The proliferation of research chemicals in the market has given rise to many sellers and vendors, including those offering 2C-B-FLY, a designer drug with psychedelic properties. While scientists and researchers need to access such compounds for legitimate studies, the online marketplace for these substances remains a double-edged sword.
One of the significant advantages of buying 2C-B-FLY from online vendors is convenience. Researchers can access various research chemicals with just a few clicks. However, the ease of purchase often comes at the cost of quality and safety. The unregulated nature of the market means that not all sellers can be trusted.
It’s critical to exercise caution when choosing a seller for 2C-B-FLY or any other research chemical. Not all vendors adhere to strict quality control standards, potentially jeopardizing the integrity and reliability of scientific studies. Researchers must seek reputable sellers with detailed product information, including purity levels, batch testing results, and safety precautions.
Moreover, the legality of 2C-B-FLY varies from one region to another. Purchasing this designer drug without knowing local regulations can lead to legal consequences. Responsible vendors should provide clear guidance on the legal status of their products in different jurisdictions to ensure researchers comply with the law.
In addition to legality, pricing is another critical aspect to consider. Some sellers may offer 2C-B-FLY at exorbitant prices, taking advantage of the high demand for research chemicals. Researchers should compare prices among different vendors to ensure they get a fair deal.
- 1 Summary
- 2 History and culture
- 3 Chemistry
- 4 Pharmacology
- 5 Subjective effects
- 6 Toxicity
- 7 Legal status
- 8 FAQ
- 8.1 1. What is 2C-B-FLY?
- 8.2 2. What are the effects of 2C-B-FLY?
- 8.3 3. Is 2C-B-FLY safe to use?
- 8.4 4. Can 2C-B-FLY be addictive?
- 8.5 5. What is the recommended dosage for 2C-B-FLY?
- 8.6 6. How long do the effects of 2C-B-FLY last?
- 8.7 7. Are there any dangerous interactions with 2C-B-FLY?
- 8.8 8. Is 2C-B-FLY legal?
- 8.9 9. Can 2C-B-FLY cause tolerance?
- 8.10 10. How can I reduce the risks associated with using 2C-B-FLY?
- 9 References
2C-B-FLY is a relatively lesser-known psychedelic compound categorized within the phenethylamine and benzodihydrodifuran classes. Its administration induces a diverse spectrum of psychedelic and entactogenic effects. Some liken its effects to a fusion of traits reminiscent of 2C-B, mescaline, and MDA. Its effects typically span 6 to 8 hours, with the potential for extended experiences of up to 12 hours at higher dosages.
Within the 2C-x family of psychedelic phenethylamines, where 2C-B is its closest relative, 2C-B-FLY stands apart due to significant differences in potency, metabolic pathways, and potential toxicity. This unique compound was initially synthesized by Aaron P. Monte in 1996.
In the mid-2000s, 2C-B-FLY debuted and generated some interest within the online market for research chemicals. However, its presence significantly diminished in October 2009 following a tragic incident. During this period, a mislabeled batch of Bromo-DragonFLY (measured in micrograms, unlike 2C-B-FLY, which is dosed in milligrams) led to two fatalities as individuals inadvertently consumed lethal overdoses of Bromo-DragonFLY, mistaking it for a standard dose of 2C-B-FLY. This unfortunate event resulted in the immediate withdrawal of 2C-B-FLY from the market. It later reemerged around 2016.
Remarkably, data concerning the pharmacological properties, metabolism, and toxicity of 2C-B-FLY are scarce. Additionally, its history of human usage remains notably limited. Street-level sales of this substance are undocumented, with online research chemical vendors being its primary distribution source.
Given its marked potency and the sensitivity of its dose response, numerous reports emphasize the importance of distinguishing the effects of 2C-B-FLY from a mere substitute for 2C-B. Individuals contemplating its use are strongly urged to cautiously approach this formidable, long-lasting, and unpredictable hallucinogenic substance. Employing appropriate harm reduction strategies and taking necessary precautions becomes imperative when engaging with 2C-B-FLY.
|show IUPAC name|
|CompTox Dashboard (EPA)||DTXSID00170510|
|Chemical and physical data|
|Molar mass||284.153 g·mol−1|
History and culture
In a 2007 interview featured in a MAPS newsletter, Ann Shulgin disclosed her fondness for 2C-B-FLY, considering it one of her preferred psychedelic substances. She also acknowledged that this compound exhibited a notably wide range of user responses.
Ann Shulgin said, “I frequently mentioned that something called 2CB Fly (sic) was delightful for me. I found it to be an exquisite experience, particularly in eroticism. However, I realized that my enthusiasm didn’t resonate with others. I noticed that by sharing my positive experiences, I inadvertently sparked curiosity. The internet became inundated with discussions about 2CB Fly (sic), and people began to inquire about it. To my chagrin, it was a letdown for most individuals.”
2C-B-FLY represents a substituted compound situated within the phenethylamine and dihydrobenzofuran chemical categories. This intriguing molecule consists of a phenyl ring linked to an amino (NH2) group through an ethyl chain and encompasses a bromine atom attached to carbon R4 of the phenyl ring.
This substance is an unconventional psychedelic phenethylamine, closely akin to 2C-B. It functions as the dihydrofuran counterpart of 2C-B, integrating the methoxy groups connected to R2 and R5 of 2C-B into five-member dihydrofuran rings fused to the central benzene ring.
Within the realm of phenethylamine derivatives, 2C-B-FLY finds its place in the category known as the FLY compounds, named for their distinctive resemblance to insect wings. These compounds feature two tetrahydrofuran rings that assume a wing-like formation adjoined on opposite sides of the central benzene ring. The strategic placement of the two methoxy groups within the five-member rings ensures optimal receptor binding, resulting in heightened potency compared to the less rigid structure of its counterpart, 2C-B.
2C-B-FLY represents a psychedelic phenethylamine, and it serves as the dihydrodifuran counterpart of 2C-B.
While our understanding of the comprehensive mechanism behind its effects remains limited, it is hypothesized that 2C-B-FLY’s psychedelic impact stems from its activity at the 5-HT2A receptor, acting as a partial agonist. Nevertheless, the precise nature of these interactions and their contribution to the psychedelic experience continue to be the focus of ongoing scientific inquiry.
Compared to 2C-B, this compound exhibits significantly heightened physical sensations, intensified visual effects, more intricate geometric patterns, and profound internal hallucinations akin to substances like mescaline, 2C-E, or MDA at higher doses. Lower doses tend to lean towards entactogenic effects rather than the classic psychedelic experience.
Please note that the effects listed below are based on the Subjective Effect Index (SEI), a collection of anecdotal user reports and personal observations from contributors to PsychonautWiki. As such, they should be approached with a degree of skepticism.
It’s also important to recognize that these effects may not manifest consistently or predictably, with higher doses more likely to encompass the full spectrum of effects. Higher doses also increase the risk of adverse effects, including addiction, severe harm, or even death ☠.
- Stimulation and Sedation: This compound provides gentle stimulation at lower dosages, similar to 2C-B or mescaline. At higher doses, it can become uncomfortably stimulating with undertones of sedation, resembling the effects of 2C-C or 2C-T-7.
- Spontaneous Physical Sensations: The “body high” of 2C-B-FLY is described as a pleasant, warm, all-encompassing tingling sensation, resembling milder experiences with mescaline, 2C-B, or 2C-E.
- Physical Euphoria
- Tactile Enhancement
- Temperature Regulation Suppression: Compared to 2C-B, this effect is more pronounced and unpredictable with small dosage increases.
- Increased Bodily Temperature
- Enhanced Bodily Control
- Bodily Pressures
- Increased Blood Pressure
- Increased Libido
- Headaches: More commonly reported than with 2C-B or other traditional phenethylamines.
- Muscle Cramps
- Stomach Bloating
- Stomach Cramps
- Difficulty Urinating
- Excessive Yawning
- Watery Eyes
- Pupil Dilation
- Teeth Grinding
- Color Enhancement
- Pattern Recognition Enhancement
- Visual Acuity Enhancement
- Drifting (melting, breathing, morphing, flowing): Described as highly detailed, slow, smooth, intricate, and somewhat unrealistic, similar to 2C-B or mescaline.
- After Images
- Colour Shifting
- Depth Perception Distortions
- Perspective Distortions
- Symmetrical Texture Repetition
- Geometry: The visual geometry resembles mescaline, 2C-B, and 2C-D, characterized by intricate complexity, abstract forms, synthetic styling, structured organization, bright multicolored schemes, glossy shading, flat edges, large size, rapid movement, smooth flow, angular corners, shallow depth, and consistent intensity. At higher doses, it may transition into level 8B visual geometry.
- Hallucinatory States: Comparable to mescaline or moderate doses of 2C-E, offering more consistent and reproducible effects. Typically, it occurs at heavier doses and blends seamlessly with the geometric visuals, including transformations and internal hallucinations (autonomous entities, scenes, perspectives, scenarios, and plots).
- Standard and Sober Thought Structure: Users often maintain a relatively straightforward thought structure despite the intensity of accompanying effects. This allows for more control than compounds like 4-AcO-DMT or LSD.
- Conceptual Thinking
- Creativity Enhancement
- Emotion Enhancement
- Empathy, Affection, and Sociability Enhancement: This compound elicits entactogenic effects similar in quality to mescaline or 2C-E, albeit less intense than 2C-B or MDMA.
- Increased Libido
- Increased Music Appreciation
- Increased Sense of Humor
- Memory Suppression
- Novelty Enhancement
- Thought Acceleration
- Time Distortion
- The offset effects of this compound resemble those of a mild stimulant or entactogen, often perceived as negative and uncomfortable compared to the peak experience. These effects include headaches, diarrhea, cognitive fatigue, motivation suppression, and thought deceleration.
The toxicity and long-term health consequences of recreational 2C-B-FLY use have not been scientifically investigated due to its status as a research chemical with limited human usage history. As a result, the exact toxic dosage remains unknown.
Anecdotal reports from individuals in the community who have experimented with 2C-B-FLY suggest that trying the substance at low to moderate doses on its own is not associated with apparent adverse health effects. However, absolute certainty cannot be guaranteed. It is essential, however, to conduct independent research to ensure the safety of combining two or more substances before consumption.
It is highly recommended to practice harm reduction when using this substance.
Tolerance and Addiction Potential:
2C-B-FLY is not considered habit-forming, and repeated use may decrease the desire to use it. It typically self-regulates.
Tolerance to the effects of 2C-B-FLY builds almost immediately after ingestion. Subsequently, it takes approximately three days for the tolerance to reduce by half and about seven days to return to baseline (assuming no further consumption). Notably, 2C-B-FLY produces cross-tolerance with all psychedelics, meaning that after using 2C-B-FLY, the effects of other psychedelics will be diminished.
Warning: Many psychoactive substances, which are reasonably safe when used individually, can become hazardous and even life-threatening when combined with specific other substances. The following list highlights some known dangerous interactions (though it may not cover all possibilities).
Always conduct independent research (e.g., through Google, DuckDuckGo, PubMed) to ensure the safety of combining two or more substances. Some of the interactions listed below have been sourced from TripSit.
- Lithium: Lithium, typically prescribed for bipolar disorder treatment, is known to significantly increase the risk of psychosis and seizures when used with psychedelics. This combination is strongly discouraged.
- Cannabis: Cannabis can unexpectedly amplify and unpredictably interact with the effects of 2C-B-FLY. Caution is advised due to the potential for increased risk of adverse psychological reactions such as anxiety, paranoia, panic attacks, and psychosis. Users should start with a fraction of their usual cannabis dose and take extended breaks between hits to minimize the risk of unintentional overdose.
- Stimulants: Stimulants like amphetamine, cocaine, or methylphenidate have wide-ranging effects on the brain and alter dopaminergic function. Combining these with 2C-B-FLY can elevate the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also increase the risk of mania and psychosis.
- Tramadol: Tramadol is known to lower the seizure threshold, and psychedelics can potentially trigger seizures in susceptible individuals.
- Potential MAO-Altering Effects: If 2C-B-FLY has suspected monoamine oxidase (MAO)-altering effects, it might raise the risk of serotonin syndrome or general monoamine overload, particularly at high doses, when combined with MAOIs, stimulants, or substances that modulate neurotransmitter levels like serotonin, dopamine, and norepinephrine through unknown mechanisms. Some of these substances include but are not limited to:
- Harmala alkaloids
Austria: The possession, production, and sale of 2C-B-FLY are prohibited under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
Canada: 2C-B-FLY would be categorized as Schedule III due to its relationship with 2,5-dimethoxyphenethylamine.
Germany: 2C-B-FLY has been under the NpSG’s (New Psychoactive Substances Act) control since November 26, 2016. Producing and importing it for market purposes, administering it to others, and engaging in trading are punishable offenses. While possession is illegal, it is not penalized.
Italy: 2C-B-FLY is classified as a Schedule I substance, making possessing, producing, selling, or purchasing illegal.
Sweden: As of April 2018, Swedish law prohibits the possession, sale, purchase, and use of 2C-B-FLY.
Switzerland: The status of 2C-B-FLY in Switzerland is unclear, as it does not neatly fit the definition of a substituted phenethylamine. Its classification depends on specific criteria, such as whether it can be considered an alkoxy derivative or an ether analog, which may place it under regulation.
The Netherlands: In the Netherlands, 2C-B-FLY is legally available as a research chemical, but it is explicitly not meant for human consumption.
Turkey: 2C-B-FLY is classified as a drug in Turkey and is illegal to possess, produce, supply, or import.
United Kingdom: The Psychoactive Substance Act, effective since May 26, 2016, makes it illegal to produce, supply, or import 2C-B-FLY in the United Kingdom.
United States: 2C-B-FLY is currently unscheduled and uncontrolled in the United States. However, if it is intended for human consumption and bears similarity to 2C-B, it may fall under the scope of the Federal Analogue Act.
1. What is 2C-B-FLY?
2C-B-FLY is a psychedelic phenethylamine compound that is structurally related to 2C-B. It is known for its psychedelic effects and is considered a research chemical due to its limited history of human usage.
2. What are the effects of 2C-B-FLY?
The effects of 2C-B-FLY can vary depending on the dose. At lower doses, it may produce entactogenic effects, while at higher doses, it can lead to more intense psychedelic experiences. Effects may include visual distortions, altered thinking, enhanced creativity, and changes in perception.
3. Is 2C-B-FLY safe to use?
The safety of 2C-B-FLY is not well-established due to its limited research. While anecdotal reports suggest that low to moderate doses may not have significant adverse health effects, it’s crucial to exercise caution and practice harm reduction when using any psychoactive substance.
4. Can 2C-B-FLY be addictive?
2C-B-FLY is generally not considered habit-forming, and users may not experience a strong desire to use it repeatedly.
5. What is the recommended dosage for 2C-B-FLY?
Dosage recommendations can vary widely, and it’s essential to start with a low dose and proceed cautiously. Due to variations in individual tolerance and sensitivity, there is no one-size-fits-all answer. Always follow harm reduction principles and do thorough research before use.
6. How long do the effects of 2C-B-FLY last?
The effects of 2C-B-FLY typically last for several hours, with the peak experience occurring within the first few hours and gradually diminishing afterward. The duration can vary based on the dose and individual factors.
7. Are there any dangerous interactions with 2C-B-FLY?
Yes, there are potentially dangerous interactions. Combining 2C-B-FLY with other substances, such as lithium, cannabis, stimulants, or substances that modulate neurotransmitter levels, can increase the risk of adverse reactions. Always research potential interactions thoroughly.
8. Is 2C-B-FLY legal?
Legal status can vary by country and region. In many places, 2C-B-FLY falls into a legal gray area due to its status as a research chemical. Always check the local laws and regulations regarding its possession and use.
9. Can 2C-B-FLY cause tolerance?
Yes, tolerance to 2C-B-FLY can develop rapidly, often after a single use. Afterward, it takes a few days for the tolerance to decrease by half and about a week to return to baseline. Additionally, 2C-B-FLY may produce cross-tolerance with other psychedelics.
10. How can I reduce the risks associated with using 2C-B-FLY?
To reduce potential risks, follow these guidelines:
- Start with a low dose.
- Use in a safe and comfortable environment.
- Have a trusted friend with you, preferably someone experienced with psychedelics.
- Research potential interactions with other substances.
- Stay hydrated and ensure you have access to water.
- Avoid driving or operating heavy machinery while under the influence.
- Be aware of your mental state and seek professional help if needed.
- The Erowid 2C-B-Fly Vaults: Exploring 2C-B-FLY
- Erowid’s 2C-B-Fly Vault: A Chronicle of 2009’s Tragic Endings
- “A Profound Dialogue with Ann Shulgin on Psychedelics and Personal Revelation” (PDF). Published in MAPS Journal, Volume 17, Issue 2, pages 23–24, 2007.
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). “Seizures Unleashed by Tramadol: A Dose-Independent Phenomenon.” Journal of Medical Toxicology. Volume 5, Issue 2, pages 63–67. doi:10.1007/BF03161089. ISSN 1556-9039.
- Gallardo-Godoy, A., Fierro, A., McLean, T. H., Castillo, M., Cassels, B. K., Reyes-Parada, M., Nichols, D. E. (April 1, 2005). “Unlocking the Secrets of Sulfur-Substituted α-Alkyl Phenethylamines: Potent MAO-A Inhibitors.” Journal of Medicinal Chemistry. Volume 48, Issue 7, pages 2407–2419. doi:10.1021/jm0493109. ISSN 0022-2623.
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) | Canadian Legislation: URL
- “Combatting the Proliferation of Novel Psychoactive Substances Act” (PDF) (in German). Published by Bundesanzeiger Verlag. Retrieved on December 11, 2019.
- “Anlage NpSG” (in German). Published by Bundesministerium der Justiz und für Verbraucherschutz. Retrieved on December 11, 2019.
- “§ 4 NpSG” (in German). Published by Bundesministerium der Justiz und für Verbraucherschutz. Retrieved on December 11, 2019.
- Nyhetsarkiv — Folkhälsomyndigheten (News Archive – Public Health Agency of Sweden)
- “Regulation by the Federal Department of Home Affairs on Lists of Narcotic Drugs, Psychotropic Substances, Precursors, and Auxiliary Chemicals” (in German). Published by Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved on January 1, 2020.
- Turkish Official Gazette: URL
- Turkish Official Gazette (PDF): URL
- Psychoactive Substances Act 2016: Legislation Addressing Novel Psychoactive Substances
- Drug Control: A Summary of P.L. 99-570, the Anti-Drug Abuse Act of 1986 (Focus on Drug-Related Provisions) – 1986 Bill.
- “Controlled Substances: Classified by CSA Schedule” (PDF). Published by the U.S. Department of Justice. November 18, 2021, page 1.