Ephenidine, also recognized under the aliases NEDPA and EPE, is categorized as a dissociative anaesthetic with a history of availability as a designer drug via online markets. While its legality status varies globally, certain nations have prohibited it due to its structural resemblance to the banned opioid, lefetamine. Nevertheless, Ephenidine continues to be commercially available in regions where it remains legal.
|CAS Number||60951-19-1HCl: 6272-97-5|
|PubChem CID||110821HCl: 110820|
|Chemical and physical data|
|Molar mass||225.335 g·mol−1|
Ephedrine and its related diarylethylamines have been subject to in vitro research aimed at evaluating their potential as treatments for neurotoxic injuries. They exhibit antagonistic properties towards the NMDA receptor, with ephedrine displaying a binding affinity (Ki = 66.4 nM). Furthermore, ephedrine demonstrates lesser affinities for dopamine and norepinephrine transporters, measuring 379 nM and 841 nM, respectively. It also interacts with σ1R (629 nM) and σ2R (722 nM) binding sites.
The metabolic transformation of phenetidine follows a specific pathway. This process includes N-oxidation, N-dealkylation, mono- and bis-hydroxylation of the benzene ring, and hydroxylation of the phenyl ring, occurring only after N-dealkylation. Dihydroxy metabolites are further modified through methylation of one hydroxy group, while hydroxy metabolites undergo conjugation via glucuronidation or sulfation.
|Marquis||Orange > Brown|
|Liebermann||Deep red > Brown (fast)|
Society and culture
On June 1, 2015, a recommendation was made to classify ephenidine as a controlled substance, leading to its official scheduling in Sweden on August 18, 2015. In Canada, both MT-45 and its analogues were designated as Schedule I controlled substances. Unauthorized possession of these substances can result in a maximum prison sentence of 7 years. Additionally, in May 2016, Health Canada made amendments to the Food and Drug Regulations to categorize AH-7921 as a restricted drug. This means that only individuals associated with law enforcement agencies, those holding an exemption permit, or institutions with authorization from the Minister are permitted to possess this particular drug.
- What is Ephenidine?
- Ephenidine is a dissociative anaesthetic and research chemical that has been marketed as a designer drug. Various aliases, including NEDPA and EPE, know it.
- Is Ephenidine Legal?
- The legality of Ephenidine varies from country to country. In some nations, it is illegal due to its structural similarity to banned substances, while in others, it remains unregulated. Always check your local laws and regulations before considering its use.
- How is Ephenidine Typically Used?
- Ephenidine is primarily used for research purposes in laboratory settings. It is not intended for human or animal consumption, and its effects on the human body are not well understood.
- What are the Pharmacological Effects of Ephenidine?
- Ephedrine is known to act as an antagonist of the NMDA receptor. It also displays some affinity for other receptors, such as dopamine and norepinephrine transporters, as well as σ1R and σ2R binding sites. However, its exact effects on these receptors are still being studied.
- Are There Any Known Side Effects or Risks?
- Due to the limited research on Ephenidine, its potential side effects and risks need to be well-documented. Its use may carry health and safety risks, and it is strongly advised to exercise caution and avoid its consumption.
- Can I Use Ephenidine for Recreational Purposes?
- Using Ephenidine for recreational purposes is strongly discouraged. It is not a regulated pharmaceutical or recreational substance, and the risks associated with its use are not well understood.
- Where Can I Buy Ephenidine?
- The availability of Ephenidine varies by region and is subject to legal restrictions. It is important to note that the online sale of designer drugs may be illegal in many places.
- Is Ephenidine Addictive?
- The addictive potential of Ephenidine is not well-known due to limited research. However, like many dissociative substances, it may carry the risk of psychological dependence.
- Is Ephenidine Safe for Human Consumption?
- Ephenidine is not intended for human consumption, and its safety for such use has not been established. Using unregulated research chemicals for human consumption can be extremely dangerous.
- Where Can I Find More Information About Ephenidine?
- If you require additional information about Ephenidine or its research applications, consult with academic and scientific sources or contact appropriate regulatory agencies to understand the legal status in your area. Always prioritize safety and compliance with local laws and regulations.
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