremely dangerous.

3. What are the effects of Acrylfentanyl?

The effects of Acrylfentanyl are similar to those of fentanyl, including potent pain relief and euphoria. However, it also poses severe risks, such as potential life-threatening respiratory depression. Users may also experience side effects like itching and nausea.

4. Is Acrylfentanyl legal?

No, Acrylfentanyl is illegal in many countries, including the United States and Sweden, where it is classified as a controlled substance. It is crucial to be aware of local laws and regulations regarding this substance.

5. Is Acrylfentanyl safe to use?

Acryl fentanyl is not safe for any use, whether recreational or medicinal. It is a highly potent opioid with a significant risk of overdose, addiction, and severe adverse effects, including fatal consequences. Its use is strongly discouraged.

6. Can Acrylfentanyl be addictive?

Yes, like other opioids, Acrylfentanyl has the potential for addiction and physical dependence. Continued use can lead to the development of tolerance and withdrawal symptoms upon cessation.

7. What are the potential dangers of Acrylfentanyl?

The dangers associated with Acrylfentanyl use include the risk of overdose and life-threatening respiratory depression. Additionally, this substance may be adulterated with impurities or other harmful substances, increasing the danger of consumption.

8. Are there any medical uses for Acrylfentanyl?

No, Acrylfentanyl is not approved for any medical or therapeutic purposes. It is primarily intended for scientific research and should not be used outside of controlled laboratory settings.

9. Where can I seek help for Acrylfentanyl-related issues?

If you or someone you know is struggling with substance abuse or addiction related to Acrylfentanyl or any other opioid, it is essential to seek professional help. Reach out to local addiction treatment centers, medical professionals, or addiction support services for guidance and support.

10. How can Acrylfentanyl-related harm be prevented?

Preventing harm associated with Acrylfentanyl involves raising awareness, educating the public, and enforcing strict legal regulations. Avoid using this substance and encourage others to do the same. Promote responsible drug use and seek assistance for addiction or substance abuse issues promptly.


  1. Acrylfentanyl: Unveiling a Synthetic Marvel Delve into the world of Acrylfentanyl, a potent synthetic opioid, and its fascinating properties.
  2. A Comprehensive Review: Insights into Acrylfentanyl In July 2017, Ujváry, Jorge, Christie, Le Ruez, Danielsson, Kronstrand, Elliott, Gallegos, Sedefov, and Evans-Brown presented a comprehensive review titled “Acryloylfentanyl, a Recently Emerged New Psychoactive Substance” in Forensic Toxicology. Their research offers a detailed exploration of this novel substance. [doi:10.1007/s11419-017-0367-8]
  3. Unveiling Acrylfentanyl: A Synthetic Opioid Discovery March 2017 witnessed the identification of a new psychoactive substance, the synthetic opioid N-phenyl-N-[1-(2-phenethyl)piperidin-4-yl]prop-2-enamide, commonly known as Acrylfentanyl. This discovery was detailed in “Drug Testing and Analysis.” [doi:10.1002/dta.2046]
  4. The Hydra Monster of Recreational Drugs: Acrylfentanyl Helander and Bäckberg, in January 2017, discussed the challenges posed by New Psychoactive Substances (NPS), referring to them as the “Hydra monster of recreational drugs.” [doi:10.1080/15563650.2016.1217003]
  5. Pharmacodynamic Exploration of Novel Fentanyl Derivatives In May 2022, Bilel, Azevedo Neto, Arfè, Tirri, Gaudio, and their colleagues conducted in vitro and in vivo pharmacodynamic studies of novel fentanyl derivatives, including Acrylfentanyl. [doi:10.1016/j.neuropharm.2022.109020]
  6. Potential Affinity Labels for the Opiate Receptor Maryanoff, Simon, Gioannini, and Gorissen’s August 1982 research explored the potential affinity labels for the opiate receptor based on compounds like fentanyl and its derivatives. [doi:10.1021/jm00350a006]
  7. Support Vector Classification in SAR Studies In January 2005, Dong, Lu, Chen, Zhu, and Chen employed support vector classification for Structure-Activity Relationship (SAR) studies of fentanyl derivatives. [doi:10.1111/j.1745-7254.2005.00014.x]
  8. Fentanyl Analogues with Modified Propanamido Group Essawi’s research in April 1999 introduced fentanyl analogues with modified propanamido groups, exploring their synthesis and in vivo activity. [Die Pharmazie, 54(4), 307–308]
  9. Exploring Potent Analgesics: Derivatives of Fentanyl Zhu, Ge, Fang, Dai, Tan, and their colleagues, in March 1981, investigated the synthesis and analgesic activity of derivatives of fentanyl. [Yao Xue Xue Bao (Acta Pharmaceutica Sinica), 16(3), 199–210]
  10. Rising Fentanyls in Europe In July 2015, Mounteney, Giraudon, Denissov, and Griffiths examined the surge of fentanyls in Europe in their article titled “Fentanyls: Are We Missing the Signs?” [doi:10.1016/j.drugpo.2015.04.003]
  11. Community Overdose Alert: PHDMC’s Concern On February 1, 2017, the Community Overdose Action Team, PHDMC, issued a noteworthy alert addressing concerns related to the use of Acrylfentanyl. []
  12. Acrylfentanyl: A Classified Drug On August 9, 2016, Acrylfentanyl was officially classified as a drug by the Rättsmedicinalverket (Forensic Medicine Agency) in Sweden. [Rättsmedicinalverket (in Swedish)]
  13. Dangerous Substance in Circulation On September 6, 2016, suspicions surrounding the circulation of Acrylfentanyl were confirmed as it was reported to be a dangerous substance. [mynewsdesk (in Danish)]
  14. DEA Drug Code: Controlled Substances List The Drug Enforcement Administration (DEA) maintains a Controlled Substances List, providing insight into the classification of various substances, including Acrylfentanyl. [Drug Enforcement Administration (DEA) (PDF)]
  15. Classification of New Substances as Narcotic Drugs In June 2016, The Public Health Authority in Sweden discussed the classification of 31 new substances as narcotic drugs or hazardous materials, potentially including Acrylfentanyl. [Folkhälsomyndigheten (The Public Health Authority) (in Swedish)]

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