Methylbenzylpiperazine

Summary

Methylbenzylpiperazine (MBZP), also known as 1-methyl-4-benzylpiperazine, is a stimulant drug that originates from the benzylpiperazine family. This substance gained popularity as an ingredient in legal recreational substances commonly referred to as “party pills.” These party pills were initially introduced in New Zealand and later became available in various countries worldwide.
MBZP produces effects akin to those of benzylpiperazine (BZP), though with a slightly milder stimulant impact and a reduced propensity for inducing adverse effects like headaches and nausea.
In New Zealand, following the recommendations of the EACD (Expert Advisory Committee on Drugs), the government passed legislation placing BZP, along with other piperazine derivatives like TFMPP, mCPP, pFPP, MeOPP, and MBZP, under Class C of the New Zealand Misuse of Drugs Act 1975. Although the ban was initially slated for December 18, 2007, it wasn’t enacted until the following year, ultimately making the sale of BZP and the listed piperazines illegal in New Zealand as of April 1, 2008. An amnesty for possession and use of these substances persisted until October 2008, when they were entirely prohibited.
In the United Kingdom, MBZP is categorized as a Class C drug.
In Canada, as of January 2015, MBZP remains unregulated and unscheduled. It lacks approval for any medical use but can be legally obtained as a research chemical. MBZP bears a chemical likeness to the controlled Schedule III substance BZP. Still, BZP’s scheduling status affords protection to most of its close analogs from the stringent regulations governing analog imports in Canada, which mainly apply to Schedule I compounds under CDSA (Controlled Drugs and Substances Act) regulations. Schedule I comprises both explicitly illegal substances and legal drugs with a high potential for abuse and dependency, most of which are listed as US Schedule II drugs in the United States.
Notably, Canada classifies stimulants commonly used in the treatment of conditions such as ADHD and narcolepsy under Schedule III to avoid the administrative complexities associated with dispensing Schedule I substances. This situation encourages healthcare providers to prescribe the most appropriate treatments without fear of legal complications or burdensome record-keeping unrelated to patient care. BZP, while not having an abuse profile comparable to drugs used in ADHD treatment, was still considered a significant concern and was thus placed under Schedule III, enabling Health Canada to suspend its sale. However, this regulation did not extend to its less potent derivatives, including MBZP, which remains unregulated in Canada as of 2015.

Identifiers
IUPAC name
CAS Number62226-74-8 
PubChem CID763557
ChemSpider667589 
UNII4GD4YEE2WP
CompTox Dashboard (EPA)DTXSID90354100
ECHA InfoCard100.133.648
Chemical and physical data
FormulaC12H18N2
Molar mass190.290 g·mol−1

FAq

  • What is Methylbenzylpiperazine (MBZP)?
  • Methylbenzylpiperazine, also known as MBZP, is a stimulant drug that belongs to the benzylpiperazine family of compounds. It has been used in the production of legal recreational drugs and “party pills.”
  • How does MBZP work?
  • MBZP functions as a stimulant, affecting the central nervous system. Its mode of action is similar to other substances like amphetamines, causing an increase in energy and alertness.
  • What are the effects of MBZP?
  • The effects of MBZP are comparable to those of benzylpiperazine (BZP) but with a slightly milder stimulant effect. Users may experience increased energy, alertness, and sociability.
  • Are there any side effects of MBZP?
  • While MBZP is considered to have a milder side effect profile compared to BZP, some users have reported side effects like headaches and nausea. The severity of side effects can vary from person to person.
  • Is MBZP legal?
  • The legal status of MBZP varies by country. In some regions, it may be categorized as a controlled substance, while in others, it might be available as a research chemical or in specific legal formulations like party pills.
  • What is the status of MBZP in New Zealand?
  • In New Zealand, MBZP, along with other piperazine derivatives, was classified under Class C of the Misuse of Drugs Act 1975. Sales of these substances were initially banned in 2008 after a period of amnesty for possession and usage.
  • Is MBZP regulated in the United Kingdom?
  • Yes, MBZP is classified as a Class C drug in the United Kingdom, making its possession and distribution subject to legal restrictions.
  • What is the legal status of MBZP in Canada?
  • As of January 2015, MBZP remained unscheduled and unregulated in Canada. It is not approved for any medical use but is legally available as a research chemical.
  • Is MBZP related to other substances?
  • MBZP is chemically related to benzylpiperazine (BZP) and belongs to the piperazine family of compounds. It shares similarities with BZP but is considered less potent.
  • Is MBZP used for any medical purposes?
  • MBZP is not approved for medical use, and its use is primarily associated with recreational or research purposes.

References

  1. Polish Legislation Update: The legal amendment titled “Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )” pertains to changes in the existing law on combating drug addiction. This amendment was published in the official journal “Dziennik Ustaw” in 2011, issue number 105, page 614.
  2. Online Legal Documentation: This information was documented in the Internetowy System Aktów Prawnych (Internet System of Legal Acts). The original publication date was on June 27, 2012.
  3. Retrieval Date: The data cited here was retrieved on June 17, 2011, reflecting the status of the legal provisions at that time.
  4. Bill Amendment for BZP Classification: Additionally, the “Misuse of Drugs (Classification of BZP) Amendment Bill 2008” is noteworthy. This bill was introduced to address the classification and regulation of substances like BZP (Benzylpiperazine) and may have impacted the legal status of related compounds.

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