Summary JWH-019, a member of the naphthoylindole family, is recognized as an analgesic compound acting as a cannabinoid agonist at both CB1 and CB2 receptors. Notably, it is the N-hexyl homolog of the known synthetic cannabinoid JWH-018. In contrast to…
Summary JWH-015, a member of the naphthoylindole family, functions as a cannabinoid agonist with subtype selectivity. Notably, it exhibits a high affinity for CB2 receptors, with a binding relationship of 13.8 nM, while its affinity for CB1 receptors is notably…
Summary JWH-007, a member of the naphthoylindole family, is a chemical compound primarily recognized for its analgesic properties. It functions as a cannabinoid agonist, engaging both CB1 and CB2 receptors. This compound was initially documented in 1994, and its discovery…
Summary FUB-JWH-018, sometimes referred to as FUB-018, is a synthetic cannabinoid derived from naphthoylindole. It can be described as a molecular hybrid, combining elements of JWH-018 and AB-FUBICA or ADB-FUBICA. Identifiers IUPAC name CAS Number 2365471-45-8 ChemSpider 34450892 UNII U0Z5KO073G…
Summary EAM-2201, also known as 4′-ethyl-AM-2201, 5″-fluoro-JWH-210, or SGT-14, is a substance believed to function as a potent agonist for cannabinoid receptors. This compound was not documented in scientific or patent literature until Japanese laboratories initially detected it in July…
Summary AM-2232, known chemically as 1-4-cyclobutyl)-3-(naphthalene-1-oyl)indole, is a potent yet non-specific agonist for cannabinoid receptors. It exhibits a Ki of 0.28 nM at CB1 and 1.48 nM at CB2, indicating its affinity for these receptor types.In the United States, all…
Summary AM-1235, also known as 1-(5-fluorophenyl)-3-(naphthalene-1-oyl)-6-nitroindole, is a potent and moderately selective agonist targeting the cannabinoid receptor CB1. Identifiers IUPAC name CAS Number 335161-27-8 ChemSpider 26633899 UNII 2HV9AH611M CompTox Dashboard (EPA) DTXSID10187159 Chemical and physical data Formula C24H21FN2O3 Molar mass…
Summary AM-1221 is a potent and selective agonist that primarily targets the cannabinoid receptor CB2, exhibiting a remarkable Ki of 0.28 nM at CB2 and 52.3 Nm at CB1. This translates to an approximately 180-fold preference for CB2 over CB1.…
Summary AM-1220 is recognized for its potent and moderately selective agonistic effects on the cannabinoid receptor CB1, demonstrating approximately 19-fold selectivity for CB1 compared to the related CB2 receptor. This compound initially emerged in the early 1990s as a creation…
Summary AM-1248 is a compound with disputed potency and selectivity, acting as a moderately potent agonist for both cannabinoid receptors CB1 and CB2. When the typical 3-(1-naphthyl) group found in many indole-derived cannabinoid ligands is replaced with an adamantyl group,…
