Methoxypiperamide, often referred to as MeOP or MEXP, is a psychoactive substance belonging to the piperazine class and has been available for purchase on the internet as a designer drug. It serves as the 4-methoxy-α-keto analog of methylbenzylpiperazine.

Information about the pharmacology and potential toxicity of methoxypiperamide is quite limited. Nevertheless, the state of Vermont in the United States has categorized it as a hallucinogenic substance.

IUPAC name
CAS Number67023-02-3
PubChem CID805654
Chemical and physical data
Molar mass234.299 g·mol−1

Legal status

As of January 2016, Methoxypiperamide is classified as a controlled substance in Vermont, and it is similarly regulated in Hungary.


  • What is Methoxypiperamide (MeOP or MEXP)?Methoxypiperamide is a psychoactive drug belonging to the piperazine class. It is sometimes marketed and sold as a designer drug.
  • How does Methoxypiperamide differ from other piperazine compounds?Methoxypiperamide is the 4-methoxy-α-keto analog of methylbenzylpiperazine. This structural distinction sets it apart from other piperazine derivatives.
  • Is Methoxypiperamide legal?The legal status of Methoxypiperamide varies by location. It is classified as a controlled substance in certain areas, such as Vermont and Hungary. Make sure to check the specific regulations in your region.
  • What are the pharmacological effects of Methoxypiperamide?Currently, there is very limited information available regarding the pharmacology and toxicity of Methoxypiperamide. Research on its effects is quite scarce.
  • Is Methoxypiperamide safe to use?Due to the lack of comprehensive data on its pharmacology and potential risks, the safety of Methoxypiperamide is uncertain. It is advisable to exercise caution and avoid its use, especially given its legal restrictions in some areas.
  • Where can I find more information about Methoxypiperamide?For the most up-to-date and accurate information about Methoxypiperamide, refer to your local drug enforcement agency or consult medical professionals. Keep in mind that staying informed about the legal status and potential risks is essential when considering any substance use.


  1. Power JD, Scott KR, Gardner EA, Curran McAteer BM, O’Brien JE, Brehon M, Talbot B, Kavanagh PV (January 2014). “Research on the syntheses, characterization, and in vitro metabolism of nitracaine, methoxypiperamide, and mephtetramine.” This study was published in Drug Testing and Analysis, offering insights into the properties and metabolic behavior of these substances.
  2. Markus R. Meyer; Anna Holderbaum; Pierce Kavanagh; Hans H. Maurer (October 2015). “Exploring the use of low resolution and high-resolution mass spectrometry in studying the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP).” This research, published in the Journal of Mass Spectrometry, delves into the analytical techniques employed to understand the metabolism and toxicological implications of MeOP.
  3. “Regulated Drugs Rule” (PDF). Vermont Department of Health. Retrieved 14 October 2015. This document outlines the regulatory framework for controlled substances in Vermont, including Methoxypiperamide.
  4. “A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása.” This statement concerns the classification of controlled substances in Hungary, including those reported to the European Monitoring Centre for Drugs and Drug Addiction’s Early Warning System (EMCDDA EWS) since 2005.

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