The online market for research chemicals, including substances like 4-HO-MET, is a complex and potentially risky landscape. While it is crucial for scientific research and exploration, evaluating the seller’s credibility when considering a purchase is equally important.
One of the primary concerns when buying 4-HO-MET or any other research chemical online is the authenticity and reliability of the vendor. Unfortunately, numerous unscrupulous sellers are offering these designer drugs for sale. These vendors often prioritize profit over safety, potentially jeopardizing the integrity of scientific research and the well-being of individuals.
A critical review of 4-HO-MET research chemical sellers should consider the following aspects:
- Product Quality: Reputable sellers should provide high-quality research chemicals with accurate chemical compositions. However, some vendors may offer adulterated or impure substances, putting the scientific community at risk.
- Transparency: Trustworthy sellers are transparent about the source, purity, and potential risks associated with their products. A lack of transparency can be a red flag, indicating the vendor’s intentions.
- Safety Measures: Responsible vendors prioritize safety by providing guidelines for safe handling, storage, and disposal of research chemicals. They should also discourage any form of human consumption.
- Compliance: Legitimate vendors adhere to legal regulations surrounding research chemicals and ensure their products are intended solely for research purposes. Unscrupulous sellers may need to pay more attention to these regulations.
- Customer Reviews: Reading customer reviews and seeking recommendations from trusted sources can help evaluate a seller’s reputation and reliability.
Contents
- 1 Abstract
- 2 Chemistry
- 3 Dosage
- 4 Pharmacology
- 5 Subjective Effects
- 6 Physical Effects of 4-HO-MET
- 7 Cognitive Effects
- 8 Visual Effects
- 9 Combination Effects Cannabis:
- 10 Toxicity
- 11 Tolerance
- 12 Legal Status Austria:
- 13 FAQ
- 13.1 1. What is 4-HO-MET?
- 13.2 2. How does 4-HO-MET work?
- 13.3 3. Is 4-HO-MET legal?
- 13.4 4. What are the effects of 4-HO-MET?
- 13.5 5. Is 4-HO-MET safe to use?
- 13.6 6. Where can I get 4-HO-MET?
- 13.7 7. Are there any known side effects of 4-HO-MET?
- 13.8 8. Can 4-HO-MET be detected in drug tests?
- 13.9 9. Is there any legitimate research on 4-HO-MET?
- 13.10 10. What precautions should I take when using 4-HO-MET?
- 14 References
Abstract
4-Hydroxy-N-methyl-N-ethyltryptamine, also known as “color,” “methylcybin,” “metocin,” and “4-HO-MET,” belongs to the lesser-known category of novel psychedelic compounds within the tryptamine class. Its structural similarity to psilocin, the active compound found in magic mushrooms, suggests that its effects are likely mediated through serotonin receptor binding in the brain.
The synthesis of 4-HO-MET can be credited to the American chemist Alexander Shulgin, who extensively detailed it in his 1997 publication, “TiHKAL” (Tryptamines I Have Known and Loved). Human reports of its use began to emerge in the late 2000s, coinciding with its availability on the online research chemical market. It has been sold alongside other psilocybin analogs like 4-AcO-DMT and 4-HO-MiPT.
The subjective experiences associated with 4-HO-MET encompass geometric visual hallucinations, distortions of time perception, enhanced introspection, and a sense of ego dissolution. Users often describe it as a recreational alternative to psilocybin mushrooms or psilocin (4-HO-DMT), mainly due to its lighter psychological effects and greater emphasis on visual phenomena. The reported psychedelic visuals are often described as vivid and rich in color.
| Clinical data | |
|---|---|
| Other names | 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol; 4-Hydroxy-N-methyl-N-ethyltryptamine; Colour |
| Identifiers | |
| showIUPAC name | |
| CAS Number | 77872-41-4 |
| PubChem CID | 21786582 |
| ChemSpider | 10513072 |
| UNII | 6RN01B78NY |
| CompTox Dashboard (EPA) | DTXSID70228491 |
| Chemical and physical data | |
| Formula | C13H18N2O |
| Molar mass | 218.300 g·mol−1 |
Chemistry
4-HO-MET, scientifically known as 4-hydroxy-N-ethyl-N-methyltryptamine, belongs to the synthetic indole alkaloid group within the tryptamine chemical classification. Tryptamines, in general, possess a fundamental structure characterized by a bicyclic indole heterocycle bonded at R3 to an amino group via an ethyl side chain. The case of 4-HO-MET, it is distinguished by the presence of a hydroxyl functional group (OH−) at R4 of its indole heterocycle. Additionally, it includes a methyl group and an ethyl chain attached to the terminal amine RN of its tryptamine framework (MET).
4-HO-MET serves as a 4-hydroxy counterpart to 4-AcO-MET and represents the N-substituted ethyl variant of psilocin (4-HO-DMT). Furthermore, it acts as the 4-hydroxyl analog of the foundational tryptamine compound, MET.
Dosage
| Dosage | |
|---|---|
| Threshold | 5 mg |
| Light | 5 – 15 mg |
| Common | 15 – 25 mg |
| Strong | 25 – 45 mg |
| Heavy | 45 mg + |
| Duration | |
| Total | 4 – 6 hours |
| Onset | 15 – 40 minutes |
| Come up | 30 – 60 minutes |
| Peak | 2 – 3 hours |
| Offset | 1 – 1.5 hours |
| After effects | 2 – 12 hours |
Pharmacology
Additional insights:
Serotonergic psychedelics The psychedelic effects attributed to 4-HO-MET are thought to arise through its partial agonistic activity at the 5-HT2A receptor. Nevertheless, the precise mechanisms of these interactions and their contribution to the psychedelic encounter continue to be under continuous scientific scrutiny and exploration.
| Binding Sites | Binding Affinity Ki (μM)[7] |
|---|---|
| 5-HT1A | 0.228 |
| 5-HT2A | 0.057 |
| 5-HT2C | 0.141 |
| D1 | >25 |
| D2 | 4 |
| D3 | 6.7 |
| α1A | 9.7 |
| α2A | 2.4 |
| TAAR1 | 3.1 |
| H1 | 0.82 |
| SERT | 0.2 |
| DAT | >26 |
| NET | 13 |
Subjective Effects
A substantial collection of anecdotal accounts suggests that the effective dosage can exhibit significant variation. Some users have reported profound experiences with doses as low as 17mg, while others have described milder effects even with doses as high as 30 mg. These variations may be attributed to individual variances in neurochemistry and metabolism and disparities in batch quality and physical forms (such as HCl versus fumarate salt).
The reported experiences typically involve hallucinatory states that manifest in waves of euphoria, alternating between moments of clarity and intense visual phenomena. Due to its pronounced visual effects and relatively mild cognitive distress, 4-HO-MET is often characterized as a recreational and pragmatic alternative to psilocybin mushrooms, sharing thematic similarities in its visual effects.
Physical Effects of 4-HO-MET
Stimulation:
4-HO-MET primarily induces stimulation, although it can also elicit relaxation and a sense of stoning. This sets it apart from tryptamines like psilocybin and 4-AcO-DMT, which tend to be primarily sedating.
Spontaneous Bodily Sensations:
The “body high” associated with 4-HO-MET can be characterized as a pleasurable, warm, soft, and all-encompassing tingling sensation. This sensation remains consistently present, gradually intensifying after the onset and reaching its peak during the experience’s zenith.
Changes in Felt Bodily Form:
This effect often accompanies feelings of warmth or unity and typically occurs during or immediately after the peak of the experience. Users may perceive themselves as physically connected to or merged with other objects, creating a seamless sense of continuity. This is commonly reported as comfortable, tranquil, and mindful, although it can manifest as bodily tension.
Nausea:
Nausea associated with 4-HO-MET can be significantly reduced or completely avoided if the individual consumes the substance on an empty stomach. It is sometimes recommended to abstain from eating for approximately 6 to 8 hours beforehand or to have a light meal 2 hours prior, especially if the user feels physically fatigued or undernourished. The nausea induced by 4-HO-MET is generally considered less pronounced than that of psilocybin mushrooms, possibly due to the absence of fungal matter that the body has to digest when consuming the isolated synthetic form.
Temperature Regulation Suppression: 4-HO-MET can lead to fluctuations in the user’s internal perception of temperature, resulting in sudden episodes of uncomfortable coldness or warmth.
Muscle Contractions:
Muscle contractions occasionally experienced with 4-HO-MET tend to be brief and benign, differing from many other tryptamines, phenethylamines, and lysergamides.
Increased Heart Rate
Olfactory Hallucination
Pupil Dilation
Increased Salivation
Excessive Yawning:
This effect appears particularly pronounced among psilocin and related tryptamines. It can occur less with LSD and rarely with psychedelic phenethylamines like mescaline. Typically, it coincides with watery eyes.
Watery Eyes:
Teeth Grinding: Teeth grinding with 4-HO-MET is notably less intense compared to substances like MDMA, but it occurs more readily than with related substances such as psilocin or psilocybin, possibly due to the higher degree of stimulation it induces.
Brain Zaps:
Brain zaps are infrequent and affect only those susceptible to them. They are less common and intense than those associated with serotonin-releasing agents like MDMA.
Cognitive Effects
Many users describe the mental effects of 4-HO-MET as somewhat relaxing yet brisk in style, bearing similarities to psychedelics like LSD or 2C-B, known for their cognitive vitality and stimulation.
- Analysis Enhancement
- Conceptual Thinking
- Delusion
- Autonomous Voice Communication
- Memory Suppression
- Ego Dissolution
- Analysis Enhancement: This effect consistently enhances analytical thinking and leans toward outward-focused contemplation.
- Novelty Enhancement
- Immersion Enhancement
- Creativity Enhancement
- Heightened Music Appreciation
- Enhanced Sense of Humor
- Laughter Fits
- Suppression of Personal Biases
- Accelerated Thought Processes
- Enhanced Thought Connectivity
- Thought Loops
- Time Distortion
- Increased Wakefulne
Visual Effects
4-HO-MET is frequently reported to induce visual effects with minimal associated cognitive effects or “head space,” particularly at lower doses. Enhancements: Color, Enhancement, Pattern, Recognition, Enhancement, Visual, Acuity, Enhancement
Distortions:Hallucinatory States:
4-HO-MET and its various forms consistently induce a wide range of high-level hallucinatory states, often more reliably than many other commonly used psychedelics. These effects typically encompass:Transformations Internal Hallucinations (Autonomous Entities, Settings, Sceneries, Landscapes, Perspective Hallucinations, Scenarios, and Plots): These experiences are remarkably consistent in dark environments at appropriately high doses. They can be described as vividly believable, interactive, novel, autonomously controllable, geometry-based, and predominantly featuring themes of personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or metaphysical nature.External Hallucinations (Autonomous Entities, Settings, Sceneries, Landscapes, Perspective Hallucinations, Scenarios, and Plots): These experiences are vividly believable, interactive, novel, autonomously controllable, geometry-based, and predominantly feature themes of personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or metaphysical nature.
Combination Effects Cannabis:
When combined with cannabis, both the visual and cognitive effects of 4-HO-MET can be significantly heightened and prolonged, but this should be approached with great caution. Particularly for those inexperienced with psychedelics, this combination can amplify not only the positive aspects but also the potential for anxiety, confusion, and psychosis associated with cannabis.
Dissociatives:
When used alongside dissociatives, the geometric patterns, euphoria, dissociation, and hallucinatory effects of 4-HO-MET often experience a substantial boost. The presence of dissociative-induced holes, spaces, and voids, while under the influence of 4-HO-MET, can lead to markedly more vivid visuals compared to using dissociatives alone. However, this combination may also intensify internal hallucinations, confusion, delusions, and the risk of a psychotic reaction.
MDMA:
Combining 4-HO-MET with MDMA results in an amplification of the physical and cognitive effects of both substances. This combination yields a unique and overwhelmingly euphoric experience, characterized by exceptionally pleasurable body sensations and mental states, as well as vivid and awe-inspiring visuals. The synergy between these substances can be unpredictable, so it’s advisable to start with lower doses than what one would take when using each substance separately.
Alcohol: While not generally recommended due to alcohol’s dehydrating effects, which can negatively impact a trip at high dosages, low doses of alcohol used responsibly can sometimes “take the edge off” a 4-HO-MET trip and reduce its psychedelic effects, somewhat akin to benzodiazepines, albeit with more physical stress on the body.
Benzodiazepines:
Combining benzodiazepines with 4-HO-MET can, depending on the dosage, slightly to significantly reduce the intensity of cognitive, physical, and visual effects during a 4-HO-MET trip. At higher doses, benzodiazepines can effectively halt “bad trips,” albeit at the cost of diminished trip intensity, and in extreme cases, memory loss and blackout. Caution is essential when considering benzodiazepines for this purpose, as they carry a high addiction potential. It is generally advised to avoid using them unless the trip becomes overwhelmingly distressing.
Toxicity
The toxicity and potential long-term health consequences associated with the recreational use of 4-HO-MET have not been systematically studied within the scientific community, and the precise toxic dose remains unknown. This knowledge gap exists because 4-HO-MET is categorized as a research chemical with minimal historical human usage. Nevertheless, there have been reports of high doses leading to drug-induced psychosis.
Anecdotal insights from individuals who have experimented with 4-HO-MET suggest that there have been no discernible adverse health effects when the substance is used on its own at low to moderate doses and when employed sparingly (although absolute assurance cannot be provided). It is imperative to emphasize the necessity of conducting independent research to ascertain the safety of combining two or more substances before consumption.
It is strongly recommended that individuals employ harm-reduction strategies when using this substance.
Tolerance
4-HO-MET is non-addictive, and the inclination to use it may diminish with continued use. It typically exhibits self-regulation.
Tolerance to the effects of 4-HO-MET develops almost immediately after ingestion. Subsequently, it takes approximately three days for the tolerance to decrease by half and about seven days to return to baseline (without further consumption). Notably, 4-HO-MET induces cross-tolerance with all psychedelics, meaning that after its consumption, the effectiveness of all other psychedelics will be diminished.
Hazardous Interactions Warning:
Many psychoactive substances that are reasonably safe when used individually can suddenly become dangerous and potentially life-threatening when combined with specific other substances. The following list outlines some known dangerous interactions (though they may not encompass all).
It is imperative to conduct thorough independent research (e.g., using search engines and medical databases like PubMed) to ensure the safety of consuming a combination of two or more substances. Some of the interactions mentioned here have been sourced from TripSit.
Lithium:
Lithium is frequently prescribed for the management of bipolar disorder. There is substantial anecdotal evidence suggesting that when taken with psychedelics, it significantly elevates the risk of psychosis and seizures. Consequently, this combination is strongly discouraged.
Cannabis:
The synergy between cannabis and the effects of 4-HO-MET can be unexpectedly potent and unpredictable. Caution is advised, as this combination may significantly heighten the risk of adverse psychological reactions, such as anxiety, paranoia, panic attacks, and even psychosis. Users should start with a fraction of their typical cannabis dose and take extended breaks between hits to minimize the risk of unintended overdose.
Stimulants:
Stimulants like amphetamine, cocaine, or methylphenidate affect multiple brain regions and alter dopaminergic function. Combining these with 4-HO-MET can increase the likelihood of experiencing anxiety, paranoia, panic attacks, and thought loops. Furthermore, this interaction may elevate the risk of mania and psychosis.
Tramadol:
Tramadol is well-documented to lower the seizure threshold, and psychedelics may trigger seizures in susceptible individuals. Therefore, combining tramadol with psychedelics should be approached with caution.
Legal Status Austria:
The possession, production, and sale of 4-HO-MET are illegal in Austria under the Neue-Psychoaktive-Substanzen-Gesetz Österreich (NPSG)
Canada:
4-HO-MET is not subject to scheduling in Canada.
Germany:
4-HO-MET is regulated under the New Psychoactive Substances Act (NpSG) as of July 18, 2019. Offenses related to its production, import with the intent to distribute, administration to others, and trading are punishable by law. Possession is illegal but not subject to penalties. The legislature also considers that orders of 4-HO-MET may be punishable as incitement to distribute it [citation needed].
Japan:
4-HO-MET is a controlled substance in Japan, effective as of March 2525, 2015.
Poland:
4-HO-MET is illegal to possess, manufacture, and sell under “Wykaz środków odurzających i substancji psychotropowych” (Group I-P).
Sweden:
4-HO-MET was classified as a Schedule I narcotic in Sweden as of May 1, 2012, falling under the category of substances, plant materials, and fungi that typically lack medical use.
Switzerland:
4-HO-MET is a controlled substance listed explicitly under Verzeichnis E.
United Kingdom:
4-HO-MET is categorized as a Class A drug in the United Kingdom due to the inclusion of the tryptamine catch-all clause.
United States:
4-HO-MET remains unscheduled in the United States. However, it may be considered an analog of psilocin (4-HO-DMT), a Schedule I substance under the Controlled Substances Act. Consequently, the sale for human consumption or illicit non-medical or industrial use could be prosecuted as an offense under the Federal Analogue Act.
FAQ
1. What is 4-HO-MET?
- 4-HO-MET, or metocin or “color,” is a synthetic psychedelic substance. It belongs to the tryptamine class of compounds and is structurally related to psilocin, the active compound in magic mushrooms.
2. How does 4-HO-MET work?
- 4-HO-MET primarily acts as a serotonergic psychedelic, affecting the serotonin receptors in the brain. It is believed to induce altered states of consciousness and visual hallucinations.
3. Is 4-HO-MET legal?
- The legal status of 4-HO-MET varies by country and jurisdiction. It may be considered a controlled substance in some places, while in others, it may not be explicitly regulated. Always check your local laws and regulations before considering its purchase or use.
4. What are the effects of 4-HO-MET?
- 4-HO-MET is known for producing psychedelic effects, such as visual distortions, mood enhancement, altered perception of time, and increased introspection. It often results in a relatively gentle and colorful trip compared to other psychedelics.
5. Is 4-HO-MET safe to use?
- While 4-HO-MET generally has a favorable safety profile, it can still pose risks. Like all psychedelics, it should be used responsibly and in a safe environment. Individuals with a history of mental health issues or those taking medications should exercise caution or avoid their use altogether.
6. Where can I get 4-HO-MET?
- 4-HO-MET may be available from various online sources and research chemical vendors. However, purchasing from reputable and trusted suppliers is crucial to ensure product quality and purity.
7. Are there any known side effects of 4-HO-MET?
- Common side effects may include nausea, anxiety, and confusion during the trip. In rare cases, individuals may experience more severe psychological distress or panic attacks. It’s essential to have a sober and experienced trip sitter if you choose to use 4-HO-MET.
8. Can 4-HO-MET be detected in drug tests?
- Standard drug tests do not typically screen for 4-HO-MET. However, specialized tests may be able to detect its presence. Always be aware of the potential legal and employment consequences of consuming such substances.
9. Is there any legitimate research on 4-HO-MET?
- Scientific research on 4-HO-MET is limited compared to more established psychedelics like psilocybin or LSD. However, some studies and reports have explored its effects and potential therapeutic applications.
10. What precautions should I take when using 4-HO-MET?
If you decide to use 4-HO-MET, it is crucial to do so in a safe and controlled environment, with a trusted and sober trip sitter if possible. Start with a low dose, be aware of your mental state, and have access to appropriate resources in case of emergencies. Always prioritize your physical and mental well-being.
References
- “4-HO-MET”. The Vaults of Erowid. Erowid. August 18, 2011. Retrieved August 27, 2020.
- ↑ Shulgin, Alexander; Shulgin, Ann (1997). “#21. 4-HO-MET”. TiHKAL: The Continuation. United States: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
- ↑ Rickli, A.; Moning, O.D.; Hoener, M. C.; Liechti, M. E. (2016). “Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens”. 26 (8): 1327–1337doi=10.1016/j.euroneuro.2016.05.001. ISSN 0924-977X. OCLC 795935172. PMID 27216487.
- ↑ “4-HO-MET: Dose”. The Vaults of Erowid. Erowid. August 18, 2011. Retrieved August 27, 2020.
- ↑ Täljemark, J.; Johansson, B. A. (2012). “Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET”. European Child & Adolescent Psychiatry. 21 (9): 527–528. doi:10.1007/s00787-012-0282-9. eISSN 1435-165X. ISSN 1018-8827. OCLC 26585556. PMID 22580963.
- ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). “Dose-independent occurrence of seizure with tramadol”. Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039.
- ↑ “Anlage NpSG” (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019.
- ↑ “Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes” (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. ISSN 0341-1095.
- ↑ “§ 4 NpSG” (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019.
- ↑ “§ 3 NpSG” (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019.
- ↑ “Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe” (PDF) (in German). Deutscher Bundestag. May 30, 2016. p. 20. Drucksache 18/8579.
- ↑ “危険ドラッグの成分１６物質を新たに指定薬物に指定” (in Japanese). 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)]. Retrieved May 2, 2022.
- ↑ Wykaz środków odurzających i substancji psychotropowych (in Polish), 2022
- ↑ “Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika” (PDF) (in Swedish). Läkemedelsverket [Medical Products Agency ] (published April 30, 2012). April 20, 2012. ISSN 1101-5225. LVFS 2012:6. Archived from the original (PDF) on October 31, 2018.
- ↑ “Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien” (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020.
- ↑ “Schedule 2: Part I: Class A Drugs”. “Misuse of Drugs Act 1971”. UK Government. Retrieved August 20, 2020.