- 1 Summary
- 2 Legality
- 3 FAQ
- 3.1 1. What is 3-Chloromethcathinone (3-CMC)?
- 3.2 2. How has 3-CMC been marketed?
- 3.3 3. What is the legal status of 3-CMC in different countries?
- 3.4 4. What is known about the pharmacology of 3-CMC?
- 3.5 5. Are there any health risks associated with 3-CMC use?
- 3.6 6. Is 3-CMC used for any medical purposes?
- 4 References
3-Chloromethcathinone, commonly called 3-CMC or clophedrone, is a stimulant in the cathinone class. It has been marketed online as a designer drug, primarily in European nations like Ireland, Italy, Poland, and Sweden.
The specific pharmacological actions of 3-CMC remain unclear, but it is believed to function as a dopamine and serotonin-releasing agent. Its chemical structure shares some similarities with bupropion and even more closely resembles para-chloromethamphetamine, a compound known to have neurotoxic properties. Research conducted in mice suggests that 3-CMC may also have neurotoxic effects.
|CompTox Dashboard (EPA)||DTXSID501014162|
|Chemical and physical data|
|Molar mass||197.66 g·mol−1|
- In October 2015, 3-CMC became classified as a controlled substance in China.
- As of April 2019, Sweden categorized 3-CMC as a dangerous and prohibited drug.
- As of March 2023, 3-CMC was designated as a controlled substance in Romania.
1. What is 3-Chloromethcathinone (3-CMC)?
- 3-CMC is a synthetic stimulant substance in the cathinone class, which includes various compounds with stimulant properties. It is often encountered as a research chemical or designer drug.
2. How has 3-CMC been marketed?
- 3-CMC has been sold online, particularly as a designer drug. It has been available in various forms and marketed as a recreational substance.
3. What is the legal status of 3-CMC in different countries?
- The legal status of 3-CMC varies from country to country and can change over time. As of the most recent information available:
- In October 2015, 3-CMC was classified as a controlled substance in China.
- As of April 2019, it was categorized as a dangerous and prohibited drug in Sweden.
- As of March 2023, 3-CMC became a controlled substance in Romania.
- It’s crucial to check local laws and regulations in your area for the most up-to-date information regarding the legal status of 3-CMC.
4. What is known about the pharmacology of 3-CMC?
- The exact pharmacological properties of 3-CMC need to be better understood. However, it is believed to function as a dopamine and serotonin-releasing agent, similar to many other cathinone derivatives. Further research is needed to elucidate its pharmacological effects fully.
5. Are there any health risks associated with 3-CMC use?
- Due to limited scientific research, the potential health risks of 3-CMC are not well-documented. Like other stimulant substances, it may carry risks such as increased heart rate, blood pressure, and potential for addiction. Its neurotoxicity has been suggested in studies involving mice.
6. Is 3-CMC used for any medical purposes?
- As of my last knowledge update in September 2021, 3-CMC had no recognized medical applications and was primarily encountered as a recreational or designer drug.
Please note that the legal and scientific landscape surrounding 3-CMC may have evolved since my last update in September 2021. Stay informed about this compound’s latest developments and regulations if you have any concerns or interests in its use or research.
- In August 2016, Odoardi S, Romolo FS, and Strano-Rossi S conducted a study titled “A snapshot on NPS in Italy: Distribution of drugs in seized materials analyzed in an Italian forensic laboratory in the period 2013-2015.” This research was published in Forensic Science International (Volume 265) and can be referenced with the DOI: 10.1016/j.forsciint.2016.01.037. It is also available through hdl:10446/145558. The PMID is 26874736.
- In February 2019, Błażewicz A, Bednarek E, Popławska M, and others conducted research on the “Identification and structural characterization of synthetic cathinones.” The study covered various compounds, including N-propylcathinone, 2,4-dimethylmethcathinone, and others. It was published in Forensic Toxicology (Volume 37, Issue 2) and can be accessed with the DOI: 10.1007/s11419-018-00463-w.
- Killeen, N., McNamara, S., Stokes, S, & Keenan, E conducted the “Safer Nightlife Programme 2022” and published the results in a report by the National Social Inclusion Office, Health Service Executive [HSE] of Ireland. The ISBN is 978-1-898098-08-9.
- Wojcieszak, Jakub, Kuczyńska, Katarzyna, and Zawilska, Jolanta conducted research on four synthetic cathinones, including 3-Chloromethcathinone, and their effects on mice’s spontaneous locomotor activity and motor performance. The research was published in Neurotoxicity Research.
- The “关于印发《非药用类麻醉药品和精神药品列管办法》的通知” was issued by the China Food and Drug Administration on September 27, 2015, concerning the management of non-medical narcotics and psychotropic substances.
- On April 5, 2019, Åtta nya ämnen (eight new substances) were classified as narcotics.
- “Legea nr. 143/2000 privind prevenirea şi combaterea traficului şi consumului ilicit de droguri. Legea nr. 194/2011 privind combaterea operaţiunilor cu produse susceptibile de a avea efecte psihoactive – modificări (Legea nr. 45/2023)” is a legal document in Romanian that pertains to the prevention and combat of illicit drug trafficking and consumption. It was last retrieved on March 24, 2023.