Summary JWH-398 is an analgesic compound belonging to the naphthoylindole family, functioning as a cannabinoid agonist with activity at both the CB1 and CB2 receptors. It exhibits mild selectivity for CB1, demonstrating a Ki of 2.3 nM while registering 2.8 nM at CB2 receptors. The EMCDDA identified this synthetic chemical as an ingredient in three …
Summary JWH-200, also known as WIN 55,225, is a member of the aminoalkylindole family, functioning as an analgesic compound with cannabinoid receptor agonist properties. This chemical exhibits a binding affinity, denoted as Ki, of 42 nM at the CB1 receptor, a level of relationship similar to that of THC. Notably, in vivo studies revealed that …
Summary JWH-198 is a medication hailing from both the aminoalkyl indole and naphthoylindole drug families, and it functions as a cannabinoid receptor agonist. This compound was initially developed by the pharmaceutical company Sanofi-Winthrop during the early 1990s. JWH-198 exhibits a notable binding affinity for the CB1 receptor, measuring at 10 nM, approximately four times stronger …
Summary JWH-210, a member of the naphthoylindole family, is a potent analgesic compound. It is a robust cannabinoid agonist, acting on CB1 and CB2 receptors. It demonstrates a remarkable binding affinity with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. Notably, JWH-210 ranks among the most potent 4-substituted naphthoyl derivatives within …
Summary JWH-149, a synthetic cannabimimetic compound, was initially identified by John W. Huffman. This substance is the N-pentyl analog of JWH-148. Notably, it demonstrates significant binding affinity for the CB2 receptor, with a Ki (inhibition constant) of approximately 0.73 ± 0.03 nM for this subtype. Additionally, it exhibits more than six times selectivity for CB2 …
Summary JWH-122, a synthetic cannabimimetic compound, was first identified by John W. Huffman. This compound is a methylated derivative of JWH-018 and exhibits a Ki of 0.69 nM at CB1 and 1.2 nM at CB2 receptors.In January 2015, a concerning incident occurred when more than 40 individuals reportedly fell ill after consuming Rosca de Reyes, …
Summary JWH-116, a member of the naphthoylindole family, is a synthetic ligand that interacts with cannabinoid receptors. It represents the indole 2-ethyl variant of its closely related compound, JWH-018. JWH-116 exhibits a binding affinity for the CB1 receptor with a reported Ki value of approximately 52 ± 5 nM.In the United States, JWH-116, like other …
Summary JWH-098 belongs to the naphthoylindole family and is classified as a synthetic cannabinoid receptor agonist. It represents the indole 2-methyl variant of a closely related compound, JWH-081. Notably, JWH-098 exhibits distinctive binding preferences for the CB1 and CB2 receptors compared to JWH-081. While JWH-081 displays approximately tenfold selectivity for CB1 over CB2, JWH-098 reverses …
Summary JWH-081, a member of the naphthoylindole family, is an analgesic compound that functions as a cannabinoid agonist, affecting both CB1 and CB2 receptors. It exhibits a degree of selectivity for the CB1 subtype, with a Ki of 1.2nM, making its affinity for CB1 approximately 10 times greater than its affinity for CB2 (12.4nM). This …
Summary WH-073, a synthetic cannabinoid, is a member of the naphthoylindole family known for its analgesic properties. It functions as a partial agonist at both the CB1 and CB2 cannabinoid receptors, displaying a degree of selectivity for the CB1 subtype, with approximately 5 times the affinity for CB1 compared to CB2. The abbreviation “JWH” represents …
